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Q64527 (WNT8A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-8a
Alternative name(s):
Protein Wnt-8d
Stimulated by retinoic acid gene 11 protein
Gene names
Name:Wnt8a
Synonyms:Stra11, Wnt8d
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Developmental stage

Expression in early stages of embryogenesis. Expression begins in the posterior region of early primitive streak-stage embryos and after it spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds. Expressed transiently in the newly formed mesoderm. Expression is down-regulated during somitogenesis. The expression is highly restricted during gastrulation and neurulation, both temporally and spatially.

Induction

By retinoic acid.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cell morphogenesis

Inferred from mutant phenotype PubMed 16256739. Source: MGI

endoderm development

Inferred from mutant phenotype PubMed 16256739. Source: MGI

establishment of organ orientation

Inferred from mutant phenotype PubMed 16256739. Source: MGI

neuron differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

palate development

Inferred from electronic annotation. Source: Ensembl

polarity specification of anterior/posterior axis

Inferred from mutant phenotype PubMed 16256739. Source: MGI

polarity specification of proximal/distal axis

Inferred from mutant phenotype PubMed 16256739. Source: MGI

regionalization

Inferred from mutant phenotype PubMed 16256739. Source: MGI

regulation of protein localization

Inferred from mutant phenotype PubMed 16256739. Source: MGI

   Cellular_componentextracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 354335Protein Wnt-8a
PRO_0000041449

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict321R → G in CAA93117. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64527 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: A91D5245F5B6FE65

FASTA35439,573
        10         20         30         40         50         60 
MGHLLMLWVA AGMCYPALGA SAWSVNNFLI TRPKAYLTYT ASVALGAQIG IEECKFQFAW 

        70         80         90        100        110        120 
ERWNCPEHAF QFSTHNRLRA ATRETSFIHA IRSAAIMYAV TKNCSMGDLE NCGCDESQNG 

       130        140        150        160        170        180 
KTGGHGWIWG GCSDNVEFGE KISRLFVDSL EKGKDARALV NLHNNRAGRL AVRASTKRTC 

       190        200        210        220        230        240 
KCHGISGSCS IQTCWLQLAD FRQMGNYLKA KYDRALKIEM DKRQLRAGNR AEGRWALTEA 

       250        260        270        280        290        300 
FLPSTEAELI FLEGSPDYCN RNASLSIQGT EGRECLQNAR SASRREQRSC GRLCTECGLQ 

       310        320        330        340        350 
VEERRAEAVS SCDCNFQWCC TVKCGQCRRV VSRYYCTRPV GSARPRGRGK DSAW 

« Hide

References

« Hide 'large scale' references
[1]"A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid."
Bouillet P., Oulad-Abdelghani M., Ward S.J., Bronner S., Chambon P., Dolle P.
Mech. Dev. 58:141-152(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z68889 mRNA. Translation: CAA93117.1.
AC074335 Genomic DNA. No translation available.
RefSeqNP_033316.1. NM_009290.2.
XP_006525801.1. XM_006525738.1.
UniGeneMm.558.

3D structure databases

ProteinModelPortalQ64527.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203552. 1 interaction.

PTM databases

PhosphoSiteQ64527.

Proteomic databases

PRIDEQ64527.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000012426; ENSMUSP00000012426; ENSMUSG00000012282.
GeneID20890.
KEGGmmu:20890.

Organism-specific databases

CTD7478.
MGIMGI:107924. Wnt8a.

Phylogenomic databases

eggNOGNOG277037.
GeneTreeENSGT00690000101857.
HOGENOMHOG000039529.
HOVERGENHBG001595.
InParanoidQ64527.
KOK00714.
OMACCTVRCD.
OrthoDBEOG7C8GJ8.
TreeFamTF105310.

Gene expression databases

BgeeQ64527.
CleanExMM_WNT8A.
GenevestigatorQ64527.

Family and domain databases

InterProIPR005817. Wnt.
IPR013301. Wnt8.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF6. PTHR12027:SF6. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299745.
PROQ64527.
SOURCESearch...

Entry information

Entry nameWNT8A_MOUSE
AccessionPrimary (citable) accession number: Q64527
Secondary accession number(s): E9QL90
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot