Q645M6 (FADD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FADD

Alternative name(s):
FAS-associated death domain protein
FAS-associating death domain-containing protein

Gene names

Name:

FADD

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis By similarity. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling By similarity.
Subunit structure	Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with LRDD By similarity. Interacts with FAS By similarity.
Domain	Contains a death domain involved in the binding of the corresponding domain within Fas receptor By similarity.
Post-translational modification	Phosphorylated By similarity.
Sequence similarities	Contains 1 death domain. Contains 1 DED (death effector) domain.

Ontologies

Keywords
Biological process	Apoptosis Immunity Innate immunity
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Protein FADD		PRO_0000281928
Regions
	Domain	3 – 81	79	DED
	Domain	97 – 181	85	Death
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity
	Modified residue	41	1	Phosphoserine By similarity
	Modified residue	195	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q645M6 [UniParc]. Last modified October 25, 2004. Version 1. Checksum: 2EB6BA41F6DB0F9D	FASTA	209	23,002
	10 20 30 40 50 60 MDPFLVLLHS VSAGLSSSDL TQLKFLCQNH ISKRKLELAQ SGLDLFTVLL QQNELNAEHT 70 80 90 100 110 120 ALLRELLCSL RRKDLLLRLD DFERGAAGGA APEDRDLRAA MEIICDNVGK DWRRLARHLG 130 140 150 160 170 180 VSDVKIEAIE EKYPRNLAEQ VRELLRVWKN STRENAAVSC LVGALRGCQL NVVADLIEED 190 200 QRARALQSGS ANPGSFTAWD SGSAAPGAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of bovine FAS-associated death domain gene." Szperka M.E., Connor E.E., Paape M.J., Williams J.L., Bannerman D.D. Anim. Genet. 36:63-66(2005) [PubMed: 15670133] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal medulla.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY725483 mRNA. Translation: AAU20801.1. BC120180 mRNA. Translation: AAI20181.1.
IPI	IPI00702752.
RefSeq	NP_001007817.1. NM_001007816.1.
UniGene	Bt.88785.
3D structure databases
HSSP	HSSP built from PDB template 1A1Z based on UniProtKB Q13158.
ProteinModelPortal	Q645M6.
SMR	Q645M6. Positions 2-191.
ModBase	Search...
Protein-protein interaction databases
STRING	Q645M6.
Proteomic databases
PRIDE	Q645M6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000024322; ENSBTAP00000024322; ENSBTAG00000018274.
GeneID	493720.
KEGG	bta:493720.
Organism-specific databases
CTD	8772.
Phylogenomic databases
eggNOG	maNOG20397.
GeneTree	ENSGT00390000002105.
HOVERGEN	HBG000853.
InParanoid	Q645M6.
OMA	EQNDLEP.
OrthoDB	EOG4JHCH7.
Family and domain databases
InterPro	IPR000488. Death. IPR011029. DEATH-like. IPR001875. DED. IPR016729. FADD. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 2 hits.
KO	K02373.
Pfam	PF00531. Death. 1 hit. PF01335. DED. 1 hit. [Graphical view]
PIRSF	PIRSF018586. FADD. 1 hit.
SMART	SM00005. DEATH. 1 hit. SM00031. DED. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 2 hits.
PROSITE	PS50017. DEATH_DOMAIN. 1 hit. PS50168. DED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FADD_BOVIN

Accession

Primary (citable) accession number: Q645M6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	October 25, 2004
Last modified:	November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program