Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q64448 (CXA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction alpha-3 protein
Alternative name(s):
Connexin-46
Short name=Cx46
Gene names
Name:Gja3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subunit structure

A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction.

Sequence similarities

Belongs to the connexin family. Alpha-type (group II) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Gap junction alpha-3 protein
PRO_0000057811

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 7636Extracellular Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 15861Cytoplasmic Potential
Transmembrane159 – 17921Helical; Potential
Topological domain180 – 20728Extracellular Potential
Transmembrane208 – 22821Helical; Potential
Topological domain229 – 417189Cytoplasmic Potential

Experimental info

Sequence conflict2611T → A in AAB03211. Ref.1
Sequence conflict2881A → G in AAB03211. Ref.1
Sequence conflict3901H → Y in AAB03211. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64448 [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: FF235977E26F55F0

FASTA41746,321
        10         20         30         40         50         60 
MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS DFTCNTQQPG 

        70         80         90        100        110        120 
CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV RMEEKKKERE EELLRRDNPQ 

       130        140        150        160        170        180 
HGRGREPMRT GSPRDPPLRD DRGKVRIAGA LLRTYVFNII FKTLFEVGFI AGQYFLYGFQ 

       190        200        210        220        230        240 
LQPLYRCDRW PCPNTVDCFI SRPTEKTIFV IFMLAVACAS LVLNMLEIYH LGWKKLKQGV 

       250        260        270        280        290        300 
TNHFNPDASE ARHKPLDPLP TATSSGPPSV SIGFPPYYTH PACPTVQAKA IGFPGAPLSP 

       310        320        330        340        350        360 
ADFTVVTLND AQGRNHPVKH CNGHHLTTEQ NWTRQVAEQQ TPASKPSSAA SSPDGRKGLI 

       370        380        390        400        410 
DSSGSSLQES ALVVTPEEGE QALATTVEMH SPPLVLLDPG RSSKSSNGRA RPGDLAI 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and expression of a lens gap junction connexin."
Kumar N.M., Nishi M., Klier F.G., Gilula N.B.
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6 X CBA.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U44955 Genomic DNA. Translation: AAB03211.1.
CH466535 Genomic DNA. Translation: EDL36182.1.
CH466535 Genomic DNA. Translation: EDL36184.1.
BC138492 mRNA. Translation: AAI38493.1.
BC138493 mRNA. Translation: AAI38494.1.
CCDSCCDS27152.1.
RefSeqNP_001258552.1. NM_001271623.1.
NP_058671.2. NM_016975.3.
XP_006518622.1. XM_006518559.1.
UniGeneMm.57207.

3D structure databases

ProteinModelPortalQ64448.
SMRQ64448. Positions 3-231.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000059587.

PTM databases

PhosphoSiteQ64448.

Proteomic databases

PRIDEQ64448.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061614; ENSMUSP00000059587; ENSMUSG00000048582.
GeneID14611.
KEGGmmu:14611.
UCSCuc007ucv.1. mouse.

Organism-specific databases

CTD2700.
MGIMGI:95714. Gja3.

Phylogenomic databases

eggNOGNOG47291.
GeneTreeENSGT00740000115285.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidB2RRM1.
KOK07612.
OMAIGFPPYY.
OrthoDBEOG7P2XSS.
TreeFamTF329606.

Gene expression databases

BgeeQ64448.
CleanExMM_GJA3.
GenevestigatorQ64448.

Family and domain databases

InterProIPR000500. Connexin.
IPR002262. Connexin46.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
PR01133. CONNEXINA3.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286412.
PROQ64448.
SOURCESearch...

Entry information

Entry nameCXA3_MOUSE
AccessionPrimary (citable) accession number: Q64448
Secondary accession number(s): B2RRM1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot