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Protein

Cytochrome P450 3A13

Gene

Cyp3a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can activate aflatoxin B1 to a genotoxic product.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi442Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • lipid hydroxylation Source: MGI
  • positive regulation of gene expression Source: MGI
  • steroid metabolic process Source: MGI

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-5423646 Aflatoxin activation and detoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A13 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA13
Gene namesi
Name:Cyp3a13
Synonyms:Cyp3a-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88610 Cyp3a13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3637781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517961 – 503Cytochrome P450 3A13Add BLAST503

Proteomic databases

MaxQBiQ64464
PaxDbiQ64464
PRIDEiQ64464

PTM databases

iPTMnetiQ64464
PhosphoSitePlusiQ64464

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000029727
ExpressionAtlasiQ64464 baseline and differential
GenevisibleiQ64464 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031741

Structurei

3D structure databases

ProteinModelPortaliQ64464
SMRiQ64464
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0158 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140779
HOGENOMiHOG000039127
HOVERGENiHBG108567
InParanoidiQ64464
KOiK07424
OMAiPAIAKHI
OrthoDBiEOG091G0JNC
PhylomeDBiQ64464
TreeFamiTF105087

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR008072 Cyt_P450_E_CYP3A
IPR002402 Cyt_P450_E_grp-II
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00464 EP450II
PR01689 EP450IICYP3A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q64464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLIPNFSME TWMLLATSLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI
60 70 80 90 100
LAYQKGFWEC DIQCHKKYGK MWGLYDGRQP VLAITDPDII KTVLVKECYS
110 120 130 140 150
TFTNRRRFGP VGILKKAISI SENEEWKRIR ALLSPTFTSG RLKEMFPIIN
160 170 180 190 200
QFTDVLVRNM RQGLGEGKPT SMKDIFGAYS MDVITATSFG VNIDSLNNPQ
210 220 230 240 250
DPFVEKIKKL LKFDIFDPLF LSVTLFPFLT PVFDALNVSL FPRDVISFFT
260 270 280 290 300
TSVERMKENR MKEKEKQRVD FLQLMINSQN YKTKESHKAL SDVEIVAQSV
310 320 330 340 350
IFIFAGYETT SSALSFALYL LAIHPDVQKK LQDEIDAALP NKAPATYDTL
360 370 380 390 400
LQMEYLDMVV NETLRLYPIA GRLERVCKTD VEINGLFIPK GTVVMIPTFA
410 420 430 440 450
LHKDPKYWPE PEEFRPERFS KKNQDSINPY MYLPFGSGPR NCIGMRFALI
460 470 480 490 500
NMKVALVRVL QNFTVQPCKE TEIPLKLSKQ GLLQPENPLL LKVVSRDETV

SDE
Length:503
Mass (Da):57,492
Last modified:November 1, 1996 - v1
Checksum:i15DDE2606B337FCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63023 mRNA Translation: CAA44754.1
BC046592 mRNA Translation: AAH46592.1
CCDSiCCDS19781.1
PIRiS50211
RefSeqiNP_031845.1, NM_007819.4
UniGeneiMm.289886

Genome annotation databases

EnsembliENSMUST00000031741; ENSMUSP00000031741; ENSMUSG00000029727
GeneIDi13113
KEGGimmu:13113
UCSCiuc009aef.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCP3AD_MOUSE
AccessioniPrimary (citable) accession number: Q64464
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health