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Protein

Taste receptor type 2 member 10

Gene

TAS2R10

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 10
Short name:
T2R10
Gene namesi
Name:TAS2R10
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini28 – 42CytoplasmicSequence analysisAdd BLAST15
Transmembranei43 – 63Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini64 – 100ExtracellularSequence analysisAdd BLAST37
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 126CytoplasmicSequence analysis5
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 179ExtracellularSequence analysisAdd BLAST32
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 227CytoplasmicSequence analysisAdd BLAST27
Transmembranei228 – 248Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini249 – 257ExtracellularSequence analysis9
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 307CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822371 – 307Taste receptor type 2 member 10Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ645Z4.

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000009834.

Structurei

3D structure databases

ProteinModelPortaliQ645Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG060698.
InParanoidiQ645Z4.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q645Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRVVEGIFI FVVISEXVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL
60 70 80 90 100
AISRIFLIWI IITDGFIQIF SPDIYASGNL IEYISYFWVI GNQSSMWFAT
110 120 130 140 150
SLSIFYFLKI ANFSNYIFLW LKSRTNMVLP FMIVFLLISS LLNFAHIAKI
160 170 180 190 200
LNDYKMKNDT VWDLNMYKSE YFIKQILLNL GVIFFFTLSL ITCVFLIISL
210 220 230 240 250
WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFXILFILYF IGMAIEISCF
260 270 280 290 300
TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK

RKNLRVT
Length:307
Mass (Da):35,393
Last modified:October 25, 2004 - v1
Checksum:i78E13B4A5349D0C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724915 Genomic DNA. Translation: AAU21125.1.

Similar proteinsi

Entry informationi

Entry nameiT2R10_GORGO
AccessioniPrimary (citable) accession number: Q645Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 25, 2004
Last modified: July 5, 2017
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families