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Protein

Reticulon-1

Gene

Rtn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
S-rex
Gene namesi
Name:Rtn1
Synonyms:Nsp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620986. Rtn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei604 – 62421HelicalSequence analysisAdd
BLAST
Transmembranei706 – 72621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 777777Reticulon-1PRO_0000168161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineCombined sources
Modified residuei68 – 681PhosphoserineCombined sources
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei241 – 2411PhosphoserineCombined sources
Modified residuei325 – 3251PhosphoserineCombined sources
Modified residuei348 – 3481PhosphoserineCombined sources
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei485 – 4851PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ64548.

PTM databases

iPTMnetiQ64548.
SwissPalmiQ64548.

Expressioni

Tissue specificityi

Expressed predominantly in central and peripheral nervous system of newborn and adult rats. Low levels have been also detected in heart, adrenal gland and spleen. Expression of isoform RTN1-B is restricted to particular neuronal types.

Developmental stagei

Detected on embryonic day E10 in the hindbrain and in E11 in the forebrain. During the next 3 embryonic days the levels of RTN1-S increases and remains stable at E13 in the hindbrain and at E14 in the forebrain. The levels of RTN1-B does not change as significantly during development of the hindbrain.

Gene expression databases

ExpressionAtlasiQ64548. baseline and differential.
GenevisibleiQ64548. RN.

Interactioni

Subunit structurei

Interacts with NDRG1. Interacts with TMEM33.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ64548.
SMRiQ64548. Positions 640-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini590 – 777188ReticulonPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi610 – 6134Poly-Leu

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009934.
HOGENOMiHOG000015254.
HOVERGENiHBG008971.
InParanoidiQ64548.
PhylomeDBiQ64548.
TreeFamiTF105431.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RTN1-B (identifier: Q64548-1) [UniParc]FASTAAdd to basket

Also known as: S-RexB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPDLQDE PLSPANPGSQ LFGGRGEGEE ATPKGARPAQ QDGEPAWGSG
60 70 80 90 100
AGAGVVSSRG LCSGPARSPP VAMETASTGV AAVPDALDHS SSPTLKDGEG
110 120 130 140 150
ACYTSLISDI CYPPREDSAY FTGILQKENG HITTSESPEE LGTPGPSLPE
160 170 180 190 200
VPGTEPHGLL SSDSGIEMTP AESTEVNKIL ADPLDQMKAE ACKYIDITRP
210 220 230 240 250
QEAKGQEEQS PGLEDKDLDF KDKDSEVSTK PEGVHAPNQP SPVEGKLIKD
260 270 280 290 300
NLFEESTFAP YIDELSDEQH RMSLVTAPVK ITLTEIGPPV MTATHETIPE
310 320 330 340 350
KQDLCLKPSP DTVPTVTVSE PEDDSPGSVT PPSSGTEPSA AESQGKGSVS
360 370 380 390 400
EDELIAAIKE AKGLSYETTE SPRPVGQAAD RPKVKARSGL PTIPSSLDQE
410 420 430 440 450
ASSAESGDSE IELVSEDPMA SEDALPSGYV SFGHVSGPPP SPASPSIQYS
460 470 480 490 500
ILREEREAEL DSELIIESCD ASSASEESPK REQDSPPMKP GVLDAIREET
510 520 530 540 550
SSRATEERAP SHQGPVEPDP ILSFTPVTLQ SRPEPSSGDG APVPEPPKSQ
560 570 580 590 600
QQKPEEEAVS SSQSPAATEI PGPLGSDLVP PLPFFNKQKA IDLLYWRDIK
610 620 630 640 650
QTGIVFGSFL LLLFSLTQFS VVSVVAYLAL AALSATISFR IYKSVLQAVQ
660 670 680 690 700
KTDEGHPFKA YLELEITLSQ EQIQKYTDCL QLYVNSTLKE LRRLFLVQDL
710 720 730 740 750
VDSLKFAVLM WLLTYVGALF NGLTLLLMAV VSMFTLPVVY VKHQAQVDQY
760 770
LGLVRTHINT VVAKIQAKIP GAKRHAE
Length:777
Mass (Da):83,002
Last modified:November 1, 1996 - v1
Checksum:iAF7479C50F28D0AC
GO
Isoform RTN1-S (identifier: Q64548-2) [UniParc]FASTAAdd to basket

Also known as: S-RexS

The sequence of this isoform differs from the canonical sequence as follows:
     1-569: Missing.
     570-589: IPGPLGSDLVPPLPFFNKQK → MQATADSTKMDCVWSNWKSQ

Show »
Length:208
Mass (Da):23,558
Checksum:i22A069D1DE63A0EC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 569569Missing in isoform RTN1-S. 1 PublicationVSP_005647Add
BLAST
Alternative sequencei570 – 58920IPGPL…FNKQK → MQATADSTKMDCVWSNWKSQ in isoform RTN1-S. 1 PublicationVSP_005648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17604 mRNA. Translation: AAC53046.1.
U17603 mRNA. Translation: AAC53045.1.
RefSeqiNP_446317.1. NM_053865.1. [Q64548-1]
XP_008762912.1. XM_008764690.1. [Q64548-2]
UniGeneiRn.55126.

Genome annotation databases

EnsembliENSRNOT00000006373; ENSRNOP00000006373; ENSRNOG00000004794. [Q64548-2]
GeneIDi116644.
KEGGirno:116644.
UCSCiRGD:620986. rat. [Q64548-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17604 mRNA. Translation: AAC53046.1.
U17603 mRNA. Translation: AAC53045.1.
RefSeqiNP_446317.1. NM_053865.1. [Q64548-1]
XP_008762912.1. XM_008764690.1. [Q64548-2]
UniGeneiRn.55126.

3D structure databases

ProteinModelPortaliQ64548.
SMRiQ64548. Positions 640-699.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ64548.
SwissPalmiQ64548.

Proteomic databases

PRIDEiQ64548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006373; ENSRNOP00000006373; ENSRNOG00000004794. [Q64548-2]
GeneIDi116644.
KEGGirno:116644.
UCSCiRGD:620986. rat. [Q64548-1]

Organism-specific databases

CTDi6252.
RGDi620986. Rtn1.

Phylogenomic databases

GeneTreeiENSGT00390000009934.
HOGENOMiHOG000015254.
HOVERGENiHBG008971.
InParanoidiQ64548.
PhylomeDBiQ64548.
TreeFamiTF105431.

Miscellaneous databases

PROiQ64548.

Gene expression databases

ExpressionAtlasiQ64548. baseline and differential.
GenevisibleiQ64548. RN.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Intracellular compartmentalization of two differentially spliced s-rex/NSP mRNAs in neurons."
    Baka I.D., Ninkina N.N., Pinon L.G.P., Adu J., Davies A.M., Georgiev G.P., Buchman V.L.
    Mol. Cell. Neurosci. 7:289-303(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS RTN1-B AND RTN1-S).
    Strain: Wistar.
    Tissue: Brain cortex.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-68; SER-210; SER-241; SER-325; SER-348; SER-350 AND SER-485, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRTN1_RAT
AccessioniPrimary (citable) accession number: Q64548
Secondary accession number(s): Q64547
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.