UniProtKB - Q64568 (AT2B3_RAT)
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Plasma membrane calcium-transporting ATPase 3
Atp2b3
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 473 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 794 | MagnesiumBy similarity | 1 | |
Metal bindingi | 798 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium ion transmembrane transporter activity Source: RGD
- calcium-transporting ATPase activity Source: GO_Central
- calmodulin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- PDZ domain binding Source: RGD
GO - Biological processi
- brain development Source: RGD
- calcium ion export across plasma membrane Source: RGD
- cellular calcium ion homeostasis Source: GO_Central
- neural retina development Source: RGD
- regulation of cytosolic calcium ion concentration Source: RGD
Keywordsi
Molecular function | Calmodulin-binding, Hydrolase |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-RNO-418359. Reduction of cytosolic Ca++ levels. R-RNO-5578775. Ion homeostasis. R-RNO-936837. Ion transport by P-type ATPases. |
Names & Taxonomyi
Protein namesi | Recommended name: Plasma membrane calcium-transporting ATPase 3 (EC:3.6.3.8)Short name: PMCA3 Alternative name(s): Plasma membrane calcium ATPase isoform 3 Plasma membrane calcium pump isoform 3 |
Gene namesi | Name:Atp2b3 Synonyms:Pmca3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621304. Atp2b3. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 97 | CytoplasmicSequence analysisAdd BLAST | 97 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 155 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 364 | CytoplasmicSequence analysisAdd BLAST | 188 | |
Transmembranei | 365 – 384 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 385 – 417 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 418 – 435 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 436 – 849 | CytoplasmicSequence analysisAdd BLAST | 414 | |
Transmembranei | 850 – 869 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 870 – 879 | ExtracellularSequence analysis | 10 | |
Transmembranei | 880 – 900 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 901 – 920 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 921 – 943 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 944 – 961 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 962 – 983 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 984 – 1002 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 1003 – 1024 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 1025 – 1034 | ExtracellularSequence analysis | 10 | |
Transmembranei | 1035 – 1056 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 1057 – 1258 | CytoplasmicSequence analysisAdd BLAST | 202 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046219 | 1 – 1258 | Plasma membrane calcium-transporting ATPase 3Add BLAST | 1258 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1079 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1113 | Phosphothreonine; by PKCBy similarity | 1 | |
Modified residuei | 1126 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q64568. |
PRIDEi | Q64568. |
PTM databases
iPTMneti | Q64568. |
PhosphoSitePlusi | Q64568. |
SwissPalmi | Q64568. |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000061304. |
ExpressionAtlasi | Q64568. differential. |
Interactioni
Subunit structurei
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- PDZ domain binding Source: RGD
Protein-protein interaction databases
BioGridi | 248231. 1 interactor. |
STRINGi | 10116.ENSRNOP00000035695. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1097 – 1114 | Calmodulin-binding subdomain ABy similarityAdd BLAST | 18 | |
Regioni | 1115 – 1124 | Calmodulin-binding subdomain BBy similarity | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 297 – 300 | Poly-Glu | 4 | |
Compositional biasi | 1212 – 1217 | Poly-Pro | 6 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0204. Eukaryota. ENOG410XNNC. LUCA. |
GeneTreei | ENSGT00510000046331. |
HOGENOMi | HOG000265623. |
HOVERGENi | HBG061286. |
InParanoidi | Q64568. |
KOi | K05850. |
PhylomeDBi | Q64568. |
Family and domain databases
Gene3Di | 3.40.1110.10. 1 hit. 3.40.50.1000. 2 hits. |
InterProi | View protein in InterPro IPR030325. ATP2B3. IPR022141. ATP_Ca_trans_C. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_dom_N. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom_sf. IPR008250. ATPase_P-typ_transduc_dom_A_sf. IPR036412. HAD-like_sf. IPR023214. HAD_sf. IPR006408. P-type_ATPase_IIB. IPR001757. P_typ_ATPase. |
PANTHERi | PTHR24093:SF284. PTHR24093:SF284. 1 hit. |
Pfami | View protein in Pfam PF12424. ATP_Ca_trans_C. 2 hits. PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. |
SMARTi | View protein in SMART SM00831. Cation_ATPase_N. 1 hit. |
SUPFAMi | SSF56784. SSF56784. 2 hits. SSF81653. SSF81653. 1 hit. SSF81660. SSF81660. 1 hit. SSF81665. SSF81665. 3 hits. |
TIGRFAMsi | TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 3 hits. |
PROSITEi | View protein in PROSITE PS00154. ATPASE_E1_E2. 1 hit. |
s (12)i Sequence
Sequence statusi: Complete.
This entry describes 12 produced by isoformsialternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGDMANSSIE FHPKPQQQRE VPHVGGFGCT LAELRSLMEL RGAEALQKIQ
60 70 80 90 100
EAYGDVSGLC RRLKTSPTEG LADNTNDLEK RRQIYGQNFI PPKQPKTFLQ
110 120 130 140 150
LVWEALQDVT LIILEVAAIV SLGLSFYAPP GEESEACGNV SGGAEDEGEA
160 170 180 190 200
EAGWIEGAAI LLSVICVVLV TAFNDWSKEK QFRGLQSRIE QEQKFTVIRN
210 220 230 240 250
GQLLQVPVAA LVVGDIAQVK YGDLLPADGV LIQGNDLKID ESSLTGESDH
260 270 280 290 300
VRKSADKDPM LLSGTHVMEG SGRMVVTAVG VNSQTGIIFT LLGAGGEEEE
310 320 330 340 350
KKDKKGKQQD GAMESSQTKA KKQDGAVAME MQPLKSAEGG EMEEREKKKA
360 370 380 390 400
NVPKKEKSVL QGKLTKLAVQ IGKAGLVMSA ITVIILVLYF VIETFVVDGR
410 420 430 440 450
VWLAECTPVY VQYFVKFFII GVTVLVVAVP EGLPLAVTIS LAYSVKKMMK
460 470 480 490 500
DNNLVRHLDA CETMGNATAI CSDKTGTLTT NRMTVVQSYL GDTHYKEIPA
510 520 530 540 550
PSALTPKILD LLVHAISINS AYTTKILPPE KEGALPRQVG NKTECALLGF
560 570 580 590 600
ILDLKRDFQP VREQIPEDQL YKVYTFNSVR KSMSTVIRMP DGGFRLFSKG
610 620 630 640 650
ASEILLKKCT NILNSNGELR GFRPRDRDDM VKKIIEPMAC DGLRTICIAY
660 670 680 690 700
RDFSAIQEPD WDNENEVVGD LTCIAVVGIE DPVRPEVPEA IRKCQRAGIT
710 720 730 740 750
VRMVTGDNIN TARAIAAKCG IIQPGEDFLC LEGKEFNRRI RNEKGEIEQE
760 770 780 790 800
RLDKVWPKLR VLARSSPTDK HTLVKGIIDS TTGEQRQVVA VTGDGTNDGP
810 820 830 840 850
ALKKADVGFA MGIAGTDVAK EASDIILTDD NFTSIVKAVM WGRNVYDSIS
860 870 880 890 900
KFLQFQLTVN VVAVIVAFTG ACITQDSPLK AVQMLWVNLI MDTFASLALA
910 920 930 940 950
TEPPTESLLL RKPYGRDKPL ISRTMMKNIL GHAVYQLTII FTLLFVGELF
960 970 980 990 1000
FDIDSGRNAP LHSPPSEHYT IIFNTFVMMQ LFNEINARKI HGERNVFDGI
1010 1020 1030 1040 1050
FSNPIFCTIV LGTFGIQIVI VQFGGKPFSC SPLSTEQWLW CLFVGVGELV
1060 1070 1080 1090 1100
WGQVIATIPT SQLKCLKEAG HGPGKDEMTD EELAEGEEEI DHAERELRRG
1110 1120 1130 1140 1150
QILWFRGLNR IQTQMEVVST FKRSGSFQGA VRRRSSVLSQ LHDVTNLSTP
1160 1170 1180 1190 1200
THIRVVKAFR SSLYEGLEKP ESKSCIHNFM ATPEFLINDY THNIPLIDDT
1210 1220 1230 1240 1250
DVDENEERLR APPPPPPNQN NNAIDSGIYL TTHATKSATS SAFSSRPGSP
LHSMETSL
The sequence of this isoform differs from the canonical sequence as follows:
1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGNPSGESIP
The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGNPSGESIP
The sequence of this isoform differs from the canonical sequence as follows:
1115-1152: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1115-1152: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1144-1152: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1144-1152: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGSES
The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1153-1258: IRVVKAFRSS...SPLHSMETSL → VTLSAAKPTSAAGSES
The sequence of this isoform differs from the canonical sequence as follows:
1115-1258: MEVVSTFKRS...SPLHSMETSL → VCWDGKKMLRTTEVG
The sequence of this isoform differs from the canonical sequence as follows:
306-319: Missing.
1115-1258: MEVVSTFKRS...SPLHSMETSL → VCWDGKKMLRTTEVG
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000396 | 306 – 319 | Missing in isoform ZA, isoform ZB, isoform ZC, isoform ZD, isoform ZE and isoform ZF. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_000398 | 1115 – 1258 | MEVVS…METSL → VCWDGKKMLRTTEVG in isoform XF and isoform ZF. CuratedAdd BLAST | 144 | |
Alternative sequenceiVSP_000397 | 1115 – 1152 | Missing in isoform XB and isoform ZB. CuratedAdd BLAST | 38 | |
Alternative sequenceiVSP_000399 | 1144 – 1152 | Missing in isoform XC and isoform ZC. Curated | 9 | |
Alternative sequenceiVSP_000400 | 1153 – 1258 | IRVVK…METSL → VTLSAAKPTSAAGNPSGESI P in isoform XA and isoform ZA. 1 PublicationAdd BLAST | 106 | |
Alternative sequenceiVSP_000401 | 1153 – 1258 | IRVVK…METSL → VTLSAAKPTSAAGSES in isoform XE and isoform ZE. CuratedAdd BLAST | 106 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05565, L05558, L05564 Genomic DNA. Translation: AAA53650.1. J05087 mRNA. Translation: AAA69667.1. M96626 mRNA. Translation: AAA50821.1. |
PIRi | A34308. C44525. |
RefSeqi | NP_579822.1. NM_133288.1. [Q64568-3] XP_008771842.1. XM_008773620.2. [Q64568-7] XP_017457435.1. XM_017601946.1. [Q64568-5] XP_017457436.1. XM_017601947.1. [Q64568-3] XP_017457437.1. XM_017601948.1. [Q64568-3] |
UniGenei | Rn.11053. |
Genome annotation databases
Ensembli | ENSRNOT00000077979; ENSRNOP00000071471; ENSRNOG00000061304. [Q64568-3] |
GeneIDi | 29599. |
KEGGi | rno:29599. |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | AT2B3_RAT | |
Accessioni | Q64568Primary (citable) accession number: Q64568 Secondary accession number(s): Q01489, Q63444 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |