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Q64512 (PTN13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 13

EC=3.1.3.48
Alternative name(s):
PTP36
Protein tyrosine phosphatase DPZPTP
Protein tyrosine phosphatase PTP-BL
Protein-tyrosine phosphatase RIP
Gene names
Name:Ptpn13
Synonyms:Ptp14
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2453 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with ARHGAP29. Interacts (via PDZ 3 domain) with PKN2 (via C-terminus) By similarity. Interacts with TRIP6 and TNFRSF6 (Fas receptor) through its second PDZ domain. Interacts with the C-terminal SVP motif of NGFR through its third PDZ domain. Interacts with the LIM domain of PDLIM4 through its second and fourth PDZ domains. Binds PLEKHA1 and PLEKHA2 through its first PDZ domain. Interacts with BRD7. Ref.5 Ref.6

Subcellular location

Cytoplasmcytoskeleton By similarity. Nucleus By similarity. Cell projectionlamellipodium By similarity. Note: Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover By similarity.

Tissue specificity

Expressed predominantly in kidney and, to a lesser extent, in lung, heart, brain and testis.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 KIND domain.

Contains 5 PDZ (DHR) domains.

Contains 1 tyrosine-protein phosphatase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Brd7O886653EBI-4284057,EBI-643930

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24532453Tyrosine-protein phosphatase non-receptor type 13
PRO_0000219436

Regions

Domain3 – 190188KIND
Domain565 – 865301FERM
Domain1084 – 117087PDZ 1
Domain1357 – 144286PDZ 2
Domain1491 – 157989PDZ 3
Domain1764 – 184582PDZ 4
Domain1857 – 194286PDZ 5
Domain2180 – 2434255Tyrosine-protein phosphatase
Region2375 – 23817Substrate binding By similarity
Coiled coil458 – 49336 Potential
Compositional bias56 – 594Poly-Leu

Sites

Active site23751Phosphocysteine intermediate By similarity
Binding site23451Substrate By similarity
Binding site24191Substrate By similarity

Amino acid modifications

Modified residue10211Phosphoserine By similarity
Modified residue10251Phosphoserine By similarity

Experimental info

Sequence conflict79 – 813STA → FTG in BAA12158. Ref.2
Sequence conflict156 – 16813HIRNS…PSFSN → TSGTASRAFVSY Ref.2
Sequence conflict2331V → L in BAA12158. Ref.2
Sequence conflict3061N → I in BAA12158. Ref.2
Sequence conflict3221K → E in BAA12158. Ref.2
Sequence conflict3811Q → K in BAA12158. Ref.2
Sequence conflict8221S → L in BAA12158. Ref.2
Sequence conflict12331S → T in BAA05885. Ref.3
Sequence conflict14491R → Q in BAA12158. Ref.2
Sequence conflict1474 – 148916QTPHV…TEDNT → KHPMSKTTALLLKII in CAA83650. Ref.1
Sequence conflict16221D → H in BAA12158. Ref.2
Sequence conflict18721S → P in CAA83650. Ref.1
Sequence conflict19791N → I in BAA05885. Ref.3
Sequence conflict20781D → N in BAA12158. Ref.2
Sequence conflict22331S → T in BAA12158. Ref.2
Sequence conflict2448 – 24525PGLPQ → GSHSDAEQPPKAPP in CAA83650. Ref.1

Secondary structure

.................. 2453
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q64512 [UniParc].

Last modified March 15, 2004. Version 2.
Checksum: 53396F27AE2582F2

FASTA2,453270,334
        10         20         30         40         50         60 
MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQEVFRRVS IADPAALGFI ISPWSLLLLP 

        70         80         90        100        110        120 
SGSVSFTDEN VSNQDLRAST APEVLQSHSL TSLADVEKIH IYSLGMTLYW GADHEVPQSQ 

       130        140        150        160        170        180 
PIKLGDHLNS ILLGMCEDVI YARVSVRTVL DACSAHIRNS NCAPSFSNVK QLVKLVLGNI 

       190        200        210        220        230        240 
SGTDPLSRSS EQKPDRSQAI RDRLRGKGLP TGRSSTSDAL DTHEAPLSQQ TFVNKGLSKS 

       250        260        270        280        290        300 
MGFLSIRDTR DEEDYLKDTP SDNNSRHEDS ETFSSPYQFK TSTPQMDALS KKKTWASSMD 

       310        320        330        340        350        360 
LLCAANRDIS GETGRYQRCD PKTVTGRTSI TPRKKEGRYS DGSIALDIFG PQKVEPVIHT 

       370        380        390        400        410        420 
RELPTSTAVS SALDRIRERQ QKLQVLREAM NVEEPVRRYK TYHSDIFSIS SESPSVISSE 

       430        440        450        460        470        480 
SDFRQVRKSE ASKRFESSSG LPGVDETGQT RPSRQYETSL EGNLINQDIM LRRQEEEMMQ 

       490        500        510        520        530        540 
LQARMALRQS RLSLYPGDTV KASMLDISRD PLREMALETA MTQRKLRNFF GPEFVKMTVE 

       550        560        570        580        590        600 
PFVSLDLPRS ILSQTKKGKS EDQRRKVNIR LLSGQRLELT CDTKTICKDV FDMVVAHIGL 

       610        620        630        640        650        660 
VEHHLFALAT RKENEYFFVD PDLKLTKVAP EGWKEEPKRK GKAAVDFTLF FRIKFFMDDV 

       670        680        690        700        710        720 
SLIQHDLTCH QYYLQLRKDL LDERVHCDDE AALLLASLAL QAEYGDYQPE VHGVSYFRLE 

       730        740        750        760        770        780 
HYLPARVMEK LDVSYIKEEL PKLHNTYAGA SEKETELEFL KVCQRLTEYG VHFHRVHPEK 

       790        800        810        820        830        840 
KSQTGILLGV CSKGVLVFEV HNGVRALVLR FPWRETKKIS FSKKKITLQN TSDGIKHAFQ 

       850        860        870        880        890        900 
TDSSKACQYL LHLCSSQHKF QLQMRARQSN QDAQDIERAS FRSLNLQAES VRGFNMGRAI 

       910        920        930        940        950        960 
STGSLASSTI NKLAVRPLSV QAEILKRLSS SEWSLYQPLQ NSSKEKTDKA SWEEKPRGMS 

       970        980        990       1000       1010       1020 
KSYHDLSQAS LCPHRKQVIN MEALPQAFAE LVGKPLYPMA RSDTESLAGL PKLDNSKSVA 

      1030       1040       1050       1060       1070       1080 
SLNRSPERRN HESDSSTEDP GQAYVVGMSL PSSGKSSSQV PFKDNDTLHK RWSIVSSPER 

      1090       1100       1110       1120       1130       1140 
EITLVNLKKD PKHGLGFQII GGEKMGRLDL GVFISAVTPG GPADLDGCLK PGDRLISVNS 

      1150       1160       1170       1180       1190       1200 
VSLEGVSHHA AVDILQNAPE DVTLVISQPK EKPSKVPSTP VHFANGMKSY TKKPAYMQDS 

      1210       1220       1230       1240       1250       1260 
AMDPSEDQPW PRGTLRHIPE SPFGLSGGLR EGSLSSQDSR TESASLSQSQ VNGFFASHLG 

      1270       1280       1290       1300       1310       1320 
DRGWQEPQHS SPSPSVTTKV NEKTFSDSNR SKAKRRGISD LIEHLDCADS DKDDSTYTSS 

      1330       1340       1350       1360       1370       1380 
QDHQTSKQEP SSSLSTSNKT SFPTSSASPP KPGDTFEVEL AKTDGSLGIS VTGGVNTSVR 

      1390       1400       1410       1420       1430       1440 
HGGIYVKAII PKGAAESDGR IHKGDRVLAV NGVSLEGATH KQAVETLRNT GQVVHLLLEK 

      1450       1460       1470       1480       1490       1500 
GQVPTSRERD PAGPQSPPPD QDAQRQAPEK VAKQTPHVKD YSFVTEDNTF EVKLFKNSSG 

      1510       1520       1530       1540       1550       1560 
LGFSFSREDN LIPEQINGSI VRVKKLFPGQ PAAESGKIDV GDVILKVNGA PLKGLSQQDV 

      1570       1580       1590       1600       1610       1620 
ISALRGTAPE VSLLLCRPAP GVLPEIDTTF LNPLYSPANS FLNSSKETSQ PSSSVEQGAS 

      1630       1640       1650       1660       1670       1680 
SDDNGVSGKT KNHCRAPSRR ESYSDHSESG EDDSVRAPAK MPNVTRVAAF PHEAPRSQEE 

      1690       1700       1710       1720       1730       1740 
SICAMFYLPR KIPGKLESES SHPPPLDVSP GQTCQPPAEC APSDATGKHF THLASQLSKE 

      1750       1760       1770       1780       1790       1800 
ENITTLKNDL GNHLEDSELE VELLITLVKS EKGSLGFTVT KGSQSIGCYV HDVIQDPAKG 

      1810       1820       1830       1840       1850       1860 
DGRLKAGDRL IKVNDTDVTN MTHTDAVNLL RAAPKTVRLV LGRILELPRM PVFPHLLPDI 

      1870       1880       1890       1900       1910       1920 
TVTCHGEELG FSLSGGQGSP HGVVYISDIN PRSAAAVDGS LQLLDIIHYV NGVSTQGMTL 

      1930       1940       1950       1960       1970       1980 
EDANRALDLS LPSVVLKVTR DGCPVVPTTR AAISAPRFTK ANGLTSMEPS GQPALMPKNS 

      1990       2000       2010       2020       2030       2040 
FSKVNGEGVH EAVCPAGEGS SSQMKESAGL TETKESNSRD DDIYDDPQEA EVIQSLLDVV 

      2050       2060       2070       2080       2090       2100 
DEEAQNLLNQ RHATRRACSP DPLRTNGEAP EEGDTDYDGS PLPEDVPESV SSGEGKVDLA 

      2110       2120       2130       2140       2150       2160 
SLTAASQEEK PIEEDATQES RNSTTETTDG EDSSKDPPFL TNEELAALPV VRVPPSGKYT 

      2170       2180       2190       2200       2210       2220 
GTQLQATIRT LQGLLDQGIP SKELENLQEL KPLDQCLIGQ TKENRRKNRY KNILPYDTTR 

      2230       2240       2250       2260       2270       2280 
VPLGDEGGYI NASFIRIPVG TQEFVYIACQ GPLPTTVGDF WQMVWEQNST VIAMMTQEVE 

      2290       2300       2310       2320       2330       2340 
GEKIKCQRYW PSILGTTTMA NERLRLALLR MQQLKGFIVR VMALEDIQTG EVRHISHLNF 

      2350       2360       2370       2380       2390       2400 
TAWPDHDTPS QPDDLLTFIS YMRHIRRSGP VITHCSAGIG RSGTLICIDV VLGLISQDLE 

      2410       2420       2430       2440       2450 
FDISDLVRCM RLQRHGMVQT EGQYVFCYQV ILYVLTHLQA EEQKAQQPGL PQP 

« Hide

References

[1]"Molecular cloning of a mouse epithelial protein-tyrosine phosphatase with similarities to submembranous proteins."
Hendriks W., Schepens J., Baechner D., Rijss J., Zeeuwen P., Zechner U., Hameister H., Wieringa B.
J. Cell. Biochem. 59:418-430(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Skin.
[2]"Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells."
Chida D., Kume T., Mukouyama Y., Tabata S., Nomura N., Thomas M., Watanabe T., Oishi M.
FEBS Lett. 358:233-239(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: DBA/2.
[3]"cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells."
Sawada M., Ogata M., Fujino Y., Hamaoka T.
Biochem. Biophys. Res. Commun. 203:479-484(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1105-2452.
Strain: CB.17 SCID.
Tissue: Thymus.
[4]"A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain."
Hendriks W., Schepens J., Brugman C., Zeeuwen P., Wieringa B.
Biochem. J. 305:499-504(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2267-2373.
Strain: BALB/c.
Tissue: Brain.
[5]"PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL."
Cuppen E., Gerrits H., Pepers B., Wieringa B., Hendriks W.
Mol. Biol. Cell 9:671-683(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PDLIM4.
[6]"Identification and molecular characterization of BP75, a novel bromodomain-containing protein."
Cuppen E., van Ham M., Pepers B., Wieringa B., Hendriks W.
FEBS Lett. 459:291-298(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BRD7.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z32740 mRNA. Translation: CAA83650.1.
D83966 mRNA. Translation: BAA12158.1.
D28529 mRNA. Translation: BAA05885.1.
Z23059 mRNA. Translation: CAA80594.1.
PIRS40290.
S71625.
RefSeqNP_035334.2. NM_011204.2.
UniGeneMm.3414.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GM1NMR-A1351-1444[»]
1OZINMR-A1351-1444[»]
1VJ6NMR-A1351-1443[»]
ProteinModelPortalQ64512.
SMRQ64512. Positions 2-174, 565-892, 1094-1165, 1351-1579, 1762-2051, 2139-2444.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202479. 2 interactions.
IntActQ64512. 9 interactions.
MINTMINT-1793569.

PTM databases

PhosphoSiteQ64512.

Proteomic databases

PaxDbQ64512.
PRIDEQ64512.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19249.
KEGGmmu:19249.

Organism-specific databases

CTD5783.
MGIMGI:103293. Ptpn13.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000115774.
HOVERGENHBG053756.
InParanoidQ64512.
KOK02374.
PhylomeDBQ64512.

Gene expression databases

GenevestigatorQ64512.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
2.30.42.10. 5 hits.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011019. KIND.
IPR001478. PDZ.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR012153. Tyr_Pase_non-rcpt_typ-13.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERPTHR19134:SF197. PTHR19134:SF197. 1 hit.
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 5 hits.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000933. Tyr-Ptase_nr13. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00750. KIND. 1 hit.
SM00228. PDZ. 5 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 5 hits.
PROSITEPS50057. FERM_3. 1 hit.
PS51377. KIND. 1 hit.
PS50106. PDZ. 5 hits.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ64512.
NextBio296082.
PROQ64512.
SOURCESearch...

Entry information

Entry namePTN13_MOUSE
AccessionPrimary (citable) accession number: Q64512
Secondary accession number(s): Q61494, Q62135, Q64499
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot