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Q64481 (CP3AG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A16

EC=1.14.14.1
Alternative name(s):
CYPIIIA16
Gene names
Name:Cyp3a16
Synonyms:Cyp3a-16
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Developmental stage

Fetal- and puberty-specific.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 3A16
PRO_0000051799

Sites

Metal binding4431Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict281C → Y in BAA05133. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64481 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 49C1B9E570DB5BC1

FASTA50457,870
        10         20         30         40         50         60 
MNLFSALSLD TLVLLAIILV LLYRYGTCTH GLFKKQGIPG PKPLPFLGTV LNYYKGLWKF 

        70         80         90        100        110        120 
DMECYEKYGK TWGLFDGQIP LFVITDPETI KNVLVKECFS VFTNRQDFFP VGIMSKSISL 

       130        140        150        160        170        180 
AKDEEWKRYR ALLSPTFTSG NLKEMFPVIE QYGDILVKYL RQEAEKGKPV AVKDVLGAYS 

       190        200        210        220        230        240 
MDVIISTTFG VNIDSLNNPE DPFVENAKKV LRFDYFDPLS LSVALFPFLT PIYEMLNICM 

       250        260        270        280        290        300 
FPKDSIEFFK KFVDRMTENR LDSKQKHRVD FIYLMMEAYN KSKDKDSHKA LSEIEITAQS 

       310        320        330        340        350        360 
IIFIFAGYET TSSILSFTVY SLATHPDIQK KLQEEIDEAL PNKAPPTYDT VMAMEYLDMV 

       370        380        390        400        410        420 
LNETLRLYPI TNRLQRVCKK DVEINGIYIP KGSTVIIPSY VLHHDPQHWP EPEEFQPERF 

       430        440        450        460        470        480 
SKENKGSIDP YVYLPFGNGP RNCIGMRFAL MNMKLALIKV LQNFSFQPCK ETQIPLKLSR 

       490        500 
ELLLQPVKPI VLKVVPRDAV ITGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26137 mRNA. Translation: BAA05133.1.
AC115895 Genomic DNA. No translation available.
CCDSCCDS19862.1.
PIRS50892.
RefSeqNP_031846.2. NM_007820.2.
UniGeneMm.378905.

3D structure databases

ProteinModelPortalQ64481.
SMRQ64481. Positions 29-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ64481. 3 interactions.
MINTMINT-4091767.

PTM databases

PhosphoSiteQ64481.

Proteomic databases

PaxDbQ64481.
PRIDEQ64481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656.
GeneID13114.
KEGGmmu:13114.
UCSCuc009amv.2. mouse.

Organism-specific databases

CTD13114.
MGIMGI:106099. Cyp3a16.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110610.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidQ64481.
KOK07424.
OrthoDBEOG7W6WKQ.
TreeFamTF105087.

Gene expression databases

BgeeQ64481.
GenevestigatorQ64481.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283130.
PROQ64481.
SOURCESearch...

Entry information

Entry nameCP3AG_MOUSE
AccessionPrimary (citable) accession number: Q64481
Secondary accession number(s): E9QP65
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot