Q64451 (Q64451_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cellular tumor antigen p53 RuleBase RU003304

Gene names

Name:	Trp53 MGI 98834
Synonyms:	p53 EMBL AAB03323.1

Organism

Mus musculus (Mouse) EMBL AAB03323.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	135 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity. RuleBase RU003304
Cofactor	Binds 1 zinc ion per subunit By similarity. RuleBase RU003304
Subunit structure	Binds DNA as a homotetramer By similarity. RuleBase RU003304
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU003304.
Sequence similarities	Belongs to the p53 family. RuleBase RU003401

Ontologies

Keywords
Biological process	Apoptosis RuleBase RU003304 Cell cycle RuleBase RU003304 Transcription Transcription regulation RuleBase RU003304 SAAS SAAS012346
Cellular component	Cytoplasm RuleBase RU003304 Nucleus SAAS SAAS012346 RuleBase RU003401
Disease	Tumor suppressor RuleBase RU003304
Ligand	DNA-binding RuleBase RU003304 Metal-binding RuleBase RU003304 Zinc RuleBase RU003304
Molecular function	Activator RuleBase RU003304
PTM	Phosphoprotein RuleBase RU003304
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB03323.1
	Non-terminal residue	135	1	EMBL AAB03323.1

Sequences

	Sequence		Length	Mass (Da)
	Q64451 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EB041A6639F2BF1C	FASTA	135	15,317
	10 20 30 40 50 60 ARISSLNKLF CQLAKTCPVQ LWVSATPPAG SRVRAMAIYK KSQHMTEVVR RCPHHERCSD 70 80 90 100 110 120 GDGLAPPQHL IRVEGNLYPE YLEDRQTFRH SVVVPYEPPE AGSEYTTIHY KYMCNSSCMG 130 GMNRRPILTI ITLDP

References

[1]	"p53 mRNA from peri-implantation blastocysts of mouse." Laloraya M., Kumar G.P., Koide S.S. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Cd-1 EMBL AAB03323.1. Tissue: Peri-implantation blastocysts EMBL AAB03323.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59757 mRNA. Translation: AAB03323.1.
IPI	IPI00648350.
UniGene	Mm.222.
3D structure databases
HSSP	HSSP built from PDB template 1GZH based on UniProtKB Q9NP68.
ProteinModelPortal	Q64451.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q64451. 2 interactions.
STRING	Q64451.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005201.
InParanoid	Q64451.
Gene expression databases
ArrayExpress	Q64451.
Genevestigator	Q64451.
Family and domain databases
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA-bd. IPR011615. p53_DNA-bd. IPR002117. p53_tumour_suppressor. [Graphical view]
Gene3D	G3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit.
PANTHER	PTHR11447. Trp53. 1 hit.
Pfam	PF00870. P53. 1 hit. [Graphical view]
PRINTS	PR00386. P53SUPPRESSR.
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS00348. P53. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q64451_MOUSE

Accession

Primary (citable) accession number: Q64451

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)