Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Taste receptor type 2 member 16

Gene

TAS2R16

Organism
Pongo pygmaeus (Bornean orangutan)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May function as a bitter taste receptor for the phytonutrient beta glucopyranosides, some of which are toxic and some of which lower the risk of cancer and cardiovascular disease. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 16
Short name:
T2R16
Gene namesi
Name:TAS2R16
OrganismiPongo pygmaeus (Bornean orangutan)
Taxonomic identifieri9600 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePongo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1ExtracellularSequence analysis1
Transmembranei2 – 22Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini23 – 41CytoplasmicSequence analysisAdd BLAST19
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 125CytoplasmicSequence analysisAdd BLAST20
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 182ExtracellularSequence analysisAdd BLAST36
Transmembranei183 – 203Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini204 – 228CytoplasmicSequence analysisAdd BLAST25
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 257ExtracellularSequence analysis8
Transmembranei258 – 278Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini279 – 291CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822661 – 291Taste receptor type 2 member 16Add BLAST291

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with RTP3 and RTP4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ645U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000234595.
HOVERGENiHBG098568.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q645U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPIQLTVFF MIIYVLESLT IIVQSSLIVA VLGREWLQVR RLMPVDMILI
60 70 80 90 100
SLGISRFCLQ WASMLNNFCS YLNLNYVLCN LTITWEFFNI LTFWLNSLLT
110 120 130 140 150
VFYCIKVSSF THHIFLWVRW RILRWFPWIL LGSLTIACVT IIPSAIGNYI
160 170 180 190 200
QIQLLTMEHL PRNSTVTDRL EKFHQYQFQS HTVALVIPFI LFLASTILLM
210 220 230 240 250
ASLTKQIQHH STGHCNPSMK AHFTALRSLA ILFIVFTSYF LIILITIIGT
260 270 280 290
LFDKRCWLWV WEAFVYAFIL MHSTSLMLSS PTLKRILKGK C
Length:291
Mass (Da):33,982
Last modified:October 25, 2004 - v1
Checksum:iC59F0E3DD289AE78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY724993 Genomic DNA. Translation: AAU21178.1.

Similar proteinsi

Entry informationi

Entry nameiT2R16_PONPY
AccessioniPrimary (citable) accession number: Q645U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: May 10, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families