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Q64581

- CP3AI_RAT

UniProt

Q64581 - CP3AI_RAT

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Protein

Cytochrome P450 3A18

Gene
Cyp3a18
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. testosterone 16-alpha-hydroxylase activity Source: RGD
  5. testosterone 6-beta-hydroxylase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A18 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA18
Cytochrome P450(6)beta-2
Gene namesi
Name:Cyp3a18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628709. Cyp3a18.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Cytochrome P450 3A18PRO_0000051801Add
BLAST

Proteomic databases

PaxDbiQ64581.
PRIDEiQ64581.

Expressioni

Inductioni

By pregnenolone-alpha-carbonitrile, dexamethasone, phenobarbital, and triacetyloleandomycin.

Gene expression databases

GenevestigatoriQ64581.

Interactioni

Protein-protein interaction databases

MINTiMINT-4567012.
STRINGi10116.ENSRNOP00000001285.

Structurei

3D structure databases

ProteinModelPortaliQ64581.
SMRiQ64581. Positions 30-496.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64581.
KOiK07424.
PhylomeDBiQ64581.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64581-1 [UniParc]FASTAAdd to Basket

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MEIIPNLSIE TWVLLATSLM LFYIYGTYSH GLFKKLGIPG PKPVPLFGTI    50
FNYGDGMWKF DDDCYKKYGK IWGFYEGPQP FLAIMDPEII KMVLVKECYS 100
VFTNRRCFGP MGFMKKAITM SEDEEWKRLR TILSPTFTSG KLKEMFPLMR 150
QYGDTLLKNL RREEAKGEPI NMKDIFGAYS MDVITGTSFG VNVDSLNNPQ 200
DPFVQKAKKI LKFQIFDPFL LSVVLFPFLT PIYEMLNFSI FPRQSMNFFK 250
KFVKTMKKNR LDSNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAI 300
IFIFGGYDAT STSISFIMYE LATRPNVQKK LQNEIDRALP NKAPVTYDAL 350
MEMEYLDMVV NESLRLYPIA TRLDRVSKKD VEINGVFIPK GTVVTIPIYP 400
LHRNPEYWLE PEEFNPERFS KENKGSIDPY VYLPFGNGPR NCIGMRFALI 450
SMKLAVIGVL QNFNIQPCEK TQIPLKISRQ PIFQPEGPII LKLVSRD 497
Length:497
Mass (Da):57,307
Last modified:November 1, 1996 - v1
Checksum:i9FA3F5B221293489
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79991 mRNA. Translation: CAA56312.1.
D38381 mRNA. Translation: BAA22526.1.
PIRiPX0033.
S52097.
RefSeqiNP_665725.1. NM_145782.1.
UniGeneiRn.32085.

Genome annotation databases

GeneIDi252931.
KEGGirno:252931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79991 mRNA. Translation: CAA56312.1 .
D38381 mRNA. Translation: BAA22526.1 .
PIRi PX0033.
S52097.
RefSeqi NP_665725.1. NM_145782.1.
UniGenei Rn.32085.

3D structure databases

ProteinModelPortali Q64581.
SMRi Q64581. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4567012.
STRINGi 10116.ENSRNOP00000001285.

Proteomic databases

PaxDbi Q64581.
PRIDEi Q64581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 252931.
KEGGi rno:252931.

Organism-specific databases

CTDi 252931.
RGDi 628709. Cyp3a18.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi Q64581.
KOi K07424.
PhylomeDBi Q64581.

Miscellaneous databases

NextBioi 624101.

Gene expression databases

Genevestigatori Q64581.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations."
    Nagata K., Murayama N., Miyata M., Shimada M., Urahashi A., Yamazoe Y., Kato R.
    Pharmacogenetics 6:103-111(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AI_RAT
AccessioniPrimary (citable) accession number: Q64581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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