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Q64464

- CP3AD_MOUSE

UniProt

Q64464 - CP3AD_MOUSE

Protein

Cytochrome P450 3A13

Gene

Cyp3a13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Can activate aflatoxin B1 to a genotoxic product.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of gene expression Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A13 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA13
    Gene namesi
    Name:Cyp3a13
    Synonyms:Cyp3a-13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:88610. Cyp3a13.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A13PRO_0000051796Add
    BLAST

    Proteomic databases

    MaxQBiQ64464.
    PaxDbiQ64464.
    PRIDEiQ64464.

    PTM databases

    PhosphoSiteiQ64464.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    BgeeiQ64464.
    GenevestigatoriQ64464.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1863519.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64464.
    SMRiQ64464. Positions 28-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiQ64464.
    KOiK07424.
    OMAiQPCKETE.
    OrthoDBiEOG744TBS.
    PhylomeDBiQ64464.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64464-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIPNFSME TWMLLATSLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI    50
    LAYQKGFWEC DIQCHKKYGK MWGLYDGRQP VLAITDPDII KTVLVKECYS 100
    TFTNRRRFGP VGILKKAISI SENEEWKRIR ALLSPTFTSG RLKEMFPIIN 150
    QFTDVLVRNM RQGLGEGKPT SMKDIFGAYS MDVITATSFG VNIDSLNNPQ 200
    DPFVEKIKKL LKFDIFDPLF LSVTLFPFLT PVFDALNVSL FPRDVISFFT 250
    TSVERMKENR MKEKEKQRVD FLQLMINSQN YKTKESHKAL SDVEIVAQSV 300
    IFIFAGYETT SSALSFALYL LAIHPDVQKK LQDEIDAALP NKAPATYDTL 350
    LQMEYLDMVV NETLRLYPIA GRLERVCKTD VEINGLFIPK GTVVMIPTFA 400
    LHKDPKYWPE PEEFRPERFS KKNQDSINPY MYLPFGSGPR NCIGMRFALI 450
    NMKVALVRVL QNFTVQPCKE TEIPLKLSKQ GLLQPENPLL LKVVSRDETV 500
    SDE 503
    Length:503
    Mass (Da):57,492
    Last modified:November 1, 1996 - v1
    Checksum:i15DDE2606B337FCF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63023 mRNA. Translation: CAA44754.1.
    BC046592 mRNA. Translation: AAH46592.1.
    CCDSiCCDS19781.1.
    PIRiS50211.
    RefSeqiNP_031845.1. NM_007819.4.
    UniGeneiMm.289886.

    Genome annotation databases

    EnsembliENSMUST00000031741; ENSMUSP00000031741; ENSMUSG00000029727.
    GeneIDi13113.
    KEGGimmu:13113.
    UCSCiuc009aef.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X63023 mRNA. Translation: CAA44754.1 .
    BC046592 mRNA. Translation: AAH46592.1 .
    CCDSi CCDS19781.1.
    PIRi S50211.
    RefSeqi NP_031845.1. NM_007819.4.
    UniGenei Mm.289886.

    3D structure databases

    ProteinModelPortali Q64464.
    SMRi Q64464. Positions 28-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1863519.

    PTM databases

    PhosphoSitei Q64464.

    Proteomic databases

    MaxQBi Q64464.
    PaxDbi Q64464.
    PRIDEi Q64464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031741 ; ENSMUSP00000031741 ; ENSMUSG00000029727 .
    GeneIDi 13113.
    KEGGi mmu:13113.
    UCSCi uc009aef.2. mouse.

    Organism-specific databases

    CTDi 13113.
    MGIi MGI:88610. Cyp3a13.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110610.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi Q64464.
    KOi K07424.
    OMAi QPCKETE.
    OrthoDBi EOG744TBS.
    PhylomeDBi Q64464.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_216259. Miscellaneous substrates.

    Miscellaneous databases

    NextBioi 283126.
    PROi Q64464.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64464.
    Genevestigatori Q64464.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1)."
      Yanagimoto T., Itoh S., Sawada M., Hashimoto H., Kamataki T.
      Biochim. Biophys. Acta 1201:405-410(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiCP3AD_MOUSE
    AccessioniPrimary (citable) accession number: Q64464
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3