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Protein

Cytochrome P450 2B15

Gene

Cyp2b15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity).By similarity

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B15 (EC:1.14.14.1)
Alternative name(s):
CYPIIB15
Gene namesi
Name:Cyp2b15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620088. Cyp2b15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Cytochrome P450 2B15PRO_0000051688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64583.
PRIDEiQ64583.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002054.

Structurei

3D structure databases

ProteinModelPortaliQ64583.
SMRiQ64583. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ64583.
KOiK07412.
PhylomeDBiQ64583.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGVLLLLT FTVGFLLLLA SQNRPKTHGH LPPGPRPLPF LGNLLQMNRR
60 70 80 90 100
GLLRSFMQLQ EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG
110 120 130 140 150
TVAVLHPVVQ GYGVIFANGE RWKILRRFSL VTMRNFGMGK RSVEERIKEE
160 170 180 190 200
AQCLVEELKK YKGALLNPTS IFQSIAANII CSIVFGERFD YKDHQFLRLL
210 220 230 240 250
DLIYQTFSLM GSLSSQVFEL FSGFLKYFPG VHKQISKNLQ EILNYIDHSV
260 270 280 290 300
EKHRATLDPN TPRDFINTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFTG
310 320 330 340 350
TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT
360 370 380 390 400
DAVIHEIQRF ADLIPIGLPH RVTNDTMFLG YLLPKNTEVY PILSSALHDP
410 420 430 440 450
RYFDHPDTFN PEHFLDVNGT LKKSEAFLPF STGKRICLGE GIAQNELFIF
460 470 480 490
FTAILQNFSL ASPVAPEDID LSPINSGISK IPSPYQIHFL SRCVG
Length:495
Mass (Da):56,320
Last modified:March 1, 2002 - v2
Checksum:i035C2E084E0B26C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17349 Genomic DNA. Translation: BAB72140.1.
PIRiI53690.
I67791.
RefSeqiNP_001129140.1. NM_001135668.1.
UniGeneiRn.198140.

Genome annotation databases

GeneIDi685222.
KEGGirno:685222.
UCSCiRGD:620088. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17349 Genomic DNA. Translation: BAB72140.1.
PIRiI53690.
I67791.
RefSeqiNP_001129140.1. NM_001135668.1.
UniGeneiRn.198140.

3D structure databases

ProteinModelPortaliQ64583.
SMRiQ64583. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002054.

Proteomic databases

PaxDbiQ64583.
PRIDEiQ64583.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi685222.
KEGGirno:685222.
UCSCiRGD:620088. rat.

Organism-specific databases

CTDi685222.
RGDi620088. Cyp2b15.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ64583.
KOiK07412.
PhylomeDBiQ64583.

Miscellaneous databases

NextBioi729232.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene."
    Nakayama K., Suwa Y., Mizukami Y., Sogawa K., Fujii-Kuriyama Y.
    Gene 136:333-336(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCP2BF_RAT
AccessioniPrimary (citable) accession number: Q64583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.