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Q64458 (CP2CT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C29

EC=1.14.14.1
Alternative name(s):
Aldehyde oxygenase
CYPIIC29
Cytochrome P-450 MUT-2
Gene names
Name:Cyp2c29
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Cytochrome P450 2C29
PRO_0000051717

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue2491N6-acetyllysine Ref.4
Modified residue2521N6-acetyllysine Ref.4
Modified residue3751N6-acetyllysine Ref.4

Experimental info

Sequence conflict1061I → M in AAH19908. Ref.3
Sequence conflict4151G → A in BAA04555. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64458 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 17D6FF46002E169A

FASTA49055,716
        10         20         30         40         50         60 
MDLVVFLALT LSCLILLSLW RQSSGRGKLP PGPTPLPIIG NFLQIDVKNI SQSFTNFSKA 

        70         80         90        100        110        120 
YGPVFTLYLG SKPTVILHGY EAVKEALIDR GEEFAGRGSF PMAEKIIKGF GVVFSNGNRW 

       130        140        150        160        170        180 
KEMRRFTLMT LRNLGMGKRN IEDRVQEEAQ CLVEELRKTK GSPCDPTFIL SCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYK DKEFLILMDK INENVKILSS PWLQVCNSFP SLIDYCPGSH HKIVKNFNYL 

       250        260        270        280        290        300 
KSYLLEKIKE HKESLDVTNP RDFIDYYLIK QKQVNHIEQS EFSLENLAST INDLFGAGTE 

       310        320        330        340        350        360 
TTSTTLRYAL LLLLKYPDVT AKVQEEIDRV VGRHRSPCMQ DRSHMPYTDA MIHEVQRFID 

       370        380        390        400        410        420 
LLPTSLPHAV TCDIKFRKYL IPKGTTVITS LSSVLHDSKE FPNPEMFDPG HFLNGNGNFK 

       430        440        450        460        470        480 
KSDYFMPFST GKRICAGEGL ARMELFLILT TILQNFKLKS LVHPKEIDIT PVMNGFASLP 

       490 
PPYQLCFIPL 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase."
Matsunaga T., Watanabe K., Yamamoto I., Negishi M., Gonzalez F.J., Yoshimura H.
Biochim. Biophys. Acta 1184:299-301(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Liver.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[4]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-249; LYS-252 AND LYS-375, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D17674 mRNA. Translation: BAA04555.1.
AC120840 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
BC019908 mRNA. Translation: AAH19908.1.
CCDSCCDS29793.1.
PIRI49610.
RefSeqNP_031841.3. NM_007815.3.
UniGeneMm.20764.

3D structure databases

ProteinModelPortalQ64458.
SMRQ64458. Positions 30-490.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ64458. 3 interactions.
MINTMINT-1864139.

PTM databases

PhosphoSiteQ64458.

Proteomic databases

MaxQBQ64458.
PaxDbQ64458.
PRIDEQ64458.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003137; ENSMUSP00000003137; ENSMUSG00000003053.
GeneID13095.
KEGGmmu:13095.
UCSCuc008hjz.1. mouse.

Organism-specific databases

CTD13095.
MGIMGI:103238. Cyp2c29.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidQ64458.
KOK07413.
OMAKQANNIE.
TreeFamTF352043.

Gene expression databases

BgeeQ64458.
GenevestigatorQ64458.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCyp2c29. mouse.
NextBio283074.
PROQ64458.
SOURCESearch...

Entry information

Entry nameCP2CT_MOUSE
AccessionPrimary (citable) accession number: Q64458
Secondary accession number(s): E9QMD8, Q8WUN8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot