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Q64550

- UD11_RAT

UniProt

Q64550 - UD11_RAT

Protein

UDP-glucuronosyltransferase 1-1

Gene

Ugt1a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Glucuronates opioids and bilirubin.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. enzyme binding Source: RGD
    2. enzyme inhibitor activity Source: Ensembl
    3. glucuronosyltransferase activity Source: RGD
    4. retinoic acid binding Source: Ensembl
    5. steroid binding Source: Ensembl

    GO - Biological processi

    1. acute-phase response Source: RGD
    2. bilirubin conjugation Source: RGD
    3. biphenyl catabolic process Source: RGD
    4. cellular response to ethanol Source: RGD
    5. cellular response to glucocorticoid stimulus Source: RGD
    6. cellular response to hormone stimulus Source: RGD
    7. flavone metabolic process Source: Ensembl
    8. flavonoid glucuronidation Source: Ensembl
    9. liver development Source: RGD
    10. organ regeneration Source: RGD
    11. response to drug Source: RGD
    12. response to ethanol Source: RGD
    13. response to glucocorticoid Source: RGD
    14. response to lipopolysaccharide Source: RGD
    15. response to nutrient Source: RGD
    16. response to organic cyclic compound Source: RGD
    17. response to organic substance Source: RGD
    18. response to starvation Source: RGD
    19. response to steroid hormone Source: RGD
    20. xenobiotic glucuronidation Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.17. 5301.
    ReactomeiREACT_221439. Glucuronidation.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-1 (EC:2.4.1.17)
    Short name:
    UDPGT 1-1
    Short name:
    UGT1*1
    Short name:
    UGT1-01
    Short name:
    UGT1.1
    Alternative name(s):
    B1
    UDP-glucuronosyltransferase 1A1
    Gene namesi
    Name:Ugt1a1
    Synonyms:Ugt1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi3935. Ugt1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytochrome complex Source: RGD
    2. endoplasmic reticulum Source: HGNC
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. integral component of plasma membrane Source: Ensembl
    5. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 29291 PublicationAdd
    BLAST
    Chaini30 – 535506UDP-glucuronosyltransferase 1-1PRO_0000036011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ64550.
    PRIDEiQ64550.

    Expressioni

    Inductioni

    Overexpressed of two- to threefold upon clofibrate and dexamethasone administration.1 Publication

    Gene expression databases

    ArrayExpressiQ64550.
    GenevestigatoriQ64550.

    Interactioni

    Subunit structurei

    Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64550.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei493 – 50917HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1819.
    GeneTreeiENSGT00640000091365.
    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.
    InParanoidiQ64550.
    KOiK00699.
    OMAiSEIDEAY.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. The different isozymes have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q64550-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVVCRSSCS LLLLPCLLLC VLGPSASHAG KLLVIPIDGS HWLSMLGVIQ    50
    QLQQKGHEVV VIAPEASIHI KEGSFYTMRK YPVPFQNENV TAAFVELGRS 100
    VFDQDPFLLR VVKTYNKVKR DSSMLLSGCS HLLHNAEFMA SLEQSHFDAL 150
    LTDPFLPCGS IVAQYLSLPA VYFLNALPCS LDLEATQCPA PLSYVPKSLS 200
    SNTDRMNFLQ RVKNMIIALT ENFLCRVVYS PYGSLATEIL QKEVTVKDLL 250
    SPASIWLMRN DFVKDYPRPI MPNMVFIGGI NCLQKKALSQ EFEAYVNASG 300
    EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN 350
    TILVKWLPQN DLLGHPKARA FITHSGSHGI YEGICNGVPM VMMPLFGDQM 400
    DNAKRMETRG AGVTLNVLEM TADDLENALK TVINNKSYKE NIMRLSSLHK 450
    DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA HDLTWYQYHS LDVIGFLLAI 500
    VLTVVFIVYK SCAYGCRKCF GGKGRVKKSH KSKTH 535
    Length:535
    Mass (Da):59,663
    Last modified:November 1, 1997 - v1
    Checksum:i26B642FCA7DD4082
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti253 – 2531A → D in BAA07260. (PubMed:7608130)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20551 Genomic DNA. Translation: AAC52219.1.
    D38065 Genomic DNA. Translation: BAA07260.1.
    PIRiI57961.
    RefSeqiNP_036815.1. NM_012683.2. [Q64550-1]
    UniGeneiRn.26489.

    Genome annotation databases

    EnsembliENSRNOT00000025045; ENSRNOP00000025045; ENSRNOG00000018740. [Q64550-1]
    GeneIDi24861.
    KEGGirno:24861.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20551 Genomic DNA. Translation: AAC52219.1 .
    D38065 Genomic DNA. Translation: BAA07260.1 .
    PIRi I57961.
    RefSeqi NP_036815.1. NM_012683.2. [Q64550-1 ]
    UniGenei Rn.26489.

    3D structure databases

    ProteinModelPortali Q64550.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q64550.
    PRIDEi Q64550.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025045 ; ENSRNOP00000025045 ; ENSRNOG00000018740 . [Q64550-1 ]
    GeneIDi 24861.
    KEGGi rno:24861.

    Organism-specific databases

    CTDi 54658.
    RGDi 3935. Ugt1a1.

    Phylogenomic databases

    eggNOGi COG1819.
    GeneTreei ENSGT00640000091365.
    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.
    InParanoidi Q64550.
    KOi K00699.
    OMAi SEIDEAY.
    TreeFami TF315472.

    Enzyme and pathway databases

    BRENDAi 2.4.1.17. 5301.
    Reactomei REACT_221439. Glucuronidation.

    Miscellaneous databases

    NextBioi 604668.

    Gene expression databases

    ArrayExpressi Q64550.
    Genevestigatori Q64550.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin."
      Coffman B.L., Green M.D., King C.O., Tephly T.R.
      Mol. Pharmacol. 47:1101-1105(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
    2. "Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex."
      Emi Y., Ikushiro S., Iyanagi T.
      J. Biochem. 117:392-399(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-290.
      Strain: Wistar.
    3. "Purification of a phenobarbital-inducible morphine UDP-glucuronyltransferase isoform, absent from Gunn rat liver."
      Ishii Y., Tsuruda K., Tanaka M., Oguri K.
      Arch. Biochem. Biophys. 315:345-351(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 30-41.
    4. "Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies."
      Ikushiro S., Emi Y., Iyanagi T.
      Arch. Biochem. Biophys. 324:267-272(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. "A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins."
      Meunier L., Usherwood Y.-K., Chung K.T., Hendershot L.M.
      Mol. Biol. Cell 13:4456-4469(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: COMPONENT OF A CHAPERONE COMPLEX.

    Entry informationi

    Entry nameiUD11_RAT
    AccessioniPrimary (citable) accession number: Q64550
    Secondary accession number(s): Q64635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3