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Q64448

- CXA3_MOUSE

UniProt

Q64448 - CXA3_MOUSE

Protein

Gap junction alpha-3 protein

Gene

Gja3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 4 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

    GO - Molecular functioni

    1. gap junction channel activity Source: InterPro

    GO - Biological processi

    1. cell communication Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction alpha-3 protein
    Alternative name(s):
    Connexin-46
    Short name:
    Cx46
    Gene namesi
    Name:Gja3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:95714. Gja3.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. gap junction Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Gap junction alpha-3 proteinPRO_0000057811Add
    BLAST

    Proteomic databases

    PRIDEiQ64448.

    PTM databases

    PhosphoSiteiQ64448.

    Expressioni

    Gene expression databases

    BgeeiQ64448.
    CleanExiMM_GJA3.
    GenevestigatoriQ64448.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000059587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64448.
    SMRiQ64448. Positions 3-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 7636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 15861CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 417189CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei159 – 17921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47291.
    GeneTreeiENSGT00740000115285.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiB2RRM1.
    KOiK07612.
    OMAiIGFPPYY.
    OrthoDBiEOG7P2XSS.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR002262. Connexin46.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    PR01133. CONNEXINA3.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64448-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS    50
    DFTCNTQQPG CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV 100
    RMEEKKKERE EELLRRDNPQ HGRGREPMRT GSPRDPPLRD DRGKVRIAGA 150
    LLRTYVFNII FKTLFEVGFI AGQYFLYGFQ LQPLYRCDRW PCPNTVDCFI 200
    SRPTEKTIFV IFMLAVACAS LVLNMLEIYH LGWKKLKQGV TNHFNPDASE 250
    ARHKPLDPLP TATSSGPPSV SIGFPPYYTH PACPTVQAKA IGFPGAPLSP 300
    ADFTVVTLND AQGRNHPVKH CNGHHLTTEQ NWTRQVAEQQ TPASKPSSAA 350
    SSPDGRKGLI DSSGSSLQES ALVVTPEEGE QALATTVEMH SPPLVLLDPG 400
    RSSKSSNGRA RPGDLAI 417
    Length:417
    Mass (Da):46,321
    Last modified:July 27, 2011 - v4
    Checksum:iFF235977E26F55F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti261 – 2611T → A in AAB03211. 1 PublicationCurated
    Sequence conflicti288 – 2881A → G in AAB03211. 1 PublicationCurated
    Sequence conflicti390 – 3901H → Y in AAB03211. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44955 Genomic DNA. Translation: AAB03211.1.
    CH466535 Genomic DNA. Translation: EDL36182.1.
    CH466535 Genomic DNA. Translation: EDL36184.1.
    BC138492 mRNA. Translation: AAI38493.1.
    BC138493 mRNA. Translation: AAI38494.1.
    CCDSiCCDS27152.1.
    RefSeqiNP_001258552.1. NM_001271623.1.
    NP_058671.2. NM_016975.3.
    XP_006518622.1. XM_006518559.1.
    UniGeneiMm.57207.

    Genome annotation databases

    EnsembliENSMUST00000061614; ENSMUSP00000059587; ENSMUSG00000048582.
    GeneIDi14611.
    KEGGimmu:14611.
    UCSCiuc007ucv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44955 Genomic DNA. Translation: AAB03211.1 .
    CH466535 Genomic DNA. Translation: EDL36182.1 .
    CH466535 Genomic DNA. Translation: EDL36184.1 .
    BC138492 mRNA. Translation: AAI38493.1 .
    BC138493 mRNA. Translation: AAI38494.1 .
    CCDSi CCDS27152.1.
    RefSeqi NP_001258552.1. NM_001271623.1.
    NP_058671.2. NM_016975.3.
    XP_006518622.1. XM_006518559.1.
    UniGenei Mm.57207.

    3D structure databases

    ProteinModelPortali Q64448.
    SMRi Q64448. Positions 3-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000059587.

    PTM databases

    PhosphoSitei Q64448.

    Proteomic databases

    PRIDEi Q64448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061614 ; ENSMUSP00000059587 ; ENSMUSG00000048582 .
    GeneIDi 14611.
    KEGGi mmu:14611.
    UCSCi uc007ucv.1. mouse.

    Organism-specific databases

    CTDi 2700.
    MGIi MGI:95714. Gja3.

    Phylogenomic databases

    eggNOGi NOG47291.
    GeneTreei ENSGT00740000115285.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi B2RRM1.
    KOi K07612.
    OMAi IGFPPYY.
    OrthoDBi EOG7P2XSS.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 286412.
    PROi Q64448.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64448.
    CleanExi MM_GJA3.
    Genevestigatori Q64448.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR002262. Connexin46.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    PR01133. CONNEXINA3.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and expression of a lens gap junction connexin."
      Kumar N.M., Nishi M., Klier F.G., Gilula N.B.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6 X CBA.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCXA3_MOUSE
    AccessioniPrimary (citable) accession number: Q64448
    Secondary accession number(s): B2RRM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3