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Q64481

- CP3AG_MOUSE

UniProt

Q64481 - CP3AG_MOUSE

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Protein
Cytochrome P450 3A16
Gene
Cyp3a16, Cyp3a-16
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_216259. Miscellaneous substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A16 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA16
Gene namesi
Name:Cyp3a16
Synonyms:Cyp3a-16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:106099. Cyp3a16.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 3A16
PRO_0000051799Add
BLAST

Proteomic databases

PaxDbiQ64481.
PRIDEiQ64481.

PTM databases

PhosphoSiteiQ64481.

Expressioni

Developmental stagei

Fetal- and puberty-specific.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiQ64481.
GenevestigatoriQ64481.

Interactioni

Protein-protein interaction databases

IntActiQ64481. 3 interactions.
MINTiMINT-4091767.

Structurei

3D structure databases

ProteinModelPortaliQ64481.
SMRiQ64481. Positions 29-498.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00730000110610.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64481.
KOiK07424.
OrthoDBiEOG7W6WKQ.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64481-1 [UniParc]FASTAAdd to Basket

« Hide

MNLFSALSLD TLVLLAIILV LLYRYGTCTH GLFKKQGIPG PKPLPFLGTV    50
LNYYKGLWKF DMECYEKYGK TWGLFDGQIP LFVITDPETI KNVLVKECFS 100
VFTNRQDFFP VGIMSKSISL AKDEEWKRYR ALLSPTFTSG NLKEMFPVIE 150
QYGDILVKYL RQEAEKGKPV AVKDVLGAYS MDVIISTTFG VNIDSLNNPE 200
DPFVENAKKV LRFDYFDPLS LSVALFPFLT PIYEMLNICM FPKDSIEFFK 250
KFVDRMTENR LDSKQKHRVD FIYLMMEAYN KSKDKDSHKA LSEIEITAQS 300
IIFIFAGYET TSSILSFTVY SLATHPDIQK KLQEEIDEAL PNKAPPTYDT 350
VMAMEYLDMV LNETLRLYPI TNRLQRVCKK DVEINGIYIP KGSTVIIPSY 400
VLHHDPQHWP EPEEFQPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL 450
MNMKLALIKV LQNFSFQPCK ETQIPLKLSR ELLLQPVKPI VLKVVPRDAV 500
ITGA 504
Length:504
Mass (Da):57,870
Last modified:July 27, 2011 - v2
Checksum:i49C1B9E570DB5BC1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281C → Y in BAA05133. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26137 mRNA. Translation: BAA05133.1.
AC115895 Genomic DNA. No translation available.
CCDSiCCDS19862.1.
PIRiS50892.
RefSeqiNP_031846.2. NM_007820.2.
UniGeneiMm.378905.

Genome annotation databases

EnsembliENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656.
GeneIDi13114.
KEGGimmu:13114.
UCSCiuc009amv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26137 mRNA. Translation: BAA05133.1 .
AC115895 Genomic DNA. No translation available.
CCDSi CCDS19862.1.
PIRi S50892.
RefSeqi NP_031846.2. NM_007820.2.
UniGenei Mm.378905.

3D structure databases

ProteinModelPortali Q64481.
SMRi Q64481. Positions 29-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64481. 3 interactions.
MINTi MINT-4091767.

PTM databases

PhosphoSitei Q64481.

Proteomic databases

PaxDbi Q64481.
PRIDEi Q64481.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031633 ; ENSMUSP00000031633 ; ENSMUSG00000038656 .
GeneIDi 13114.
KEGGi mmu:13114.
UCSCi uc009amv.2. mouse.

Organism-specific databases

CTDi 13114.
MGIi MGI:106099. Cyp3a16.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00730000110610.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi Q64481.
KOi K07424.
OrthoDBi EOG7W6WKQ.
TreeFami TF105087.

Enzyme and pathway databases

Reactomei REACT_216259. Miscellaneous substrates.

Miscellaneous databases

NextBioi 283130.
PROi Q64481.
SOURCEi Search...

Gene expression databases

Bgeei Q64481.
Genevestigatori Q64481.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver."
    Itoh S., Satoh M., Abe Y., Hashimoto H., Yanagimoto T., Kamataki T.
    Eur. J. Biochem. 226:877-882(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCP3AG_MOUSE
AccessioniPrimary (citable) accession number: Q64481
Secondary accession number(s): E9QP65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi