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Q64595 (KGP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
cGMP-dependent protein kinase 2
Short name=cGK 2
Short name=cGK2
EC=2.7.11.12
Alternative name(s):
cGMP-dependent protein kinase II
Short name=cGKII
Gene names
Name:Prkg2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length762 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Binding of cGMP results in enzyme activation.

Tissue specificity

Highly expressed in intestinal mucosa and is 20 times less abundant in brain and kidney.

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 762762cGMP-dependent protein kinase 2
PRO_0000086125

Regions

Domain453 – 711259Protein kinase
Domain712 – 76251AGC-kinase C-terminal
Nucleotide binding168 – 285118cGMP 1
Nucleotide binding286 – 417132cGMP 2
Nucleotide binding459 – 4679ATP By similarity

Sites

Active site5761Proton acceptor By similarity
Binding site4821ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64595 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F0DF4F7684675B38

FASTA76287,182
        10         20         30         40         50         60 
MGNGSVKPKH SKHPDGQSGN LSNEALRSKV AELEREVKRK DAELQEREYH LKELREQLAK 

        70         80         90        100        110        120 
QTVAIAELTE ELQSKCIQLN KLQDVIHVQG GSPLQASPDK VPLDVHRKTS GLVSLHSRRG 

       130        140        150        160        170        180 
AKAGVSAEPT SRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM 

       190        200        210        220        230        240 
VECMYGRNYQ QGSYIVKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC 

       250        260        270        280        290        300 
TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEEYRNF LRSVSLLKNL PEDKLTKIID 

       310        320        330        340        350        360 
CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL 

       370        380        390        400        410        420 
ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFDELQKY LEGYVATLNR DDEKRHAKRS 

       430        440        450        460        470        480 
MSSWKLSKAL SLEMIQLKEK VARFSSTSPF QNLEIIATLG VGGFGRVELV KVKNENIAFA 

       490        500        510        520        530        540 
MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS 

       550        560        570        580        590        600 
ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDADGYL KLVDFGFAKK 

       610        620        630        640        650        660 
IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGIDQMMTYN 

       670        680        690        700        710        720 
LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK 

       730        740        750        760 
ARSLPSPLRR ELSGPIDHSY FDKYPPEKGV PPDEMSGWDK DF

« Hide

References

[1]"Cloning, expression, and in situ localization of rat intestinal cGMP-dependent protein kinase II."
Jarchau T., Haeusler C., Markert T., Poehler D., Vandekerckhove J., de Jonge H.R., Lohmann S.M., Walter U.
Proc. Natl. Acad. Sci. U.S.A. 91:9426-9430(1994) [PubMed: 7937783] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Intestine.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z36276 mRNA. Translation: CAA85284.1.
IPIIPI00213665.
PIRI59329.
RefSeqNP_037144.1. NM_013012.1.
UniGeneRn.87721.

3D structure databases

ProteinModelPortalQ64595.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ64595.

PTM databases

PhosphoSiteQ64595.

Proteomic databases

PRIDEQ64595.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003237; ENSRNOP00000003237; ENSRNOG00000002361.
GeneID25523.
KEGGrno:25523.
NMPDRfig|10116.3.peg.10050.
UCSCNM_013012. rat.

Organism-specific databases

CTD5593.
RGD3401. Prkg2.

Phylogenomic databases

eggNOGroNOG10582.
GeneTreeENSGT00550000074358.
HOVERGENHBG006211.
InParanoidQ64595.
OMATKQQEHI.
OrthoDBEOG4V6ZFZ.
PhylomeDBQ64595.

Enzyme and pathway databases

BRENDA2.7.11.12. 5301.

Gene expression databases

ArrayExpressQ64595.
GenevestigatorQ64595.
GermOnlineENSRNOG00000002361. Rattus norvegicus.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR016232. cGMP-dependent_protein_kinase.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR017442. Se/Thr_kinase-like_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR002290. Ser/Thr_kinase_dom.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.
KOK07376.
PfamPF00027. cNMP_binding. 2 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF000559. cGMP-dep_kinase. 1 hit.
PRINTSPR00104. CGMPKINASE.
SMARTSM00100. cNMP. 2 hits.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF51206. cNMP_binding. 2 hits.
SSF56112. Kinase_like. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio606995.

Entry information

Entry nameKGP2_RAT
AccessionPrimary (citable) accession number: Q64595
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 16, 2011
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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