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Protein

Taste receptor type 2 member 13

Gene

TAS2R13

Organism
Pongo pygmaeus (Bornean orangutan)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 13
Short name:
T2R13
Gene namesi
Name:TAS2R13
OrganismiPongo pygmaeus (Bornean orangutan)
Taxonomic identifieri9600 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 55CytoplasmicSequence analysisAdd BLAST27
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 85ExtracellularSequence analysis9
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 128CytoplasmicSequence analysisAdd BLAST22
Transmembranei129 – 149Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini150 – 184ExtracellularSequence analysisAdd BLAST35
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 232CytoplasmicSequence analysisAdd BLAST27
Transmembranei233 – 253Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini254 – 261ExtracellularSequence analysis8
Transmembranei262 – 282Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini283 – 303CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822511 – 303Taste receptor type 2 member 13Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ645V1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234595.
HOVERGENiHBG060698.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q645V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESALPSILT LVIIAEFIIG NLSNGFIVLI NYIDWVSKRE LSSVDKLLII
60 70 80 90 100
LAISRIGLIW EILVSWFLAL HYLAIFVSGT GLRIMIFSWI VSNHFSLWLA
110 120 130 140 150
TILSIFYLLK IASFSSPAFL YLKWRVNKVI LMILLGSLVF LFLNLIQINI
160 170 180 190 200
HIKDWLDRYE GNTTWNFSMS DFVTFSVSVK FTMTMFSLTP FTVALISFSL
210 220 230 240 250
LIFSLQKHLQ KMQLNYKGHR EPRTKVHTNA LKIVISFLLL YASFFLCILI
260 270 280 290 300
SWISELYQNT AIYMLCETIG LFYPSSHSFL LILGNPKLRQ AFLLVAAKVW

AKR
Length:303
Mass (Da):34,944
Last modified:October 25, 2004 - v1
Checksum:i814B9BA3CE9632FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724976 Genomic DNA. Translation: AAU21168.1.

Similar proteinsi

Entry informationi

Entry nameiT2R13_PONPY
AccessioniPrimary (citable) accession number: Q645V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: May 10, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families