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Q64481

- CP3AG_MOUSE

UniProt

Q64481 - CP3AG_MOUSE

Protein

Cytochrome P450 3A16

Gene

Cyp3a16

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A16 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA16
    Gene namesi
    Name:Cyp3a16
    Synonyms:Cyp3a-16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:106099. Cyp3a16.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 3A16PRO_0000051799Add
    BLAST

    Proteomic databases

    PaxDbiQ64481.
    PRIDEiQ64481.

    PTM databases

    PhosphoSiteiQ64481.

    Expressioni

    Developmental stagei

    Fetal- and puberty-specific.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiQ64481.
    GenevestigatoriQ64481.

    Interactioni

    Protein-protein interaction databases

    IntActiQ64481. 3 interactions.
    MINTiMINT-4091767.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64481.
    SMRiQ64481. Positions 29-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiQ64481.
    KOiK07424.
    OrthoDBiEOG7W6WKQ.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64481-1 [UniParc]FASTAAdd to Basket

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    MNLFSALSLD TLVLLAIILV LLYRYGTCTH GLFKKQGIPG PKPLPFLGTV    50
    LNYYKGLWKF DMECYEKYGK TWGLFDGQIP LFVITDPETI KNVLVKECFS 100
    VFTNRQDFFP VGIMSKSISL AKDEEWKRYR ALLSPTFTSG NLKEMFPVIE 150
    QYGDILVKYL RQEAEKGKPV AVKDVLGAYS MDVIISTTFG VNIDSLNNPE 200
    DPFVENAKKV LRFDYFDPLS LSVALFPFLT PIYEMLNICM FPKDSIEFFK 250
    KFVDRMTENR LDSKQKHRVD FIYLMMEAYN KSKDKDSHKA LSEIEITAQS 300
    IIFIFAGYET TSSILSFTVY SLATHPDIQK KLQEEIDEAL PNKAPPTYDT 350
    VMAMEYLDMV LNETLRLYPI TNRLQRVCKK DVEINGIYIP KGSTVIIPSY 400
    VLHHDPQHWP EPEEFQPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL 450
    MNMKLALIKV LQNFSFQPCK ETQIPLKLSR ELLLQPVKPI VLKVVPRDAV 500
    ITGA 504
    Length:504
    Mass (Da):57,870
    Last modified:July 27, 2011 - v2
    Checksum:i49C1B9E570DB5BC1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281C → Y in BAA05133. (PubMed:7813478)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26137 mRNA. Translation: BAA05133.1.
    AC115895 Genomic DNA. No translation available.
    CCDSiCCDS19862.1.
    PIRiS50892.
    RefSeqiNP_031846.2. NM_007820.2.
    UniGeneiMm.378905.

    Genome annotation databases

    EnsembliENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656.
    GeneIDi13114.
    KEGGimmu:13114.
    UCSCiuc009amv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26137 mRNA. Translation: BAA05133.1 .
    AC115895 Genomic DNA. No translation available.
    CCDSi CCDS19862.1.
    PIRi S50892.
    RefSeqi NP_031846.2. NM_007820.2.
    UniGenei Mm.378905.

    3D structure databases

    ProteinModelPortali Q64481.
    SMRi Q64481. Positions 29-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64481. 3 interactions.
    MINTi MINT-4091767.

    PTM databases

    PhosphoSitei Q64481.

    Proteomic databases

    PaxDbi Q64481.
    PRIDEi Q64481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031633 ; ENSMUSP00000031633 ; ENSMUSG00000038656 .
    GeneIDi 13114.
    KEGGi mmu:13114.
    UCSCi uc009amv.2. mouse.

    Organism-specific databases

    CTDi 13114.
    MGIi MGI:106099. Cyp3a16.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110610.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi Q64481.
    KOi K07424.
    OrthoDBi EOG7W6WKQ.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_216259. Miscellaneous substrates.

    Miscellaneous databases

    NextBioi 283130.
    PROi Q64481.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64481.
    Genevestigatori Q64481.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver."
      Itoh S., Satoh M., Abe Y., Hashimoto H., Yanagimoto T., Kamataki T.
      Eur. J. Biochem. 226:877-882(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCP3AG_MOUSE
    AccessioniPrimary (citable) accession number: Q64481
    Secondary accession number(s): E9QP65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3