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Protein

Syndecan-3

Gene

Sdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-3000170. Syndecan interactions.
R-MMU-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-3
Short name:
SYND3
Gene namesi
Name:Sdc3
Synonyms:Kiaa0468
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1349163. Sdc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 387343ExtracellularSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Topological domaini409 – 44234CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence analysisAdd
BLAST
Chaini45 – 442398Syndecan-3PRO_0000033508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi78 – 781O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi80 – 801O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi82 – 821O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi89 – 891O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi315 – 3151O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Glycosylationi367 – 3671O-linked (Xyl...) (glycosaminoglycan)Sequence analysis
Modified residuei409 – 4091PhosphotyrosineBy similarity
Modified residuei419 – 4191PhosphotyrosineBy similarity
Modified residuei431 – 4311PhosphotyrosineBy similarity
Modified residuei441 – 4411PhosphotyrosineBy similarity

Post-translational modificationi

O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei383 – 3842Cleavage of ectodomainSequence analysis

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiQ64519.
PaxDbiQ64519.
PeptideAtlasiQ64519.
PRIDEiQ64519.

PTM databases

iPTMnetiQ64519.
PhosphoSiteiQ64519.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025743.
CleanExiMM_SDC3.
ExpressionAtlasiQ64519. baseline and differential.
GenevisibleiQ64519. MM.

Interactioni

Subunit structurei

Interacts with TIAM1.By similarity

Protein-protein interaction databases

IntActiQ64519. 1 interaction.
STRINGi10090.ENSMUSP00000065877.

Structurei

3D structure databases

ProteinModelPortaliQ64519.
SMRiQ64519. Positions 410-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi114 – 302189Ser/Thr-rich (mucin-like)Add
BLAST

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJZ0. Eukaryota.
ENOG410Y2QY. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000049151.
HOVERGENiHBG004144.
InParanoidiQ64519.
KOiK16337.
OMAiTQEPDIP.
OrthoDBiEOG091G0UGA.
PhylomeDBiQ64519.
TreeFamiTF320463.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031194. Syndecan-3.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 2 hits.
PTHR10915:SF7. PTHR10915:SF7. 2 hits.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPGPPRRGT AQGQRVDTAT HAPGARGLLL PPLLLLLLAG RAAGAQRWRN
60 70 80 90 100
ENFERPVDLE GSGDDDSFPD DELDDLYSGS GSGYFEQESG LETAMRFIPD
110 120 130 140 150
MALAAPTAPA MLPTTVIQPV DTPFEELLSE HPSPEPVTSP PLVTEVTEVV
160 170 180 190 200
EESSQKATTI STTTSTTAAT TTGAPTMATA PATAATTAPS TPEAPPATAT
210 220 230 240 250
VADVRTTGIQ GMLPLPLTTA ATAKITTPAA PSPPTTVATL DTEAPTPRLV
260 270 280 290 300
NTATSRPRAL PRPVTTQEPD VAERSTLPLG TTAPGPTEMA QTPTPESLLT
310 320 330 340 350
TIQDEPEVPV SGGPSGDFEL QEETTQPDTA NEVVAVEGAA AKPSPPLGTL
360 370 380 390 400
PKGARPGPGL HDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA
410 420 430 440
AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA
Length:442
Mass (Da):46,002
Last modified:September 5, 2006 - v2
Checksum:iE8FF8B90C5F0706B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331S → R in AAB03283 (Ref. 1) Curated
Sequence conflicti147 – 1471T → K in AAB03283 (Ref. 1) Curated
Sequence conflicti258 – 2592RA → QS in AAB03283 (Ref. 1) Curated
Sequence conflicti264 – 2641V → I in AAB03283 (Ref. 1) Curated
Sequence conflicti270 – 2701D → E in AAB03283 (Ref. 1) Curated
Sequence conflicti289 – 2891M → V in AAB03283 (Ref. 1) Curated
Sequence conflicti302 – 3021I → T in AAB03283 (Ref. 1) Curated
Sequence conflicti358 – 3581P → L in AAB03283 (Ref. 1) Curated
Sequence conflicti375 – 3751P → L in AAB03283 (Ref. 1) Curated
Sequence conflicti429 – 4291V → D in BAE29322 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52826 mRNA. Translation: AAB03283.1.
AK129153 mRNA. Translation: BAC97963.1.
AK150120 mRNA. Translation: BAE29322.1.
AK155127 mRNA. Translation: BAE33064.1.
BC054795 mRNA. Translation: AAH54795.1.
BC062093 mRNA. Translation: AAH62093.1.
CCDSiCCDS38894.1.
RefSeqiNP_035650.2. NM_011520.3.
UniGeneiMm.206536.

Genome annotation databases

EnsembliENSMUST00000070478; ENSMUSP00000065877; ENSMUSG00000025743.
GeneIDi20970.
KEGGimmu:20970.
UCSCiuc008uzr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52826 mRNA. Translation: AAB03283.1.
AK129153 mRNA. Translation: BAC97963.1.
AK150120 mRNA. Translation: BAE29322.1.
AK155127 mRNA. Translation: BAE33064.1.
BC054795 mRNA. Translation: AAH54795.1.
BC062093 mRNA. Translation: AAH62093.1.
CCDSiCCDS38894.1.
RefSeqiNP_035650.2. NM_011520.3.
UniGeneiMm.206536.

3D structure databases

ProteinModelPortaliQ64519.
SMRiQ64519. Positions 410-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64519. 1 interaction.
STRINGi10090.ENSMUSP00000065877.

PTM databases

iPTMnetiQ64519.
PhosphoSiteiQ64519.

Proteomic databases

MaxQBiQ64519.
PaxDbiQ64519.
PeptideAtlasiQ64519.
PRIDEiQ64519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070478; ENSMUSP00000065877; ENSMUSG00000025743.
GeneIDi20970.
KEGGimmu:20970.
UCSCiuc008uzr.1. mouse.

Organism-specific databases

CTDi9672.
MGIiMGI:1349163. Sdc3.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJZ0. Eukaryota.
ENOG410Y2QY. LUCA.
GeneTreeiENSGT00530000063116.
HOGENOMiHOG000049151.
HOVERGENiHBG004144.
InParanoidiQ64519.
KOiK16337.
OMAiTQEPDIP.
OrthoDBiEOG091G0UGA.
PhylomeDBiQ64519.
TreeFamiTF320463.

Enzyme and pathway databases

ReactomeiR-MMU-1971475. A tetrasaccharide linker sequence is required for GAG synthesis.
R-MMU-2022928. HS-GAG biosynthesis.
R-MMU-2024096. HS-GAG degradation.
R-MMU-3000170. Syndecan interactions.
R-MMU-975634. Retinoid metabolism and transport.

Miscellaneous databases

ChiTaRSiSdc3. mouse.
PROiQ64519.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025743.
CleanExiMM_SDC3.
ExpressionAtlasiQ64519. baseline and differential.
GenevisibleiQ64519. MM.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031194. Syndecan-3.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 2 hits.
PTHR10915:SF7. PTHR10915:SF7. 2 hits.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDC3_MOUSE
AccessioniPrimary (citable) accession number: Q64519
Secondary accession number(s): Q3UDD9, Q6ZQA4, Q7TQD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 5, 2006
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.