Reviewed, UniProtKB/Swiss-Prot Q64527 (WNT8A_MOUSE)

Names and origin

Protein names

Recommended name:
    Protein Wnt-8a
Alternative name(s):
    Wnt-8d
      Short name=Wnt-8
    Stimulated by retinoic acid gene 11 protein

Gene names

Name:	Wnt8a
Synonyms:	Stra11, Wnt8d

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Developmental stage	Expression in early stages of embryogenesis. Expression begins in the posterior region of early primitive streak-stage embryos and after it spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds. Expressed transiently in the newly formed mesoderm. Expression is down-regulated during somitogenesis. The expression is highly restricted during gastrulation and neurulation, both temporally and spatially.
Induction	By retinoic acid.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway, calcium modulating pathway Inferred from electronic annotation. Source: InterPro multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 354	335	Protein Wnt-8a		PRO_0000041449
Amino acid modifications
	Glycosylation	103	1	N-linked (GlcNAc...) Potential
	Glycosylation	262	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q64527-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 1CA65E83840184D9	FASTA	354	39,474
	10 20 30 40 50 60 MGHLLMLWVA AGMCYPALGA SAWSVNNFLI TGPKAYLTYT ASVALGAQIG IEECKFQFAW 70 80 90 100 110 120 ERWNCPEHAF QFSTHNRLRA ATRETSFIHA IRSAAIMYAV TKNCSMGDLE NCGCDESQNG 130 140 150 160 170 180 KTGGHGWIWG GCSDNVEFGE KISRLFVDSL EKGKDARALV NLHNNRAGRL AVRASTKRTC 190 200 210 220 230 240 KCHGISGSCS IQTCWLQLAD FRQMGNYLKA KYDRALKIEM DKRQLRAGNR AEGRWALTEA 250 260 270 280 290 300 FLPSTEAELI FLEGSPDYCN RNASLSIQGT EGRECLQNAR SASRREQRSC GRLCTECGLQ 310 320 330 340 350 VEERRAEAVS SCDCNFQWCC TVKCGQCRRV VSRYYCTRPV GSARPRGRGK DSAW

References

[1]	"A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid." Bouillet P., Oulad-Abdelghani M., Ward S.J., Bronner S., Chambon P., Dolle P. Mech. Dev. 58:141-152(1996) [PubMed: 8887323] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z68889 mRNA. Translation: CAA93117.1.
IPI	IPI00135504.
RefSeq	NP_033316.1.
UniGene	Mm.558
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000012282. Mus musculus. [Contig view]
GeneID	20890.
KEGG	mmu:20890.
Organism-specific databases
MGI	MGI:107924. Wnt8a.
Phylogenomic databases
HOGENOM	Q64527.
HOVERGEN	Q64527.
Gene expression databases
ArrayExpress	Q64527.
Bgee	Q64527.
CleanEx	MM_WNT8A.
GermOnline	ENSMUSG00000012282. Mus musculus.
Family and domain databases
InterPro	IPR013301. Wnt8. IPR005816. Wnt_grthfactor. IPR018161. Wnt_grthfactor_CS. IPR005817. Wnt_SF. [Graphical view]
PANTHER	PTHR12027. Wnt. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01892. WNT8PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	299745.
SOURCE	Search...

Entry information

Entry name

WNT8A_MOUSE

Accession

Primary (citable) accession number: Q64527

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)