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Protein

Cytochrome P450 3A13

Gene

Cyp3a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Can activate aflatoxin B1 to a genotoxic product.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • positive regulation of gene expression Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_288150. Aflatoxin activation and detoxification.
REACT_314116. Miscellaneous substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A13 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA13
Gene namesi
Name:Cyp3a13
Synonyms:Cyp3a-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88610. Cyp3a13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A13PRO_0000051796Add
BLAST

Proteomic databases

MaxQBiQ64464.
PaxDbiQ64464.
PRIDEiQ64464.

PTM databases

PhosphoSiteiQ64464.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiQ64464.
ExpressionAtlasiQ64464. baseline and differential.
GenevestigatoriQ64464.

Interactioni

Protein-protein interaction databases

MINTiMINT-1863519.

Structurei

3D structure databases

ProteinModelPortaliQ64464.
SMRiQ64464. Positions 28-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64464.
KOiK07424.
OMAiEAINISM.
OrthoDBiEOG744TBS.
PhylomeDBiQ64464.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIPNFSME TWMLLATSLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI
60 70 80 90 100
LAYQKGFWEC DIQCHKKYGK MWGLYDGRQP VLAITDPDII KTVLVKECYS
110 120 130 140 150
TFTNRRRFGP VGILKKAISI SENEEWKRIR ALLSPTFTSG RLKEMFPIIN
160 170 180 190 200
QFTDVLVRNM RQGLGEGKPT SMKDIFGAYS MDVITATSFG VNIDSLNNPQ
210 220 230 240 250
DPFVEKIKKL LKFDIFDPLF LSVTLFPFLT PVFDALNVSL FPRDVISFFT
260 270 280 290 300
TSVERMKENR MKEKEKQRVD FLQLMINSQN YKTKESHKAL SDVEIVAQSV
310 320 330 340 350
IFIFAGYETT SSALSFALYL LAIHPDVQKK LQDEIDAALP NKAPATYDTL
360 370 380 390 400
LQMEYLDMVV NETLRLYPIA GRLERVCKTD VEINGLFIPK GTVVMIPTFA
410 420 430 440 450
LHKDPKYWPE PEEFRPERFS KKNQDSINPY MYLPFGSGPR NCIGMRFALI
460 470 480 490 500
NMKVALVRVL QNFTVQPCKE TEIPLKLSKQ GLLQPENPLL LKVVSRDETV

SDE
Length:503
Mass (Da):57,492
Last modified:November 1, 1996 - v1
Checksum:i15DDE2606B337FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63023 mRNA. Translation: CAA44754.1.
BC046592 mRNA. Translation: AAH46592.1.
CCDSiCCDS19781.1.
PIRiS50211.
RefSeqiNP_031845.1. NM_007819.4.
UniGeneiMm.289886.

Genome annotation databases

EnsembliENSMUST00000031741; ENSMUSP00000031741; ENSMUSG00000029727.
GeneIDi13113.
KEGGimmu:13113.
UCSCiuc009aef.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63023 mRNA. Translation: CAA44754.1.
BC046592 mRNA. Translation: AAH46592.1.
CCDSiCCDS19781.1.
PIRiS50211.
RefSeqiNP_031845.1. NM_007819.4.
UniGeneiMm.289886.

3D structure databases

ProteinModelPortaliQ64464.
SMRiQ64464. Positions 28-497.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1863519.

PTM databases

PhosphoSiteiQ64464.

Proteomic databases

MaxQBiQ64464.
PaxDbiQ64464.
PRIDEiQ64464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031741; ENSMUSP00000031741; ENSMUSG00000029727.
GeneIDi13113.
KEGGimmu:13113.
UCSCiuc009aef.2. mouse.

Organism-specific databases

CTDi13113.
MGIiMGI:88610. Cyp3a13.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64464.
KOiK07424.
OMAiEAINISM.
OrthoDBiEOG744TBS.
PhylomeDBiQ64464.
TreeFamiTF105087.

Enzyme and pathway databases

ReactomeiREACT_274299. Xenobiotics.
REACT_288150. Aflatoxin activation and detoxification.
REACT_314116. Miscellaneous substrates.

Miscellaneous databases

NextBioi283126.
PROiQ64464.
SOURCEiSearch...

Gene expression databases

BgeeiQ64464.
ExpressionAtlasiQ64464. baseline and differential.
GenevestigatoriQ64464.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1)."
    Yanagimoto T., Itoh S., Sawada M., Hashimoto H., Kamataki T.
    Biochim. Biophys. Acta 1201:405-410(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiCP3AD_MOUSE
AccessioniPrimary (citable) accession number: Q64464
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.