Plasma membrane calcium-transporting ATPase 3

Preferred order of sections

Names and origin

Protein names

Recommended name:
Plasma membrane calcium-transporting ATPase 3
Short name=PMCA3
EC=3.6.3.8

Alternative name(s):
Plasma membrane calcium ATPase isoform 3
Plasma membrane calcium pump isoform 3

Gene names

Name:	Atp2b3
Synonyms:	Pmca3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1258 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H₂O + Ca²⁺(Side 1) = ADP + phosphate + Ca²⁺(Side 2).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Isoform XA is the most abundant form in brain and most other tissues. Isoform XB is the most abundant form in skeletal muscle and is also found in brain and at low levels in testis and kidney. The other isoforms are only found at low levels in various tissues.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from expression pattern PubMed 1328526. Source: RGD neural retina development Inferred from expression pattern PubMed 16079002. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane raft Inferred from direct assay PubMed 17596212. Source: RGD plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 12 isoforms produced by alternative splicing. [Align] [Select] Note: There is a combination of two alternative spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, C, D, E and F). So far the splice sites have been studied independently. Experimental confirmation may be lacking for some isoforms.

Isoform XD (identifier: Q64568-1) Also known as: AIICIV; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform XA (identifier: Q64568-2) Also known as: AIICII; The sequence of this isoform differs from the canonical sequence as follows: 1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGNPSGESIP

Isoform ZA (identifier: Q64568-3) Also known as: AICII; The sequence of this isoform differs from the canonical sequence as follows: 306-319: Missing. 1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGNPSGESIP

Isoform XB (identifier: Q64568-4) Also known as: AIICI; The sequence of this isoform differs from the canonical sequence as follows: 1115-1152: Missing.

Isoform ZB (identifier: Q64568-5) Also known as: AICI; The sequence of this isoform differs from the canonical sequence as follows: 306-319: Missing. 1115-1152: Missing.

Isoform XC (identifier: Q64568-6) Also known as: AIICIII; The sequence of this isoform differs from the canonical sequence as follows: 1144-1152: Missing.

Isoform ZC (identifier: Q64568-7) Also known as: AICIII; The sequence of this isoform differs from the canonical sequence as follows: 306-319: Missing. 1144-1152: Missing.

Isoform ZD (identifier: Q64568-8) Also known as: AICIV; The sequence of this isoform differs from the canonical sequence as follows: 306-319: Missing.

Isoform XE (identifier: Q64568-9) Also known as: AIICV; The sequence of this isoform differs from the canonical sequence as follows: 1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGSES

Isoform ZE (identifier: Q64568-10) Also known as: AICV; The sequence of this isoform differs from the canonical sequence as follows: 306-319: Missing. 1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGSES

Isoform XF (identifier: Q64568-11) Also known as: AIICVI; The sequence of this isoform differs from the canonical sequence as follows: 1115-1258: MEVVSTFKRS...SPLHSMETSL → VCWDGKKMLRTTEVG

Isoform ZF (identifier: Q64568-12) Also known as: AICVI; The sequence of this isoform differs from the canonical sequence as follows: 306-319: Missing. 1115-1258: MEVVSTFKRS...SPLHSMETSL → VCWDGKKMLRTTEVG

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1258

1258

Plasma membrane calcium-transporting ATPase 3

PRO_0000046219

Regions

Topological domain

1 – 97

97

Cytoplasmic Potential

Transmembrane

98 – 118

21

Helical; Potential

Topological domain

119 – 155

37

Extracellular Potential

Transmembrane

156 – 176

21

Helical; Potential

Topological domain

177 – 364

188

Cytoplasmic Potential

Transmembrane

365 – 384

20

Helical; Potential

Topological domain

385 – 417

33

Extracellular Potential

Transmembrane

418 – 435

18

Helical; Potential

Topological domain

436 – 849

414

Cytoplasmic Potential

Transmembrane

850 – 869

20

Helical; Potential

Topological domain

870 – 879

10

Extracellular Potential

Transmembrane

880 – 900

21

Helical; Potential

Topological domain

901 – 920

20

Cytoplasmic Potential

Transmembrane

921 – 943

23

Helical; Potential

Topological domain

944 – 961

18

Extracellular Potential

Transmembrane

962 – 983

22

Helical; Potential

Topological domain

984 – 1002

19

Cytoplasmic Potential

Transmembrane

1003 – 1024

22

Helical; Potential

Topological domain

1025 – 1034

10

Extracellular Potential

Transmembrane

1035 – 1056

22

Helical; Potential

Topological domain

1057 – 1258

202

Cytoplasmic Potential

Region

1097 – 1114

18

Calmodulin-binding subdomain A By similarity

Region

1115 – 1124

10

Calmodulin-binding subdomain B By similarity

Compositional bias

297 – 300

4

Poly-Glu

Compositional bias

1212 – 1217

6

Poly-Pro

Sites

Active site

473

1

4-aspartylphosphate intermediate By similarity

Metal binding

794

1

Magnesium By similarity

Metal binding

798

1

Magnesium By similarity

Amino acid modifications

Modified residue

1113

1

Phosphothreonine; by PKC By similarity

Natural variations

Alternative sequence

306 – 319

14

Missing in isoform ZA, isoform ZB, isoform ZC, isoform ZD, isoform ZE and isoform ZF.

VSP_000396

Alternative sequence

1115 – 1258

144

MEVVS…METSL → VCWDGKKMLRTTEVG in isoform XF and isoform ZF.

VSP_000398

Alternative sequence

1115 – 1152

38

Missing in isoform XB and isoform ZB.

VSP_000397

Alternative sequence

1144 – 1152

9

Missing in isoform XC and isoform ZC.

VSP_000399

Alternative sequence

1153 – 1258

106

IRVVK…METSL → VTLSAAKPTSAAGNPSGESI P in isoform XA and isoform ZA.

VSP_000400

Alternative sequence

1153 – 1258

106

IRVVK…METSL → VTLSAAKPTSAAGSES in isoform XE and isoform ZE.

VSP_000401

Sequences

Sequence		Length	Mass (Da)
Isoform XD (AIICIV) [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 3A13781D21042BA6 Show »	FASTA	1,258	138,559
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NVPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR VWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY RDFSAIQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQMEVVST FKRSGSFQGA VRRRSSVLSQ 1150 1160 1170 1180 1190 1200 LHDVTNLSTP THIRVVKAFR SSLYEGLEKP ESKSCIHNFM ATPEFLINDY THNIPLIDDT 1210 1220 1230 1240 1250 DVDENEERLR APPPPPPNQN NNAIDSGIYL TTHATKSATS SAFSSRPGSP LHSMETSL « Hide
Isoform XA (AIICII) [UniParc]. Checksum: CF49538EC579E958 Show »	FASTA	1,173	128,773
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NVPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR VWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY RDFSAIQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQMEVVST FKRSGSFQGA VRRRSSVLSQ 1150 1160 1170 LHDVTNLSTP THVTLSAAKP TSAAGNPSGE SIP « Hide
Isoform ZA (AICII) [UniParc]. Checksum: A33A52545101241D Show »	FASTA	1,159	127,297
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANVPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVDGRVWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFILDL 550 560 570 580 590 600 KRDFQPVREQ IPEDQLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVKKI IEPMACDGLR TICIAYRDFS AIQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLTIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ MEVVSTFKRS GSFQGAVRRR SSVLSQLHDV TNLSTPTHVT 1150 LSAAKPTSAA GNPSGESIP « Hide
Isoform XB (AIICI) [UniParc]. Checksum: C18A4BAEBA0362ED Show »	FASTA	1,220	134,360
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NVPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR VWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY RDFSAIQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQIRVVKA FRSSLYEGLE KPESKSCIHN 1150 1160 1170 1180 1190 1200 FMATPEFLIN DYTHNIPLID DTDVDENEER LRAPPPPPPN QNNNAIDSGI YLTTHATKSA 1210 1220 TSSAFSSRPG SPLHSMETSL « Hide
Isoform ZB (AICI) [UniParc]. Checksum: F83F2E1301CB4552 Show »	FASTA	1,206	132,884
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANVPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVDGRVWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFILDL 550 560 570 580 590 600 KRDFQPVREQ IPEDQLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVKKI IEPMACDGLR TICIAYRDFS AIQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLTIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ IRVVKAFRSS LYEGLEKPES KSCIHNFMAT PEFLINDYTH 1150 1160 1170 1180 1190 1200 NIPLIDDTDV DENEERLRAP PPPPPNQNNN AIDSGIYLTT HATKSATSSA FSSRPGSPLH SMETSL « Hide
Isoform XC (AIICIII) [UniParc]. Checksum: 9825517A8B9744B1 Show »	FASTA	1,249	137,608
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NVPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR VWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY RDFSAIQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQMEVVST FKRSGSFQGA VRRRSSVLSQ 1150 1160 1170 1180 1190 1200 LHDIRVVKAF RSSLYEGLEK PESKSCIHNF MATPEFLIND YTHNIPLIDD TDVDENEERL 1210 1220 1230 1240 RAPPPPPPNQ NNNAIDSGIY LTTHATKSAT SSAFSSRPGS PLHSMETSL « Hide
Isoform ZC (AICIII) [UniParc]. Checksum: DD7B43D805121FDD Show »	FASTA	1,235	136,132
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANVPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVDGRVWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFILDL 550 560 570 580 590 600 KRDFQPVREQ IPEDQLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVKKI IEPMACDGLR TICIAYRDFS AIQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLTIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ MEVVSTFKRS GSFQGAVRRR SSVLSQLHDI RVVKAFRSSL 1150 1160 1170 1180 1190 1200 YEGLEKPESK SCIHNFMATP EFLINDYTHN IPLIDDTDVD ENEERLRAPP PPPPNQNNNA 1210 1220 1230 IDSGIYLTTH ATKSATSSAF SSRPGSPLHS METSL « Hide
Isoform ZD (AICIV) [UniParc]. Checksum: 3BA47725ACB4D4AE Show »	FASTA	1,244	137,083
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANVPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVDGRVWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFILDL 550 560 570 580 590 600 KRDFQPVREQ IPEDQLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVKKI IEPMACDGLR TICIAYRDFS AIQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLTIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ MEVVSTFKRS GSFQGAVRRR SSVLSQLHDV TNLSTPTHIR 1150 1160 1170 1180 1190 1200 VVKAFRSSLY EGLEKPESKS CIHNFMATPE FLINDYTHNI PLIDDTDVDE NEERLRAPPP 1210 1220 1230 1240 PPPNQNNNAI DSGIYLTTHA TKSATSSAFS SRPGSPLHSM ETSL « Hide
Isoform XE (AIICV) [UniParc]. Checksum: 09F539391396F9A2 Show »	FASTA	1,168	128,295
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NVPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR VWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY RDFSAIQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 1130 1140 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQMEVVST FKRSGSFQGA VRRRSSVLSQ 1150 1160 LHDVTNLSTP THVTLSAAKP TSAAGSES « Hide
Isoform ZE (AICV) [UniParc]. Checksum: 81387C79448BCC0F Show »	FASTA	1,154	126,818
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANVPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVDGRVWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFILDL 550 560 570 580 590 600 KRDFQPVREQ IPEDQLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVKKI IEPMACDGLR TICIAYRDFS AIQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLTIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 1120 1130 1140 RELRRGQILW FRGLNRIQTQ MEVVSTFKRS GSFQGAVRRR SSVLSQLHDV TNLSTPTHVT 1150 LSAAKPTSAA GSES « Hide
Isoform XF (AIICVI) [UniParc]. Checksum: 7B4F423A0C709026 Show »	FASTA	1,129	124,342
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA NVPKKEKSVL 370 380 390 400 410 420 QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR VWLAECTPVY VQYFVKFFII 430 440 450 460 470 480 GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTT 490 500 510 520 530 540 NRMTVVQSYL GDTHYKEIPA PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG 550 560 570 580 590 600 NKTECALLGF ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG 610 620 630 640 650 660 ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY RDFSAIQEPD 670 680 690 700 710 720 WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT VRMVTGDNIN TARAIAAKCG 730 740 750 760 770 780 IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE RLDKVWPKLR VLARSSPTDK HTLVKGIIDS 790 800 810 820 830 840 TTGEQRQVVA VTGDGTNDGP ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM 850 860 870 880 890 900 WGRNVYDSIS KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA 910 920 930 940 950 960 TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF FDIDSGRNAP 970 980 990 1000 1010 1020 LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI FSNPIFCTIV LGTFGIQIVI 1030 1040 1050 1060 1070 1080 VQFGGKPFSC SPLSTEQWLW CLFVGVGELV WGQVIATIPT SQLKCLKEAG HGPGKDEMTD 1090 1100 1110 1120 EELAEGEEEI DHAERELRRG QILWFRGLNR IQTQVCWDGK KMLRTTEVG « Hide
Isoform ZF (AICVI) [UniParc]. Checksum: 1A545F41D1A951EB Show »	FASTA	1,115	122,866
10 20 30 40 50 60 MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ EAYGDVSGLC 70 80 90 100 110 120 RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ LVWEALQDVT LIILEVAAIV 130 140 150 160 170 180 SLGLSFYAPP GEESEACGNV SGGAEDEGEA EAGWIEGAAI LLSVICVVLV TAFNDWSKEK 190 200 210 220 230 240 QFRGLQSRIE QEQKFTVIRN GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID 250 260 270 280 290 300 ESSLTGESDH VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE 310 320 330 340 350 360 KKDKKAKKQD GAVAMEMQPL KSAEGGEMEE REKKKANVPK KEKSVLQGKL TKLAVQIGKA 370 380 390 400 410 420 GLVMSAITVI ILVLYFVIET FVVDGRVWLA ECTPVYVQYF VKFFIIGVTV LVVAVPEGLP 430 440 450 460 470 480 LAVTISLAYS VKKMMKDNNL VRHLDACETM GNATAICSDK TGTLTTNRMT VVQSYLGDTH 490 500 510 520 530 540 YKEIPAPSAL TPKILDLLVH AISINSAYTT KILPPEKEGA LPRQVGNKTE CALLGFILDL 550 560 570 580 590 600 KRDFQPVREQ IPEDQLYKVY TFNSVRKSMS TVIRMPDGGF RLFSKGASEI LLKKCTNILN 610 620 630 640 650 660 SNGELRGFRP RDRDDMVKKI IEPMACDGLR TICIAYRDFS AIQEPDWDNE NEVVGDLTCI 670 680 690 700 710 720 AVVGIEDPVR PEVPEAIRKC QRAGITVRMV TGDNINTARA IAAKCGIIQP GEDFLCLEGK 730 740 750 760 770 780 EFNRRIRNEK GEIEQERLDK VWPKLRVLAR SSPTDKHTLV KGIIDSTTGE QRQVVAVTGD 790 800 810 820 830 840 GTNDGPALKK ADVGFAMGIA GTDVAKEASD IILTDDNFTS IVKAVMWGRN VYDSISKFLQ 850 860 870 880 890 900 FQLTVNVVAV IVAFTGACIT QDSPLKAVQM LWVNLIMDTF ASLALATEPP TESLLLRKPY 910 920 930 940 950 960 GRDKPLISRT MMKNILGHAV YQLTIIFTLL FVGELFFDID SGRNAPLHSP PSEHYTIIFN 970 980 990 1000 1010 1020 TFVMMQLFNE INARKIHGER NVFDGIFSNP IFCTIVLGTF GIQIVIVQFG GKPFSCSPLS 1030 1040 1050 1060 1070 1080 TEQWLWCLFV GVGELVWGQV IATIPTSQLK CLKEAGHGPG KDEMTDEELA EGEEEIDHAE 1090 1100 1110 RELRRGQILW FRGLNRIQTQ VCWDGKKMLR TTEVG « Hide

References

[1]	"Molecular cloning of a third isoform of the calmodulin-sensitive plasma membrane Ca2+-transporting ATPase that is expressed predominantly in brain and skeletal muscle." Greeb J., Shull G.E. J. Biol. Chem. 264:18569-18576(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZA). Tissue: Brain.
[2]	"Structure of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and characterization of alternative splicing and transcription products. Skeletal muscle-specific splicing results in a plasma membrane Ca(2+)-ATPase with a novel calmodulin-binding domain." Burk S.E., Shull G.E. J. Biol. Chem. 267:19683-19690(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1016-1258 (ISOFORMS XF/ZF), ALTERNATIVE SPLICING. Strain: CD Charles River.
[3]	"Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4." Keeton T.P., Burk S.E., Shull G.E. J. Biol. Chem. 268:2740-2748(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1054-1258, ALTERNATIVE SPLICING (ISOFORMS XA/ZA). Strain: CD Charles River.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05565, L05558, L05564 Genomic DNA. Translation: AAA53650.1. J05087 mRNA. Translation: AAA69667.1. M96626 mRNA. Translation: AAA50821.1.
IPI	IPI00213586. IPI00231519. IPI00231520. IPI00231521. IPI00231522. IPI00231523. IPI00231524. IPI00231525. IPI00231526. IPI00231665. IPI00231666. IPI00567465.
PIR	A34308. C44525.
RefSeq	NP_579822.1. NM_133288.1.
UniGene	Rn.11053.
3D structure databases
ProteinModelPortal	Q64568.
ModBase	Search...
PTM databases
PhosphoSite	Q64568.
Proteomic databases
PaxDb	Q64568.
PRIDE	Q64568.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000023934; ENSRNOP00000023934; ENSRNOG00000017798.
GeneID	29599.
KEGG	rno:29599.
Organism-specific databases
CTD	492.
RGD	621304. Atp2b3.
Phylogenomic databases
eggNOG	COG0474.
GeneTree	ENSGT00510000046331.
HOGENOM	HOG000265623.
HOVERGEN	HBG061286.
InParanoid	Q64568.
KO	K05850.
Gene expression databases
ArrayExpress	Q64568.
Genevestigator	Q64568.
GermOnline	ENSRNOG00000017798. Rattus norvegicus.
Family and domain databases
Gene3D	1.20.1110.10. 3 hits.
InterPro	IPR022141. ATP_Ca_trans_C. IPR006408. ATPase_P-typ_Ca-transp_plasma. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF12424. ATP_Ca_trans_C. 2 hits. PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	609754.

Entry information

Entry name

AT2B3_RAT

Accession

Primary (citable) accession number: Q64568
Secondary accession number(s): Q01489, Q63444

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents