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Reviewed, UniProtKB/Swiss-Prot Q64527 (WNT8A_MOUSE)

Last modified June 16, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein Wnt-8a
Alternative name(s):
    Wnt-8d
      Short name=Wnt-8
    Stimulated by retinoic acid gene 11 protein
Gene names
Name: Wnt8a
Synonyms: Stra11, Wnt8d
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Developmental stage

Expression in early stages of embryogenesis. Expression begins in the posterior region of early primitive streak-stage embryos and after it spreads into the embryonic ectoderm up to a sharp rostral boundary at the base of the developing headfolds. Expressed transiently in the newly formed mesoderm. Expression is down-regulated during somitogenesis. The expression is highly restricted during gastrulation and neurulation, both temporally and spatially.

Induction

By retinoic acid.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 354335Protein Wnt-8a
PRO_0000041449

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q64527-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 1CA65E83840184D9

FASTA35439,474
        10         20         30         40         50         60 
MGHLLMLWVA AGMCYPALGA SAWSVNNFLI TGPKAYLTYT ASVALGAQIG IEECKFQFAW 

        70         80         90        100        110        120 
ERWNCPEHAF QFSTHNRLRA ATRETSFIHA IRSAAIMYAV TKNCSMGDLE NCGCDESQNG 

       130        140        150        160        170        180 
KTGGHGWIWG GCSDNVEFGE KISRLFVDSL EKGKDARALV NLHNNRAGRL AVRASTKRTC 

       190        200        210        220        230        240 
KCHGISGSCS IQTCWLQLAD FRQMGNYLKA KYDRALKIEM DKRQLRAGNR AEGRWALTEA 

       250        260        270        280        290        300 
FLPSTEAELI FLEGSPDYCN RNASLSIQGT EGRECLQNAR SASRREQRSC GRLCTECGLQ 

       310        320        330        340        350 
VEERRAEAVS SCDCNFQWCC TVKCGQCRRV VSRYYCTRPV GSARPRGRGK DSAW 

« Hide

References

[1]"A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid."
Bouillet P., Oulad-Abdelghani M., Ward S.J., Bronner S., Chambon P., Dolle P.
Mech. Dev. 58:141-152(1996) [PubMed: 8887323] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

Z68889 mRNA. Translation: CAA93117.1.
IPIIPI00135504.
RefSeqNP_033316.1.
UniGeneMm.558

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000012282. Mus musculus. [Contig view]
GeneID20890.
KEGGmmu:20890.

Organism-specific databases

MGIMGI:107924. Wnt8a.

Phylogenomic databases

HOGENOMQ64527.
HOVERGENQ64527.

Gene expression databases

ArrayExpressQ64527.
BgeeQ64527.
CleanExMM_WNT8A.
GermOnlineENSMUSG00000012282. Mus musculus.

Family and domain databases

InterProIPR013301. Wnt8.
IPR005816. Wnt_grthfactor.
IPR018161. Wnt_grthfactor_CS.
IPR005817. Wnt_SF.
[Graphical view]
PANTHERPTHR12027. Wnt. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01892. WNT8PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio299745.
SOURCESearch...

Entry information

Entry nameWNT8A_MOUSE
AccessionPrimary (citable) accession number: Q64527
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents