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Q64487

- PTPRD_MOUSE

UniProt

Q64487 - PTPRD_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

Ptprd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1181 – 11822CleavageBy similarity
Binding sitei1521 – 15211SubstrateBy similarity
Active sitei1553 – 15531Phosphocysteine intermediateBy similarity
Binding sitei1597 – 15971SubstrateBy similarity
Active sitei1844 – 18441Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC
  3. receptor binding Source: BHF-UCL

GO - Biological processi

  1. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  2. neuron differentiation Source: BHF-UCL
  3. positive regulation of dendrite morphogenesis Source: BHF-UCL
  4. presynaptic membrane assembly Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
Gene namesi
Name:Ptprd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:97812. Ptprd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 12661246ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1267 – 128721HelicalSequence AnalysisAdd
BLAST
Topological domaini1288 – 1912625CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 19121892Receptor-type tyrosine-protein phosphatase deltaPRO_0000025438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ64487.
PaxDbiQ64487.
PRIDEiQ64487.

PTM databases

PhosphoSiteiQ64487.

Expressioni

Tissue specificityi

Brain, kidney, heart, and some B-cell lines.

Gene expression databases

BgeeiQ64487.
CleanExiMM_PTPRD.
ExpressionAtlasiQ64487. baseline and differential.
GenevestigatoriQ64487.

Interactioni

Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Interacts with IL1RAPL1 (via extracellular region); this interaction is required for IL1RAPL1-mediated synapse formation.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Il1rapl1P598236EBI-771834,EBI-5452114

Protein-protein interaction databases

IntActiQ64487. 3 interactions.
MINTiMINT-129768.

Structurei

3D structure databases

ProteinModelPortaliQ64487.
SMRiQ64487. Positions 21-318, 323-719, 921-1016, 1331-1906.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 11491Ig-like C2-type 1Add
BLAST
Domaini126 – 22499Ig-like C2-type 2Add
BLAST
Domaini236 – 31883Ig-like C2-type 3Add
BLAST
Domaini325 – 41591Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini420 – 51697Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini518 – 60790Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini612 – 70998Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini714 – 822109Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini823 – 91694Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini921 – 101696Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1020 – 110687Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1357 – 1612256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1644 – 1903260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 18910Sufficient for interaction with IL1RAPL1
Regioni227 – 2304Contributes to IL1RAPL1 binding
Regioni1553 – 15597Substrate bindingBy similarity

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiQ64487.
KOiK06777.
OMAiTMDPSQH.
OrthoDBiEOG7M98FB.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (12)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform D (identifier: Q64487-4) [UniParc]FASTAAdd to Basket

Also known as: delta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPVARPLSL LLTFFLCACA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEEPYKEI DGIATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPASEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIASYELV
560 570 580 590 600
YRDGDQGEEQ RITIEPGTSY RLQGLKPNSL YYFRLSARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSLKYA
660 670 680 690 700
AVDGEDFKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTDEDV PSGPPRKVEV EAVNATAVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVKMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISVPEEIPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGV
960 970 980 990 1000
ITKYTLLYRD INVPLLPMEH LIVPADTSMT LTGLKSDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPD VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMDHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESESR
1310 1320 1330 1340 1350
KSSLPNSKEV PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFLDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFCYRAA
1910
LEYLGSFDHY AT
Length:1,912
Mass (Da):214,410
Last modified:May 16, 2012 - v3
Checksum:iDEF494AA5A2CE814
GO
Isoform C (identifier: Q64487-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     775-783: Missing.

Show »
Length:1,893
Mass (Da):212,139
Checksum:i75E8EA527026E69B
GO
Isoform A (identifier: Q64487-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCLTSCFILASHMLSCDLVFVP
     2-230: Missing.
     608-1018: Missing.
     1019-1019: V → M

Show »
Length:1,293
Mass (Da):146,050
Checksum:iBB720DA7CCF34DD6
GO
Isoform B (identifier: Q64487-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCLTSCFILASHMLSCDLVFVP
     2-230: Missing.
     775-783: Missing.

Show »
Length:1,695
Mass (Da):190,371
Checksum:i386F0DB5ACDD4C89
GO
Isoform E (identifier: Q64487-5) [UniParc]FASTAAdd to Basket

Also known as: delta-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     227-230: Missing.

Show »
Length:1,908
Mass (Da):213,882
Checksum:iD95358289FF1576B
GO
Isoform F (identifier: Q64487-6) [UniParc]FASTAAdd to Basket

Also known as: deltaA6

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.

Show »
Length:1,909
Mass (Da):214,080
Checksum:iA4103C1071DB834A
GO
Isoform G (identifier: Q64487-7) [UniParc]FASTAAdd to Basket

Also known as: deltaA6-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     227-230: Missing.

Show »
Length:1,905
Mass (Da):213,553
Checksum:iB2A43376C7BFBA17
GO
Isoform H (identifier: Q64487-8) [UniParc]FASTAAdd to Basket

Also known as: deltaA3

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.

Show »
Length:1,906
Mass (Da):213,828
Checksum:i5CD10161556D78FC
GO
Isoform I (identifier: Q64487-9) [UniParc]FASTAAdd to Basket

Also known as: deltaA3-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.

Show »
Length:1,902
Mass (Da):213,300
Checksum:iE612C8C07FCF9632
GO
Isoform J (identifier: Q64487-10) [UniParc]FASTAAdd to Basket

Also known as: delta-DelA

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.

Show »
Length:1,903
Mass (Da):213,499
Checksum:i978F592FB8113D1A
GO
Isoform K (identifier: Q64487-11) [UniParc]FASTAAdd to Basket

Also known as: delta-DelAB

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     227-230: Missing.

Show »
Length:1,899
Mass (Da):212,971
Checksum:iEB6E8D26E1900A38
GO
Isoform L (identifier: Q64487-12) [UniParc]FASTAAdd to Basket

Also known as: delta A

The sequence of this isoform differs from the canonical sequence as follows:
     608-1018: Missing.
     1019-1019: V → M

Show »
Length:1,501
Mass (Da):168,928
Checksum:i141D4F9E90F088AD
GO

Sequence cautioni

The sequence BAA03004.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51A → R in BAA03004. (PubMed:8355697)Curated
Sequence conflicti349 – 3491E → G in BAA03003. (PubMed:8355697)Curated
Sequence conflicti416 – 4161A → T in BAA03003. (PubMed:8355697)Curated
Sequence conflicti551 – 5511Y → D in BAA03003. (PubMed:8355697)Curated
Sequence conflicti588 – 5881R → T in BAA03003. (PubMed:8355697)Curated
Sequence conflicti657 – 6571F → Y in BAA03005. (PubMed:8355697)Curated
Sequence conflicti663 – 6664LGIP → IGNS in BAA03005. (PubMed:8355697)Curated
Sequence conflicti696 – 6961G → W in BAA03005. (PubMed:8355697)Curated
Sequence conflicti761 – 7633GQP → SA in BAA03005. (PubMed:8355697)Curated
Sequence conflicti822 – 8221A → S in BAA03005. (PubMed:8355697)Curated
Sequence conflicti852 – 8521Missing in BAA03005. (PubMed:8355697)Curated
Sequence conflicti1001 – 10011G → R in BAA03005. (PubMed:8355697)Curated
Sequence conflicti1004 – 10041P → A in BAA03005. (PubMed:8355697)Curated
Sequence conflicti1046 – 105510SAMPFKILYD → PAILSKFFMMM in BAA03003. (PubMed:8355697)Curated
Sequence conflicti1084 – 10841V → A in BAA03003. (PubMed:8355697)Curated
Sequence conflicti1298 – 12981E → D in BAA03003. (PubMed:8355697)Curated
Sequence conflicti1447 – 14482RS → E in BAA03003. (PubMed:8355697)Curated
Sequence conflicti1491 – 150212ATYCV…FALYK → HILCPDICTLN in BAA03003. (PubMed:8355697)CuratedAdd
BLAST
Sequence conflicti1510 – 15101E → K in BAA03003. (PubMed:8355697)Curated
Sequence conflicti1531 – 154212FLAFL…VKTCN → VPSFLTESQNLH in BAA03003. (PubMed:8355697)CuratedAdd
BLAST
Sequence conflicti1684 – 16841T → G in BAA03003. (PubMed:8355697)Curated
Sequence conflicti1786 – 179510EFKVTDARDG → NSRSRMPGI in BAA03003. (PubMed:8355697)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MCLTSCFILASHMLSCDLVF VP in isoform A and isoform B. 1 PublicationVSP_043545
Alternative sequencei2 – 230229Missing in isoform A and isoform B. 1 PublicationVSP_043546Add
BLAST
Alternative sequencei181 – 1899Missing in isoform J and isoform K. CuratedVSP_043547
Alternative sequencei181 – 1833Missing in isoform F and isoform G. CuratedVSP_043548
Alternative sequencei184 – 1896Missing in isoform C, isoform H and isoform I. CuratedVSP_043549
Alternative sequencei227 – 2304Missing in isoform C, isoform E, isoform G, isoform I and isoform K. CuratedVSP_043550
Alternative sequencei608 – 1018411Missing in isoform A and isoform L. 2 PublicationsVSP_043551Add
BLAST
Alternative sequencei775 – 7839Missing in isoform B and isoform C. CuratedVSP_043552
Alternative sequencei1019 – 10191V → M in isoform A and isoform L. 2 PublicationsVSP_043553

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13903 mRNA. Translation: BAA03003.1.
D13905 mRNA. Translation: BAA03005.1.
D13904 mRNA. Translation: BAA03004.1. Different initiation.
AF326559 mRNA. Translation: AAL37405.1.
AF326560 mRNA. Translation: AAL37406.1.
AL844848 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
Z23051 mRNA. Translation: CAA80586.1.
PIRiC54689.
D54689.
RefSeqiNP_035341.2. NM_011211.3.
UniGeneiMm.184021.
Mm.403663.
Mm.477158.
Mm.489057.

Genome annotation databases

EnsembliENSMUST00000107289; ENSMUSP00000102910; ENSMUSG00000028399. [Q64487-4]
GeneIDi19266.
KEGGimmu:19266.
UCSCiuc008tjl.1. mouse.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13903 mRNA. Translation: BAA03003.1 .
D13905 mRNA. Translation: BAA03005.1 .
D13904 mRNA. Translation: BAA03004.1 . Different initiation.
AF326559 mRNA. Translation: AAL37405.1 .
AF326560 mRNA. Translation: AAL37406.1 .
AL844848 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
Z23051 mRNA. Translation: CAA80586.1 .
PIRi C54689.
D54689.
RefSeqi NP_035341.2. NM_011211.3.
UniGenei Mm.184021.
Mm.403663.
Mm.477158.
Mm.489057.

3D structure databases

ProteinModelPortali Q64487.
SMRi Q64487. Positions 21-318, 323-719, 921-1016, 1331-1906.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64487. 3 interactions.
MINTi MINT-129768.

PTM databases

PhosphoSitei Q64487.

Proteomic databases

MaxQBi Q64487.
PaxDbi Q64487.
PRIDEi Q64487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107289 ; ENSMUSP00000102910 ; ENSMUSG00000028399 . [Q64487-4 ]
GeneIDi 19266.
KEGGi mmu:19266.
UCSCi uc008tjl.1. mouse.

Organism-specific databases

CTDi 5789.
MGIi MGI:97812. Ptprd.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000010250.
HOVERGENi HBG053758.
InParanoidi Q64487.
KOi K06777.
OMAi TMDPSQH.
OrthoDBi EOG7M98FB.

Miscellaneous databases

ChiTaRSi Ptprd. mouse.
NextBioi 296140.
PROi Q64487.
SOURCEi Search...

Gene expression databases

Bgeei Q64487.
CleanExi MM_PTPRD.
ExpressionAtlasi Q64487. baseline and differential.
Genevestigatori Q64487.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage."
    Mizuno K., Hasegawa K., Katagiri T., Ogimoto M., Ichikawa T., Yakura H.
    Mol. Cell. Biol. 13:5513-5523(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), NUCLEOTIDE SEQUENCE [MRNA] OF 1-224 (ISOFORMS C/H/I), NUCLEOTIDE SEQUENCE [MRNA] OF 606-1018 (ISOFORMS B/C), ALTERNATIVE SPLICING (ISOFORMS A; B AND C).
    Strain: BALB/c.
    Tissue: Brain.
  2. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
    Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
    J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L).
    Strain: C57BL/6J and DBA/2J.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain."
    Hendriks W., Schepens J., Brugman C., Zeeuwen P., Wieringa B.
    Biochem. J. 305:499-504(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1446-1551.
    Strain: BALB/c.
    Tissue: Brain.
  5. "IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase delta."
    Yoshida T., Yasumura M., Uemura T., Lee S.J., Ra M., Taguchi R., Iwakura Y., Mishina M.
    J. Neurosci. 31:13485-13499(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IL1RAPL1, ALTERNATIVE SPLICING (ISOFORMS D/E/F/G/H/I/J/K), IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPTPRD_MOUSE
AccessioniPrimary (citable) accession number: Q64487
Secondary accession number(s): G3X9S7
, Q64486, Q64488, Q64495, Q8VBV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 16, 2012
Last modified: November 26, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3