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Protein

Cytochrome P450 3A18

Gene

Cyp3a18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • testosterone 16-alpha-hydroxylase activity Source: RGD
  • testosterone 6-beta-hydroxylase activity Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A18 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA18
Cytochrome P450(6)beta-2
Gene namesi
Name:Cyp3a18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628709 Cyp3a18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518011 – 497Cytochrome P450 3A18Add BLAST497

Proteomic databases

PaxDbiQ64581
PRIDEiQ64581

Expressioni

Inductioni

By pregnenolone-alpha-carbonitrile, dexamethasone, phenobarbital, and triacetyloleandomycin.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001285

Structurei

3D structure databases

ProteinModelPortaliQ64581
SMRiQ64581
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiQ64581
KOiK07424
PhylomeDBiQ64581

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q64581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIPNLSIE TWVLLATSLM LFYIYGTYSH GLFKKLGIPG PKPVPLFGTI
60 70 80 90 100
FNYGDGMWKF DDDCYKKYGK IWGFYEGPQP FLAIMDPEII KMVLVKECYS
110 120 130 140 150
VFTNRRCFGP MGFMKKAITM SEDEEWKRLR TILSPTFTSG KLKEMFPLMR
160 170 180 190 200
QYGDTLLKNL RREEAKGEPI NMKDIFGAYS MDVITGTSFG VNVDSLNNPQ
210 220 230 240 250
DPFVQKAKKI LKFQIFDPFL LSVVLFPFLT PIYEMLNFSI FPRQSMNFFK
260 270 280 290 300
KFVKTMKKNR LDSNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAI
310 320 330 340 350
IFIFGGYDAT STSISFIMYE LATRPNVQKK LQNEIDRALP NKAPVTYDAL
360 370 380 390 400
MEMEYLDMVV NESLRLYPIA TRLDRVSKKD VEINGVFIPK GTVVTIPIYP
410 420 430 440 450
LHRNPEYWLE PEEFNPERFS KENKGSIDPY VYLPFGNGPR NCIGMRFALI
460 470 480 490
SMKLAVIGVL QNFNIQPCEK TQIPLKISRQ PIFQPEGPII LKLVSRD
Length:497
Mass (Da):57,307
Last modified:November 1, 1996 - v1
Checksum:i9FA3F5B221293489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79991 mRNA Translation: CAA56312.1
D38381 mRNA Translation: BAA22526.1
PIRiPX0033
S52097
RefSeqiNP_665725.1, NM_145782.1
UniGeneiRn.32085

Genome annotation databases

GeneIDi252931
KEGGirno:252931

Similar proteinsi

Entry informationi

Entry nameiCP3AI_RAT
AccessioniPrimary (citable) accession number: Q64581
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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