Tyrosine-protein phosphatase non-receptor type 13

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Q64512 (PTN13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 110. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase non-receptor type 13
EC=3.1.3.48

Alternative name(s):
PTP36
Protein tyrosine phosphatase DPZPTP
Protein tyrosine phosphatase PTP-BL
Protein-tyrosine phosphatase RIP

Gene names

Name:	Ptpn13
Synonyms:	Ptp14

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2453 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
Subunit structure	Interacts with ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus) By similarity. Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7. Ref.5 Ref.6
Subcellular location	Cytoplasm › cytoskeleton By similarity. Nucleus By similarity. Cell projection › lamellipodium By similarity. Note: Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover By similarity.
Tissue specificity	Expressed predominantly in kidney and, to a lesser extent, in lung, heart, brain and testis.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 1 FERM domain. Contains 1 KIND domain. Contains 5 PDZ (DHR) domains. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm Cytoskeleton Nucleus
Domain	Coiled coil Repeat
Molecular function	Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay Ref.6. Source: MGI cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell lamellipodium Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.6. Source: MGI
Molecular_function	protein tyrosine phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2453

2453

Tyrosine-protein phosphatase non-receptor type 13

PRO_0000219436

Regions

Domain

3 – 190

188

KIND

Domain

565 – 865

301

FERM

Domain

1084 – 1170

PDZ 1

Domain

1357 – 1442

PDZ 2

Domain

1491 – 1579

PDZ 3

Domain

1764 – 1845

PDZ 4

Domain

1857 – 1942

PDZ 5

Domain

2180 – 2434

255

Tyrosine-protein phosphatase

Region

2375 – 2381

Substrate binding By similarity

Coiled coil

458 – 493

Potential

Compositional bias

56 – 59

Poly-Leu

Sites

Active site

2375

Phosphocysteine intermediate By similarity

Binding site

2345

Substrate By similarity

Binding site

2419

Substrate By similarity

Amino acid modifications

Modified residue

1021

Phosphoserine By similarity

Modified residue

1025

Phosphoserine By similarity

Modified residue

1310

Phosphoserine Ref.7

Experimental info

Sequence conflict

79 – 81

STA → FTG in BAA12158. Ref.2

Sequence conflict

156 – 168

HIRNS…PSFSN → TSGTASRAFVSY Ref.2

Sequence conflict

233

V → L in BAA12158. Ref.2

Sequence conflict

306

N → I in BAA12158. Ref.2

Sequence conflict

322

K → E in BAA12158. Ref.2

Sequence conflict

381

Q → K in BAA12158. Ref.2

Sequence conflict

822

S → L in BAA12158. Ref.2

Sequence conflict

1233

S → T in BAA05885. Ref.3

Sequence conflict

1449

R → Q in BAA12158. Ref.2

Sequence conflict

1474 – 1489

QTPHV…TEDNT → KHPMSKTTALLLKII in CAA83650. Ref.1

Sequence conflict

1622

D → H in BAA12158. Ref.2

Sequence conflict

1872

S → P in CAA83650. Ref.1

Sequence conflict

1979

N → I in BAA05885. Ref.3

Sequence conflict

2078

D → N in BAA12158. Ref.2

Sequence conflict

2233

S → T in BAA12158. Ref.2

Sequence conflict

2448 – 2452

PGLPQ → GSHSDAEQPPKAPP in CAA83650. Ref.1

Secondary structure

2453

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q64512 [UniParc].

Last modified March 15, 2004. Version 2.
Checksum: 53396F27AE2582F2
Show »

FASTA

2,453

270,334

        10         20         30         40         50         60 
MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQEVFRRVS IADPAALGFI ISPWSLLLLP 

        70         80         90        100        110        120 
SGSVSFTDEN VSNQDLRAST APEVLQSHSL TSLADVEKIH IYSLGMTLYW GADHEVPQSQ 

       130        140        150        160        170        180 
PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSNVK QLVKLVLGNI 

       190        200        210        220        230        240 
SGTDPLSRSS EQKPDRSQAI RDRLRGKGLP TGRSSTSDAL DTHEAPLSQQ TFVNKGLSKS 

       250        260        270        280        290        300 
MGFLSIRDTR DEEDYLKDTP SDNNSRHEDS ETFSSPYQFK TSTPQMDALS KKKTWASSMD 

       310        320        330        340        350        360 
LLCAANRDIS GETGRYQRCD PKTVTGRTSI TPRKKEGRYS DGSIALDIFG PQKVEPVIHT 

       370        380        390        400        410        420 
RELPTSTAVS SALDRIRERQ QKLQVLREAM NVEEPVRRYK TYHSDIFSIS SESPSVISSE 

       430        440        450        460        470        480 
SDFRQVRKSE ASKRFESSSG LPGVDETGQT RPSRQYETSL EGNLINQDIM LRRQEEEMMQ 

       490        500        510        520        530        540 
LQARMALRQS RLSLYPGDTV KASMLDISRD PLREMALETA MTQRKLRNFF GPEFVKMTVE 

       550        560        570        580        590        600 
PFVSLDLPRS ILSQTKKGKS EDQRRKVNIR LLSGQRLELT CDTKTICKDV FDMVVAHIGL 

       610        620        630        640        650        660 
VEHHLFALAT RKENEYFFVD PDLKLTKVAP EGWKEEPKRK GKAAVDFTLF FRIKFFMDDV 

       670        680        690        700        710        720 
SLIQHDLTCH QYYLQLRKDL LDERVHCDDE AALLLASLAL QAEYGDYQPE VHGVSYFRLE 

       730        740        750        760        770        780 
HYLPARVMEK LDVSYIKEEL PKLHNTYAGA SEKETELEFL KVCQRLTEYG VHFHRVHPEK 

       790        800        810        820        830        840 
KSQTGILLGV CSKGVLVFEV HNGVRALVLR FPWRETKKIS FSKKKITLQN TSDGIKHAFQ 

       850        860        870        880        890        900 
TDSSKACQYL LHLCSSQHKF QLQMRARQSN QDAQDIERAS FRSLNLQAES VRGFNMGRAI 

       910        920        930        940        950        960 
STGSLASSTI NKLAVRPLSV QAEILKRLSS SEWSLYQPLQ NSSKEKTDKA SWEEKPRGMS 

       970        980        990       1000       1010       1020 
KSYHDLSQAS LCPHRKQVIN MEALPQAFAE LVGKPLYPMA RSDTESLAGL PKLDNSKSVA 

      1030       1040       1050       1060       1070       1080 
SLNRSPERRN HESDSSTEDP GQAYVVGMSL PSSGKSSSQV PFKDNDTLHK RWSIVSSPER 

      1090       1100       1110       1120       1130       1140 
EITLVNLKKD PKHGLGFQII GGEKMGRLDL GVFISAVTPG GPADLDGCLK PGDRLISVNS 

      1150       1160       1170       1180       1190       1200 
VSLEGVSHHA AVDILQNAPE DVTLVISQPK EKPSKVPSTP VHFANGMKSY TKKPAYMQDS 

      1210       1220       1230       1240       1250       1260 
AMDPSEDQPW PRGTLRHIPE SPFGLSGGLR EGSLSSQDSR TESASLSQSQ VNGFFASHLG 

      1270       1280       1290       1300       1310       1320 
DRGWQEPQHS SPSPSVTTKV NEKTFSDSNR SKAKRRGISD LIEHLDCADS DKDDSTYTSS 

      1330       1340       1350       1360       1370       1380 
QDHQTSKQEP SSSLSTSNKT SFPTSSASPP KPGDTFEVEL AKTDGSLGIS VTGGVNTSVR 

      1390       1400       1410       1420       1430       1440 
HGGIYVKAII PKGAAESDGR IHKGDRVLAV NGVSLEGATH KQAVETLRNT GQVVHLLLEK 

      1450       1460       1470       1480       1490       1500 
GQVPTSRERD PAGPQSPPPD QDAQRQAPEK VAKQTPHVKD YSFVTEDNTF EVKLFKNSSG 

      1510       1520       1530       1540       1550       1560 
LGFSFSREDN LIPEQINGSI VRVKKLFPGQ PAAESGKIDV GDVILKVNGA PLKGLSQQDV 

      1570       1580       1590       1600       1610       1620 
ISALRGTAPE VSLLLCRPAP GVLPEIDTTF LNPLYSPANS FLNSSKETSQ PSSSVEQGAS 

      1630       1640       1650       1660       1670       1680 
SDDNGVSGKT KNHCRAPSRR ESYSDHSESG EDDSVRAPAK MPNVTRVAAF PHEAPRSQEE 

      1690       1700       1710       1720       1730       1740 
SICAMFYLPR KIPGKLESES SHPPPLDVSP GQTCQPPAEC APSDATGKHF THLASQLSKE 

      1750       1760       1770       1780       1790       1800 
ENITTLKNDL GNHLEDSELE VELLITLVKS EKGSLGFTVT KGSQSIGCYV HDVIQDPAKG 

      1810       1820       1830       1840       1850       1860 
DGRLKAGDRL IKVNDTDVTN MTHTDAVNLL RAAPKTVRLV LGRILELPRM PVFPHLLPDI 

      1870       1880       1890       1900       1910       1920 
TVTCHGEELG FSLSGGQGSP HGVVYISDIN PRSAAAVDGS LQLLDIIHYV NGVSTQGMTL 

      1930       1940       1950       1960       1970       1980 
EDANRALDLS LPSVVLKVTR DGCPVVPTTR AAISAPRFTK ANGLTSMEPS GQPALMPKNS 

      1990       2000       2010       2020       2030       2040 
FSKVNGEGVH EAVCPAGEGS SSQMKESAGL TETKESNSRD DDIYDDPQEA EVIQSLLDVV 

      2050       2060       2070       2080       2090       2100 
DEEAQNLLNQ RHATRRACSP DPLRTNGEAP EEGDTDYDGS PLPEDVPESV SSGEGKVDLA 

      2110       2120       2130       2140       2150       2160 
SLTAASQEEK PIEEDATQES RNSTTETTDG EDSSKDPPFL TNEELAALPV VRVPPSGKYT 

      2170       2180       2190       2200       2210       2220 
GTQLQATIRT LQGLLDQGIP SKELENLQEL KPLDQCLIGQ TKENRRKNRY KNILPYDTTR 

      2230       2240       2250       2260       2270       2280 
VPLGDEGGYI NASFIRIPVG TQEFVYIACQ GPLPTTVGDF WQMVWEQNST VIAMMTQEVE 

      2290       2300       2310       2320       2330       2340 
GEKIKCQRYW PSILGTTTMA NERLRLALLR MQQLKGFIVR VMALEDIQTG EVRHISHLNF 

      2350       2360       2370       2380       2390       2400 
TAWPDHDTPS QPDDLLTFIS YMRHIRRSGP VITHCSAGIG RSGTLICIDV VLGLISQDLE 

      2410       2420       2430       2440       2450 
FDISDLVRCM RLQRHGMVQT EGQYVFCYQV ILYVLTHLQA EEQKAQQPGL PQP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a mouse epithelial protein-tyrosine phosphatase with similarities to submembranous proteins." Hendriks W., Schepens J., Baechner D., Rijss J., Zeeuwen P., Zechner U., Hameister H., Wieringa B. J. Cell. Biochem. 59:418-430(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Skin.
[2]	"Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells." Chida D., Kume T., Mukouyama Y., Tabata S., Nomura N., Thomas M., Watanabe T., Oishi M. FEBS Lett. 358:233-239(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: DBA/2.
[3]	"cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells." Sawada M., Ogata M., Fujino Y., Hamaoka T. Biochem. Biophys. Res. Commun. 203:479-484(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-2452. Strain: CB.17 SCID. Tissue: Thymus.
[4]	"A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain." Hendriks W., Schepens J., Brugman C., Zeeuwen P., Wieringa B. Biochem. J. 305:499-504(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2267-2373. Strain: BALB/c. Tissue: Brain.
[5]	"PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL." Cuppen E., Gerrits H., Pepers B., Wieringa B., Hendriks W. Mol. Biol. Cell 9:671-683(1998) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDLIM4.
[6]	"Identification and molecular characterization of BP75, a novel bromodomain-containing protein." Cuppen E., van Ham M., Pepers B., Wieringa B., Hendriks W. FEBS Lett. 459:291-298(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BRD7.
[7]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1310, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z32740 mRNA. Translation: CAA83650.1.
D83966 mRNA. Translation: BAA12158.1.
D28529 mRNA. Translation: BAA05885.1.
Z23059 mRNA. Translation: CAA80594.1.

IPI

IPI00750472.

PIR

S40290.
S71625.

RefSeq

NP_035334.2. NM_011204.2.

UniGene

Mm.3414.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1GM1	NMR	-	A	1351-1444	[»]
1OZI	NMR	-	A	1351-1444	[»]
1VJ6	NMR	-	A	1351-1443	[»]

ProteinModelPortal

Q64512.

SMR

Q64512. Positions 565-892, 1094-1165, 1351-1579, 1762-1940, 2139-2444.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q64512. 1 interaction.

PTM databases

PhosphoSite

Q64512.

Proteomic databases

PaxDb

Q64512.

PRIDE

Q64512.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

19249.

KEGG

mmu:19249.

UCSC

uc008yjl.1. mouse.

Organism-specific databases

CTD

5783.

MGI

MGI:103293. Ptpn13.

Phylogenomic databases

eggNOG

COG5599.

HOGENOM

HOG000115774.

HOVERGEN

HBG053756.

InParanoid

Q64512.

K02374.

OrthoDB

EOG45DWNG.

Gene expression databases

Genevestigator

Q64512.

GermOnline

ENSMUSG00000034573. Mus musculus.

Family and domain databases

Gene3D

1.20.80.10. 1 hit.
2.30.29.30. 1 hit.

InterPro

IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011019. KIND.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR012153. Tyr_Pase_non-rcpt_typ-13.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 5 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]

PIRSF

PIRSF000933. Tyr-Ptase_nr13. 1 hit.

PRINTS

PR00935. BAND41.
PR00700. PRTYPHPHTASE.

SMART

SM00295. B41. 1 hit.
SM00750. KIND. 1 hit.
SM00228. PDZ. 5 hits.
SM00194. PTPc. 1 hit.
[Graphical view]

SUPFAM

SSF47031. FERM_3-hlx. 1 hit.
SSF50156. PDZ. 5 hits.

PROSITE

PS00660. FERM_1. False negative.
PS00661. FERM_2. False negative.
PS50057. FERM_3. 1 hit.
PS51377. KIND. 1 hit.
PS50106. PDZ. 5 hits.
PS00383. TYR_PHOSPHATASE_1. False negative.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q64512.

NextBio

296082.

SOURCE

Search...

Entry information

Entry name

PTN13_MOUSE

Accession

Primary (citable) accession number: Q64512
Secondary accession number(s): Q61494, Q62135, Q64499

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	March 15, 2004
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents