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Q64581

- CP3AI_RAT

UniProt

Q64581 - CP3AI_RAT

Protein

Cytochrome P450 3A18

Gene

Cyp3a18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. testosterone 16-alpha-hydroxylase activity Source: RGD
    5. testosterone 6-beta-hydroxylase activity Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A18 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA18
    Cytochrome P450(6)beta-2
    Gene namesi
    Name:Cyp3a18
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628709. Cyp3a18.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Cytochrome P450 3A18PRO_0000051801Add
    BLAST

    Proteomic databases

    PaxDbiQ64581.
    PRIDEiQ64581.

    Expressioni

    Inductioni

    By pregnenolone-alpha-carbonitrile, dexamethasone, phenobarbital, and triacetyloleandomycin.

    Gene expression databases

    GenevestigatoriQ64581.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4567012.
    STRINGi10116.ENSRNOP00000001285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64581.
    SMRiQ64581. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiQ64581.
    KOiK07424.
    PhylomeDBiQ64581.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64581-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIIPNLSIE TWVLLATSLM LFYIYGTYSH GLFKKLGIPG PKPVPLFGTI    50
    FNYGDGMWKF DDDCYKKYGK IWGFYEGPQP FLAIMDPEII KMVLVKECYS 100
    VFTNRRCFGP MGFMKKAITM SEDEEWKRLR TILSPTFTSG KLKEMFPLMR 150
    QYGDTLLKNL RREEAKGEPI NMKDIFGAYS MDVITGTSFG VNVDSLNNPQ 200
    DPFVQKAKKI LKFQIFDPFL LSVVLFPFLT PIYEMLNFSI FPRQSMNFFK 250
    KFVKTMKKNR LDSNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAI 300
    IFIFGGYDAT STSISFIMYE LATRPNVQKK LQNEIDRALP NKAPVTYDAL 350
    MEMEYLDMVV NESLRLYPIA TRLDRVSKKD VEINGVFIPK GTVVTIPIYP 400
    LHRNPEYWLE PEEFNPERFS KENKGSIDPY VYLPFGNGPR NCIGMRFALI 450
    SMKLAVIGVL QNFNIQPCEK TQIPLKISRQ PIFQPEGPII LKLVSRD 497
    Length:497
    Mass (Da):57,307
    Last modified:November 1, 1996 - v1
    Checksum:i9FA3F5B221293489
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79991 mRNA. Translation: CAA56312.1.
    D38381 mRNA. Translation: BAA22526.1.
    PIRiPX0033.
    S52097.
    RefSeqiNP_665725.1. NM_145782.1.
    UniGeneiRn.32085.

    Genome annotation databases

    GeneIDi252931.
    KEGGirno:252931.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79991 mRNA. Translation: CAA56312.1 .
    D38381 mRNA. Translation: BAA22526.1 .
    PIRi PX0033.
    S52097.
    RefSeqi NP_665725.1. NM_145782.1.
    UniGenei Rn.32085.

    3D structure databases

    ProteinModelPortali Q64581.
    SMRi Q64581. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4567012.
    STRINGi 10116.ENSRNOP00000001285.

    Proteomic databases

    PaxDbi Q64581.
    PRIDEi Q64581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 252931.
    KEGGi rno:252931.

    Organism-specific databases

    CTDi 252931.
    RGDi 628709. Cyp3a18.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi Q64581.
    KOi K07424.
    PhylomeDBi Q64581.

    Miscellaneous databases

    NextBioi 624101.

    Gene expression databases

    Genevestigatori Q64581.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    2. "Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations."
      Nagata K., Murayama N., Miyata M., Shimada M., Urahashi A., Yamazoe Y., Kato R.
      Pharmacogenetics 6:103-111(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AI_RAT
    AccessioniPrimary (citable) accession number: Q64581
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3