Unreviewed, UniProtKB/TrEMBL Q64451 (Q64451_MOUSE)

Names and origin

Protein names

Recommended name:
    Cellular tumor antigen p53 RuleBase RU003304V0

Gene names

Name:	Trp53 MGI 98834
Synonyms:	p53 EMBL AAB03323.1

Organism

Mus musculus (Mouse) EMBL AAB03323.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	135 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity. RuleBase RU003304V0
Subunit structure	Binds DNA as a homotetramer By similarity. RuleBase RU003304V0
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU003304V0.
Sequence similarities	Belongs to the p53 family.

Ontologies

Keywords
Biological process	Apoptosis RuleBase RU003304V0 Cell cycle RuleBase RU003304V0 Transcription Transcription regulation RuleBase RU003304V0 Spearmint SPM012346
Cellular component	Nucleus RuleBase RU003401V0 Spearmint SPM012346
Ligand	DNA-binding RuleBase RU003304V0 Metal-binding RuleBase RU003304V0 Zinc RuleBase RU003304V0
Molecular function	Activator RuleBase RU003304V0
PTM	Phosphoprotein RuleBase RU003304V0
Gene Ontology (GO)
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis Inferred from electronic annotation. Source: Compara ER overload response Inferred from electronic annotation. Source: Compara activation of caspase activity by cytochrome c Inferred from electronic annotation. Source: Compara cell aging Inferred from electronic annotation. Source: Compara cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cellular response to glucose starvation Inferred from electronic annotation. Source: Compara multicellular organismal development Inferred from electronic annotation. Source: Compara negative regulation of cell growth Inferred from electronic annotation. Source: Compara nucleotide-excision repair Inferred from electronic annotation. Source: Compara positive regulation of gene-specific transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein complex assembly Inferred from electronic annotation. Source: Compara protein localization Inferred from electronic annotation. Source: Compara transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	PML body Inferred from electronic annotation. Source: Compara insoluble fraction Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara nuclear matrix Inferred from electronic annotation. Source: Compara nucleolus Inferred from electronic annotation. Source: Compara transcription factor TFIID complex Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: Compara DNA strand annealing activity Inferred from electronic annotation. Source: Compara chaperone binding Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara copper ion binding Inferred from electronic annotation. Source: Compara enzyme binding Inferred from electronic annotation. Source: Compara promoter binding Inferred from electronic annotation. Source: Compara protein N-terminus binding Inferred from electronic annotation. Source: Compara protein heterodimerization activity Inferred from electronic annotation. Source: Compara transcription factor activity Inferred from electronic annotation. Source: Compara transcription factor binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9ERT0	1	EBI-493476,EBI-493494
Crebbp	P45481	1	EBI-493476,EBI-296306

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAB03323.1
	Non-terminal residue	135	1	EMBL AAB03323.1

Sequences

	Sequence		Length	Mass (Da)
	Q64451-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: EB041A6639F2BF1C	FASTA	135	15,317
	10 20 30 40 50 60 ARISSLNKLF CQLAKTCPVQ LWVSATPPAG SRVRAMAIYK KSQHMTEVVR RCPHHERCSD 70 80 90 100 110 120 GDGLAPPQHL IRVEGNLYPE YLEDRQTFRH SVVVPYEPPE AGSEYTTIHY KYMCNSSCMG 130 GMNRRPILTI ITLDP

References

[1]	"p53 mRNA from peri-implantation blastocysts of mouse." Laloraya M., Kumar G.P., Koide S.S. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Cd-1 EMBL AAB03323.1. Tissue: Peri-implantation blastocysts EMBL AAB03323.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U59757 mRNA. Translation: AAB03323.1.
IPI	IPI00648350.
UniGene	Mm.222
3D structure databases
HSSP	HSSP built from PDB template 1GZH based on UniProtKB Q9NP68.
SMR	Q64451. Positions 6-134.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q64451. 2 interactions.
STRING	Q64451.
Genome annotation databases
Ensembl	ENSMUST00000005371; ENSMUSP00000005371; ENSMUSG00000059552; Mus musculus. [Genome view] ENSMUST00000108657; ENSMUSP00000104297; ENSMUSG00000059552; Mus musculus. [Genome view] ENSMUST00000108658; ENSMUSP00000104298; ENSMUSG00000059552; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:98834. Trp53.
Phylogenomic databases
HOVERGEN	Q64451.
InParanoid	Q64451.
Gene expression databases
ArrayExpress	Q64451.
Bgee	Q64451.
Genevestigator	Q64451.
Family and domain databases
InterPro	IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA_bd. IPR011615. p53_DNA_bd. IPR002117. p53_tumour_Ag. IPR015551. Trp53. [Graphical view]
Gene3D	G3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit.
PANTHER	PTHR11447. Trp53. 1 hit.
Pfam	PF00870. P53. 1 hit. [Graphical view]
PRINTS	PR00386. P53SUPPRESSR.
PROSITE	PS00348. P53. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q64451_MOUSE

Accession

Primary (citable) accession number: Q64451

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)