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Protein

Alanine--glyoxylate aminotransferase 2, mitochondrial

Gene

Agxt2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).By similarity

Catalytic activityi

L-alanine + glyoxylate = pyruvate + glycine.
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-RNO-389661. Glyoxylate metabolism and glycine degradation.
R-RNO-73621. Pyrimidine catabolism.
SABIO-RKQ64565.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine--glyoxylate aminotransferase 2, mitochondrial (EC:2.6.1.44)
Short name:
AGT 2
Alternative name(s):
(R)-3-amino-2-methylpropionate--pyruvate transaminase (EC:2.6.1.40)
Beta-ALAAT II
Beta-alanine-pyruvate aminotransferase
D-AIBAT
Gene namesi
Name:Agxt2
Synonyms:Agt2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621767. Agxt2.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion1 PublicationAdd
BLAST
Chaini40 – 512473Alanine--glyoxylate aminotransferase 2, mitochondrialPRO_0000001270Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551N6-acetyllysineBy similarity
Modified residuei69 – 691N6-acetyllysine; alternateBy similarity
Modified residuei69 – 691N6-succinyllysine; alternateBy similarity
Modified residuei82 – 821N6-acetyllysineBy similarity
Modified residuei260 – 2601N6-acetyllysine; alternateBy similarity
Modified residuei260 – 2601N6-succinyllysine; alternateBy similarity
Modified residuei302 – 3021N6-succinyllysineBy similarity
Modified residuei348 – 3481N6-(pyridoxal phosphate)lysineBy similarity
Modified residuei415 – 4151N6-acetyllysine; alternateBy similarity
Modified residuei415 – 4151N6-succinyllysine; alternateBy similarity
Modified residuei418 – 4181N6-acetyllysine; alternateBy similarity
Modified residuei418 – 4181N6-succinyllysine; alternateBy similarity
Modified residuei452 – 4521N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ64565.
PRIDEiQ64565.

PTM databases

iPTMnetiQ64565.
PhosphoSiteiQ64565.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017821.
GenevisibleiQ64565. RN.

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024035.

Structurei

3D structure databases

ProteinModelPortaliQ64565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1404. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ64565.
KOiK00827.
OMAiASKTVHR.
OrthoDBiEOG091G06LW.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 2 hits.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64565-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLAWRTLQK AFYLETSLRI LQMRPSLSCA SRIYVPKLTL HTKHNMPPCD
60 70 80 90 100
FSPEKYQSLA YNHVLEIHKQ HLSPVNTAYF QKPLLLHQGH MEWLFDSEGN
110 120 130 140 150
RYLDFFSGIV TVGVGHCHPK VTAVAKKQMD RLWHTSSVFF HSPMHEYAER
160 170 180 190 200
LSALLPEPLK VIFLVNSGSE ANDLAMVMAR AYSNHTDIIS FRGAYHGCSP
210 220 230 240 250
YTLGLTNVGI YKMKVPSTIA CQSTMCPDVF RGPWGGSHCR DSPVQTVRKC
260 270 280 290 300
SCAPDGCQAK ERYIEQFKDT LNTSVATSIA GFFAEPIQGV NGVVQYPKEF
310 320 330 340 350
LKEAFALVRE RGGVCIADEV QTGFGRLGSH FWGFQTHDTM PDIVTMAKGI
360 370 380 390 400
GNGFPMAAVV TTPEIASSLA KHLHHFSTFG GSPLACAIGS AVLEVIEEEN
410 420 430 440 450
LQRNSQEVGT YMLLKFAKLR DEFDIVGDVR GKGLMVGIEM VQDKISRQPL
460 470 480 490 500
PKTEVNQIHE DCKDMGLLVG RGGNFSQTFR IAPPMRVTKL EVDFAFEVFR
510
SALTQHMERR AK
Length:512
Mass (Da):57,201
Last modified:September 13, 2005 - v2
Checksum:iC35E389789516B5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051F → L in BAA07281 (PubMed:7592550).Curated
Sequence conflicti332 – 3321W → Y in BAA07281 (PubMed:7592550).Curated
Sequence conflicti337 – 3382HD → QA in BAA07281 (PubMed:7592550).Curated
Sequence conflicti435 – 4362MV → WW in BAA07281 (PubMed:7592550).Curated
Sequence conflicti494 – 4963FAF → LAL in BAA07281 (PubMed:7592550).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38100 mRNA. Translation: BAA07281.1.
AB002584 mRNA. Translation: BAA19549.1.
BC081765 mRNA. Translation: AAH81765.1.
RefSeqiNP_114023.1. NM_031835.2.
UniGeneiRn.1874.

Genome annotation databases

EnsembliENSRNOT00000024035; ENSRNOP00000024035; ENSRNOG00000017821.
GeneIDi83784.
KEGGirno:83784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38100 mRNA. Translation: BAA07281.1.
AB002584 mRNA. Translation: BAA19549.1.
BC081765 mRNA. Translation: AAH81765.1.
RefSeqiNP_114023.1. NM_031835.2.
UniGeneiRn.1874.

3D structure databases

ProteinModelPortaliQ64565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024035.

PTM databases

iPTMnetiQ64565.
PhosphoSiteiQ64565.

Proteomic databases

PaxDbiQ64565.
PRIDEiQ64565.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024035; ENSRNOP00000024035; ENSRNOG00000017821.
GeneIDi83784.
KEGGirno:83784.

Organism-specific databases

CTDi64902.
RGDi621767. Agxt2.

Phylogenomic databases

eggNOGiKOG1404. Eukaryota.
COG0160. LUCA.
GeneTreeiENSGT00530000062907.
HOGENOMiHOG000020206.
HOVERGENiHBG004196.
InParanoidiQ64565.
KOiK00827.
OMAiASKTVHR.
OrthoDBiEOG091G06LW.

Enzyme and pathway databases

ReactomeiR-RNO-389661. Glyoxylate metabolism and glycine degradation.
R-RNO-73621. Pyrimidine catabolism.
SABIO-RKQ64565.

Miscellaneous databases

PROiQ64565.

Gene expression databases

BgeeiENSRNOG00000017821.
GenevisibleiQ64565. RN.

Family and domain databases

CDDicd00610. OAT_like. 1 hit.
Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 2 hits.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGT2_RAT
AccessioniPrimary (citable) accession number: Q64565
Secondary accession number(s): O08616, Q642F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 13, 2005
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.