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Protein

Glutathione S-transferase theta-1

Gene

Gstt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

SABIO-RKiQ64471

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-1 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-1
Gene namesi
Name:Gstt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107379 Gstt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi234R → W: Strongly reduced catalytic activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859401 – 240Glutathione S-transferase theta-1Add BLAST240

Proteomic databases

EPDiQ64471
PaxDbiQ64471
PeptideAtlasiQ64471
PRIDEiQ64471

2D gel databases

SWISS-2DPAGEiQ64471

PTM databases

iPTMnetiQ64471
PhosphoSitePlusiQ64471

Expressioni

Tissue specificityi

In liver, highest expression found in central vein limiting plate hepatocytes. Also expressed in interlobular bile duct epithelial cells. In lung, expressed in Clara cells and ciliated cells of the bronchiolar epithelium and in type II alveolar cells of the lung parenchyma.

Gene expression databases

BgeeiENSMUSG00000001663
CleanExiMM_GSTT1
ExpressionAtlasiQ64471 baseline and differential
GenevisibleiQ64471 MM

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi200102, 1 interactor
IntActiQ64471, 2 interactors
MINTiQ64471
STRINGi10090.ENSMUSP00000001713

Structurei

3D structure databases

ProteinModelPortaliQ64471
SMRiQ64471
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 222GST C-terminalAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
GeneTreeiENSGT00540000069741
HOGENOMiHOG000125747
HOVERGENiHBG051854
InParanoidiQ64471
KOiK00799
OMAiDYWYPQD
OrthoDBiEOG091G0PCG
TreeFamiTF325759

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q64471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLELYLDLL SQPCRAIYIF AKKNNIPFQM HTVELRKGEH LSDAFARVNP
60 70 80 90 100
MKRVPAMMDG GFTLCESVAI LLYLAHKYKV PDHWYPQDLQ ARARVDEYLA
110 120 130 140 150
WQHTGLRRSC LRALWHKVMF PVFLGEQIPP ETLAATLAEL DVNLQVLEDK
160 170 180 190 200
FLQDKDFLVG PHISLADLVA ITELMHPVGG GCPVFEGHPR LAAWYQRVEA
210 220 230 240
AVGKDLFREA HEVILKVKDC PPADLIIKQK LMPRVLAMIQ
Length:240
Mass (Da):27,374
Last modified:October 3, 2012 - v4
Checksum:iEDCB477D557466DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53R → K in CAA66665 (PubMed:8761485).Curated1
Sequence conflicti237A → T in CAA66665 (PubMed:8761485).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98055 mRNA Translation: CAA66665.1
AC142499 Genomic DNA No translation available.
CH466553 Genomic DNA Translation: EDL31888.1
BC012254 mRNA Translation: AAH12254.1
BC055020 mRNA Translation: AAH55020.1
CCDSiCCDS23932.1
PIRiS71878
RefSeqiNP_032211.3, NM_008185.3
UniGeneiMm.2746

Genome annotation databases

EnsembliENSMUST00000001713; ENSMUSP00000001713; ENSMUSG00000001663
GeneIDi14871
KEGGimmu:14871
UCSCiuc007frc.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTT1_MOUSE
AccessioniPrimary (citable) accession number: Q64471
Secondary accession number(s): Q91X50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 132 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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