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Q64462

- CP4B1_MOUSE

UniProt

Q64462 - CP4B1_MOUSE

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Protein
Cytochrome P450 4B1
Gene
Cyp4b1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Responsible for mutagenic activation of 3-methoxy-4-aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2-aminofluorene and 2-aminoanthracene.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei315 – 3151Heme (covalent; via 1 link) By similarity
Metal bindingi453 – 4531Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. drug binding Source: Ensembl
  3. fluorene oxygenase activity Source: Ensembl
  4. heme binding Source: InterPro
  5. iron ion binding Source: InterPro

GO - Biological processi

  1. biphenyl metabolic process Source: Ensembl
  2. exogenous drug catabolic process Source: Ensembl
  3. fluorene metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4B1 (EC:1.14.14.1)
Alternative name(s):
CYPIVB1
Gene namesi
Name:Cyp4b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:103225. Cyp4b1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 511510Cytochrome P450 4B1
PRO_0000051820Add
BLAST

Proteomic databases

MaxQBiQ64462.
PaxDbiQ64462.
PRIDEiQ64462.

PTM databases

PhosphoSiteiQ64462.

Expressioni

Tissue specificityi

Present abundantly in renal microsomes of male mice but not in those of female mice. Also present in pulmonary microsomes of male and female mice. Not found in liver.

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

ArrayExpressiQ64462.
BgeeiQ64462.
GenevestigatoriQ64462.

Interactioni

Protein-protein interaction databases

IntActiQ64462. 3 interactions.
MINTiMINT-4091779.
STRINGi10090.ENSMUSP00000099768.

Structurei

3D structure databases

ProteinModelPortaliQ64462.
SMRiQ64462. Positions 65-506.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00740000115505.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ64462.
KOiK07426.
OMAiKWLIATA.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ64462.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64462-1 [UniParc]FASTAAdd to Basket

« Hide

MALSFLSPSL SRLGLWASVV ILMVTVLKLL SLLFRRQKLA RALDSFPGPP    50
KHWLFGHALE IQKTGGLDKV VTWTEQFPYA HPLWLGQFIV FLNIYEPDYA 100
KAVYSRGDPK AAYVYDFFLQ WIGKGLLVLE GPKWFQHRKL LTPGFHYDVL 150
KPYVAIFAES TRVMLDKWEK KASENKSFDI FCDVGHMALD TLMKCTFGKG 200
DSGLSHSDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT PHGRRFLRAC 250
QIAHDHTDHV IRQRKAALQD EKEQKKLQER RHLDFLDILL GARDESGIKL 300
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPMHQQR CREEVREILG 350
DRDSFQWDDL AQMTYLTMCM KECFRLYPPV PQVYRQLSKP VTFVDGRSLP 400
AGSLISLHIY ALHRNSAVWP DPEVFDPLRF SPENMTGRHP FAFMPFSAGP 450
RNCIGQQFAM NEMKVVTALC LLRFEFSPDP SKIPIKVPQL ILRSKNGIHL 500
YLKPLGPGSG K 511
Length:511
Mass (Da):58,900
Last modified:November 1, 1996 - v1
Checksum:i35463ACDFFE6328B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50834 mRNA. Translation: BAA09446.1.
BC008996 mRNA. Translation: AAH08996.1.
CCDSiCCDS18493.1.
PIRiS66472.
RefSeqiNP_031849.1. NM_007823.2.
UniGeneiMm.1840.

Genome annotation databases

EnsembliENSMUST00000102707; ENSMUSP00000099768; ENSMUSG00000028713.
GeneIDi13120.
KEGGimmu:13120.
UCSCiuc008ufc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50834 mRNA. Translation: BAA09446.1 .
BC008996 mRNA. Translation: AAH08996.1 .
CCDSi CCDS18493.1.
PIRi S66472.
RefSeqi NP_031849.1. NM_007823.2.
UniGenei Mm.1840.

3D structure databases

ProteinModelPortali Q64462.
SMRi Q64462. Positions 65-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64462. 3 interactions.
MINTi MINT-4091779.
STRINGi 10090.ENSMUSP00000099768.

PTM databases

PhosphoSitei Q64462.

Proteomic databases

MaxQBi Q64462.
PaxDbi Q64462.
PRIDEi Q64462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102707 ; ENSMUSP00000099768 ; ENSMUSG00000028713 .
GeneIDi 13120.
KEGGi mmu:13120.
UCSCi uc008ufc.1. mouse.

Organism-specific databases

CTDi 1580.
MGIi MGI:103225. Cyp4b1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00740000115505.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi Q64462.
KOi K07426.
OMAi KWLIATA.
OrthoDBi EOG7CNZFK.
PhylomeDBi Q64462.
TreeFami TF105088.

Miscellaneous databases

NextBioi 283154.
PROi Q64462.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64462.
Bgeei Q64462.
Genevestigatori Q64462.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1."
    Imaoka S., Hiroi T., Tamura Y., Yamazaki H., Shimada T., Komori M., Degawa M., Funae Y.
    Arch. Biochem. Biophys. 321:255-262(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: BALB/c.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiCP4B1_MOUSE
AccessioniPrimary (citable) accession number: Q64462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi