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Protein

Receptor-type tyrosine-protein phosphatase delta

Gene

Ptprd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451).2 Publications

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei266Required for interaction with IL1RAP1 Publication1
Binding sitei1521SubstrateBy similarity1
Active sitei1553Phosphocysteine intermediateBy similarity1
Binding sitei1597SubstrateBy similarity1
Active sitei1844Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • protein tyrosine phosphatase activity Source: UniProtKB-EC
  • receptor binding Source: BHF-UCL

GO - Biological processi

  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  • negative regulation of JAK-STAT cascade Source: MGI
  • neuron differentiation Source: BHF-UCL
  • positive regulation of dendrite morphogenesis Source: BHF-UCL
  • positive regulation of synapse assembly Source: UniProtKB
  • presynaptic membrane assembly Source: BHF-UCL
  • regulation of immune response Source: MGI

Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

ReactomeiR-MMU-388844. Receptor-type tyrosine-protein phosphatases.
R-MMU-8849932. Synaptic adhesion-like molecules.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase delta (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase delta
Short name:
R-PTP-delta
Gene namesi
Name:Ptprd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97812. Ptprd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 1266ExtracellularSequence analysisAdd BLAST1246
Transmembranei1267 – 1287HelicalSequence analysisAdd BLAST21
Topological domaini1288 – 1912CytoplasmicSequence analysisAdd BLAST625

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68R → A: Reduces affinity with IL1RAPL1. Reduces the synaptogenic activity to ~7%. 1 Publication1
Mutagenesisi189R → A: Decreases affinity for interaction with IL1RAPL1. 1 Publication1
Mutagenesisi229R → E: Abolishes interaction with SLITRK2. 1 Publication1
Mutagenesisi266Y → A: No effect on interaction with SLITRK2. Decreases the affinity for IL1RAPL1. Abolishes interaction with IL1RAP. 2 Publications1
Mutagenesisi279E → A: Decreases affinity for IL1RAP. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002543821 – 1912Receptor-type tyrosine-protein phosphatase deltaAdd BLAST1892

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 98PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi147 ↔ 207PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysisCombined sources2 Publications1
Disulfide bondi257 ↔ 302PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysisCombined sources2 Publications1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi832N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1181 – 1182CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ64487.
PeptideAtlasiQ64487.
PRIDEiQ64487.

PTM databases

iPTMnetiQ64487.
PhosphoSitePlusiQ64487.

Expressioni

Tissue specificityi

Brain, kidney, heart, and some B-cell lines.

Gene expression databases

BgeeiENSMUSG00000028399.
CleanExiMM_PTPRD.
ExpressionAtlasiQ64487. baseline and differential.
GenevisibleiQ64487. MM.

Interactioni

Subunit structurei

Interacts with PPFIA1, PPFIA2 and PPFIA3 (By similarity). Interacts (via extracellular domain) with SLITRK4 (via LRR 1 and 2 repeats) (PubMed:25989451). Interacts with SLITRK2; induces presynaptic differentiation (PubMed:25989451). Interacts (via the second immunoglobilin domain) with IL1RAPL1 (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons and synapse formation. Isoform G, isoform H, isoform I, isoform J, and isoform K do not interact with IL1RAPL1 (PubMed:25908590, PubMed:21940441). Interacts (via the third immunoglobilin domain) with IL1RAP (via the first immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (PubMed:25908590).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Il1rapl1P598236EBI-771834,EBI-5452114

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

IntActiQ64487. 4 interactors.
MINTiMINT-129768.
STRINGi10090.ENSMUSP00000133468.

Structurei

Secondary structure

11912
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 28Combined sources7
Beta strandi33 – 36Combined sources4
Beta strandi41 – 51Combined sources11
Beta strandi54 – 59Combined sources6
Beta strandi69 – 73Combined sources5
Beta strandi75 – 84Combined sources10
Turni89 – 92Combined sources4
Beta strandi94 – 102Combined sources9
Beta strandi105 – 116Combined sources12
Helixi118 – 120Combined sources3
Beta strandi127 – 130Combined sources4
Beta strandi135 – 138Combined sources4
Beta strandi143 – 150Combined sources8
Beta strandi156 – 161Combined sources6
Beta strandi174 – 179Combined sources6
Beta strandi184 – 186Combined sources3
Beta strandi188 – 194Combined sources7
Helixi199 – 201Combined sources3
Beta strandi203 – 211Combined sources9
Beta strandi214 – 217Combined sources4
Beta strandi221 – 226Combined sources6
Beta strandi234 – 240Combined sources7
Beta strandi245 – 247Combined sources3
Beta strandi253 – 263Combined sources11
Beta strandi266 – 271Combined sources6
Beta strandi274 – 277Combined sources4
Beta strandi284 – 291Combined sources8
Beta strandi298 – 306Combined sources9
Beta strandi309 – 318Combined sources10
Beta strandi330 – 334Combined sources5
Beta strandi339 – 342Combined sources4
Beta strandi353 – 360Combined sources8
Beta strandi368 – 373Combined sources6
Beta strandi375 – 380Combined sources6
Beta strandi388 – 396Combined sources9
Beta strandi401 – 404Combined sources4
Beta strandi408 – 411Combined sources4
Beta strandi422 – 432Combined sources11
Beta strandi434 – 439Combined sources6
Beta strandi450 – 457Combined sources8
Helixi463 – 465Combined sources3
Beta strandi466 – 473Combined sources8
Beta strandi475 – 479Combined sources5
Beta strandi487 – 495Combined sources9
Beta strandi507 – 510Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y61X-ray3.36A21-411[»]
4YFCX-ray2.70A21-318[»]
4YFDX-ray3.25A21-511[»]
4YFEX-ray1.97A/B321-511[»]
4YFGX-ray3.49A/B21-511[»]
4YH7X-ray4.40A21-1265[»]
ProteinModelPortaliQ64487.
SMRiQ64487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 114Ig-like C2-type 1Add BLAST91
Domaini126 – 224Ig-like C2-type 2Add BLAST99
Domaini236 – 318Ig-like C2-type 3Add BLAST83
Domaini325 – 415Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini420 – 516Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini518 – 607Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini612 – 709Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST98
Domaini714 – 822Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST109
Domaini823 – 916Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini921 – 1016Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST96
Domaini1020 – 1106Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST87
Domaini1357 – 1612Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST256
Domaini1644 – 1903Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST260

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 189Mini-exon peptide A9; sufficient for interaction with IL1RAPL12 Publications9
Regioni227 – 230Mini-exon peptide B; required for interaction with SLITRK2 and in the function in pre-synaptic differentiation; Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP; Modulates affinity for IL1RAPL1 and IL1RAP2 Publications4
Regioni1553 – 1559Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
HOVERGENiHBG053758.
InParanoidiQ64487.
KOiK06777.
OMAiQGFNDRR.
OrthoDBiEOG091G11WG.

Family and domain databases

CDDicd00063. FN3. 8 hits.
Gene3Di2.60.40.10. 11 hits.
3.90.190.10. 2 hits.
InterProiView protein in InterPro
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
PfamiView protein in Pfam
PF00041. fn3. 7 hits.
PF07679. I-set. 2 hits.
PF00102. Y_phosphatase. 2 hits.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00060. FN3. 8 hits.
SM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF49265. SSF49265. 6 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiView protein in PROSITE
PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.

Sequences (12)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform D (identifier: Q64487-4) [UniParc]FASTAAdd to basket
Also known as: delta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPVARPLSL LLTFFLCACA ETPPRFTRTP VDQTGVSGGV ASFICQATGD
60 70 80 90 100
PRPKIVWNKK GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA
110 120 130 140 150
SNNVGEISVS TRLTVLREDQ IPRGFPTIDM GPQLKVVERT RTATMLCAAS
160 170 180 190 200
GNPDPEITWF KDFLPVDTSN NNGRIKQLRS ESIGGTPIRG ALQIEQSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI PPTNHEIMPG
260 270 280 290 300
GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY
310 320 330 340 350
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP
360 370 380 390 400
VSYYIIQHKP KNSEEPYKEI DGIATTRYSV AGLSPYSDYE FRVVAVNNIG
410 420 430 440 450
RGPASEPVLT QTSEQAPSSA PRDVQARMLS STTILVQWKE PEEPNGQIQG
460 470 480 490 500
YRVYYTMDPT QHVNNWMKHN VADSQITTIG NLVPQKTYSV KVLAFTSIGD
510 520 530 540 550
GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR SDTIASYELV
560 570 580 590 600
YRDGDQGEEQ RITIEPGTSY RLQGLKPNSL YYFRLSARSP QGLGASTAEI
610 620 630 640 650
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSLKYA
660 670 680 690 700
AVDGEDFKPH EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL
710 720 730 740 750
SVLIRTDEDV PSGPPRKVEV EAVNATAVKV SWRSPVPNKQ HGQIRGYQVH
760 770 780 790 800
YVKMENGEPK GQPMLKDVML ADAQWEFDDT TEHDMIISGL QPETSYSLTV
810 820 830 840 850
TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL IQWHPPVDTF
860 870 880 890 900
GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK
910 920 930 940 950
VGFGEEMVKE ISVPEEIPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGV
960 970 980 990 1000
ITKYTLLYRD INVPLLPMEH LIVPADTSMT LTGLKSDTTY DVKVRAHTSK
1010 1020 1030 1040 1050
GPGPYSPSVQ FRTLPVDQVF AKNFHVKAVM KTSVLLSWEI PENYNSAMPF
1060 1070 1080 1090 1100
KILYDDGKMV EEVDGRATQK LIVNLKPEKS YSFVLTNRGN SAGGLQHRVT
1110 1120 1130 1140 1150
AKTAPDVLRT KPAFIGKTNL DGMITVQLPD VPANENIKGY YIIIVPLKKS
1160 1170 1180 1190 1200
RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP
1210 1220 1230 1240 1250
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMDHAESKM YATSPYSDPV
1260 1270 1280 1290 1300
VSMDLDPQPI TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESESR
1310 1320 1330 1340 1350
KSSLPNSKEV PSHHPTDPVE LRRLNFQTPG MASHPPIPIL ELADHIERLK
1360 1370 1380 1390 1400
ANDNLKFSQE YESIDPGQQF TWEHSNLEVN KPKNRYANVI AYDHSRVLLS
1410 1420 1430 1440 1450
AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW RMIWEQRSAT
1460 1470 1480 1490 1500
VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL
1510 1520 1530 1540 1550
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV
1560 1570 1580 1590 1600
VHCSAGVGRT GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED
1610 1620 1630 1640 1650
QYIFIHDALL EAVTCGNTEV PARNLYAYIQ KLTQIETGEN VTGMELEFKR
1660 1670 1680 1690 1700
LASSKAHTSR FISANLPCNK FKNRLVNIMP YESTRVCLQP IRGVEGSDYI
1710 1720 1730 1740 1750
NASFLDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV VMLTKLREMG
1760 1770 1780 1790 1800
REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV
1810 1820 1830 1840 1850
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR
1860 1870 1880 1890 1900
TGVFITLSIV LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFCYRAA
1910
LEYLGSFDHY AT
Length:1,912
Mass (Da):214,410
Last modified:May 16, 2012 - v3
Checksum:iDEF494AA5A2CE814
GO
Isoform C (identifier: Q64487-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.
     775-783: Missing.

Show »
Length:1,893
Mass (Da):212,139
Checksum:i75E8EA527026E69B
GO
Isoform A (identifier: Q64487-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCLTSCFILASHMLSCDLVFVP
     2-230: Missing.
     608-1018: Missing.
     1019-1019: V → M

Show »
Length:1,293
Mass (Da):146,050
Checksum:iBB720DA7CCF34DD6
GO
Isoform B (identifier: Q64487-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MCLTSCFILASHMLSCDLVFVP
     2-230: Missing.
     775-783: Missing.

Show »
Length:1,695
Mass (Da):190,371
Checksum:i386F0DB5ACDD4C89
GO
Isoform E (identifier: Q64487-5) [UniParc]FASTAAdd to basket
Also known as: delta-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     227-230: Missing.

Show »
Length:1,908
Mass (Da):213,882
Checksum:iD95358289FF1576B
GO
Isoform F (identifier: Q64487-6) [UniParc]FASTAAdd to basket
Also known as: deltaA6

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.

Show »
Length:1,909
Mass (Da):214,080
Checksum:iA4103C1071DB834A
GO
Isoform G (identifier: Q64487-7) [UniParc]FASTAAdd to basket
Also known as: deltaA6-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     181-183: Missing.
     227-230: Missing.

Show »
Length:1,905
Mass (Da):213,553
Checksum:iB2A43376C7BFBA17
GO
Isoform H (identifier: Q64487-8) [UniParc]FASTAAdd to basket
Also known as: deltaA3

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.

Show »
Length:1,906
Mass (Da):213,828
Checksum:i5CD10161556D78FC
GO
Isoform I (identifier: Q64487-9) [UniParc]FASTAAdd to basket
Also known as: deltaA3-DelB

The sequence of this isoform differs from the canonical sequence as follows:
     184-189: Missing.
     227-230: Missing.

Show »
Length:1,902
Mass (Da):213,300
Checksum:iE612C8C07FCF9632
GO
Isoform J (identifier: Q64487-10) [UniParc]FASTAAdd to basket
Also known as: delta-DelA

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.

Show »
Length:1,903
Mass (Da):213,499
Checksum:i978F592FB8113D1A
GO
Isoform K (identifier: Q64487-11) [UniParc]FASTAAdd to basket
Also known as: delta-DelAB

The sequence of this isoform differs from the canonical sequence as follows:
     181-189: Missing.
     227-230: Missing.

Show »
Length:1,899
Mass (Da):212,971
Checksum:iEB6E8D26E1900A38
GO
Isoform L (identifier: Q64487-12) [UniParc]FASTAAdd to basket
Also known as: delta A

The sequence of this isoform differs from the canonical sequence as follows:
     608-1018: Missing.
     1019-1019: V → M

Show »
Length:1,501
Mass (Da):168,928
Checksum:i141D4F9E90F088AD
GO

Sequence cautioni

The sequence BAA03004 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → R in BAA03004 (PubMed:8355697).Curated1
Sequence conflicti349E → G in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti416A → T in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti551Y → D in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti588R → T in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti657F → Y in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti663 – 666LGIP → IGNS in BAA03005 (PubMed:8355697).Curated4
Sequence conflicti696G → W in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti761 – 763GQP → SA in BAA03005 (PubMed:8355697).Curated3
Sequence conflicti822A → S in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti852Missing in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti1001G → R in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti1004P → A in BAA03005 (PubMed:8355697).Curated1
Sequence conflicti1046 – 1055SAMPFKILYD → PAILSKFFMMM in BAA03003 (PubMed:8355697).Curated10
Sequence conflicti1084V → A in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1298E → D in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1447 – 1448RS → E in BAA03003 (PubMed:8355697).Curated2
Sequence conflicti1491 – 1502ATYCV…FALYK → HILCPDICTLN in BAA03003 (PubMed:8355697).CuratedAdd BLAST12
Sequence conflicti1510E → K in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1531 – 1542FLAFL…VKTCN → VPSFLTESQNLH in BAA03003 (PubMed:8355697).CuratedAdd BLAST12
Sequence conflicti1684T → G in BAA03003 (PubMed:8355697).Curated1
Sequence conflicti1786 – 1795EFKVTDARDG → NSRSRMPGI in BAA03003 (PubMed:8355697).Curated10

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0435451M → MCLTSCFILASHMLSCDLVF VP in isoform A and isoform B. 1 Publication1
Alternative sequenceiVSP_0435462 – 230Missing in isoform A and isoform B. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_043547181 – 189Missing in isoform J and isoform K. Curated9
Alternative sequenceiVSP_043548181 – 183Missing in isoform F and isoform G. Curated3
Alternative sequenceiVSP_043549184 – 189Missing in isoform C, isoform H and isoform I. Curated6
Alternative sequenceiVSP_043550227 – 230Missing in isoform C, isoform E, isoform G, isoform I and isoform K. Curated4
Alternative sequenceiVSP_043551608 – 1018Missing in isoform A and isoform L. 2 PublicationsAdd BLAST411
Alternative sequenceiVSP_043552775 – 783Missing in isoform B and isoform C. Curated9
Alternative sequenceiVSP_0435531019V → M in isoform A and isoform L. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13903 mRNA. Translation: BAA03003.1.
D13905 mRNA. Translation: BAA03005.1.
D13904 mRNA. Translation: BAA03004.1. Different initiation.
AF326559 mRNA. Translation: AAL37405.1.
AF326560 mRNA. Translation: AAL37406.1.
AL844848 Genomic DNA. No translation available.
AL845517 Genomic DNA. No translation available.
AL929181 Genomic DNA. No translation available.
Z23051 mRNA. Translation: CAA80586.1.
PIRiC54689.
D54689.
RefSeqiNP_035341.2. NM_011211.3.
UniGeneiMm.184021.
Mm.403663.
Mm.477158.
Mm.489057.

Genome annotation databases

EnsembliENSMUST00000107289; ENSMUSP00000102910; ENSMUSG00000028399. [Q64487-4]
GeneIDi19266.
KEGGimmu:19266.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTPRD_MOUSE
AccessioniPrimary (citable) accession number: Q64487
Secondary accession number(s): G3X9S7
, Q64486, Q64488, Q64495, Q8VBV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 16, 2012
Last modified: September 27, 2017
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families