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Q64527

- WNT8A_MOUSE

UniProt

Q64527 - WNT8A_MOUSE

Protein

Protein Wnt-8a

Gene

Wnt8a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.By similarity

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome
    2. protein binding Source: MGI

    GO - Biological processi

    1. canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: Ensembl
    2. cell fate commitment Source: RefGenome
    3. cell morphogenesis Source: MGI
    4. endoderm development Source: MGI
    5. establishment of organ orientation Source: MGI
    6. neuron differentiation Source: RefGenome
    7. palate development Source: Ensembl
    8. polarity specification of anterior/posterior axis Source: MGI
    9. polarity specification of proximal/distal axis Source: MGI
    10. regionalization Source: MGI
    11. regulation of protein localization Source: MGI
    12. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_207044. TCF dependent signaling in response to WNT.
    REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-8a
    Alternative name(s):
    Protein Wnt-8d
    Stimulated by retinoic acid gene 11 protein
    Gene namesi
    Name:Wnt8a
    Synonyms:Stra11, Wnt8d
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:107924. Wnt8a.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RefGenome
    2. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 354335Protein Wnt-8aPRO_0000041449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 65By similarity
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 112By similarity
    Disulfide bondi114 ↔ 132By similarity
    Disulfide bondi180 ↔ 194By similarity
    Disulfide bondi182 ↔ 189By similarity
    Disulfide bondi259 ↔ 297By similarity
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi275 ↔ 290By similarity
    Disulfide bondi294 ↔ 336By similarity
    Disulfide bondi312 ↔ 327By similarity
    Disulfide bondi314 ↔ 324By similarity
    Disulfide bondi319 ↔ 320By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ64527.

    PTM databases

    PhosphoSiteiQ64527.

    Expressioni

    Developmental stagei

    Expression in early stages of embryogenesis. Expression begins in the posterior region of early primitive streak-stage embryos and after it spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds. Expressed transiently in the newly formed mesoderm. Expression is down-regulated during somitogenesis. The expression is highly restricted during gastrulation and neurulation, both temporally and spatially.

    Inductioni

    By retinoic acid.

    Gene expression databases

    BgeeiQ64527.
    CleanExiMM_WNT8A.
    GenevestigatoriQ64527.

    Interactioni

    Protein-protein interaction databases

    BioGridi203552. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG277037.
    GeneTreeiENSGT00690000101857.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ64527.
    KOiK00714.
    OMAiCCTVRCD.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF92. PTHR12027:SF92. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64527-1 [UniParc]FASTAAdd to Basket

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    MGHLLMLWVA AGMCYPALGA SAWSVNNFLI TRPKAYLTYT ASVALGAQIG    50
    IEECKFQFAW ERWNCPEHAF QFSTHNRLRA ATRETSFIHA IRSAAIMYAV 100
    TKNCSMGDLE NCGCDESQNG KTGGHGWIWG GCSDNVEFGE KISRLFVDSL 150
    EKGKDARALV NLHNNRAGRL AVRASTKRTC KCHGISGSCS IQTCWLQLAD 200
    FRQMGNYLKA KYDRALKIEM DKRQLRAGNR AEGRWALTEA FLPSTEAELI 250
    FLEGSPDYCN RNASLSIQGT EGRECLQNAR SASRREQRSC GRLCTECGLQ 300
    VEERRAEAVS SCDCNFQWCC TVKCGQCRRV VSRYYCTRPV GSARPRGRGK 350
    DSAW 354
    Length:354
    Mass (Da):39,573
    Last modified:July 27, 2011 - v2
    Checksum:iA91D5245F5B6FE65
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321R → G in CAA93117. (PubMed:8887323)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68889 mRNA. Translation: CAA93117.1.
    AC074335 Genomic DNA. No translation available.
    CCDSiCCDS29129.1.
    RefSeqiNP_033316.1. NM_009290.2.
    XP_006525801.1. XM_006525738.1.
    UniGeneiMm.558.

    Genome annotation databases

    EnsembliENSMUST00000012426; ENSMUSP00000012426; ENSMUSG00000012282.
    GeneIDi20890.
    KEGGimmu:20890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z68889 mRNA. Translation: CAA93117.1 .
    AC074335 Genomic DNA. No translation available.
    CCDSi CCDS29129.1.
    RefSeqi NP_033316.1. NM_009290.2.
    XP_006525801.1. XM_006525738.1.
    UniGenei Mm.558.

    3D structure databases

    ProteinModelPortali Q64527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203552. 1 interaction.

    PTM databases

    PhosphoSitei Q64527.

    Proteomic databases

    PRIDEi Q64527.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000012426 ; ENSMUSP00000012426 ; ENSMUSG00000012282 .
    GeneIDi 20890.
    KEGGi mmu:20890.

    Organism-specific databases

    CTDi 7478.
    MGIi MGI:107924. Wnt8a.

    Phylogenomic databases

    eggNOGi NOG277037.
    GeneTreei ENSGT00690000101857.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q64527.
    KOi K00714.
    OMAi CCTVRCD.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_207044. TCF dependent signaling in response to WNT.
    REACT_213918. WNT ligand biogenesis and trafficking.
    REACT_216784. disassembly of the destruction complex and recruitment of AXIN to the membrane.

    Miscellaneous databases

    NextBioi 299745.
    PROi Q64527.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64527.
    CleanExi MM_WNT8A.
    Genevestigatori Q64527.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013301. Wnt8.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    PTHR12027:SF92. PTHR12027:SF92. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01892. WNT8PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid."
      Bouillet P., Oulad-Abdelghani M., Ward S.J., Bronner S., Chambon P., Dolle P.
      Mech. Dev. 58:141-152(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiWNT8A_MOUSE
    AccessioniPrimary (citable) accession number: Q64527
    Secondary accession number(s): E9QL90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3