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Protein

2,4-dienoyl-CoA reductase, mitochondrial

Gene

Decr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911NADPBy similarity
Binding sitei91 – 911SubstrateBy similarity
Binding sitei117 – 1171NADPBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei149 – 1491SubstrateBy similarity
Binding sitei157 – 1571SubstrateBy similarity
Active sitei199 – 1991Proton acceptorSequence analysis
Binding sitei214 – 2141NADPBy similarity
Binding sitei251 – 2511SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 716NADPBy similarity
Nucleotide bindingi240 – 2434NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
2,4-dienoyl-CoA reductase, mitochondrial (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase [NADPH]
Short name:
4-enoyl-CoA reductase [NADPH]
Gene namesi
Name:Decr1
Synonyms:Decr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70999. Decr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion1 PublicationAdd
BLAST
Chaini35 – 3353012,4-dienoyl-CoA reductase, mitochondrialPRO_0000031967Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421N6-acetyllysine; alternateBy similarity
Modified residuei42 – 421N6-succinyllysine; alternateBy similarity
Modified residuei49 – 491N6-acetyllysine; alternateBy similarity
Modified residuei49 – 491N6-succinyllysine; alternateBy similarity
Modified residuei69 – 691PhosphothreonineBy similarity
Modified residuei73 – 731N6-succinyllysineBy similarity
Modified residuei97 – 971N6-acetyllysine; alternateBy similarity
Modified residuei97 – 971N6-succinyllysine; alternateBy similarity
Modified residuei106 – 1061N6-acetyllysine; alternateBy similarity
Modified residuei106 – 1061N6-succinyllysine; alternateBy similarity
Modified residuei244 – 2441N6-acetyllysine; alternateBy similarity
Modified residuei244 – 2441N6-succinyllysine; alternateBy similarity
Modified residuei260 – 2601N6-acetyllysine; alternateBy similarity
Modified residuei260 – 2601N6-succinyllysine; alternateBy similarity
Modified residuei315 – 3151N6-acetyllysineBy similarity
Modified residuei319 – 3191N6-acetyllysine; alternateBy similarity
Modified residuei319 – 3191N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ64591.
PRIDEiQ64591.

PTM databases

iPTMnetiQ64591.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ64591. 1 interaction.
STRINGi10116.ENSRNOP00000011330.

Structurei

3D structure databases

ProteinModelPortaliQ64591.
SMRiQ64591. Positions 37-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG005465.
InParanoidiQ64591.
KOiK13236.
PhylomeDBiQ64591.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLARAFFA GVSRLPCDPG PQRFFSFGTK TLYQSIDAPQ SKFFPPILKP
60 70 80 90 100
MLPPNAFQGK VAFITGGGTG LGKAMTTFLS SLGAQCVIAS RNIDVLKATA
110 120 130 140 150
EEITSKTGNK VYAIRCDVRD PDMVHNTVLE LIKVAGHPDV VINNAAGNFI
160 170 180 190 200
SPSERLSPNG WKTITDIVLN GTAYVTIEIG KQLIKAQKGA AFLAITTIYA
210 220 230 240 250
ESGSGFVMPS SSAKSGVEAM NKSLAAEWGR YGMRFNIIQP GPIKTKGAFS
260 270 280 290 300
RLDPTGKFEK DMIERIPCGR LGTVEELANL ATFLCSDYAS WINGAVIRFD
310 320 330
GGEEVFLSGE FNSLKKVTKE EWDVIEGLIR KTKGS
Length:335
Mass (Da):36,133
Last modified:June 7, 2005 - v2
Checksum:iC4386C65E49A4D2F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111G → R in AAH59120 (PubMed:15489334).Curated
Sequence conflicti23 – 231R → K in BAA00446 (PubMed:2383590).Curated
Sequence conflicti79 – 791L → R in BAA00446 (PubMed:2383590).Curated
Sequence conflicti162 – 1621K → R in BAA00446 (PubMed:2383590).Curated
Sequence conflicti190 – 1901A → V in BAA00446 (PubMed:2383590).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00569 mRNA. Translation: BAA00446.1.
BC059120 mRNA. Translation: AAH59120.1.
PIRiS11021.
RefSeqiNP_476545.2. NM_057197.2.
UniGeneiRn.2854.

Genome annotation databases

GeneIDi117543.
KEGGirno:117543.
UCSCiRGD:70999. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00569 mRNA. Translation: BAA00446.1.
BC059120 mRNA. Translation: AAH59120.1.
PIRiS11021.
RefSeqiNP_476545.2. NM_057197.2.
UniGeneiRn.2854.

3D structure databases

ProteinModelPortaliQ64591.
SMRiQ64591. Positions 37-328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64591. 1 interaction.
STRINGi10116.ENSRNOP00000011330.

PTM databases

iPTMnetiQ64591.

Proteomic databases

PaxDbiQ64591.
PRIDEiQ64591.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117543.
KEGGirno:117543.
UCSCiRGD:70999. rat.

Organism-specific databases

CTDi1666.
RGDi70999. Decr1.

Phylogenomic databases

eggNOGiKOG0725. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG005465.
InParanoidiQ64591.
KOiK13236.
PhylomeDBiQ64591.

Miscellaneous databases

NextBioi620365.
PROiQ64591.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-53.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiDECR_RAT
AccessioniPrimary (citable) accession number: Q64591
Secondary accession number(s): Q6PCV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 7, 2005
Last modified: May 11, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.