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Protein

Cytochrome P450 2C29

Gene

Cyp2c29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metabolizes arachidonic acid to produce 14,15-cis-epoxyeicosatrienoic acid (EET).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi435Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKQ64458.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C29 (EC:1.14.14.1)
Alternative name(s):
Aldehyde oxygenase
CYPIIC29
Cytochrome P-450 MUT-2
Gene namesi
Name:Cyp2c29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:103238. Cyp2c29.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517171 – 490Cytochrome P450 2C29Add BLAST490

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-acetyllysineCombined sources1
Modified residuei252N6-acetyllysineCombined sources1
Modified residuei375N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ64458.
PaxDbiQ64458.
PeptideAtlasiQ64458.
PRIDEiQ64458.

PTM databases

iPTMnetiQ64458.
PhosphoSitePlusiQ64458.
SwissPalmiQ64458.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiENSMUSG00000003053.
ExpressionAtlasiQ64458. baseline and differential.
GenevisibleiQ64458. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64458. 3 interactors.
MINTiMINT-1864139.
STRINGi10090.ENSMUSP00000003137.

Structurei

3D structure databases

ProteinModelPortaliQ64458.
SMRiQ64458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ64458.
KOiK07413.
OMAiKQANNIE.
OrthoDBiEOG091G0BT8.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64458-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVVFLALT LSCLILLSLW RQSSGRGKLP PGPTPLPIIG NFLQIDVKNI
60 70 80 90 100
SQSFTNFSKA YGPVFTLYLG SKPTVILHGY EAVKEALIDR GEEFAGRGSF
110 120 130 140 150
PMAEKIIKGF GVVFSNGNRW KEMRRFTLMT LRNLGMGKRN IEDRVQEEAQ
160 170 180 190 200
CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DKEFLILMDK
210 220 230 240 250
INENVKILSS PWLQVCNSFP SLIDYCPGSH HKIVKNFNYL KSYLLEKIKE
260 270 280 290 300
HKESLDVTNP RDFIDYYLIK QKQVNHIEQS EFSLENLAST INDLFGAGTE
310 320 330 340 350
TTSTTLRYAL LLLLKYPDVT AKVQEEIDRV VGRHRSPCMQ DRSHMPYTDA
360 370 380 390 400
MIHEVQRFID LLPTSLPHAV TCDIKFRKYL IPKGTTVITS LSSVLHDSKE
410 420 430 440 450
FPNPEMFDPG HFLNGNGNFK KSDYFMPFST GKRICAGEGL ARMELFLILT
460 470 480 490
TILQNFKLKS LVHPKEIDIT PVMNGFASLP PPYQLCFIPL
Length:490
Mass (Da):55,716
Last modified:July 27, 2011 - v2
Checksum:i17D6FF46002E169A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106I → M in AAH19908 (PubMed:15489334).Curated1
Sequence conflicti415G → A in BAA04555 (PubMed:8130255).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17674 mRNA. Translation: BAA04555.1.
AC120840 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
BC019908 mRNA. Translation: AAH19908.1.
CCDSiCCDS29793.1.
PIRiI49610.
RefSeqiNP_031841.3. NM_007815.3.
UniGeneiMm.20764.

Genome annotation databases

EnsembliENSMUST00000003137; ENSMUSP00000003137; ENSMUSG00000003053.
GeneIDi13095.
KEGGimmu:13095.
UCSCiuc008hjz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17674 mRNA. Translation: BAA04555.1.
AC120840 Genomic DNA. No translation available.
AC139233 Genomic DNA. No translation available.
BC019908 mRNA. Translation: AAH19908.1.
CCDSiCCDS29793.1.
PIRiI49610.
RefSeqiNP_031841.3. NM_007815.3.
UniGeneiMm.20764.

3D structure databases

ProteinModelPortaliQ64458.
SMRiQ64458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64458. 3 interactors.
MINTiMINT-1864139.
STRINGi10090.ENSMUSP00000003137.

PTM databases

iPTMnetiQ64458.
PhosphoSitePlusiQ64458.
SwissPalmiQ64458.

Proteomic databases

MaxQBiQ64458.
PaxDbiQ64458.
PeptideAtlasiQ64458.
PRIDEiQ64458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003137; ENSMUSP00000003137; ENSMUSG00000003053.
GeneIDi13095.
KEGGimmu:13095.
UCSCiuc008hjz.1. mouse.

Organism-specific databases

CTDi13095.
MGIiMGI:103238. Cyp2c29.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ64458.
KOiK07413.
OMAiKQANNIE.
OrthoDBiEOG091G0BT8.
TreeFamiTF352043.

Enzyme and pathway databases

SABIO-RKQ64458.

Miscellaneous databases

ChiTaRSiCyp2c29. mouse.
PROiQ64458.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003053.
ExpressionAtlasiQ64458. baseline and differential.
GenevisibleiQ64458. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2CT_MOUSE
AccessioniPrimary (citable) accession number: Q64458
Secondary accession number(s): E9QMD8, Q8WUN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.