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Q64459

- CP3AB_MOUSE

UniProt

Q64459 - CP3AB_MOUSE

Protein

Cytochrome P450 3A11

Gene

Cyp3a11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A11 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA11
    Cytochrome P-450IIIAM1
    Cytochrome P-450UT
    Gene namesi
    Name:Cyp3a11
    Synonyms:Cyp3a-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:88609. Cyp3a11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 3A11PRO_0000051794Add
    BLAST

    Proteomic databases

    MaxQBiQ64459.
    PaxDbiQ64459.
    PRIDEiQ64459.

    PTM databases

    PhosphoSiteiQ64459.

    Expressioni

    Tissue specificityi

    Highly expressed in liver.

    Inductioni

    By dexamethasone.

    Gene expression databases

    BgeeiQ64459.
    GenevestigatoriQ64459.

    Interactioni

    Protein-protein interaction databases

    IntActiQ64459. 6 interactions.
    MINTiMINT-4091753.
    STRINGi10090.ENSMUSP00000037665.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64459.
    SMRiQ64459. Positions 30-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110610.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiQ64459.
    KOiK07424.
    OMAiISKDDEW.
    OrthoDBiEOG744TBS.
    PhylomeDBiQ64459.
    TreeFamiTF105087.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64459-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLVSALSLE TWVLLAISLV LLYRYGTRKH ELFKKQGIPG PKPLPFLGTV    50
    LNYYKGLWKF DMECYKKYGK TWGLFDGQTP LLAVTDPETI KNVLVKECFS 100
    VFTNRRDFGP VGIMSKAISI SKDDEWKRYR ALLSPTFTSG KLKEMFPVIE 150
    QYGDILVKYL RQKAKKGKPV TMKDVLGAYS MDVITSTSFG VNVDSLNNPE 200
    DPFVEKAKKL LRFDFFDPLL FSVVLFPFLT PVYEMLNICM FPKDSIEFFK 250
    KFVDRMKESR LDSKQKHRVD FLQLMMNSHN NSKDKVSHKA LSDMEITAQS 300
    IIFIFAGYET TSSTLSFTLH SLATHPDIQK KLQDEIDEAL PNKAPPTYDT 350
    VMEMEYLDMV LNETLRLYPI ANRLERVCKK DVELNGVYIP KGSTVMIPSY 400
    ALHHDPQHWS EPEEFQPERF SKENKGSIDP YVYLPFGNGP RNCLGMRFAL 450
    MNMKLALTKI MQNFSFQPCK ETQIPLKLSR QGLLQPEKPI VLKVVPRDAV 500
    ITGA 504
    Length:504
    Mass (Da):57,855
    Last modified:November 1, 1996 - v1
    Checksum:iE369AF71CE23F180
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60452 mRNA. Translation: CAA42981.1.
    BC010528 mRNA. Translation: AAH10528.1.
    CCDSiCCDS19865.1.
    PIRiS22334. A60564.
    RefSeqiNP_031844.1. NM_007818.3.
    UniGeneiMm.332844.

    Genome annotation databases

    EnsembliENSMUST00000035918; ENSMUSP00000037665; ENSMUSG00000056035.
    GeneIDi13112.
    KEGGimmu:13112.
    UCSCiuc009amy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60452 mRNA. Translation: CAA42981.1 .
    BC010528 mRNA. Translation: AAH10528.1 .
    CCDSi CCDS19865.1.
    PIRi S22334. A60564.
    RefSeqi NP_031844.1. NM_007818.3.
    UniGenei Mm.332844.

    3D structure databases

    ProteinModelPortali Q64459.
    SMRi Q64459. Positions 30-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64459. 6 interactions.
    MINTi MINT-4091753.
    STRINGi 10090.ENSMUSP00000037665.

    Chemistry

    ChEMBLi CHEMBL1907984.

    PTM databases

    PhosphoSitei Q64459.

    Proteomic databases

    MaxQBi Q64459.
    PaxDbi Q64459.
    PRIDEi Q64459.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035918 ; ENSMUSP00000037665 ; ENSMUSG00000056035 .
    GeneIDi 13112.
    KEGGi mmu:13112.
    UCSCi uc009amy.1. mouse.

    Organism-specific databases

    CTDi 13112.
    MGIi MGI:88609. Cyp3a11.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110610.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi Q64459.
    KOi K07424.
    OMAi ISKDDEW.
    OrthoDBi EOG744TBS.
    PhylomeDBi Q64459.
    TreeFami TF105087.

    Enzyme and pathway databases

    Reactomei REACT_216259. Miscellaneous substrates.

    Miscellaneous databases

    NextBioi 283122.
    PROi Q64459.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64459.
    Genevestigatori Q64459.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone."
      Yanagimoto T., Itoh S., Muller-Enoch D., Kamataki T.
      Biochim. Biophys. Acta 1130:329-332(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    3. "Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol."
      Bornheim L.M., Correia M.A.
      Mol. Pharmacol. 38:319-326(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-17 AND 22-24.

    Entry informationi

    Entry nameiCP3AB_MOUSE
    AccessioniPrimary (citable) accession number: Q64459
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3