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Q64458

- CP2CT_MOUSE

UniProt

Q64458 - CP2CT_MOUSE

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Protein

Cytochrome P450 2C29

Gene

Cyp2c29

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C29 (EC:1.14.14.1)
Alternative name(s):
Aldehyde oxygenase
CYPIIC29
Cytochrome P-450 MUT-2
Gene namesi
Name:Cyp2c29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:103238. Cyp2c29.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Cytochrome P450 2C29PRO_0000051717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-acetyllysine1 Publication
Modified residuei252 – 2521N6-acetyllysine1 Publication
Modified residuei375 – 3751N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64458.
PaxDbiQ64458.
PRIDEiQ64458.

PTM databases

PhosphoSiteiQ64458.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiQ64458.
ExpressionAtlasiQ64458. baseline and differential.
GenevestigatoriQ64458.

Interactioni

Protein-protein interaction databases

IntActiQ64458. 3 interactions.
MINTiMINT-1864139.

Structurei

3D structure databases

ProteinModelPortaliQ64458.
SMRiQ64458. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ64458.
KOiK07413.
OMAiKQANNIE.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64458-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLVVFLALT LSCLILLSLW RQSSGRGKLP PGPTPLPIIG NFLQIDVKNI
60 70 80 90 100
SQSFTNFSKA YGPVFTLYLG SKPTVILHGY EAVKEALIDR GEEFAGRGSF
110 120 130 140 150
PMAEKIIKGF GVVFSNGNRW KEMRRFTLMT LRNLGMGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DKEFLILMDK
210 220 230 240 250
INENVKILSS PWLQVCNSFP SLIDYCPGSH HKIVKNFNYL KSYLLEKIKE
260 270 280 290 300
HKESLDVTNP RDFIDYYLIK QKQVNHIEQS EFSLENLAST INDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKYPDVT AKVQEEIDRV VGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
MIHEVQRFID LLPTSLPHAV TCDIKFRKYL IPKGTTVITS LSSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLNGNGNFK KSDYFMPFST GKRICAGEGL ARMELFLILT
460 470 480 490
TILQNFKLKS LVHPKEIDIT PVMNGFASLP PPYQLCFIPL
Length:490
Mass (Da):55,716
Last modified:July 27, 2011 - v2
Checksum:i17D6FF46002E169A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061I → M in AAH19908. (PubMed:15489334)Curated
Sequence conflicti415 – 4151G → A in BAA04555. (PubMed:8130255)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17674 mRNA. Translation: BAA04555.1.
AC120840 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
BC019908 mRNA. Translation: AAH19908.1.
CCDSiCCDS29793.1.
PIRiI49610.
RefSeqiNP_031841.3. NM_007815.3.
UniGeneiMm.20764.

Genome annotation databases

EnsembliENSMUST00000003137; ENSMUSP00000003137; ENSMUSG00000003053.
GeneIDi13095.
KEGGimmu:13095.
UCSCiuc008hjz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D17674 mRNA. Translation: BAA04555.1 .
AC120840 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
BC019908 mRNA. Translation: AAH19908.1 .
CCDSi CCDS29793.1.
PIRi I49610.
RefSeqi NP_031841.3. NM_007815.3.
UniGenei Mm.20764.

3D structure databases

ProteinModelPortali Q64458.
SMRi Q64458. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64458. 3 interactions.
MINTi MINT-1864139.

PTM databases

PhosphoSitei Q64458.

Proteomic databases

MaxQBi Q64458.
PaxDbi Q64458.
PRIDEi Q64458.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003137 ; ENSMUSP00000003137 ; ENSMUSG00000003053 .
GeneIDi 13095.
KEGGi mmu:13095.
UCSCi uc008hjz.1. mouse.

Organism-specific databases

CTDi 13095.
MGIi MGI:103238. Cyp2c29.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi Q64458.
KOi K07413.
OMAi KQANNIE.
TreeFami TF352043.

Enzyme and pathway databases

Reactomei REACT_196570. Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

ChiTaRSi Cyp2c29. mouse.
NextBioi 283074.
PROi Q64458.
SOURCEi Search...

Gene expression databases

Bgeei Q64458.
ExpressionAtlasi Q64458. baseline and differential.
Genevestigatori Q64458.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase."
    Matsunaga T., Watanabe K., Yamamoto I., Negishi M., Gonzalez F.J., Yoshimura H.
    Biochim. Biophys. Acta 1184:299-301(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-249; LYS-252 AND LYS-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCP2CT_MOUSE
AccessioniPrimary (citable) accession number: Q64458
Secondary accession number(s): E9QMD8, Q8WUN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3