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Protein

2,4-dienoyl-CoA reductase, mitochondrial

Gene

Decr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.

Catalytic activityi

Trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91NADPBy similarity1
Binding sitei91SubstrateBy similarity1
Binding sitei117NADPBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei149SubstrateBy similarity1
Binding sitei157SubstrateBy similarity1
Active sitei199Proton acceptorSequence analysis1
Binding sitei214NADPBy similarity1
Binding sitei251SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 71NADPBy similarity6
Nucleotide bindingi240 – 243NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
2,4-dienoyl-CoA reductase, mitochondrial (EC:1.3.1.34)
Alternative name(s):
2,4-dienoyl-CoA reductase [NADPH]
Short name:
4-enoyl-CoA reductase [NADPH]
Gene namesi
Name:Decr1
Synonyms:Decr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70999 Decr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000003196735 – 3352,4-dienoyl-CoA reductase, mitochondrialAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42N6-acetyllysine; alternateBy similarity1
Modified residuei42N6-succinyllysine; alternateBy similarity1
Modified residuei49N6-acetyllysine; alternateBy similarity1
Modified residuei49N6-succinyllysine; alternateBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei73N6-succinyllysineBy similarity1
Modified residuei97N6-acetyllysine; alternateBy similarity1
Modified residuei97N6-succinyllysine; alternateBy similarity1
Modified residuei106N6-acetyllysine; alternateBy similarity1
Modified residuei106N6-succinyllysine; alternateBy similarity1
Modified residuei244N6-acetyllysine; alternateBy similarity1
Modified residuei244N6-succinyllysine; alternateBy similarity1
Modified residuei260N6-acetyllysine; alternateBy similarity1
Modified residuei260N6-succinyllysine; alternateBy similarity1
Modified residuei315N6-acetyllysineBy similarity1
Modified residuei319N6-acetyllysine; alternateBy similarity1
Modified residuei319N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ64591
PRIDEiQ64591

PTM databases

iPTMnetiQ64591
PhosphoSitePlusiQ64591

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ64591, 1 interactor
STRINGi10116.ENSRNOP00000011330

Structurei

3D structure databases

ProteinModelPortaliQ64591
SMRiQ64591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0725 Eukaryota
COG1028 LUCA
HOVERGENiHBG005465
InParanoidiQ64591
KOiK13236
PhylomeDBiQ64591

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLARAFFA GVSRLPCDPG PQRFFSFGTK TLYQSIDAPQ SKFFPPILKP
60 70 80 90 100
MLPPNAFQGK VAFITGGGTG LGKAMTTFLS SLGAQCVIAS RNIDVLKATA
110 120 130 140 150
EEITSKTGNK VYAIRCDVRD PDMVHNTVLE LIKVAGHPDV VINNAAGNFI
160 170 180 190 200
SPSERLSPNG WKTITDIVLN GTAYVTIEIG KQLIKAQKGA AFLAITTIYA
210 220 230 240 250
ESGSGFVMPS SSAKSGVEAM NKSLAAEWGR YGMRFNIIQP GPIKTKGAFS
260 270 280 290 300
RLDPTGKFEK DMIERIPCGR LGTVEELANL ATFLCSDYAS WINGAVIRFD
310 320 330
GGEEVFLSGE FNSLKKVTKE EWDVIEGLIR KTKGS
Length:335
Mass (Da):36,133
Last modified:June 7, 2005 - v2
Checksum:iC4386C65E49A4D2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11G → R in AAH59120 (PubMed:15489334).Curated1
Sequence conflicti23R → K in BAA00446 (PubMed:2383590).Curated1
Sequence conflicti79L → R in BAA00446 (PubMed:2383590).Curated1
Sequence conflicti162K → R in BAA00446 (PubMed:2383590).Curated1
Sequence conflicti190A → V in BAA00446 (PubMed:2383590).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00569 mRNA Translation: BAA00446.1
BC059120 mRNA Translation: AAH59120.1
PIRiS11021
RefSeqiNP_476545.2, NM_057197.2
UniGeneiRn.2854

Genome annotation databases

GeneIDi117543
KEGGirno:117543
UCSCiRGD:70999 rat

Similar proteinsi

Entry informationi

Entry nameiDECR_RAT
AccessioniPrimary (citable) accession number: Q64591
Secondary accession number(s): Q6PCV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 7, 2005
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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