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Q64448

- CXA3_MOUSE

UniProt

Q64448 - CXA3_MOUSE

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Protein
Gap junction alpha-3 protein
Gene
Gja3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  1. gap junction channel activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell communication Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-3 protein
Alternative name(s):
Connexin-46
Short name:
Cx46
Gene namesi
Name:Gja3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:95714. Gja3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei20 – 4021Helical; Reviewed prediction
Add
BLAST
Topological domaini41 – 7636Extracellular Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 15861Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei159 – 17921Helical; Reviewed prediction
Add
BLAST
Topological domaini180 – 20728Extracellular Reviewed prediction
Add
BLAST
Transmembranei208 – 22821Helical; Reviewed prediction
Add
BLAST
Topological domaini229 – 417189Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. gap junction Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Gap junction alpha-3 protein
PRO_0000057811Add
BLAST

Proteomic databases

PRIDEiQ64448.

PTM databases

PhosphoSiteiQ64448.

Expressioni

Gene expression databases

BgeeiQ64448.
CleanExiMM_GJA3.
GenevestigatoriQ64448.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059587.

Structurei

3D structure databases

ProteinModelPortaliQ64448.
SMRiQ64448. Positions 3-231.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47291.
GeneTreeiENSGT00740000115285.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiB2RRM1.
KOiK07612.
OMAiIGFPPYY.
OrthoDBiEOG7P2XSS.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002262. Connexin46.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01133. CONNEXINA3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64448-1 [UniParc]FASTAAdd to Basket

« Hide

MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS    50
DFTCNTQQPG CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV 100
RMEEKKKERE EELLRRDNPQ HGRGREPMRT GSPRDPPLRD DRGKVRIAGA 150
LLRTYVFNII FKTLFEVGFI AGQYFLYGFQ LQPLYRCDRW PCPNTVDCFI 200
SRPTEKTIFV IFMLAVACAS LVLNMLEIYH LGWKKLKQGV TNHFNPDASE 250
ARHKPLDPLP TATSSGPPSV SIGFPPYYTH PACPTVQAKA IGFPGAPLSP 300
ADFTVVTLND AQGRNHPVKH CNGHHLTTEQ NWTRQVAEQQ TPASKPSSAA 350
SSPDGRKGLI DSSGSSLQES ALVVTPEEGE QALATTVEMH SPPLVLLDPG 400
RSSKSSNGRA RPGDLAI 417
Length:417
Mass (Da):46,321
Last modified:July 27, 2011 - v4
Checksum:iFF235977E26F55F0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611T → A in AAB03211. 1 Publication
Sequence conflicti288 – 2881A → G in AAB03211. 1 Publication
Sequence conflicti390 – 3901H → Y in AAB03211. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U44955 Genomic DNA. Translation: AAB03211.1.
CH466535 Genomic DNA. Translation: EDL36182.1.
CH466535 Genomic DNA. Translation: EDL36184.1.
BC138492 mRNA. Translation: AAI38493.1.
BC138493 mRNA. Translation: AAI38494.1.
CCDSiCCDS27152.1.
RefSeqiNP_001258552.1. NM_001271623.1.
NP_058671.2. NM_016975.3.
XP_006518622.1. XM_006518559.1.
UniGeneiMm.57207.

Genome annotation databases

EnsembliENSMUST00000061614; ENSMUSP00000059587; ENSMUSG00000048582.
GeneIDi14611.
KEGGimmu:14611.
UCSCiuc007ucv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U44955 Genomic DNA. Translation: AAB03211.1 .
CH466535 Genomic DNA. Translation: EDL36182.1 .
CH466535 Genomic DNA. Translation: EDL36184.1 .
BC138492 mRNA. Translation: AAI38493.1 .
BC138493 mRNA. Translation: AAI38494.1 .
CCDSi CCDS27152.1.
RefSeqi NP_001258552.1. NM_001271623.1.
NP_058671.2. NM_016975.3.
XP_006518622.1. XM_006518559.1.
UniGenei Mm.57207.

3D structure databases

ProteinModelPortali Q64448.
SMRi Q64448. Positions 3-231.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000059587.

PTM databases

PhosphoSitei Q64448.

Proteomic databases

PRIDEi Q64448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000061614 ; ENSMUSP00000059587 ; ENSMUSG00000048582 .
GeneIDi 14611.
KEGGi mmu:14611.
UCSCi uc007ucv.1. mouse.

Organism-specific databases

CTDi 2700.
MGIi MGI:95714. Gja3.

Phylogenomic databases

eggNOGi NOG47291.
GeneTreei ENSGT00740000115285.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi B2RRM1.
KOi K07612.
OMAi IGFPPYY.
OrthoDBi EOG7P2XSS.
TreeFami TF329606.

Miscellaneous databases

NextBioi 286412.
PROi Q64448.
SOURCEi Search...

Gene expression databases

Bgeei Q64448.
CleanExi MM_GJA3.
Genevestigatori Q64448.

Family and domain databases

InterProi IPR000500. Connexin.
IPR002262. Connexin46.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
PR01133. CONNEXINA3.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and expression of a lens gap junction connexin."
    Kumar N.M., Nishi M., Klier F.G., Gilula N.B.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6 X CBA.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCXA3_MOUSE
AccessioniPrimary (citable) accession number: Q64448
Secondary accession number(s): B2RRM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi