Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction alpha-3 protein

Gene

Gja3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-3 protein
Alternative name(s):
Connexin-46
Short name:
Cx46
Gene namesi
Name:Gja3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95714 Gja3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 158CytoplasmicSequence analysisAdd BLAST61
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 207ExtracellularSequence analysisAdd BLAST28
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 417CytoplasmicSequence analysisAdd BLAST189

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578111 – 417Gap junction alpha-3 proteinAdd BLAST417

Proteomic databases

PaxDbiQ64448
PRIDEiQ64448

PTM databases

PhosphoSitePlusiQ64448

Expressioni

Gene expression databases

BgeeiENSMUSG00000048582
CleanExiMM_GJA3
ExpressionAtlasiQ64448 baseline and differential
GenevisibleiQ64448 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059587

Structurei

3D structure databases

ProteinModelPortaliQ64448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z Eukaryota
ENOG410ZC96 LUCA
GeneTreeiENSGT00910000143998
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiQ64448
KOiK07612
OMAiTTVEMHE
OrthoDBiEOG091G0BF2
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002262 Connexin46
IPR034634 Connexin_C
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF12 PTHR11984:SF12, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01133 CONNEXINA3
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
SUPFAMiSSF118220 SSF118220, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q64448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS
60 70 80 90 100
DFTCNTQQPG CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV
110 120 130 140 150
RMEEKKKERE EELLRRDNPQ HGRGREPMRT GSPRDPPLRD DRGKVRIAGA
160 170 180 190 200
LLRTYVFNII FKTLFEVGFI AGQYFLYGFQ LQPLYRCDRW PCPNTVDCFI
210 220 230 240 250
SRPTEKTIFV IFMLAVACAS LVLNMLEIYH LGWKKLKQGV TNHFNPDASE
260 270 280 290 300
ARHKPLDPLP TATSSGPPSV SIGFPPYYTH PACPTVQAKA IGFPGAPLSP
310 320 330 340 350
ADFTVVTLND AQGRNHPVKH CNGHHLTTEQ NWTRQVAEQQ TPASKPSSAA
360 370 380 390 400
SSPDGRKGLI DSSGSSLQES ALVVTPEEGE QALATTVEMH SPPLVLLDPG
410
RSSKSSNGRA RPGDLAI
Length:417
Mass (Da):46,321
Last modified:July 27, 2011 - v4
Checksum:iFF235977E26F55F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261T → A in AAB03211 (Ref. 1) Curated1
Sequence conflicti288A → G in AAB03211 (Ref. 1) Curated1
Sequence conflicti390H → Y in AAB03211 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44955 Genomic DNA Translation: AAB03211.1
CH466535 Genomic DNA Translation: EDL36182.1
CH466535 Genomic DNA Translation: EDL36184.1
BC138492 mRNA Translation: AAI38493.1
BC138493 mRNA Translation: AAI38494.1
CCDSiCCDS27152.1
RefSeqiNP_001258552.1, NM_001271623.1
NP_058671.2, NM_016975.3
XP_011243261.1, XM_011244959.1
UniGeneiMm.57207

Genome annotation databases

EnsembliENSMUST00000061614; ENSMUSP00000059587; ENSMUSG00000048582
GeneIDi14611
KEGGimmu:14611
UCSCiuc007ucv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCXA3_MOUSE
AccessioniPrimary (citable) accession number: Q64448
Secondary accession number(s): B2RRM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 130 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health