UDP-glucuronosyltransferase 1-1 precursor

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Reviewed, UniProtKB/Swiss-Prot Q64550 (UD11_RAT)

Last modified June 16, 2009. Version 64. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-1
      Short name=UDPGT
      Short name=UGT1*1
    EC=2.4.1.17
Alternative name(s):
    UGT1-01
      Short name=UGT1.1
    UGT1A1
    B1

Gene names

Name:	Ugt1a1
Synonyms:	Ugt1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length	535 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subunit structure	Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Induction	Overexpressed of two- to threefold upon clofibrate and dexamethasone administration. Ref.4
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

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Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	bilirubin conjugation Traceable author statement. Source: RGD biphenyl metabolic process Inferred from direct assay. Source: RGD response to drug Inferred from expression pattern. Source: RGD response to ethanol Inferred from expression pattern. Source: RGD response to glucocorticoid stimulus Inferred from expression pattern. Source: RGD response to nutrient Inferred from expression pattern. Source: RGD response to starvation Inferred from expression pattern. Source: RGD
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from direct assay. Source: RGD
Molecular function	glucuronosyltransferase activity Inferred from direct assay. Source: RGD
Complete GO annotation...

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Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64550-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

Ref.3

Chain

30 – 535

506

UDP-glucuronosyltransferase 1-1

PRO_0000036011

Regions

Transmembrane

493 – 509

Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

297

N-linked (GlcNAc...) Potential

Glycosylation

435

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

253

A → D in BAA07260. Ref.2

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Sequences

Sequence

Length

Mass (Da)

Tools

Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 26B642FCA7DD4082
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FASTA

535

59,663

        10         20         30         40         50         60 
MSVVCRSSCS LLLLPCLLLC VLGPSASHAG KLLVIPIDGS HWLSMLGVIQ QLQQKGHEVV 

        70         80         90        100        110        120 
VIAPEASIHI KEGSFYTMRK YPVPFQNENV TAAFVELGRS VFDQDPFLLR VVKTYNKVKR 

       130        140        150        160        170        180 
DSSMLLSGCS HLLHNAEFMA SLEQSHFDAL LTDPFLPCGS IVAQYLSLPA VYFLNALPCS 

       190        200        210        220        230        240 
LDLEATQCPA PLSYVPKSLS SNTDRMNFLQ RVKNMIIALT ENFLCRVVYS PYGSLATEIL 

       250        260        270        280        290        300 
QKEVTVKDLL SPASIWLMRN DFVKDYPRPI MPNMVFIGGI NCLQKKALSQ EFEAYVNASG 

       310        320        330        340        350        360 
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN 

       370        380        390        400        410        420 
DLLGHPKARA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM 

       430        440        450        460        470        480 
TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA 

       490        500        510        520        530 
HDLTWYQYHS LDVIGFLLAI VLTVVFIVYK SCAYGCRKCF GGKGRVKKSH KSKTH

« Hide

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References

[1]	"Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin." Coffman B.L., Green M.D., King C.O., Tephly T.R. Mol. Pharmacol. 47:1101-1105(1995) [PubMed: 7603447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Wistar.
[2]	"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex." Emi Y., Ikushiro S., Iyanagi T. J. Biochem. 117:392-399(1995) [PubMed: 7608130] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-290. Strain: Wistar.
[3]	"Purification of a phenobarbital-inducible morphine UDP-glucuronyltransferase isoform, absent from Gunn rat liver." Ishii Y., Tsuruda K., Tanaka M., Oguri K. Arch. Biochem. Biophys. 315:345-351(1994) [PubMed: 7986077] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-41.
[4]	"Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies." Ikushiro S., Emi Y., Iyanagi T. Arch. Biochem. Biophys. 324:267-272(1995) [PubMed: 8554318] [Abstract] Cited for: INDUCTION.
[5]	"A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins." Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M. Mol. Biol. Cell 13:4456-4469(2002) [PubMed: 12475965] [Abstract] Cited for: COMPONENT OF A CHAPERONE COMPLEX.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	U20551 Genomic DNA. Translation: AAC52219.1. D38065 Genomic DNA. Translation: BAA07260.1.
IPI	IPI00213569.
PIR	I57961.
RefSeq	NP_036815.1.
UniGene	Rn.26489
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Proteomic databases
PRIDE	Q64550.
Genome annotation databases
Ensembl	ENSRNOG00000018740. Rattus norvegicus. [Contig view]
GeneID	24861.
KEGG	rno:24861.
Organism-specific databases
RGD	3935. Ugt1a1.
Phylogenomic databases
HOVERGEN	Q64550.
OMA	Q64550. RVIKTYK.
Enzyme and pathway databases
BRENDA	2.4.1.17. 248.
Gene expression databases
ArrayExpress	Q64550.
GermOnline	ENSRNOG00000018740. Rattus norvegicus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	604668.

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Entry information

Entry name

UD11_RAT

Accession

Primary (citable) accession number: Q64550
Secondary accession number(s): Q64635

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents