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Q64583 (CP2BF_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2B15

EC=1.14.14.1
Alternative name(s):
CYPIIB15
Gene names
Name:Cyp2b15
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Cytochrome P450 2B15
PRO_0000051688

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1291Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64583 [UniParc].

Last modified March 1, 2002. Version 2.
Checksum: 035C2E084E0B26C3

FASTA49556,320
        10         20         30         40         50         60 
MELGVLLLLT FTVGFLLLLA SQNRPKTHGH LPPGPRPLPF LGNLLQMNRR GLLRSFMQLQ 

        70         80         90        100        110        120 
EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG TVAVLHPVVQ GYGVIFANGE 

       130        140        150        160        170        180 
RWKILRRFSL VTMRNFGMGK RSVEERIKEE AQCLVEELKK YKGALLNPTS IFQSIAANII 

       190        200        210        220        230        240 
CSIVFGERFD YKDHQFLRLL DLIYQTFSLM GSLSSQVFEL FSGFLKYFPG VHKQISKNLQ 

       250        260        270        280        290        300 
EILNYIDHSV EKHRATLDPN TPRDFINTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFTG 

       310        320        330        340        350        360 
TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT DAVIHEIQRF 

       370        380        390        400        410        420 
ADLIPIGLPH RVTNDTMFLG YLLPKNTEVY PILSSALHDP RYFDHPDTFN PEHFLDVNGT 

       430        440        450        460        470        480 
LKKSEAFLPF STGKRICLGE GIAQNELFIF FTAILQNFSL ASPVAPEDID LSPINSGISK 

       490 
IPSPYQIHFL SRCVG 

« Hide

References

[1]"Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene."
Nakayama K., Suwa Y., Mizukami Y., Sogawa K., Fujii-Kuriyama Y.
Gene 136:333-336(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D17349 Genomic DNA. Translation: BAB72140.1.
PIRI53690.
I67791.
RefSeqNP_001129140.1. NM_001135668.1.
UniGeneRn.198140.

3D structure databases

ProteinModelPortalQ64583.
SMRQ64583. Positions 29-492.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ64583.
PRIDEQ64583.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID685222.
KEGGrno:685222.
UCSCRGD:620088. rat.

Organism-specific databases

CTD685222.
RGD620088. Cyp2b15.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidQ64583.
PhylomeDBQ64583.

Gene expression databases

GenevestigatorQ64583.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio729232.

Entry information

Entry nameCP2BF_RAT
AccessionPrimary (citable) accession number: Q64583
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families