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Protein

Alcohol dehydrogenase 4

Gene

Adh4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the reduction of benzoquinones.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi98Zinc 2By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 49NADBy similarity2
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3
Nucleotide bindingi320 – 322NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: RGD
  • alcohol dehydrogenase activity, zinc-dependent Source: InterPro
  • ethanol binding Source: RGD
  • NAD binding Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • aging Source: RGD
  • ethanol oxidation Source: RGD
  • ovulation cycle Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 4 (EC:1.1.1.1)
Alternative name(s):
ADH2
Alcohol dehydrogenase class II
Short name:
Alcohol dehydrogenase II
Gene namesi
Name:Adh4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71028. Adh4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606831 – 377Alcohol dehydrogenase 4Add BLAST377

Proteomic databases

PaxDbiQ64563.
PRIDEiQ64563.

Expressioni

Tissue specificityi

Liver specific.

Interactioni

Subunit structurei

Dimer.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016891.

Structurei

3D structure databases

ProteinModelPortaliQ64563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ64563.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR028632. Zinc_ADH_II.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PTHR11695:SF308. PTHR11695:SF308. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTQGKVITC KAAIAWKTDS PLCIEEIEVS PPKAHEVRIK VIATCVCPTD
60 70 80 90 100
INATNPKKKA LFPVVLGHEC AGIVESVGPG VTNFKPGDKV IPFFAPQCKK
110 120 130 140 150
CKLCLSPLTN LCGKLRNFKY PTIDQELMED RTSRFTSKER SIYHFMGVSS
160 170 180 190 200
FSQYTVVSEA NLARVDDEAN LERVCLIGCG FTSGYGAAIN TAKVTPGSAC
210 220 230 240 250
AVFGLGCVGL SAVIGCKIAG ASRIIAIDIN SEKFPKAKAL GATDCLNPRD
260 270 280 290 300
LDKPVQDVIT ELTGGGVDFS LDCAGTAQTL KAAVDCTVVG WGSCTVVGAK
310 320 330 340 350
VDEMNISTVD MILGRSVKGT FFGGWKSVDS VPNLVTDYKN KKFDLDLLVT
360 370
HALPFDKIND AIDLMNQGKS IRTILTF
Length:377
Mass (Da):40,277
Last modified:January 23, 2007 - v3
Checksum:i9944E04A86868CBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90710 mRNA. Translation: CAA62241.1.
PIRiS66286.
UniGeneiRn.98159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90710 mRNA. Translation: CAA62241.1.
PIRiS66286.
UniGeneiRn.98159.

3D structure databases

ProteinModelPortaliQ64563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016891.

Proteomic databases

PaxDbiQ64563.
PRIDEiQ64563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi71028. Adh4.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ64563.

Miscellaneous databases

PROiQ64563.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR028632. Zinc_ADH_II.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 2 hits.
PTHR11695:SF308. PTHR11695:SF308. 2 hits.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH4_RAT
AccessioniPrimary (citable) accession number: Q64563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Has much lower enzymatic activity towards alcohols and aldehydes compared to human class II ADH. Strongly inhibited by omega-hydroxy fatty acids.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.