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Protein

Cytochrome P450 3A11

Gene

Cyp3a11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: MGI
  5. oxidoreductase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.38. 3474.
ReactomeiREACT_274299. Xenobiotics.
REACT_288150. Aflatoxin activation and detoxification.
REACT_314116. Miscellaneous substrates.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A11 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA11
Cytochrome P-450IIIAM1
Cytochrome P-450UT
Gene namesi
Name:Cyp3a11
Synonyms:Cyp3a-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88609. Cyp3a11.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 3A11PRO_0000051794Add
BLAST

Proteomic databases

MaxQBiQ64459.
PaxDbiQ64459.
PRIDEiQ64459.

PTM databases

PhosphoSiteiQ64459.

Expressioni

Tissue specificityi

Highly expressed in liver.

Inductioni

By dexamethasone.

Gene expression databases

BgeeiQ64459.
ExpressionAtlasiQ64459. baseline and differential.
GenevestigatoriQ64459.

Interactioni

Protein-protein interaction databases

IntActiQ64459. 6 interactions.
MINTiMINT-4091753.
STRINGi10090.ENSMUSP00000037665.

Structurei

3D structure databases

ProteinModelPortaliQ64459.
SMRiQ64459. Positions 30-498.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64459.
KOiK07424.
OMAiISKDDEW.
OrthoDBiEOG744TBS.
PhylomeDBiQ64459.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64459-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVSALSLE TWVLLAISLV LLYRYGTRKH ELFKKQGIPG PKPLPFLGTV
60 70 80 90 100
LNYYKGLWKF DMECYKKYGK TWGLFDGQTP LLAVTDPETI KNVLVKECFS
110 120 130 140 150
VFTNRRDFGP VGIMSKAISI SKDDEWKRYR ALLSPTFTSG KLKEMFPVIE
160 170 180 190 200
QYGDILVKYL RQKAKKGKPV TMKDVLGAYS MDVITSTSFG VNVDSLNNPE
210 220 230 240 250
DPFVEKAKKL LRFDFFDPLL FSVVLFPFLT PVYEMLNICM FPKDSIEFFK
260 270 280 290 300
KFVDRMKESR LDSKQKHRVD FLQLMMNSHN NSKDKVSHKA LSDMEITAQS
310 320 330 340 350
IIFIFAGYET TSSTLSFTLH SLATHPDIQK KLQDEIDEAL PNKAPPTYDT
360 370 380 390 400
VMEMEYLDMV LNETLRLYPI ANRLERVCKK DVELNGVYIP KGSTVMIPSY
410 420 430 440 450
ALHHDPQHWS EPEEFQPERF SKENKGSIDP YVYLPFGNGP RNCLGMRFAL
460 470 480 490 500
MNMKLALTKI MQNFSFQPCK ETQIPLKLSR QGLLQPEKPI VLKVVPRDAV

ITGA
Length:504
Mass (Da):57,855
Last modified:November 1, 1996 - v1
Checksum:iE369AF71CE23F180
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60452 mRNA. Translation: CAA42981.1.
BC010528 mRNA. Translation: AAH10528.1.
CCDSiCCDS19865.1.
PIRiS22334. A60564.
RefSeqiNP_031844.1. NM_007818.3.
UniGeneiMm.332844.

Genome annotation databases

EnsembliENSMUST00000035918; ENSMUSP00000037665; ENSMUSG00000056035.
GeneIDi13112.
KEGGimmu:13112.
UCSCiuc009amy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60452 mRNA. Translation: CAA42981.1.
BC010528 mRNA. Translation: AAH10528.1.
CCDSiCCDS19865.1.
PIRiS22334. A60564.
RefSeqiNP_031844.1. NM_007818.3.
UniGeneiMm.332844.

3D structure databases

ProteinModelPortaliQ64459.
SMRiQ64459. Positions 30-498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64459. 6 interactions.
MINTiMINT-4091753.
STRINGi10090.ENSMUSP00000037665.

Chemistry

ChEMBLiCHEMBL1907984.

PTM databases

PhosphoSiteiQ64459.

Proteomic databases

MaxQBiQ64459.
PaxDbiQ64459.
PRIDEiQ64459.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035918; ENSMUSP00000037665; ENSMUSG00000056035.
GeneIDi13112.
KEGGimmu:13112.
UCSCiuc009amy.1. mouse.

Organism-specific databases

CTDi13112.
MGIiMGI:88609. Cyp3a11.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64459.
KOiK07424.
OMAiISKDDEW.
OrthoDBiEOG744TBS.
PhylomeDBiQ64459.
TreeFamiTF105087.

Enzyme and pathway databases

BRENDAi1.14.99.38. 3474.
ReactomeiREACT_274299. Xenobiotics.
REACT_288150. Aflatoxin activation and detoxification.
REACT_314116. Miscellaneous substrates.

Miscellaneous databases

NextBioi283122.
PROiQ64459.
SOURCEiSearch...

Gene expression databases

BgeeiQ64459.
ExpressionAtlasiQ64459. baseline and differential.
GenevestigatoriQ64459.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone."
    Yanagimoto T., Itoh S., Muller-Enoch D., Kamataki T.
    Biochim. Biophys. Acta 1130:329-332(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  3. "Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol."
    Bornheim L.M., Correia M.A.
    Mol. Pharmacol. 38:319-326(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-17 AND 22-24.

Entry informationi

Entry nameiCP3AB_MOUSE
AccessioniPrimary (citable) accession number: Q64459
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.