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Protein

Taste receptor type 2 member 31

Gene

TAS2R31

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 31
Short name:
T2R31
Alternative name(s):
Taste receptor type 2 member 44
Short name:
T2R44
Gene namesi
Name:TAS2R31
Synonyms:TAS2R44
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2ExtracellularSequence analysis2
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini24 – 55CytoplasmicSequence analysisAdd BLAST32
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 100ExtracellularSequence analysisAdd BLAST24
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 126CytoplasmicSequence analysis5
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 181ExtracellularSequence analysisAdd BLAST34
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 229CytoplasmicSequence analysisAdd BLAST27
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 259ExtracellularSequence analysis9
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 309CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000823081 – 309Taste receptor type 2 member 31Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ645Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ645Z6.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q645Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFIPIIFS SLVMVMFVTG NFANGFIALV NSIESVKRQK ISYADQILTA
60 70 80 90 100
LAVSRIGLLW VLLLNWYSTV LNPAFYSVEV RTTAYNVWAV TGHFSNWLAT
110 120 130 140 150
SLSIFYLLKI ANFSNLIFLH LKRRVKSVIL VMLLGPLLFL ACQLFVINMK
160 170 180 190 200
EIVQTKEYEG NXTWKIKLRS AVYLSDATVT TLGNLVPFTL TLLCFLLLIC
210 220 230 240 250
SLCKHLKKMQ LHGKGSQDPS MKVHIKALQT VTSFLLLCAI YFLSIMISVW
260 270 280 290 300
SLGSLKNKPV FMFCKAMRFS YPSIHPFILI WGNKKLKQTF LSVLQQVRYW

VKGEKPSSP
Length:309
Mass (Da):35,154
Last modified:October 25, 2004 - v1
Checksum:iAF10E3CE75BD6AC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724912 Genomic DNA. Translation: AAU21123.1.

Similar proteinsi

Entry informationi

Entry nameiT2R31_GORGO
AccessioniPrimary (citable) accession number: Q645Z6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 25, 2004
Last modified: May 10, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families