Plasma membrane calcium-transporting ATPase 4

Names and origin

Protein names

Recommended name:
    Plasma membrane calcium-transporting ATPase 4
      Short name=PMCA4
    EC=3.6.3.8
Alternative name(s):
    Plasma membrane calcium ATPase isoform 4
    Plasma membrane calcium pump isoform 4

Gene names

Name:

Atp2b4

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Hide | Top

Protein attributes

Sequence length	1203 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Hide | Top

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
Catalytic activity	ATP + H₂O + Ca²⁺(Cis) = ADP + phosphate + Ca²⁺(Trans).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitously expressed. Not detected in liver. The highest levels are found in uterus and stomach. Isoform XA is found in uterus, brain, stomach, small intestine, colon and pancreas. Isoform XB is found in uterus, skeletal muscle, lung, kidney, spleen, stomach, small intestine and pancreas. Isoform ZA is found in testis and isoform ZB is found in testis and heart.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IIB subfamily.

Hide | Top

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Ligand	ATP-binding Calcium Calmodulin-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro calcium ion transport Inferred from direct assay. Source: RGD calcium-mediated signaling Traceable author statement. Source: RGD cellular calcium ion homeostasis Traceable author statement. Source: RGD
Cellular component	integral to plasma membrane Traceable author statement. Source: RGD
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW PDZ domain binding Inferred from physical interaction. Source: RGD calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from direct assay. Source: RGD calmodulin binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Hide | Top

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: There is a combination of two alternatively spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A and B).

Isoform XB (identifier: Q64542-1) Also known as: AIICI; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform XA (identifier: Q64542-2) Also known as: AIICII; The sequence of this isoform differs from the canonical sequence as follows: 1105-1203: RVVKVFHSFR...SPLQSQETPV → EVINKFQTGA...VGNQSGQSIS

Isoform ZA (identifier: Q64542-3) Also known as: AICII; The sequence of this isoform differs from the canonical sequence as follows: 301-312: Missing. 1105-1203: RVVKVFHSFR...SPLQSQETPV → EVINKFQTGA...VGNQSGQSIS

Isoform ZB (identifier: Q64542-4) Also known as: AICI; The sequence of this isoform differs from the canonical sequence as follows: 301-312: Missing.

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1203

1203

Plasma membrane calcium-transporting ATPase 4

PRO_0000046221

Regions

Topological domain

1 – 92

92

Cytoplasmic Potential

Transmembrane

93 – 113

21

Potential

Topological domain

114 – 150

37

Extracellular Potential

Transmembrane

151 – 171

21

Potential

Topological domain

172 – 356

185

Cytoplasmic Potential

Transmembrane

357 – 376

20

Potential

Topological domain

377 – 409

33

Extracellular Potential

Transmembrane

410 – 427

18

Potential

Topological domain

428 – 840

413

Cytoplasmic Potential

Transmembrane

841 – 860

20

Potential

Topological domain

861 – 870

10

Extracellular Potential

Transmembrane

871 – 891

21

Potential

Topological domain

892 – 911

20

Cytoplasmic Potential

Transmembrane

912 – 934

23

Potential

Topological domain

935 – 952

18

Extracellular Potential

Transmembrane

953 – 974

22

Potential

Topological domain

975 – 993

19

Cytoplasmic Potential

Transmembrane

994 – 1015

22

Potential

Topological domain

1016 – 1025

10

Extracellular Potential

Transmembrane

1026 – 1047

22

Potential

Topological domain

1048 – 1203

156

Cytoplasmic Potential

Region

1086 – 1103

18

Calmodulin-binding subdomain A By similarity

Region

1104 – 1113

10

Calmodulin-binding subdomain B By similarity

Compositional bias

297 – 303

7

Poly-Lys

Sites

Active site

465

1

4-aspartylphosphate intermediate By similarity

Metal binding

785

1

Magnesium By similarity

Metal binding

789

1

Magnesium By similarity

Amino acid modifications

Modified residue

1102

1

Phosphothreonine; by PKC By similarity

Natural variations

Alternative sequence

301 – 312

12

Missing in isoform ZA and isoform ZB.

VSP_000406

Alternative sequence

1105 – 1203

99

RVVKV…QETPV → EVINKFQTGASFKGVLRRQN LSQQLDVKLVPSSYSEAVAS VRTSPSTSSAVTPPPVGNQS GQSIS in isoform XA and isoform ZA.

VSP_000407

Experimental info

Sequence conflict

431

1

I → V in CAA53990. Ref.2

Hide | Top

Sequences

Sequence		Length	Mass (Da)
Isoform XB (AIICI) [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B7A6C8D4556F6398 Show »	FASTA	1,203	133,094
10 20 30 40 50 60 MTNPSGHNLP ANSVAESYEG EFGCTLMDLR KLMELRAADA VTQISAHYGS VQEICARLKT 70 80 90 100 110 120 SPVEGLSGNP ADLEKRRLVF GKNMIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 130 140 150 160 170 180 FYRPPGGENE ICGHIVSNPE EDEEGETGWI EGAAILASVI IVVFVTAFND WSKEKQFRGL 190 200 210 220 230 240 QSRIELEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 250 260 270 280 290 300 GESDHVKKTL DKDPMLLSGT HVMEGSGRMV VTAVGINSQT GIIFTLLGAN EEEDDEKKKK 310 320 330 340 350 360 GKKQGVSENR NKAKTQDGVA LEIQPLNSQE GLDSEEKEKK ASKGPKKEKS VLQGKLTRLA 370 380 390 400 410 420 VQIGKAGLIM SILTVLILIL YFVVDNFVIQ RRAWLPECTP VYIQYFVKFF IIGVTVLVVA 430 440 450 460 470 480 VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA 490 500 510 520 530 540 YIGGTHYRQI PKPDDLPPNV LDLIVNSICI NSAYTSKILP PEKEGGLPRQ VGNKTECGLL 550 560 570 580 590 600 GFVTDLKQDY QAVRSEMPEE KLFKVYTFNS VRKSMSTVIR KPEGGFRVFS KGASEIMLRK 610 620 630 640 650 660 CDRILNKEGG IVPFKTKDRD NMVRNVIEPM ASEGLRTIGI AYRDFDGEEP SWENENEIFT 670 680 690 700 710 720 GLVCIAVVGI EDPVRPEVPD AINKCKRAGI TVRMVTGDNV NTARAIATKC GILTPGDDFL 730 740 750 760 770 780 CLEGKEFNRL IRNEKGEVEQ EKLDKVWPRL RVLARSSPTD KHTLVKGIID SNIGEQRQVV 790 800 810 820 830 840 AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI 850 860 870 880 890 900 SKFLQFQLTV NVVAVIVAFS GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTDSLL 910 920 930 940 950 960 RRRPYGRNKP LISRTMMKNI LGHAVYQLGI VFLLVFAGDK LFDIDSGRKA PLNSPPSQHY 970 980 990 1000 1010 1020 TIVFNTFVLM QLFNEINSRK IHGEKNVFAG VYRNIIFCSV VLGTFFCQIL IVEVGGKPFS 1030 1040 1050 1060 1070 1080 CTNLTMEQWM WCLFIGIGEL LWGQVISAIP TKSLKFLKEA GHGSDKEEIS KDAEGLEEID 1090 1100 1110 1120 1130 1140 HAEMELRRGQ ILWVRGLNRI QTQIRVVKVF HSFRDVIHKS KNQVSIHSFM TQPEYAADDE 1150 1160 1170 1180 1190 1200 MSQSFLNQEE SPSLASKSRI TKRLSDAETV SQNNTNNNAV DCHQVQIVAS HPNSPLQSQE TPV « Hide
Isoform XA (AIICII). Checksum: C799FA6AC708EBE4 Show »	FASTA	1,169	128,791
10 20 30 40 50 60 MTNPSGHNLP ANSVAESYEG EFGCTLMDLR KLMELRAADA VTQISAHYGS VQEICARLKT 70 80 90 100 110 120 SPVEGLSGNP ADLEKRRLVF GKNMIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 130 140 150 160 170 180 FYRPPGGENE ICGHIVSNPE EDEEGETGWI EGAAILASVI IVVFVTAFND WSKEKQFRGL 190 200 210 220 230 240 QSRIELEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 250 260 270 280 290 300 GESDHVKKTL DKDPMLLSGT HVMEGSGRMV VTAVGINSQT GIIFTLLGAN EEEDDEKKKK 310 320 330 340 350 360 GKKQGVSENR NKAKTQDGVA LEIQPLNSQE GLDSEEKEKK ASKGPKKEKS VLQGKLTRLA 370 380 390 400 410 420 VQIGKAGLIM SILTVLILIL YFVVDNFVIQ RRAWLPECTP VYIQYFVKFF IIGVTVLVVA 430 440 450 460 470 480 VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL TMNRMTVVQA 490 500 510 520 530 540 YIGGTHYRQI PKPDDLPPNV LDLIVNSICI NSAYTSKILP PEKEGGLPRQ VGNKTECGLL 550 560 570 580 590 600 GFVTDLKQDY QAVRSEMPEE KLFKVYTFNS VRKSMSTVIR KPEGGFRVFS KGASEIMLRK 610 620 630 640 650 660 CDRILNKEGG IVPFKTKDRD NMVRNVIEPM ASEGLRTIGI AYRDFDGEEP SWENENEIFT 670 680 690 700 710 720 GLVCIAVVGI EDPVRPEVPD AINKCKRAGI TVRMVTGDNV NTARAIATKC GILTPGDDFL 730 740 750 760 770 780 CLEGKEFNRL IRNEKGEVEQ EKLDKVWPRL RVLARSSPTD KHTLVKGIID SNIGEQRQVV 790 800 810 820 830 840 AVTGDGTNDG PALKKADVGF AMGIAGTDVA KEASDIILTD DNFTSIVKAV MWGRNVYDSI 850 860 870 880 890 900 SKFLQFQLTV NVVAVIVAFS GACITQDSPL KAVQMLWVNL IMDTFASLAL ATEPPTDSLL 910 920 930 940 950 960 RRRPYGRNKP LISRTMMKNI LGHAVYQLGI VFLLVFAGDK LFDIDSGRKA PLNSPPSQHY 970 980 990 1000 1010 1020 TIVFNTFVLM QLFNEINSRK IHGEKNVFAG VYRNIIFCSV VLGTFFCQIL IVEVGGKPFS 1030 1040 1050 1060 1070 1080 CTNLTMEQWM WCLFIGIGEL LWGQVISAIP TKSLKFLKEA GHGSDKEEIS KDAEGLEEID 1090 1100 1110 1120 1130 1140 HAEMELRRGQ ILWVRGLNRI QTQIEVINKF QTGASFKGVL RRQNLSQQLD VKLVPSSYSE 1150 1160 AVASVRTSPS TSSAVTPPPV GNQSGQSIS « Hide
Isoform ZA (AICII). Checksum: EDB410076D59B247 Show »	FASTA	1,157	127,464
10 20 30 40 50 60 MTNPSGHNLP ANSVAESYEG EFGCTLMDLR KLMELRAADA VTQISAHYGS VQEICARLKT 70 80 90 100 110 120 SPVEGLSGNP ADLEKRRLVF GKNMIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 130 140 150 160 170 180 FYRPPGGENE ICGHIVSNPE EDEEGETGWI EGAAILASVI IVVFVTAFND WSKEKQFRGL 190 200 210 220 230 240 QSRIELEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 250 260 270 280 290 300 GESDHVKKTL DKDPMLLSGT HVMEGSGRMV VTAVGINSQT GIIFTLLGAN EEEDDEKKKK 310 320 330 340 350 360 AKTQDGVALE IQPLNSQEGL DSEEKEKKAS KGPKKEKSVL QGKLTRLAVQ IGKAGLIMSI 370 380 390 400 410 420 LTVLILILYF VVDNFVIQRR AWLPECTPVY IQYFVKFFII GVTVLVVAVP EGLPLAVTIS 430 440 450 460 470 480 LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTM NRMTVVQAYI GGTHYRQIPK 490 500 510 520 530 540 PDDLPPNVLD LIVNSICINS AYTSKILPPE KEGGLPRQVG NKTECGLLGF VTDLKQDYQA 550 560 570 580 590 600 VRSEMPEEKL FKVYTFNSVR KSMSTVIRKP EGGFRVFSKG ASEIMLRKCD RILNKEGGIV 610 620 630 640 650 660 PFKTKDRDNM VRNVIEPMAS EGLRTIGIAY RDFDGEEPSW ENENEIFTGL VCIAVVGIED 670 680 690 700 710 720 PVRPEVPDAI NKCKRAGITV RMVTGDNVNT ARAIATKCGI LTPGDDFLCL EGKEFNRLIR 730 740 750 760 770 780 NEKGEVEQEK LDKVWPRLRV LARSSPTDKH TLVKGIIDSN IGEQRQVVAV TGDGTNDGPA 790 800 810 820 830 840 LKKADVGFAM GIAGTDVAKE ASDIILTDDN FTSIVKAVMW GRNVYDSISK FLQFQLTVNV 850 860 870 880 890 900 VAVIVAFSGA CITQDSPLKA VQMLWVNLIM DTFASLALAT EPPTDSLLRR RPYGRNKPLI 910 920 930 940 950 960 SRTMMKNILG HAVYQLGIVF LLVFAGDKLF DIDSGRKAPL NSPPSQHYTI VFNTFVLMQL 970 980 990 1000 1010 1020 FNEINSRKIH GEKNVFAGVY RNIIFCSVVL GTFFCQILIV EVGGKPFSCT NLTMEQWMWC 1030 1040 1050 1060 1070 1080 LFIGIGELLW GQVISAIPTK SLKFLKEAGH GSDKEEISKD AEGLEEIDHA EMELRRGQIL 1090 1100 1110 1120 1130 1140 WVRGLNRIQT QIEVINKFQT GASFKGVLRR QNLSQQLDVK LVPSSYSEAV ASVRTSPSTS 1150 SAVTPPPVGN QSGQSIS « Hide
Isoform ZB (AICI). Checksum: D93D8B4839575FDB Show »	FASTA	1,191	131,768
10 20 30 40 50 60 MTNPSGHNLP ANSVAESYEG EFGCTLMDLR KLMELRAADA VTQISAHYGS VQEICARLKT 70 80 90 100 110 120 SPVEGLSGNP ADLEKRRLVF GKNMIPPKKP KTFLELVWEA LQDVTLIILE IAAIISLVLS 130 140 150 160 170 180 FYRPPGGENE ICGHIVSNPE EDEEGETGWI EGAAILASVI IVVFVTAFND WSKEKQFRGL 190 200 210 220 230 240 QSRIELEQKF SIIRNGQLIQ LPVAEIVVGD IAQVKYGDLL PADGILIQGN DLKIDESSLT 250 260 270 280 290 300 GESDHVKKTL DKDPMLLSGT HVMEGSGRMV VTAVGINSQT GIIFTLLGAN EEEDDEKKKK 310 320 330 340 350 360 AKTQDGVALE IQPLNSQEGL DSEEKEKKAS KGPKKEKSVL QGKLTRLAVQ IGKAGLIMSI 370 380 390 400 410 420 LTVLILILYF VVDNFVIQRR AWLPECTPVY IQYFVKFFII GVTVLVVAVP EGLPLAVTIS 430 440 450 460 470 480 LAYSVKKMMK DNNLVRHLDA CETMGNATAI CSDKTGTLTM NRMTVVQAYI GGTHYRQIPK 490 500 510 520 530 540 PDDLPPNVLD LIVNSICINS AYTSKILPPE KEGGLPRQVG NKTECGLLGF VTDLKQDYQA 550 560 570 580 590 600 VRSEMPEEKL FKVYTFNSVR KSMSTVIRKP EGGFRVFSKG ASEIMLRKCD RILNKEGGIV 610 620 630 640 650 660 PFKTKDRDNM VRNVIEPMAS EGLRTIGIAY RDFDGEEPSW ENENEIFTGL VCIAVVGIED 670 680 690 700 710 720 PVRPEVPDAI NKCKRAGITV RMVTGDNVNT ARAIATKCGI LTPGDDFLCL EGKEFNRLIR 730 740 750 760 770 780 NEKGEVEQEK LDKVWPRLRV LARSSPTDKH TLVKGIIDSN IGEQRQVVAV TGDGTNDGPA 790 800 810 820 830 840 LKKADVGFAM GIAGTDVAKE ASDIILTDDN FTSIVKAVMW GRNVYDSISK FLQFQLTVNV 850 860 870 880 890 900 VAVIVAFSGA CITQDSPLKA VQMLWVNLIM DTFASLALAT EPPTDSLLRR RPYGRNKPLI 910 920 930 940 950 960 SRTMMKNILG HAVYQLGIVF LLVFAGDKLF DIDSGRKAPL NSPPSQHYTI VFNTFVLMQL 970 980 990 1000 1010 1020 FNEINSRKIH GEKNVFAGVY RNIIFCSVVL GTFFCQILIV EVGGKPFSCT NLTMEQWMWC 1030 1040 1050 1060 1070 1080 LFIGIGELLW GQVISAIPTK SLKFLKEAGH GSDKEEISKD AEGLEEIDHA EMELRRGQIL 1090 1100 1110 1120 1130 1140 WVRGLNRIQT QIRVVKVFHS FRDVIHKSKN QVSIHSFMTQ PEYAADDEMS QSFLNQEESP 1150 1160 1170 1180 1190 SLASKSRITK RLSDAETVSQ NNTNNNAVDC HQVQIVASHP NSPLQSQETP V « Hide

Hide | Top

References

[1]	"Primary structure of rat plasma membrane Ca(2+)-ATPase isoform 4 and analysis of alternative splicing patterns at splice site A." Keeton T.P., Shull G.E. Biochem. J. 306:779-785(1995) [PubMed: 7702574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS XB; ZB; XA AND ZA). Strain: CD Charles River. Tissue: Testis.
[2]	"Plasma-membrane calcium-pump isoforms in human and rat liver." Howard A., Barley N.F., Legon S., Walters J.R.F. Biochem. J. 303:275-279(1994) [PubMed: 7945253] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-455 (ISOFORMS XA/XB). Tissue: Lung.
[3]	"Alternative splicing of exons encoding the calmodulin-binding domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1, 2, 3, and 4." Keeton T.P., Burk S.E., Shull G.E. J. Biol. Chem. 268:2740-2748(1993) [PubMed: 8428948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1081-1203, ALTERNATIVE SPLICING (ISOFORMS XA/ZA). Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15408 mRNA. Translation: AAA81005.1. U15408 mRNA. Translation: AAA81006.1. U15408 mRNA. Translation: AAA81007.1. U15408 mRNA. Translation: AAA81008.1. X76452 mRNA. Translation: CAA53990.1. L05569, L05566, L05567 Genomic DNA. Translation: AAA50820.1.
IPI	IPI00213557. IPI00230910. IPI00230911. IPI00230912.
PIR	G44525. S50027. S54356. S54357.
RefSeq	NP_001005871.1.
UniGene	Rn.9986
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q64542.
PTM databases
PhosphoSite	Q64542.
Proteomic databases
PRIDE	Q64542.
Genome annotation databases
Ensembl	ENSRNOT00000004078; ENSRNOP00000004078; ENSRNOG00000003031; Rattus norvegicus. [Genome view]
GeneID	29600.
KEGG	rno:29600.
UCSC	NM_001005871. rat.
Organism-specific databases
CTD	29600.
RGD	621305. Atp2b4.
Phylogenomic databases
eggNOG	maNOG04958.
HOVERGEN	Q64542.
InParanoid	Q64542.
PhylomeDB	Q64542.
Enzyme and pathway databases
BRENDA	3.6.3.8. 248.
Gene expression databases
ArrayExpress	Q64542.
Genevestigator	Q64542.
GermOnline	ENSRNOG00000003031. Rattus norvegicus.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006408. ATPase_P-typ_Ca-transp_PMCA. IPR006069. ATPase_P-typ_cation-exchng_asu. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00121. NAKATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01517. ATPase-IIB_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...

Hide | Top

Entry information

Entry name

AT2B4_RAT

Accession

Primary (citable) accession number: Q64542
Secondary accession number(s): Q63127

Q64545

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents