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Q64462

- CP4B1_MOUSE

UniProt

Q64462 - CP4B1_MOUSE

Protein

Cytochrome P450 4B1

Gene

Cyp4b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Responsible for mutagenic activation of 3-methoxy-4-aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2-aminofluorene and 2-aminoanthracene.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei315 – 3151Heme (covalent; via 1 link)By similarity
    Metal bindingi453 – 4531Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. drug binding Source: Ensembl
    3. fluorene oxygenase activity Source: Ensembl
    4. heme binding Source: InterPro
    5. iron ion binding Source: InterPro

    GO - Biological processi

    1. biphenyl metabolic process Source: Ensembl
    2. exogenous drug catabolic process Source: Ensembl
    3. fluorene metabolic process Source: Ensembl

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4B1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVB1
    Gene namesi
    Name:Cyp4b1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:103225. Cyp4b1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 511510Cytochrome P450 4B1PRO_0000051820Add
    BLAST

    Proteomic databases

    MaxQBiQ64462.
    PaxDbiQ64462.
    PRIDEiQ64462.

    PTM databases

    PhosphoSiteiQ64462.

    Expressioni

    Tissue specificityi

    Present abundantly in renal microsomes of male mice but not in those of female mice. Also present in pulmonary microsomes of male and female mice. Not found in liver.

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    ArrayExpressiQ64462.
    BgeeiQ64462.
    GenevestigatoriQ64462.

    Interactioni

    Protein-protein interaction databases

    IntActiQ64462. 3 interactions.
    MINTiMINT-4091779.
    STRINGi10090.ENSMUSP00000099768.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64462.
    SMRiQ64462. Positions 65-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00740000115505.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiQ64462.
    KOiK07426.
    OMAiKWLIATA.
    OrthoDBiEOG7CNZFK.
    PhylomeDBiQ64462.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64462-1 [UniParc]FASTAAdd to Basket

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    MALSFLSPSL SRLGLWASVV ILMVTVLKLL SLLFRRQKLA RALDSFPGPP    50
    KHWLFGHALE IQKTGGLDKV VTWTEQFPYA HPLWLGQFIV FLNIYEPDYA 100
    KAVYSRGDPK AAYVYDFFLQ WIGKGLLVLE GPKWFQHRKL LTPGFHYDVL 150
    KPYVAIFAES TRVMLDKWEK KASENKSFDI FCDVGHMALD TLMKCTFGKG 200
    DSGLSHSDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT PHGRRFLRAC 250
    QIAHDHTDHV IRQRKAALQD EKEQKKLQER RHLDFLDILL GARDESGIKL 300
    SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPMHQQR CREEVREILG 350
    DRDSFQWDDL AQMTYLTMCM KECFRLYPPV PQVYRQLSKP VTFVDGRSLP 400
    AGSLISLHIY ALHRNSAVWP DPEVFDPLRF SPENMTGRHP FAFMPFSAGP 450
    RNCIGQQFAM NEMKVVTALC LLRFEFSPDP SKIPIKVPQL ILRSKNGIHL 500
    YLKPLGPGSG K 511
    Length:511
    Mass (Da):58,900
    Last modified:November 1, 1996 - v1
    Checksum:i35463ACDFFE6328B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50834 mRNA. Translation: BAA09446.1.
    BC008996 mRNA. Translation: AAH08996.1.
    CCDSiCCDS18493.1.
    PIRiS66472.
    RefSeqiNP_031849.1. NM_007823.2.
    UniGeneiMm.1840.

    Genome annotation databases

    EnsembliENSMUST00000102707; ENSMUSP00000099768; ENSMUSG00000028713.
    GeneIDi13120.
    KEGGimmu:13120.
    UCSCiuc008ufc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50834 mRNA. Translation: BAA09446.1 .
    BC008996 mRNA. Translation: AAH08996.1 .
    CCDSi CCDS18493.1.
    PIRi S66472.
    RefSeqi NP_031849.1. NM_007823.2.
    UniGenei Mm.1840.

    3D structure databases

    ProteinModelPortali Q64462.
    SMRi Q64462. Positions 65-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64462. 3 interactions.
    MINTi MINT-4091779.
    STRINGi 10090.ENSMUSP00000099768.

    PTM databases

    PhosphoSitei Q64462.

    Proteomic databases

    MaxQBi Q64462.
    PaxDbi Q64462.
    PRIDEi Q64462.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102707 ; ENSMUSP00000099768 ; ENSMUSG00000028713 .
    GeneIDi 13120.
    KEGGi mmu:13120.
    UCSCi uc008ufc.1. mouse.

    Organism-specific databases

    CTDi 1580.
    MGIi MGI:103225. Cyp4b1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00740000115505.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi Q64462.
    KOi K07426.
    OMAi KWLIATA.
    OrthoDBi EOG7CNZFK.
    PhylomeDBi Q64462.
    TreeFami TF105088.

    Miscellaneous databases

    NextBioi 283154.
    PROi Q64462.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64462.
    Bgeei Q64462.
    Genevestigatori Q64462.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1."
      Imaoka S., Hiroi T., Tamura Y., Yamazaki H., Shimada T., Komori M., Degawa M., Funae Y.
      Arch. Biochem. Biophys. 321:255-262(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: BALB/c.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiCP4B1_MOUSE
    AccessioniPrimary (citable) accession number: Q64462
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3