true1998-07-152024-01-24205TOP2B_MOUSEMiyaike M.Adachi N.Kikuchi A.1994-09EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [MRNA]BALB/cJBrainThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]C57BL/6JEyeComprehensive identification of phosphorylation sites in postsynaptic density preparations.Trinidad J.C.Specht C.G.Thalhammer A.Schoepfer R.Burlingame A.L.doi:10.1074/mcp.t500041-mcp2002006Mol. Cell. Proteomics5914-922IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Large-scale phosphorylation analysis of mouse liver.Villen J.Beausoleil S.A.Gerber S.A.Gygi S.P.doi:10.1073/pnas.06098361042007Proc. Natl. Acad. Sci. U.S.A.1041488-1493PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1387; SER-1509; SER-1511; SER-1513; SER-1537 AND SER-1539IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]LiverThe phagosomal proteome in interferon-gamma-activated macrophages.Trost M.English L.Lemieux S.Courcelles M.Desjardins M.Thibault P.doi:10.1016/j.immuni.2008.11.0062009Immunity30143-154PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1400; SER-1509 AND SER-1511IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.Sweet S.M.Bailey C.M.Cunningham D.L.Heath J.K.Cooper H.J.doi:10.1074/mcp.m800451-mcp2002009Mol. Cell. Proteomics8904-912PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1509 AND SER-1511IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Embryonic fibroblastA tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L.Jedrychowski M.P.Elias J.E.Goswami T.Rad R.Beausoleil S.A.Villen J.Haas W.Sowa M.E.Gygi S.P.doi:10.1016/j.cell.2010.12.0012010Cell1431174-1189PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1324; TYR-1358; SER-1363; SER-1376; SER-1387; THR-1390; SER-1400; TYR-1408; SER-1453; SER-1460; SER-1509; SER-1511; SER-1513; SER-1537; SER-1539 AND SER-1568IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Brown adipose tissueHeartKidneyLungPancreasSpleenTestisSIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.Park J.Chen Y.Tishkoff D.X.Peng C.Tan M.Dai L.Xie Z.Zhang Y.Zwaans B.M.Skinner M.E.Lombard D.B.Zhao Y.doi:10.1016/j.molcel.2013.06.0012013Mol. Cell50919-930ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-3CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes.Iwamori T.Iwamori N.Matsumoto M.Ono E.Matzuk M.M.doi:10.1095/biolreprod.116.1454582017Biol. Reprod.96469-477INTERACTION WITH KIAA1210Mutations in topoisomerase IIbeta result in a B cell immunodeficiency.Broderick L.Yost S.Li D.McGeough M.D.Booshehri L.M.Guaderrama M.Brydges S.D.Kucharova K.Patel N.C.Harr M.Hakonarson H.Zackai E.Cowell I.G.Austin C.A.Huegle B.Gebauer C.Zhang J.Xu X.Wang J.Croker B.A.Frazer K.A.Putnam C.D.Hoffman H.M.doi:10.1038/s41467-019-11570-62019Nat. Commun.103644DISRUPTION PHENOTYPEFUNCTIONMUTAGENESIS OF GLU-5811681 site, 1 O-linked glycan (1 site)331 antibodies from 36 providersmouseTop2bEukaryotaSUMOylation of DNA replication proteins5 hits in 80 CRISPR screensmouseProteinExpressed in cortical plate and 266 other cell types or tissuesbaseline and differentialMMHATPase_TopII-likeTOP4cTopoIIA_Trans_ScTopoIIATOPRIM_TopoIIAHistidine kinase-like ATPase, C-terminal domainTopoisomerase II, domain 5Topoisomerase, domain 3DTHCTHATPase_CHATPase_C_sfRibosomal_Su5_D2-typ_SFRibsml_uS5_D2-typ_fold_subgrTopo_IIATopo_IIA-like_dom_sfTopo_IIA_A/C_abTopo_IIA_A_a_sfTopo_IIA_B_CTopo_IIA_bsu_dom2Topo_IIA_dom_ATopoII_eukTopoIIA_CSTOPRIM_CTOPRIM_domainTOPRIM_TopoIIDNA TOPOISOMERASE 2-BETADNA TOPOISOMERASE/GYRASEDNA_gyraseBDNA_topoisoIVDTHCTHATPase_cToprimTOPRIM_CTOPISMRASEIITPI2FAMILYTOP2cTOP4cATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinaseRibosomal protein S5 domain 2-likeType II DNA topoisomeraseTOPO_IIATOPOISOMERASE_IITOPRIMDNA topoisomerase 2-beta5.6.2.2DNA topoisomerase II, beta isozymeTop2bKey decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation.Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).Homodimer (By similarity). Interacts with KIAA1210 (PubMed:28203736). Interacts with PLSCR1 (By similarity).Knockout animals have B-cell developmental defects affecting multiple stages of development likely due to transcriptional defects. These mutant mice have altered splenic follicle structure with reduce marginal zone and follicular B-cell zones; immunophenotyping show decreased B- cells at all stages of development. Mutant mice fail to mount an antibody response to vaccination and B-cells fail to proliferate in response to stimulation, indicating deficits in B-cell function.Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.Belongs to the type II topoisomerase family.Removed1DNA topoisomerase 2-beta18177821612Toprim464581Topo IIA-type catalytic7241177Interaction with DNA351353Interaction with DNA9991008Disordered10981128Disordered12451586Interaction with PLSCR114931499Basic and acidic residues1117Basic and acidic residues1261Basic and acidic residues12881302Basic and acidic residues13181362Basic and acidic residues13761390Polar residues14281444Basic and acidic residues14881508O-(5'-phospho-DNA)-tyrosine intermediate814100129157159170177385387470550552Interaction with DNA498Interaction with DNA501Interaction with DNA670Interaction with DNA671Interaction with DNA732Interaction with DNA766Transition state stabilizer813Important for DNA bending; intercalates between base pairs of target DNA865Interaction with DNA940N-acetylalanineN6-acetyllysine3Phosphoserine1224Phosphothreonine1280Phosphoserine1324Phosphoserine1328Phosphoserine1330Phosphoserine1332Phosphoserine1346Phosphotyrosine1358Phosphoserine1363PhosphoserinePhosphoserine1387PhosphothreoninePhosphoserine1400Phosphotyrosine1408Phosphoserine1411PhosphoserinePhosphoserine1439Phosphoserine1441Phosphoserine1448Phosphoserine1453Phosphoserine1460Phosphoserine1509Phosphoserine1511Phosphoserine1513Phosphoserine1537Phosphoserine1539Phosphothreonine1562Phosphoserine1563Phosphoserine1568Phosphotyrosine1596Phosphoserine1600Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)216Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)355Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)425Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)434Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)588Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)593Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)623Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)631Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)634Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)664Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)700Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1080Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1214Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1215Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1315Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1385Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1427Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)1477Impairs B-cell development.A16P14341catalytic2false3Aicda2005-09-27218190962d9ee8e8e65782be5a8a02be86bcd07MAKSSLAGSDGALTWVNNATKKEELETANKNDSTKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQLMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCKGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVSKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEEDSQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKEDLAAFVEELDKVEAQEREDILAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIVPEITAMKADASRKLLKKKKGDPDTTVVKVEFDEEFSGTPAEGTGEETLTPSAPVNKGPKPKREKKEPGTRVRKTPTSTGKTNAKKVKKRNPWSDDESKSESDLEEAEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDAAAADDSNDLEELKVKASPITNDGEDEFVPSDGLDKDEYAFSSGKSKATPEKSSNDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDTASVFAPSFGLKQTDKLPSKTVAAKKGKPPSDTAPKAKRAPKQKKIVETINSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKPSKTASKKPKKTSFDQDSDVDIFPSDFTSEPPALPRTGRARKEVKYFAESDEEEDVDFAMFNtruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetrue