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Protein

Taste receptor type 2 member 14

Gene

TAS2R14

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 14
Short name:
T2R14
Gene namesi
Name:TAS2R14
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 55CytoplasmicSequence analysisAdd BLAST27
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 87ExtracellularSequence analysisAdd BLAST11
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 129CytoplasmicSequence analysisAdd BLAST21
Transmembranei130 – 150Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini151 – 184ExtracellularSequence analysisAdd BLAST34
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 233CytoplasmicSequence analysisAdd BLAST28
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 263ExtracellularSequence analysis9
Transmembranei264 – 284Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini285 – 319CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822561 – 319Taste receptor type 2 member 14Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ645T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9F7. Eukaryota.
ENOG4111BEG. LUCA.
HOGENOMiHOG000234595.
HOVERGENiHBG060698.
InParanoidiQ645T2.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q645T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGVIKSIFT FILIVEFIIG NLGNSFIVLV NCIDWVKRRK ISLVDQILIA
60 70 80 90 100
LAISRISLVW SIFGSWCVSV FFPALFATEK LLRMLTNIWT VTNHFSVWLA
110 120 130 140 150
TILGTFYFLK IANFSNSIFL YLKWRVKKVV LVLLLVTLGL LFLNILLINI
160 170 180 190 200
HINASINGYR GNMTCSSASC NFIRFSRAIA LTSTVFVLIP FTLSLATSLL
210 220 230 240 250
LSFSLWKHHK KMQHTVKGYR DVSTKAHRGV MQTVITFLLL YAVFLLTFFI
260 270 280 290 300
SIWASVRLKE NQIIILSEMM GLAYPSGHSC VLILGNKKLR QASLSVLWWL
310
RYRFKHGEPS GHKEFRESS
Length:319
Mass (Da):36,468
Last modified:October 25, 2004 - v1
Checksum:i7EA3750E18F3C8F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725008 Genomic DNA. Translation: AAU21187.1.

Similar proteinsi

Entry informationi

Entry nameiT2R14_MACMU
AccessioniPrimary (citable) accession number: Q645T2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: July 5, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families