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Q64566

- AT2C1_RAT

UniProt

Q64566 - AT2C1_RAT

Protein

Calcium-transporting ATPase type 2C member 1

Gene

Atp2c1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.By similarity

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei350 – 35014-aspartylphosphate intermediateBy similarity
    Metal bindingi644 – 6441MagnesiumBy similarity
    Metal bindingi648 – 6481MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. calcium ion binding Source: UniProtKB
    3. calcium-transporting ATPase activity Source: UniProtKB
    4. manganese ion binding Source: UniProtKB
    5. manganese-transporting ATPase activity Source: UniProtKB
    6. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. calcium-dependent cell-cell adhesion Source: UniProtKB
    3. calcium ion import Source: RGD
    4. calcium ion transmembrane transport Source: GOC
    5. calcium ion transport Source: UniProtKB
    6. cellular calcium ion homeostasis Source: UniProtKB
    7. cellular manganese ion homeostasis Source: UniProtKB
    8. epidermis development Source: UniProtKB
    9. Golgi calcium ion homeostasis Source: UniProtKB
    10. Golgi calcium ion transport Source: UniProtKB
    11. manganese ion transmembrane transport Source: GOC
    12. manganese ion transport Source: UniProtKB
    13. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    14. signal transduction Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
    Short name:
    ATPase 2C1
    Alternative name(s):
    ATP-dependent Ca(2+) pump PMR1
    Gene namesi
    Name:Atp2c1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621311. Atp2c1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular membrane-bounded organelle Source: RGD
    5. plasma membrane Source: RGD
    6. secretory granule Source: RGD
    7. trans-Golgi network Source: UniProtKB
    8. transport vesicle Source: RGD

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 919919Calcium-transporting ATPase type 2C member 1PRO_0000046225Add
    BLAST

    Proteomic databases

    PaxDbiQ64566.
    PRIDEiQ64566.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. The long isoform is only found in testis.1 Publication

    Gene expression databases

    GenevestigatoriQ64566.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4568586.
    STRINGi10116.ENSRNOP00000018175.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64566.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 994ExtracellularSequence Analysis
    Topological domaini122 – 263142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini284 – 29512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini318 – 700383CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini724 – 7285ExtracellularSequence Analysis
    Topological domaini753 – 77624CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini796 – 8027ExtracellularSequence Analysis
    Topological domaini829 – 84315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini864 – 87613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini894 – 91926CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei701 – 72323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei729 – 75224HelicalSequence AnalysisAdd
    BLAST
    Transmembranei777 – 79519HelicalSequence AnalysisAdd
    BLAST
    Transmembranei803 – 82826HelicalSequence AnalysisAdd
    BLAST
    Transmembranei844 – 86320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei877 – 89317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    HOGENOMiHOG000265621.
    HOVERGENiHBG106478.
    PhylomeDBiQ64566.

    Family and domain databases

    Gene3Di1.20.1110.10. 3 hits.
    InterProiIPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Short (identifier: Q64566-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE    50
    VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMRQF 100
    DDAVSITVAI LIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT 150
    LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSIDESSLTG ETTPCSKVTA 200
    PQPAATNGDL ASRSNIAFMG TLVRCGKAKG IVIGTGENSE FGEVFKMMQA 250
    EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 300
    LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD 350
    KTGTLTKNEM TVTHILTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA 400
    VSRIVEAGCV CNDAVIRNNT LMGKPTEGAL IALAMKMGLD GLQQDYIRKA 450
    EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK GAYEQVIKYC TTYNSKGQTL 500
    ALTQQQRDLY QQEKAQMGSA GLRVLALASG PDLGQLTLLG LVGIIDPPRT 550
    GVKEAVTTLI ASGVSIKMIT GDSQETAIAI ASRLGLYSKT SQSVSGEEVD 600
    TMEVQHLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV 650
    ALKAADIGVA MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK 700
    NFVRFQLSTS IAALTLISLA TLMNFPNPLN AMQILWINII MDGPPAQSLG 750
    VEPVDKDVIR KPPRNWKDSI LTKNLILKIL VSSIIIVCGT LFVFWRELRD 800
    NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS NKMFCYAVLG 850
    SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VSEIIKKVER 900
    SREKTQKNTT STPSSFLEV 919
    Length:919
    Mass (Da):100,500
    Last modified:November 1, 1996 - v1
    Checksum:iD26C8C95C14DFB8A
    GO
    Isoform Long (identifier: Q64566-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         919-919: V → FYPKI

    Show »
    Length:923
    Mass (Da):101,050
    Checksum:iD58541FD196C8C95
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti538 – 5381L → F in AAA73342. (PubMed:1380825)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei919 – 9191V → FYPKI in isoform Long. 1 PublicationVSP_000411

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93017 mRNA. Translation: AAA73341.1.
    M93018 mRNA. Translation: AAA73342.1.
    PIRiA42764.
    UniGeneiRn.5805.

    Genome annotation databases

    UCSCiRGD:621311. rat. [Q64566-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93017 mRNA. Translation: AAA73341.1 .
    M93018 mRNA. Translation: AAA73342.1 .
    PIRi A42764.
    UniGenei Rn.5805.

    3D structure databases

    ProteinModelPortali Q64566.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4568586.
    STRINGi 10116.ENSRNOP00000018175.

    Proteomic databases

    PaxDbi Q64566.
    PRIDEi Q64566.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621311. rat. [Q64566-1 ]

    Organism-specific databases

    RGDi 621311. Atp2c1.

    Phylogenomic databases

    eggNOGi COG0474.
    HOGENOMi HOG000265621.
    HOVERGENi HBG106478.
    PhylomeDBi Q64566.

    Miscellaneous databases

    PROi Q64566.

    Gene expression databases

    Genevestigatori Q64566.

    Family and domain databases

    Gene3Di 1.20.1110.10. 3 hits.
    InterProi IPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 3 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and tissue distribution of alternatively spliced mRNAs encoding possible mammalian homologues of the yeast secretory pathway calcium pump."
      Gunteski-Hamblin A.-M., Clarke D.M., Shull G.E.
      Biochemistry 31:7600-7608(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Stomach and Testis.

    Entry informationi

    Entry nameiAT2C1_RAT
    AccessioniPrimary (citable) accession number: Q64566
    Secondary accession number(s): Q64567
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3