Q64464 (CP3AD_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome P450 3A13
EC=1.14.14.1

Alternative name(s):
CYPIIIA13

Gene names

Name:	Cyp3a13
Synonyms:	Cyp3a-13

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Can activate aflatoxin B1 to a genotoxic product.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of gene expression Inferred from mutant phenotype PubMed 18794335. Source: MGI
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro monooxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Cytochrome P450 3A13		PRO_0000051796
Sites
	Metal binding	442	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64464 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 15DDE2606B337FCF	FASTA	503	57,492
	10 20 30 40 50 60 MDLIPNFSME TWMLLATSLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI LAYQKGFWEC 70 80 90 100 110 120 DIQCHKKYGK MWGLYDGRQP VLAITDPDII KTVLVKECYS TFTNRRRFGP VGILKKAISI 130 140 150 160 170 180 SENEEWKRIR ALLSPTFTSG RLKEMFPIIN QFTDVLVRNM RQGLGEGKPT SMKDIFGAYS 190 200 210 220 230 240 MDVITATSFG VNIDSLNNPQ DPFVEKIKKL LKFDIFDPLF LSVTLFPFLT PVFDALNVSL 250 260 270 280 290 300 FPRDVISFFT TSVERMKENR MKEKEKQRVD FLQLMINSQN YKTKESHKAL SDVEIVAQSV 310 320 330 340 350 360 IFIFAGYETT SSALSFALYL LAIHPDVQKK LQDEIDAALP NKAPATYDTL LQMEYLDMVV 370 380 390 400 410 420 NETLRLYPIA GRLERVCKTD VEINGLFIPK GTVVMIPTFA LHKDPKYWPE PEEFRPERFS 430 440 450 460 470 480 KKNQDSINPY MYLPFGSGPR NCIGMRFALI NMKVALVRVL QNFTVQPCKE TEIPLKLSKQ 490 500 GLLQPENPLL LKVVSRDETV SDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1)." Yanagimoto T., Itoh S., Sawada M., Hashimoto H., Kamataki T. Biochim. Biophys. Acta 1201:405-410(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ddY. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Olfactory epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63023 mRNA. Translation: CAA44754.1. BC046592 mRNA. Translation: AAH46592.1.
IPI	IPI00134519.
PIR	S50211.
RefSeq	NP_031845.1. NM_007819.4.
UniGene	Mm.289886.
3D structure databases
ProteinModelPortal	Q64464.
SMR	Q64464. Positions 28-499.
ModBase	Search...
PTM databases
PhosphoSite	Q64464.
Proteomic databases
PaxDb	Q64464.
PRIDE	Q64464.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031741; ENSMUSP00000031741; ENSMUSG00000029727.
GeneID	13113.
KEGG	mmu:13113.
Organism-specific databases
CTD	13113.
MGI	MGI:88610. Cyp3a13.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00540000069787.
HOGENOM	HOG000039127.
HOVERGEN	HBG108567.
InParanoid	Q64464.
KO	K07424.
OMA	ERVCKTD.
OrthoDB	EOG4ZW59X.
Gene expression databases
ArrayExpress	Q64464.
Bgee	Q64464.
Genevestigator	Q64464.
GermOnline	ENSMUSG00000029727. Mus musculus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR008072. Cyt_P450_E_CYP3A. IPR002402. Cyt_P450_E_grp-II. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00464. EP450II. PR01689. EP450IICYP3A. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	283126.
SOURCE	Search...

Entry information

Entry name

CP3AD_MOUSE

Accession

Primary (citable) accession number: Q64464

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program