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Q64487

- PTPRD_MOUSE

UniProt

Q64487 - PTPRD_MOUSE

Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

Ptprd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 3 (16 May 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei1181 – 11822CleavageBy similarity
    Binding sitei1521 – 15211SubstrateBy similarity
    Active sitei1553 – 15531Phosphocysteine intermediateBy similarity
    Binding sitei1597 – 15971SubstrateBy similarity
    Active sitei1844 – 18441Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC
    4. receptor binding Source: BHF-UCL

    GO - Biological processi

    1. heterophilic cell-cell adhesion Source: BHF-UCL
    2. neuron differentiation Source: BHF-UCL
    3. positive regulation of dendrite morphogenesis Source: BHF-UCL
    4. presynaptic membrane assembly Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase delta
    Short name:
    R-PTP-delta
    Gene namesi
    Name:Ptprd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:97812. Ptprd.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 19121892Receptor-type tyrosine-protein phosphatase deltaPRO_0000025438Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi147 ↔ 207PROSITE-ProRule annotation
    Glycosylationi254 – 2541N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi257 ↔ 302PROSITE-ProRule annotation
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ64487.
    PaxDbiQ64487.
    PRIDEiQ64487.

    PTM databases

    PhosphoSiteiQ64487.

    Expressioni

    Tissue specificityi

    Brain, kidney, heart, and some B-cell lines.

    Gene expression databases

    ArrayExpressiQ64487.
    BgeeiQ64487.
    CleanExiMM_PTPRD.
    GenevestigatoriQ64487.

    Interactioni

    Subunit structurei

    Interacts with PPFIA1, PPFIA2 and PPFIA3 By similarity. Interacts with IL1RAPL1 (via extracellular region); this interaction is required for IL1RAPL1-mediated synapse formation.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Il1rapl1P598236EBI-771834,EBI-5452114

    Protein-protein interaction databases

    IntActiQ64487. 3 interactions.
    MINTiMINT-129768.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64487.
    SMRiQ64487. Positions 21-318, 323-719, 921-1016, 1331-1906.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 12661246ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1288 – 1912625CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1267 – 128721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 11491Ig-like C2-type 1Add
    BLAST
    Domaini126 – 22499Ig-like C2-type 2Add
    BLAST
    Domaini236 – 31883Ig-like C2-type 3Add
    BLAST
    Domaini325 – 41591Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 51697Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini518 – 60790Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini612 – 70998Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini714 – 822109Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini823 – 91694Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini921 – 101696Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1020 – 110687Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1357 – 1612256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1644 – 1903260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 18910Sufficient for interaction with IL1RAPL1
    Regioni227 – 2304Contributes to IL1RAPL1 binding
    Regioni1553 – 15597Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00590000082937.
    HOGENOMiHOG000010250.
    HOVERGENiHBG053758.
    KOiK06777.
    OMAiTMDPSQH.
    OrthoDBiEOG7M98FB.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 6 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (12)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 12 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform D (identifier: Q64487-4) [UniParc]FASTAAdd to Basket

    Also known as: delta

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPVARPLSL LLTFFLCACA ETPPRFTRTP VDQTGVSGGV ASFICQATGD     50
    PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA 100
    SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS 150
    GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES 200
    DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG 250
    GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY 300
    TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP 350
    VSYYIIQHKP KNSEEPYKEI DGIATTRYSV AGLSPYSDYE FRVVAVNNIG 400
    RGPASEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG 450
    YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD 500
    GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIASYELV 550
    YRDGDQGEEQ RITIEPGTSY RLQGLKPNSL YYFRLSARSP QGLGASTAEI 600
    SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSLKYA 650
    AVDGEDFKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL 700
    SVLIRTDEDV PSGPPRKVEV EAVNATAVKV SWRSPVPNKQ HGQIRGYQVH 750
    YVKMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV 800
    TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF 850
    GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK 900
    VGFGEEMVKE ISVPEEIPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGV 950
    ITKYTLLYRD INVPLLPMEH LIVPADTSMT LTGLKSDTTY DVKVRAHTSK 1000
    GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF 1050
    KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT 1100
    AKTAPDVLRT KPAFIGKTNL DGMITVQLPD VPANENIKGY YIIIVPLKKS 1150
    RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP 1200
    TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMDHAESKM YATSPYSDPV 1250
    VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESESR 1300
    KSSLPNSKEV PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK 1350
    ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS 1400
    AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT 1450
    VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL 1500
    YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV 1550
    VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED 1600
    QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR 1650
    LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI 1700
    NASFLDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG 1750
    REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV 1800
    RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR 1850
    TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFCYRAA 1900
    LEYLGSFDHY AT 1912
    Length:1,912
    Mass (Da):214,410
    Last modified:May 16, 2012 - v3
    Checksum:iDEF494AA5A2CE814
    GO
    Isoform C (identifier: Q64487-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         184-189: Missing.
         227-230: Missing.
         775-783: Missing.

    Show »
    Length:1,893
    Mass (Da):212,139
    Checksum:i75E8EA527026E69B
    GO
    Isoform A (identifier: Q64487-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MCLTSCFILASHMLSCDLVFVP
         2-230: Missing.
         608-1018: Missing.
         1019-1019: V → M

    Show »
    Length:1,293
    Mass (Da):146,050
    Checksum:iBB720DA7CCF34DD6
    GO
    Isoform B (identifier: Q64487-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MCLTSCFILASHMLSCDLVFVP
         2-230: Missing.
         775-783: Missing.

    Show »
    Length:1,695
    Mass (Da):190,371
    Checksum:i386F0DB5ACDD4C89
    GO
    Isoform E (identifier: Q64487-5) [UniParc]FASTAAdd to Basket

    Also known as: delta-DelB

    The sequence of this isoform differs from the canonical sequence as follows:
         227-230: Missing.

    Show »
    Length:1,908
    Mass (Da):213,882
    Checksum:iD95358289FF1576B
    GO
    Isoform F (identifier: Q64487-6) [UniParc]FASTAAdd to Basket

    Also known as: deltaA6

    The sequence of this isoform differs from the canonical sequence as follows:
         181-183: Missing.

    Show »
    Length:1,909
    Mass (Da):214,080
    Checksum:iA4103C1071DB834A
    GO
    Isoform G (identifier: Q64487-7) [UniParc]FASTAAdd to Basket

    Also known as: deltaA6-DelB

    The sequence of this isoform differs from the canonical sequence as follows:
         181-183: Missing.
         227-230: Missing.

    Show »
    Length:1,905
    Mass (Da):213,553
    Checksum:iB2A43376C7BFBA17
    GO
    Isoform H (identifier: Q64487-8) [UniParc]FASTAAdd to Basket

    Also known as: deltaA3

    The sequence of this isoform differs from the canonical sequence as follows:
         184-189: Missing.

    Show »
    Length:1,906
    Mass (Da):213,828
    Checksum:i5CD10161556D78FC
    GO
    Isoform I (identifier: Q64487-9) [UniParc]FASTAAdd to Basket

    Also known as: deltaA3-DelB

    The sequence of this isoform differs from the canonical sequence as follows:
         184-189: Missing.
         227-230: Missing.

    Show »
    Length:1,902
    Mass (Da):213,300
    Checksum:iE612C8C07FCF9632
    GO
    Isoform J (identifier: Q64487-10) [UniParc]FASTAAdd to Basket

    Also known as: delta-DelA

    The sequence of this isoform differs from the canonical sequence as follows:
         181-189: Missing.

    Show »
    Length:1,903
    Mass (Da):213,499
    Checksum:i978F592FB8113D1A
    GO
    Isoform K (identifier: Q64487-11) [UniParc]FASTAAdd to Basket

    Also known as: delta-DelAB

    The sequence of this isoform differs from the canonical sequence as follows:
         181-189: Missing.
         227-230: Missing.

    Show »
    Length:1,899
    Mass (Da):212,971
    Checksum:iEB6E8D26E1900A38
    GO
    Isoform L (identifier: Q64487-12) [UniParc]FASTAAdd to Basket

    Also known as: delta A

    The sequence of this isoform differs from the canonical sequence as follows:
         608-1018: Missing.
         1019-1019: V → M

    Show »
    Length:1,501
    Mass (Da):168,928
    Checksum:i141D4F9E90F088AD
    GO

    Sequence cautioni

    The sequence BAA03004.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51A → R in BAA03004. (PubMed:8355697)Curated
    Sequence conflicti349 – 3491E → G in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti416 – 4161A → T in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti551 – 5511Y → D in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti588 – 5881R → T in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti657 – 6571F → Y in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti663 – 6664LGIP → IGNS in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti696 – 6961G → W in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti761 – 7633GQP → SA in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti822 – 8221A → S in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti852 – 8521Missing in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti1001 – 10011G → R in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti1004 – 10041P → A in BAA03005. (PubMed:8355697)Curated
    Sequence conflicti1046 – 105510SAMPFKILYD → PAILSKFFMMM in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti1084 – 10841V → A in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti1298 – 12981E → D in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti1447 – 14482RS → E in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti1491 – 150212ATYCV…FALYK → HILCPDICTLN in BAA03003. (PubMed:8355697)CuratedAdd
    BLAST
    Sequence conflicti1510 – 15101E → K in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti1531 – 154212FLAFL…VKTCN → VPSFLTESQNLH in BAA03003. (PubMed:8355697)CuratedAdd
    BLAST
    Sequence conflicti1684 – 16841T → G in BAA03003. (PubMed:8355697)Curated
    Sequence conflicti1786 – 179510EFKVTDARDG → NSRSRMPGI in BAA03003. (PubMed:8355697)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MCLTSCFILASHMLSCDLVF VP in isoform A and isoform B. 1 PublicationVSP_043545
    Alternative sequencei2 – 230229Missing in isoform A and isoform B. 1 PublicationVSP_043546Add
    BLAST
    Alternative sequencei181 – 1899Missing in isoform J and isoform K. CuratedVSP_043547
    Alternative sequencei181 – 1833Missing in isoform F and isoform G. CuratedVSP_043548
    Alternative sequencei184 – 1896Missing in isoform C, isoform H and isoform I. CuratedVSP_043549
    Alternative sequencei227 – 2304Missing in isoform C, isoform E, isoform G, isoform I and isoform K. CuratedVSP_043550
    Alternative sequencei608 – 1018411Missing in isoform A and isoform L. 2 PublicationsVSP_043551Add
    BLAST
    Alternative sequencei775 – 7839Missing in isoform B and isoform C. CuratedVSP_043552
    Alternative sequencei1019 – 10191V → M in isoform A and isoform L. 2 PublicationsVSP_043553

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13903 mRNA. Translation: BAA03003.1.
    D13905 mRNA. Translation: BAA03005.1.
    D13904 mRNA. Translation: BAA03004.1. Different initiation.
    AF326559 mRNA. Translation: AAL37405.1.
    AF326560 mRNA. Translation: AAL37406.1.
    AL844848 Genomic DNA. No translation available.
    AL845517 Genomic DNA. No translation available.
    AL929181 Genomic DNA. No translation available.
    Z23051 mRNA. Translation: CAA80586.1.
    PIRiC54689.
    D54689.
    RefSeqiNP_035341.2. NM_011211.3.
    UniGeneiMm.184021.
    Mm.403663.
    Mm.477158.
    Mm.489057.

    Genome annotation databases

    EnsembliENSMUST00000107289; ENSMUSP00000102910; ENSMUSG00000028399. [Q64487-4]
    GeneIDi19266.
    KEGGimmu:19266.
    UCSCiuc008tjl.1. mouse.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13903 mRNA. Translation: BAA03003.1 .
    D13905 mRNA. Translation: BAA03005.1 .
    D13904 mRNA. Translation: BAA03004.1 . Different initiation.
    AF326559 mRNA. Translation: AAL37405.1 .
    AF326560 mRNA. Translation: AAL37406.1 .
    AL844848 Genomic DNA. No translation available.
    AL845517 Genomic DNA. No translation available.
    AL929181 Genomic DNA. No translation available.
    Z23051 mRNA. Translation: CAA80586.1 .
    PIRi C54689.
    D54689.
    RefSeqi NP_035341.2. NM_011211.3.
    UniGenei Mm.184021.
    Mm.403663.
    Mm.477158.
    Mm.489057.

    3D structure databases

    ProteinModelPortali Q64487.
    SMRi Q64487. Positions 21-318, 323-719, 921-1016, 1331-1906.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64487. 3 interactions.
    MINTi MINT-129768.

    PTM databases

    PhosphoSitei Q64487.

    Proteomic databases

    MaxQBi Q64487.
    PaxDbi Q64487.
    PRIDEi Q64487.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107289 ; ENSMUSP00000102910 ; ENSMUSG00000028399 . [Q64487-4 ]
    GeneIDi 19266.
    KEGGi mmu:19266.
    UCSCi uc008tjl.1. mouse.

    Organism-specific databases

    CTDi 5789.
    MGIi MGI:97812. Ptprd.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00590000082937.
    HOGENOMi HOG000010250.
    HOVERGENi HBG053758.
    KOi K06777.
    OMAi TMDPSQH.
    OrthoDBi EOG7M98FB.

    Miscellaneous databases

    ChiTaRSi PTPRD. mouse.
    NextBioi 296140.
    PROi Q64487.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64487.
    Bgeei Q64487.
    CleanExi MM_PTPRD.
    Genevestigatori Q64487.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 6 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage."
      Mizuno K., Hasegawa K., Katagiri T., Ogimoto M., Ichikawa T., Yakura H.
      Mol. Cell. Biol. 13:5513-5523(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), NUCLEOTIDE SEQUENCE [MRNA] OF 1-224 (ISOFORMS C/H/I), NUCLEOTIDE SEQUENCE [MRNA] OF 606-1018 (ISOFORMS B/C), ALTERNATIVE SPLICING (ISOFORMS A; B AND C).
      Strain: BALB/c.
      Tissue: Brain.
    2. "Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene."
      Fehr C., Shirley R.L., Belknap J.K., Crabbe J.C., Buck K.J.
      J. Neurosci. 22:3730-3738(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L).
      Strain: C57BL/6J and DBA/2J.
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain."
      Hendriks W., Schepens J., Brugman C., Zeeuwen P., Wieringa B.
      Biochem. J. 305:499-504(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1446-1551.
      Strain: BALB/c.
      Tissue: Brain.
    5. "IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase delta."
      Yoshida T., Yasumura M., Uemura T., Lee S.J., Ra M., Taguchi R., Iwakura Y., Mishina M.
      J. Neurosci. 31:13485-13499(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IL1RAPL1, ALTERNATIVE SPLICING (ISOFORMS D/E/F/G/H/I/J/K), IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPTPRD_MOUSE
    AccessioniPrimary (citable) accession number: Q64487
    Secondary accession number(s): G3X9S7
    , Q64486, Q64488, Q64495, Q8VBV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 121 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3