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Protein

Cytochrome c oxidase subunit 8A, mitochondrial

Gene

Cox8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-liver
Cytochrome c oxidase subunit 8-2
Gene namesi
Name:Cox8a
Synonyms:Cox8, Cox8l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:105959. Cox8a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 36Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei37 – 60HelicalBy similarityAdd BLAST24
Topological domaini61 – 69Mitochondrial intermembraneBy similarity9

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionBy similarityAdd BLAST25
ChainiPRO_000000618926 – 69Cytochrome c oxidase subunit 8A, mitochondrialAdd BLAST44

Proteomic databases

MaxQBiQ64445.
PaxDbiQ64445.
PeptideAtlasiQ64445.
PRIDEiQ64445.
TopDownProteomicsiQ64445.

PTM databases

iPTMnetiQ64445.
PhosphoSitePlusiQ64445.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035885.
CleanExiMM_COX8A.
GenevisibleiQ64445. MM.

Interactioni

Protein-protein interaction databases

IntActiQ64445. 2 interactors.
MINTiMINT-4091708.
STRINGi10090.ENSMUSP00000040717.

Structurei

3D structure databases

ProteinModelPortaliQ64445.
SMRiQ64445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4WR. Eukaryota.
ENOG410ZEYR. LUCA.
GeneTreeiENSGT00390000006255.
HOGENOMiHOG000230478.
InParanoidiQ64445.
KOiK02273.
OMAiIGLTSCF.
OrthoDBiEOG091G11UL.
PhylomeDBiQ64445.
TreeFamiTF105070.

Family and domain databases

InterProiView protein in InterPro
IPR003205. Cyt_c_oxidase_su8.
PANTHERiPTHR16717. PTHR16717. 1 hit.
PfamiView protein in Pfam
PF02285. COX8. 1 hit.
SUPFAMiSSF81431. SSF81431. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64445-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLTPLLLR SLTGSARRLM VPRAQVHSKP AREQLGVLDI TIGLTSCFVC
60
CLLPAGWVLS HLESYKKRE
Length:69
Mass (Da):7,648
Last modified:November 1, 1997 - v1
Checksum:i1A85DDE42C5928E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37721 mRNA. Translation: AAB38754.1.
AK002218 mRNA. Translation: BAB21942.1.
AK002524 mRNA. Translation: BAB22161.1.
AK008594 mRNA. Translation: BAB25767.1.
BC120708 mRNA. Translation: AAI20709.1.
BC120710 mRNA. Translation: AAI20711.1.
CCDSiCCDS29521.1.
PIRiS71929.
RefSeqiNP_031776.1. NM_007750.2.
UniGeneiMm.14022.

Genome annotation databases

EnsembliENSMUST00000039758; ENSMUSP00000040717; ENSMUSG00000035885.
GeneIDi12868.
KEGGimmu:12868.
UCSCiuc008gkj.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCOX8A_MOUSE
AccessioniPrimary (citable) accession number: Q64445
Secondary accession number(s): Q0VBB1, Q545I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families