Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q64459 (CP3AB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A11

EC=1.14.14.1
Alternative name(s):
CYPIIIA11
Cytochrome P-450IIIAM1
Cytochrome P-450UT
Gene names
Name:Cyp3a11
Synonyms:Cyp3a-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Highly expressed in liver.

Induction

By dexamethasone.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504Cytochrome P450 3A11
PRO_0000051794

Sites

Metal binding4431Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64459 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E369AF71CE23F180

FASTA50457,855
        10         20         30         40         50         60 
MDLVSALSLE TWVLLAISLV LLYRYGTRKH ELFKKQGIPG PKPLPFLGTV LNYYKGLWKF 

        70         80         90        100        110        120 
DMECYKKYGK TWGLFDGQTP LLAVTDPETI KNVLVKECFS VFTNRRDFGP VGIMSKAISI 

       130        140        150        160        170        180 
SKDDEWKRYR ALLSPTFTSG KLKEMFPVIE QYGDILVKYL RQKAKKGKPV TMKDVLGAYS 

       190        200        210        220        230        240 
MDVITSTSFG VNVDSLNNPE DPFVEKAKKL LRFDFFDPLL FSVVLFPFLT PVYEMLNICM 

       250        260        270        280        290        300 
FPKDSIEFFK KFVDRMKESR LDSKQKHRVD FLQLMMNSHN NSKDKVSHKA LSDMEITAQS 

       310        320        330        340        350        360 
IIFIFAGYET TSSTLSFTLH SLATHPDIQK KLQDEIDEAL PNKAPPTYDT VMEMEYLDMV 

       370        380        390        400        410        420 
LNETLRLYPI ANRLERVCKK DVELNGVYIP KGSTVMIPSY ALHHDPQHWS EPEEFQPERF 

       430        440        450        460        470        480 
SKENKGSIDP YVYLPFGNGP RNCLGMRFAL MNMKLALTKI MQNFSFQPCK ETQIPLKLSR 

       490        500 
QGLLQPEKPI VLKVVPRDAV ITGA 

« Hide

References

« Hide 'large scale' references
[1]"Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone."
Yanagimoto T., Itoh S., Muller-Enoch D., Kamataki T.
Biochim. Biophys. Acta 1130:329-332(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[3]"Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol."
Bornheim L.M., Correia M.A.
Mol. Pharmacol. 38:319-326(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-17 AND 22-24.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60452 mRNA. Translation: CAA42981.1.
BC010528 mRNA. Translation: AAH10528.1.
CCDSCCDS19865.1.
PIRA60564. S22334.
RefSeqNP_031844.1. NM_007818.3.
UniGeneMm.332844.

3D structure databases

ProteinModelPortalQ64459.
SMRQ64459. Positions 30-498.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ64459. 6 interactions.
MINTMINT-4091753.
STRING10090.ENSMUSP00000037665.

Chemistry

ChEMBLCHEMBL1907984.

PTM databases

PhosphoSiteQ64459.

Proteomic databases

MaxQBQ64459.
PaxDbQ64459.
PRIDEQ64459.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035918; ENSMUSP00000037665; ENSMUSG00000056035.
GeneID13112.
KEGGmmu:13112.
UCSCuc009amy.1. mouse.

Organism-specific databases

CTD13112.
MGIMGI:88609. Cyp3a11.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110610.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidQ64459.
KOK07424.
OMAISKDDEW.
OrthoDBEOG744TBS.
PhylomeDBQ64459.
TreeFamTF105087.

Gene expression databases

BgeeQ64459.
GenevestigatorQ64459.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283122.
PROQ64459.
SOURCESearch...

Entry information

Entry nameCP3AB_MOUSE
AccessionPrimary (citable) accession number: Q64459
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot