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Protein

Sorbitol dehydrogenase

Gene

Sord

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.1 Publication

Catalytic activityi

L-iditol + NAD+ = L-sorbose + NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Zinc; catalyticBy similarity1
Binding sitei51SubstrateBy similarity1
Metal bindingi70Zinc; catalyticBy similarity1
Metal bindingi71Zinc; catalyticBy similarity1
Binding sitei156SubstrateBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei300SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5652227 Fructose biosynthesis
R-MMU-5661270 Catabolism of glucuronate to xylulose-5-phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Sorbitol dehydrogenase (EC:1.1.1.14)
Alternative name(s):
L-iditol 2-dehydrogenase
Gene namesi
Name:Sord
Synonyms:Sdh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98266 Sord

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000008822 – 357Sorbitol dehydrogenaseAdd BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei169PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ64442
MaxQBiQ64442
PaxDbiQ64442
PeptideAtlasiQ64442
PRIDEiQ64442

2D gel databases

REPRODUCTION-2DPAGEIPI00753038
Q64442

PTM databases

iPTMnetiQ64442
PhosphoSitePlusiQ64442
SwissPalmiQ64442

Expressioni

Tissue specificityi

Testis has the highest level of expression, followed by kidney, liver, and lung. Low levels of expression are also observed in lens, brain, and skeletal muscle. Expressed in sperm flagellum and very low expression in the sperm head.2 Publications

Developmental stagei

Detected early in spermatogenesis. Detected in condensing spermatids (at protein level) and is up-regulated during late spermatogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027227
CleanExiMM_SORD
GenevisibleiQ64442 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ64442, 5 interactors
MINTiQ64442
STRINGi10090.ENSMUSP00000106180

Structurei

3D structure databases

ProteinModelPortaliQ64442
SMRiQ64442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0024 Eukaryota
COG1063 LUCA
GeneTreeiENSGT00550000074781
HOGENOMiHOG000294670
HOVERGENiHBG005484
InParanoidiQ64442
KOiK00008
OMAiGVFHNTP
OrthoDBiEOG091G0AQY
PhylomeDBiQ64442
TreeFamiTF313060

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64442-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAKGENL SLVVHGPGDI RLENYPIPEL GPNDVLLKMH SVGICGSDVH
60 70 80 90 100
YWEHGRIGDF VVKKPMVLGH EAAGTVTKVG ELVKHLKPGD RVAIEPGVPR
110 120 130 140 150
EVDEYCKIGR YNLTPTIFFC ATPPDDGNLC RFYKHNADFC YKLPDSVTFE
160 170 180 190 200
EGALIEPLSV GIYACRRGSV SLGNKVLVCG AGPVGMVTLL VAKAMGAAQV
210 220 230 240 250
VVTDLSASRL TKAKEVGADF TIQVGKETPQ EIASKVESLL GSKPEVTIEC
260 270 280 290 300
TGAESSVQTG IYATHSGGTL VIVGMGAEMV NLPLVHAAIR EVDIKGVFRY
310 320 330 340 350
CNTWPMAISM LASKTLNVKP LVTHRFPLEK AVEAFETAKK GVGLKVMIKC

DPNDQNP
Length:357
Mass (Da):38,249
Last modified:July 10, 2007 - v3
Checksum:iFDAA462EF1EB6C21
GO

Sequence cautioni

The sequence AAA79043 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49V → L in AAA79043 (PubMed:7601136).Curated1
Sequence conflicti259T → S in AAA79043 (PubMed:7601136).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27014 mRNA Translation: AAA79043.1 Different initiation.
AK004692 mRNA Translation: BAB23478.1
AK015059 mRNA Translation: BAB29695.1
AK166988 mRNA Translation: BAE39168.1
AK166996 mRNA Translation: BAE39175.1
AL844566, AL844573 Genomic DNA Translation: CAM16325.1
AL844573, AL844566 Genomic DNA Translation: CAM19389.1
BC024124 mRNA Translation: AAH24124.1
BC030875 mRNA Translation: AAH30875.1
BC092291 mRNA Translation: AAH92291.1
CCDSiCCDS16657.1
PIRiS65956
RefSeqiNP_666238.1, NM_146126.4
UniGeneiMm.371580
Mm.471786

Genome annotation databases

EnsembliENSMUST00000110551; ENSMUSP00000106180; ENSMUSG00000027227
GeneIDi20322
KEGGimmu:20322
UCSCiuc008maj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDHSO_MOUSE
AccessioniPrimary (citable) accession number: Q64442
Secondary accession number(s): Q569V5, Q9CPS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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