Reviewed,
UniProtKB/Swiss-Prot Q64441 (CP24A_MOUSE)
Last modified
June 16, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Short name=Vitamin D(3) 24-hydroxylase Short name=24-OHase EC=1.14.13.n4 Alternative name(s): Cytochrome P450 24A1 P450-CC24 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 514 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. |
| Catalytic activity | Calcitriol + NADPH + O2 = calcitetrol + NADP+ + H2O. Calcidiol + NADPH + O2 = secalciferol + NADP+ + H2O. |
| Cofactor | Heme group By similarity. |
| Subcellular location | |
| Induction | By 1,25-dihydroxyvitamin D3 in kidney. Ref.3 |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | Heme Iron Metal-binding NADP |
| Molecular function | Monooxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW vitamin D metabolic processInferred from mutant phenotype. Source: MGI |
| Cellular component | mitochondrion Inferred from direct assay. Source: MGI |
| Molecular function | 25-hydroxycholecalciferol-24-hydroxylase activity Inferred from mutant phenotype. Source: MGI electron carrier activityInferred from electronic annotation. Source: InterPro heme bindingInferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygenInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3." Itoh S., Yoshimura T., Iemura O., Yamada E., Tsujikawa K., Kohama Y., Mimura T. Biochim. Biophys. Acta 1264:26-28(1995) [PubMed: 7578252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Kidney. |
| [2] | "Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3." Akeno N., Saikatsu S., Kawane T., Horiuchi N. Endocrinology 138:2233-2240(1997) [PubMed: 9165006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ddY. Tissue: Kidney. |
| [3] | "Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system." Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y. Mol. Endocrinol. 17:2393-2403(2003) [PubMed: 14528024] [Abstract] Cited for: INDUCTION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D49438 mRNA. Translation: BAA08416.1. D89669 mRNA. Translation: BAA21843.1. | |
| IPI | IPI00221624. |
| PIR | S60033. |
| RefSeq | NP_034126.1. |
| UniGene | Mm.6575 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q64441. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000038567. Mus musculus. [Contig view] |
| GeneID | 13081. |
| KEGG | mmu:13081. |
Organism-specific databases | |
| MGI | MGI:88593. Cyp24a1. |
Phylogenomic databases | |
| HOGENOM | Q64441. |
| HOVERGEN | Q64441. |
| OMA | Q64441. RFGLLQK. |
Gene expression databases | |
| ArrayExpress | Q64441. |
| Bgee | Q64441. |
| GermOnline | ENSMUSG00000038567. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00463. EP450I. PR00385. P450. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 283038. |
| SOURCE | Search... |
Entry information
| Entry name | CP24A_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q64441 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


