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Protein

Taste receptor type 2 member 39

Gene

TAS2R39

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity).By similarity

Miscellaneous

Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processSensory transduction, Taste

Names & Taxonomyi

Protein namesi
Recommended name:
Taste receptor type 2 member 39
Short name:
T2R39
Gene namesi
Name:TAS2R39
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 74CytoplasmicSequence analysisAdd BLAST23
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 116ExtracellularSequence analysisAdd BLAST21
Transmembranei117 – 137Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini138 – 156CytoplasmicSequence analysisAdd BLAST19
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 205ExtracellularSequence analysisAdd BLAST28
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 262CytoplasmicSequence analysisAdd BLAST36
Transmembranei263 – 283Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini284 – 291ExtracellularSequence analysis8
Transmembranei292 – 312Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini313 – 338CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000822821 – 338Taste receptor type 2 member 39Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ645S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG060698.
InParanoidiQ645S5.
KOiK08474.

Family and domain databases

InterProiView protein in InterPro
IPR007960. T2R.
PANTHERiPTHR11394. PTHR11394. 1 hit.
PfamiView protein in Pfam
PF05296. TAS2R. 1 hit.

Sequencei

Sequence statusi: Complete.

Q645S5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRCFPPNT KEKQQLRMIK LCDPAESELS PFLITLTLAV LLAEYLTGII
60 70 80 90 100
ANGFITAIHA AEWVQNKSVS TSGRILVFLS VSRIALQSLM MLEITISSTS
110 120 130 140 150
LSFYSEDAVY YAFKISFIFL NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL
160 170 180 190 200
RWRISGLIPW LLWLSVFISF SHSMFCINIC TGYCDNSFPI HSSNSTEKTY
210 220 230 240 250
FSEISVVSLA FFFNLGIVIP LIMFILAAIL LILSLKRHTL HMGSNATGSK
260 270 280 290 300
DPSMEAHIGA IKATSYFLIL YIFNAVALFI YLSNMFDINS LWNTLCQIIM
310 320 330
AAYPASHSIL LIKDNPGLRR AWKQLQHRLH LYPKQWTL
Length:338
Mass (Da):38,542
Last modified:October 25, 2004 - v1
Checksum:i283D77A7E6A14163
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY725016 Genomic DNA. Translation: AAU21194.1.
RefSeqiNP_001074232.1. NM_001080763.1.
UniGeneiMmu.16487.

Genome annotation databases

GeneIDi705958.
KEGGimcc:705958.

Similar proteinsi

Entry informationi

Entry nameiT2R39_MACMU
AccessioniPrimary (citable) accession number: Q645S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 25, 2004
Last modified: July 5, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families