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Q64464 (CP3AD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A13

EC=1.14.14.1
Alternative name(s):
CYPIIIA13
Gene names
Name:Cyp3a13
Synonyms:Cyp3a-13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Can activate aflatoxin B1 to a genotoxic product.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A13
PRO_0000051796

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64464 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 15DDE2606B337FCF

FASTA50357,492
        10         20         30         40         50         60 
MDLIPNFSME TWMLLATSLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI LAYQKGFWEC 

        70         80         90        100        110        120 
DIQCHKKYGK MWGLYDGRQP VLAITDPDII KTVLVKECYS TFTNRRRFGP VGILKKAISI 

       130        140        150        160        170        180 
SENEEWKRIR ALLSPTFTSG RLKEMFPIIN QFTDVLVRNM RQGLGEGKPT SMKDIFGAYS 

       190        200        210        220        230        240 
MDVITATSFG VNIDSLNNPQ DPFVEKIKKL LKFDIFDPLF LSVTLFPFLT PVFDALNVSL 

       250        260        270        280        290        300 
FPRDVISFFT TSVERMKENR MKEKEKQRVD FLQLMINSQN YKTKESHKAL SDVEIVAQSV 

       310        320        330        340        350        360 
IFIFAGYETT SSALSFALYL LAIHPDVQKK LQDEIDAALP NKAPATYDTL LQMEYLDMVV 

       370        380        390        400        410        420 
NETLRLYPIA GRLERVCKTD VEINGLFIPK GTVVMIPTFA LHKDPKYWPE PEEFRPERFS 

       430        440        450        460        470        480 
KKNQDSINPY MYLPFGSGPR NCIGMRFALI NMKVALVRVL QNFTVQPCKE TEIPLKLSKQ 

       490        500 
GLLQPENPLL LKVVSRDETV SDE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1)."
Yanagimoto T., Itoh S., Sawada M., Hashimoto H., Kamataki T.
Biochim. Biophys. Acta 1201:405-410(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X63023 mRNA. Translation: CAA44754.1.
BC046592 mRNA. Translation: AAH46592.1.
PIRS50211.
RefSeqNP_031845.1. NM_007819.4.
UniGeneMm.289886.

3D structure databases

ProteinModelPortalQ64464.
SMRQ64464. Positions 28-497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1863519.

PTM databases

PhosphoSiteQ64464.

Proteomic databases

PaxDbQ64464.
PRIDEQ64464.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000031741; ENSMUSP00000031741; ENSMUSG00000029727.
GeneID13113.
KEGGmmu:13113.
UCSCuc009aef.2. mouse.

Organism-specific databases

CTD13113.
MGIMGI:88610. Cyp3a13.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110610.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidQ64464.
KOK07424.
OMAFYLTHRE.
OrthoDBEOG744TBS.
PhylomeDBQ64464.
TreeFamTF105087.

Gene expression databases

BgeeQ64464.
GenevestigatorQ64464.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283126.
PROQ64464.
SOURCESearch...

Entry information

Entry nameCP3AD_MOUSE
AccessionPrimary (citable) accession number: Q64464
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot