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Q64583

- CP2BF_RAT

UniProt

Q64583 - CP2BF_RAT

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Protein

Cytochrome P450 2B15

Gene
Cyp2b15
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics By similarity.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. arachidonic acid epoxygenase activity Source: RGD
  2. aromatase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. epoxygenase P450 pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B15 (EC:1.14.14.1)
Alternative name(s):
CYPIIB15
Gene namesi
Name:Cyp2b15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620088. Cyp2b15.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. intracellular membrane-bounded organelle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Cytochrome P450 2B15PRO_0000051688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ64583.
PRIDEiQ64583.

Expressioni

Gene expression databases

GenevestigatoriQ64583.

Structurei

3D structure databases

ProteinModelPortaliQ64583.
SMRiQ64583. Positions 29-492.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ64583.
PhylomeDBiQ64583.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64583-1 [UniParc]FASTAAdd to Basket

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MELGVLLLLT FTVGFLLLLA SQNRPKTHGH LPPGPRPLPF LGNLLQMNRR    50
GLLRSFMQLQ EKYGDVFTVH LGPRPVVILC GTDTIREALV DQAEAFSGRG 100
TVAVLHPVVQ GYGVIFANGE RWKILRRFSL VTMRNFGMGK RSVEERIKEE 150
AQCLVEELKK YKGALLNPTS IFQSIAANII CSIVFGERFD YKDHQFLRLL 200
DLIYQTFSLM GSLSSQVFEL FSGFLKYFPG VHKQISKNLQ EILNYIDHSV 250
EKHRATLDPN TPRDFINTYL LRMEKEKSNH HTEFHHQNLV ISVLSLFFTG 300
TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIGSHRLPT LDDRTKMPYT 350
DAVIHEIQRF ADLIPIGLPH RVTNDTMFLG YLLPKNTEVY PILSSALHDP 400
RYFDHPDTFN PEHFLDVNGT LKKSEAFLPF STGKRICLGE GIAQNELFIF 450
FTAILQNFSL ASPVAPEDID LSPINSGISK IPSPYQIHFL SRCVG 495
Length:495
Mass (Da):56,320
Last modified:March 1, 2002 - v2
Checksum:i035C2E084E0B26C3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17349 Genomic DNA. Translation: BAB72140.1.
PIRiI53690.
I67791.
RefSeqiNP_001129140.1. NM_001135668.1.
UniGeneiRn.198140.

Genome annotation databases

GeneIDi685222.
KEGGirno:685222.
UCSCiRGD:620088. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17349 Genomic DNA. Translation: BAB72140.1 .
PIRi I53690.
I67791.
RefSeqi NP_001129140.1. NM_001135668.1.
UniGenei Rn.198140.

3D structure databases

ProteinModelPortali Q64583.
SMRi Q64583. Positions 29-492.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q64583.
PRIDEi Q64583.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 685222.
KEGGi rno:685222.
UCSCi RGD:620088. rat.

Organism-specific databases

CTDi 685222.
RGDi 620088. Cyp2b15.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi Q64583.
PhylomeDBi Q64583.

Miscellaneous databases

NextBioi 729232.

Gene expression databases

Genevestigatori Q64583.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene."
    Nakayama K., Suwa Y., Mizukami Y., Sogawa K., Fujii-Kuriyama Y.
    Gene 136:333-336(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiCP2BF_RAT
AccessioniPrimary (citable) accession number: Q64583
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi