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Q64581 (CP3AI_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A18

EC=1.14.14.1
Alternative name(s):
CYPIIIA18
Cytochrome P450(6)beta-2
Gene names
Name:Cyp3a18
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes 16-beta- and 6-alpha-hydroxylations of testosterone.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By pregnenolone-alpha-carbonitrile, dexamethasone, phenobarbital, and triacetyloleandomycin.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Cytochrome P450 3A18
PRO_0000051801

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64581 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 9FA3F5B221293489

FASTA49757,307
        10         20         30         40         50         60 
MEIIPNLSIE TWVLLATSLM LFYIYGTYSH GLFKKLGIPG PKPVPLFGTI FNYGDGMWKF 

        70         80         90        100        110        120 
DDDCYKKYGK IWGFYEGPQP FLAIMDPEII KMVLVKECYS VFTNRRCFGP MGFMKKAITM 

       130        140        150        160        170        180 
SEDEEWKRLR TILSPTFTSG KLKEMFPLMR QYGDTLLKNL RREEAKGEPI NMKDIFGAYS 

       190        200        210        220        230        240 
MDVITGTSFG VNVDSLNNPQ DPFVQKAKKI LKFQIFDPFL LSVVLFPFLT PIYEMLNFSI 

       250        260        270        280        290        300 
FPRQSMNFFK KFVKTMKKNR LDSNQKNRVD FLQLMMNTQN SKGQESQKAL SDLEMAAQAI 

       310        320        330        340        350        360 
IFIFGGYDAT STSISFIMYE LATRPNVQKK LQNEIDRALP NKAPVTYDAL MEMEYLDMVV 

       370        380        390        400        410        420 
NESLRLYPIA TRLDRVSKKD VEINGVFIPK GTVVTIPIYP LHRNPEYWLE PEEFNPERFS 

       430        440        450        460        470        480 
KENKGSIDPY VYLPFGNGPR NCIGMRFALI SMKLAVIGVL QNFNIQPCEK TQIPLKISRQ 

       490 
PIFQPEGPII LKLVSRD 

« Hide

References

[1]"A novel CYP3 gene from female rats."
Strotkamp D., Roos P.H., Hanstein W.G.
Biochim. Biophys. Acta 1260:341-344(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
[2]"Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations."
Nagata K., Murayama N., Miyata M., Shimada M., Urahashi A., Yamazoe Y., Kato R.
Pharmacogenetics 6:103-111(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X79991 mRNA. Translation: CAA56312.1.
D38381 mRNA. Translation: BAA22526.1.
PIRPX0033.
S52097.
RefSeqNP_665725.1. NM_145782.1.
UniGeneRn.32085.

3D structure databases

ProteinModelPortalQ64581.
SMRQ64581. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4567012.
STRING10116.ENSRNOP00000001285.

Proteomic databases

PaxDbQ64581.
PRIDEQ64581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID252931.
KEGGrno:252931.

Organism-specific databases

CTD252931.
RGD628709. Cyp3a18.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidQ64581.
KOK07424.
PhylomeDBQ64581.

Gene expression databases

GenevestigatorQ64581.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624101.

Entry information

Entry nameCP3AI_RAT
AccessionPrimary (citable) accession number: Q64581
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families