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Q64583

- CP2BF_RAT

UniProt

Q64583 - CP2BF_RAT

Protein

Cytochrome P450 2B15

Gene

Cyp2b15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. arachidonic acid epoxygenase activity Source: RGD
    2. aromatase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. epoxygenase P450 pathway Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2B15 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIB15
    Gene namesi
    Name:Cyp2b15
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620088. Cyp2b15.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Cytochrome P450 2B15PRO_0000051688Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ64583.
    PRIDEiQ64583.

    Expressioni

    Gene expression databases

    GenevestigatoriQ64583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64583.
    SMRiQ64583. Positions 29-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiQ64583.
    PhylomeDBiQ64583.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64583-1 [UniParc]FASTAAdd to Basket

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    MELGVLLLLT FTVGFLLLLA SQNRPKTHGH LPPGPRPLPF LGNLLQMNRR    50
    GLLRSFMQLQ EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG 100
    TVAVLHPVVQ GYGVIFANGE RWKILRRFSL VTMRNFGMGK RSVEERIKEE 150
    AQCLVEELKK YKGALLNPTS IFQSIAANII CSIVFGERFD YKDHQFLRLL 200
    DLIYQTFSLM GSLSSQVFEL FSGFLKYFPG VHKQISKNLQ EILNYIDHSV 250
    EKHRATLDPN TPRDFINTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFTG 300
    TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT 350
    DAVIHEIQRF ADLIPIGLPH RVTNDTMFLG YLLPKNTEVY PILSSALHDP 400
    RYFDHPDTFN PEHFLDVNGT LKKSEAFLPF STGKRICLGE GIAQNELFIF 450
    FTAILQNFSL ASPVAPEDID LSPINSGISK IPSPYQIHFL SRCVG 495
    Length:495
    Mass (Da):56,320
    Last modified:March 1, 2002 - v2
    Checksum:i035C2E084E0B26C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17349 Genomic DNA. Translation: BAB72140.1.
    PIRiI53690.
    I67791.
    RefSeqiNP_001129140.1. NM_001135668.1.
    UniGeneiRn.198140.

    Genome annotation databases

    GeneIDi685222.
    KEGGirno:685222.
    UCSCiRGD:620088. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D17349 Genomic DNA. Translation: BAB72140.1 .
    PIRi I53690.
    I67791.
    RefSeqi NP_001129140.1. NM_001135668.1.
    UniGenei Rn.198140.

    3D structure databases

    ProteinModelPortali Q64583.
    SMRi Q64583. Positions 29-492.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q64583.
    PRIDEi Q64583.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 685222.
    KEGGi rno:685222.
    UCSCi RGD:620088. rat.

    Organism-specific databases

    CTDi 685222.
    RGDi 620088. Cyp2b15.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi Q64583.
    PhylomeDBi Q64583.

    Miscellaneous databases

    NextBioi 729232.

    Gene expression databases

    Genevestigatori Q64583.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene."
      Nakayama K., Suwa Y., Mizukami Y., Sogawa K., Fujii-Kuriyama Y.
      Gene 136:333-336(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiCP2BF_RAT
    AccessioniPrimary (citable) accession number: Q64583
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3