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Protein

Reticulon-1

Gene

Rtn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-1
Alternative name(s):
Neuroendocrine-specific protein
S-rex
Gene namesi
Name:Rtn1
Synonyms:Nsp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi620986 Rtn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei604 – 624HelicalSequence analysisAdd BLAST21
Transmembranei706 – 726HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001681611 – 777Reticulon-1Add BLAST777

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei348PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ64548

PTM databases

iPTMnetiQ64548
PhosphoSitePlusiQ64548
SwissPalmiQ64548

Expressioni

Tissue specificityi

Expressed predominantly in central and peripheral nervous system of newborn and adult rats. Low levels have been also detected in heart, adrenal gland and spleen. Expression of isoform RTN1-B is restricted to particular neuronal types.

Developmental stagei

Detected on embryonic day E10 in the hindbrain and in E11 in the forebrain. During the next 3 embryonic days the levels of RTN1-S increases and remains stable at E13 in the hindbrain and at E14 in the forebrain. The levels of RTN1-B does not change as significantly during development of the hindbrain.

Gene expression databases

BgeeiENSRNOG00000004794
ExpressionAtlasiQ64548 baseline and differential
GenevisibleiQ64548 RN

Interactioni

Subunit structurei

Interacts with NDRG1. Interacts with TMEM33.By similarity

Protein-protein interaction databases

BioGridi250529, 3 interactors
CORUMiQ64548

Structurei

3D structure databases

ProteinModelPortaliQ64548
SMRiQ64548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini590 – 777ReticulonPROSITE-ProRule annotationAdd BLAST188

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi610 – 613Poly-Leu4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009934
HOGENOMiHOG000015254
HOVERGENiHBG008971
InParanoidiQ64548
KOiK20721
PhylomeDBiQ64548
TreeFamiTF105431

Family and domain databases

InterProiView protein in InterPro
IPR003388 Reticulon
PfamiView protein in Pfam
PF02453 Reticulon, 1 hit
PROSITEiView protein in PROSITE
PS50845 RETICULON, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform RTN1-B (identifier: Q64548-1) [UniParc]FASTAAdd to basket
Also known as: S-RexB

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPDLQDE PLSPANPGSQ LFGGRGEGEE ATPKGARPAQ QDGEPAWGSG
60 70 80 90 100
AGAGVVSSRG LCSGPARSPP VAMETASTGV AAVPDALDHS SSPTLKDGEG
110 120 130 140 150
ACYTSLISDI CYPPREDSAY FTGILQKENG HITTSESPEE LGTPGPSLPE
160 170 180 190 200
VPGTEPHGLL SSDSGIEMTP AESTEVNKIL ADPLDQMKAE ACKYIDITRP
210 220 230 240 250
QEAKGQEEQS PGLEDKDLDF KDKDSEVSTK PEGVHAPNQP SPVEGKLIKD
260 270 280 290 300
NLFEESTFAP YIDELSDEQH RMSLVTAPVK ITLTEIGPPV MTATHETIPE
310 320 330 340 350
KQDLCLKPSP DTVPTVTVSE PEDDSPGSVT PPSSGTEPSA AESQGKGSVS
360 370 380 390 400
EDELIAAIKE AKGLSYETTE SPRPVGQAAD RPKVKARSGL PTIPSSLDQE
410 420 430 440 450
ASSAESGDSE IELVSEDPMA SEDALPSGYV SFGHVSGPPP SPASPSIQYS
460 470 480 490 500
ILREEREAEL DSELIIESCD ASSASEESPK REQDSPPMKP GVLDAIREET
510 520 530 540 550
SSRATEERAP SHQGPVEPDP ILSFTPVTLQ SRPEPSSGDG APVPEPPKSQ
560 570 580 590 600
QQKPEEEAVS SSQSPAATEI PGPLGSDLVP PLPFFNKQKA IDLLYWRDIK
610 620 630 640 650
QTGIVFGSFL LLLFSLTQFS VVSVVAYLAL AALSATISFR IYKSVLQAVQ
660 670 680 690 700
KTDEGHPFKA YLELEITLSQ EQIQKYTDCL QLYVNSTLKE LRRLFLVQDL
710 720 730 740 750
VDSLKFAVLM WLLTYVGALF NGLTLLLMAV VSMFTLPVVY VKHQAQVDQY
760 770
LGLVRTHINT VVAKIQAKIP GAKRHAE
Length:777
Mass (Da):83,002
Last modified:November 1, 1996 - v1
Checksum:iAF7479C50F28D0AC
GO
Isoform RTN1-S (identifier: Q64548-2) [UniParc]FASTAAdd to basket
Also known as: S-RexS

The sequence of this isoform differs from the canonical sequence as follows:
     1-569: Missing.
     570-589: IPGPLGSDLVPPLPFFNKQK → MQATADSTKMDCVWSNWKSQ

Show »
Length:208
Mass (Da):23,558
Checksum:i22A069D1DE63A0EC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0056471 – 569Missing in isoform RTN1-S. 1 PublicationAdd BLAST569
Alternative sequenceiVSP_005648570 – 589IPGPL…FNKQK → MQATADSTKMDCVWSNWKSQ in isoform RTN1-S. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17604 mRNA Translation: AAC53046.1
U17603 mRNA Translation: AAC53045.1
RefSeqiNP_446317.1, NM_053865.1 [Q64548-1]
XP_008762912.1, XM_008764690.2 [Q64548-2]
UniGeneiRn.55126

Genome annotation databases

EnsembliENSRNOT00000006373; ENSRNOP00000006373; ENSRNOG00000004794 [Q64548-2]
GeneIDi116644
KEGGirno:116644
UCSCiRGD:620986 rat [Q64548-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRTN1_RAT
AccessioniPrimary (citable) accession number: Q64548
Secondary accession number(s): Q64547
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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