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Protein

2,4-dienoyl-CoA reductase, mitochondrial

Gene

Decr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NADPBy similarity1
Binding sitei91SubstrateBy similarity1
Binding sitei117NADPBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1
Binding sitei157SubstrateBy similarity1
Active sitei199Proton acceptorSequence analysis1
Binding sitei214NADPBy similarity1
Binding sitei251SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 71NADPBy similarity6
Nucleotide bindingi240 – 243NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
2,4-dienoyl-CoA reductase, mitochondrial (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase [NADPH]
Short name:
4-enoyl-CoA reductase [NADPH]
Gene namesi
Name:Decr1
Synonyms:Decr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70999. Decr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000003196735 – 3352,4-dienoyl-CoA reductase, mitochondrialAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-acetyllysine; alternateBy similarity1
Modified residuei42N6-succinyllysine; alternateBy similarity1
Modified residuei49N6-acetyllysine; alternateBy similarity1
Modified residuei49N6-succinyllysine; alternateBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei73N6-succinyllysineBy similarity1
Modified residuei97N6-acetyllysine; alternateBy similarity1
Modified residuei97N6-succinyllysine; alternateBy similarity1
Modified residuei106N6-acetyllysine; alternateBy similarity1
Modified residuei106N6-succinyllysine; alternateBy similarity1
Modified residuei244N6-acetyllysine; alternateBy similarity1
Modified residuei244N6-succinyllysine; alternateBy similarity1
Modified residuei260N6-acetyllysine; alternateBy similarity1
Modified residuei260N6-succinyllysine; alternateBy similarity1
Modified residuei315N6-acetyllysineBy similarity1
Modified residuei319N6-acetyllysine; alternateBy similarity1
Modified residuei319N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ64591.
PRIDEiQ64591.

PTM databases

iPTMnetiQ64591.
PhosphoSitePlusiQ64591.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ64591. 1 interactor.
STRINGi10116.ENSRNOP00000011330.

Structurei

3D structure databases

ProteinModelPortaliQ64591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG005465.
InParanoidiQ64591.
KOiK13236.
PhylomeDBiQ64591.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLARAFFA GVSRLPCDPG PQRFFSFGTK TLYQSIDAPQ SKFFPPILKP
60 70 80 90 100
MLPPNAFQGK VAFITGGGTG LGKAMTTFLS SLGAQCVIAS RNIDVLKATA
110 120 130 140 150
EEITSKTGNK VYAIRCDVRD PDMVHNTVLE LIKVAGHPDV VINNAAGNFI
160 170 180 190 200
SPSERLSPNG WKTITDIVLN GTAYVTIEIG KQLIKAQKGA AFLAITTIYA
210 220 230 240 250
ESGSGFVMPS SSAKSGVEAM NKSLAAEWGR YGMRFNIIQP GPIKTKGAFS
260 270 280 290 300
RLDPTGKFEK DMIERIPCGR LGTVEELANL ATFLCSDYAS WINGAVIRFD
310 320 330
GGEEVFLSGE FNSLKKVTKE EWDVIEGLIR KTKGS
Length:335
Mass (Da):36,133
Last modified:June 7, 2005 - v2
Checksum:iC4386C65E49A4D2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11G → R in AAH59120 (PubMed:15489334).Curated1
Sequence conflicti23R → K in BAA00446 (PubMed:2383590).Curated1
Sequence conflicti79L → R in BAA00446 (PubMed:2383590).Curated1
Sequence conflicti162K → R in BAA00446 (PubMed:2383590).Curated1
Sequence conflicti190A → V in BAA00446 (PubMed:2383590).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00569 mRNA. Translation: BAA00446.1.
BC059120 mRNA. Translation: AAH59120.1.
PIRiS11021.
RefSeqiNP_476545.2. NM_057197.2.
UniGeneiRn.2854.

Genome annotation databases

GeneIDi117543.
KEGGirno:117543.
UCSCiRGD:70999. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00569 mRNA. Translation: BAA00446.1.
BC059120 mRNA. Translation: AAH59120.1.
PIRiS11021.
RefSeqiNP_476545.2. NM_057197.2.
UniGeneiRn.2854.

3D structure databases

ProteinModelPortaliQ64591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64591. 1 interactor.
STRINGi10116.ENSRNOP00000011330.

PTM databases

iPTMnetiQ64591.
PhosphoSitePlusiQ64591.

Proteomic databases

PaxDbiQ64591.
PRIDEiQ64591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117543.
KEGGirno:117543.
UCSCiRGD:70999. rat.

Organism-specific databases

CTDi1666.
RGDi70999. Decr1.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG005465.
InParanoidiQ64591.
KOiK13236.
PhylomeDBiQ64591.

Miscellaneous databases

PROiQ64591.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDECR_RAT
AccessioniPrimary (citable) accession number: Q64591
Secondary accession number(s): Q6PCV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 7, 2005
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.