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Protein
Submitted name:

Cytochrome P-450 11-beta hydroxylase

Gene

Cyp11b3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P-450 11-beta hydroxylaseImported
Gene namesi
Name:Cyp11b3Imported
Synonyms:CYP11B3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi727886. Cyp11b3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ64539.
PRIDEiQ64539.

Expressioni

Gene expression databases

GenevisibleiQ64539. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062325.

Structurei

3D structure databases

ProteinModelPortaliQ64539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000013161.
HOVERGENiHBG051098.
KOiK00497.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRVTADVW ARPWQCLHRT RALGSTATQA PKTLKPFEAI PQYSRNKWLK
60 70 80 90 100
MIQILREQSQ ENLHLEMHQA FQELGPIFRH SAGGAQIVSV MLPEDAEKLH
110 120 130 140 150
QVESILPRRM TLESWVAHRE LRGLRRGVFL LNGADWRFNR LQLNPNMLSP
160 170 180 190 200
KAVQSFVPFV DVVARDFVEN LKKRMLENVH GSMSMDIQSN VFNYTMEASH
210 220 230 240 250
FVISGERLGL TGHDLNPESL KFIHALHSMF KSTTQLMFLP KNLTRWTSTQ
260 270 280 290 300
VWKGHFESWD IISEYVTKCI KNVYRELAEG RQQSWSVISE MVAQSTLSMD
310 320 330 340 350
AIHANSMELI AGSVDTTAIS LVMTLFELAR NPDVQQALRQ ESLAAEASIA
360 370 380 390 400
ANPQKAMSDL PLLRAALKET LRLYPIGSSL ERIVDSDLVL QNYHVPAGTL
410 420 430 440 450
VIIYLYSMGR NPAVFPRPER YMPQRWLERK RSFQHLAFGF GVRQCLGRRL
460 470 480 490
AEVEVLLLLH HMLKIFQVET LRQEDVQMAY RFVLMPNPRL VLTIRPVS
Length:498
Mass (Da):57,175
Last modified:November 1, 1996 - v1
Checksum:i7DBCE79A8A44C7FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14907 mRNA. Translation: AAB17633.1.
RefSeqiNP_861545.1. NM_181824.1.
UniGeneiRn.198236.

Genome annotation databases

GeneIDi353498.
KEGGirno:353498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14907 mRNA. Translation: AAB17633.1.
RefSeqiNP_861545.1. NM_181824.1.
UniGeneiRn.198236.

3D structure databases

ProteinModelPortaliQ64539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062325.

Proteomic databases

PaxDbiQ64539.
PRIDEiQ64539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi353498.
KEGGirno:353498.

Organism-specific databases

CTDi353498.
RGDi727886. Cyp11b3.

Phylogenomic databases

eggNOGiKOG0159. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000013161.
HOVERGENiHBG051098.
KOiK00497.

Miscellaneous databases

NextBioi672689.

Gene expression databases

GenevisibleiQ64539. RN.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002399. Cyt_P450_mitochondrial.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00408. MITP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC."
    Zhou M.Y., Gomez-Sanchez E.P., Foecking M.F., Gomez-Sanchez C.E.
    Mol. Cell. Endocrinol. 114:137-145(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: Adrenal glandImported.

Entry informationi

Entry nameiQ64539_RAT
AccessioniPrimary (citable) accession number: Q64539
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.