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Protein

Cytochrome P450 3A16

Gene

Cyp3a16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_288150. Aflatoxin activation and detoxification.
REACT_314116. Miscellaneous substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A16 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA16
Gene namesi
Name:Cyp3a16
Synonyms:Cyp3a-16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:106099. Cyp3a16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 3A16PRO_0000051799Add
BLAST

Proteomic databases

PaxDbiQ64481.
PRIDEiQ64481.

PTM databases

PhosphoSiteiQ64481.

Expressioni

Developmental stagei

Fetal- and puberty-specific.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiQ64481.
GenevisibleiQ64481. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64481. 3 interactions.
MINTiMINT-4091767.
STRINGi10090.ENSMUSP00000031633.

Structurei

3D structure databases

ProteinModelPortaliQ64481.
SMRiQ64481. Positions 29-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64481.
KOiK07424.
OrthoDBiEOG7W6WKQ.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFSALSLD TLVLLAIILV LLYRYGTCTH GLFKKQGIPG PKPLPFLGTV
60 70 80 90 100
LNYYKGLWKF DMECYEKYGK TWGLFDGQIP LFVITDPETI KNVLVKECFS
110 120 130 140 150
VFTNRQDFFP VGIMSKSISL AKDEEWKRYR ALLSPTFTSG NLKEMFPVIE
160 170 180 190 200
QYGDILVKYL RQEAEKGKPV AVKDVLGAYS MDVIISTTFG VNIDSLNNPE
210 220 230 240 250
DPFVENAKKV LRFDYFDPLS LSVALFPFLT PIYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVDRMTENR LDSKQKHRVD FIYLMMEAYN KSKDKDSHKA LSEIEITAQS
310 320 330 340 350
IIFIFAGYET TSSILSFTVY SLATHPDIQK KLQEEIDEAL PNKAPPTYDT
360 370 380 390 400
VMAMEYLDMV LNETLRLYPI TNRLQRVCKK DVEINGIYIP KGSTVIIPSY
410 420 430 440 450
VLHHDPQHWP EPEEFQPERF SKENKGSIDP YVYLPFGNGP RNCIGMRFAL
460 470 480 490 500
MNMKLALIKV LQNFSFQPCK ETQIPLKLSR ELLLQPVKPI VLKVVPRDAV

ITGA
Length:504
Mass (Da):57,870
Last modified:July 27, 2011 - v2
Checksum:i49C1B9E570DB5BC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281C → Y in BAA05133 (PubMed:7813478).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26137 mRNA. Translation: BAA05133.1.
AC115895 Genomic DNA. No translation available.
CCDSiCCDS19862.1.
PIRiS50892.
RefSeqiNP_031846.2. NM_007820.2.
UniGeneiMm.378905.

Genome annotation databases

EnsembliENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656.
GeneIDi13114.
KEGGimmu:13114.
UCSCiuc009amv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26137 mRNA. Translation: BAA05133.1.
AC115895 Genomic DNA. No translation available.
CCDSiCCDS19862.1.
PIRiS50892.
RefSeqiNP_031846.2. NM_007820.2.
UniGeneiMm.378905.

3D structure databases

ProteinModelPortaliQ64481.
SMRiQ64481. Positions 29-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64481. 3 interactions.
MINTiMINT-4091767.
STRINGi10090.ENSMUSP00000031633.

PTM databases

PhosphoSiteiQ64481.

Proteomic databases

PaxDbiQ64481.
PRIDEiQ64481.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031633; ENSMUSP00000031633; ENSMUSG00000038656.
GeneIDi13114.
KEGGimmu:13114.
UCSCiuc009amv.2. mouse.

Organism-specific databases

CTDi13114.
MGIiMGI:106099. Cyp3a16.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64481.
KOiK07424.
OrthoDBiEOG7W6WKQ.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_288150. Aflatoxin activation and detoxification.
REACT_314116. Miscellaneous substrates.

Miscellaneous databases

NextBioi283130.
PROiQ64481.
SOURCEiSearch...

Gene expression databases

BgeeiQ64481.
GenevisibleiQ64481. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel form of mouse cytochrome P450 3A (Cyp3a-16). Its cDNA cloning and expression in fetal liver."
    Itoh S., Satoh M., Abe Y., Hashimoto H., Yanagimoto T., Kamataki T.
    Eur. J. Biochem. 226:877-882(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCP3AG_MOUSE
AccessioniPrimary (citable) accession number: Q64481
Secondary accession number(s): E9QP65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: June 24, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.