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Q64441

- CP24A_MOUSE

UniProt

Q64441 - CP24A_MOUSE

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Protein

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Gene
Cyp24a1, Cyp-24, Cyp24
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.

Catalytic activityi

Calcitriol + NADPH + O2 = calcitetrol + NADP+ + H2O.
Calcidiol + NADPH + O2 = secalciferol + NADP+ + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi462 – 4621Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Source: Ensembl
  2. 25-hydroxycholecalciferol-24-hydroxylase activity Source: MGI
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. osteoblast differentiation Source: Ensembl
  2. response to vitamin D Source: Ensembl
  3. vitamin D metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiREACT_213027. Vitamins.
REACT_218811. Vitamin D (calciferol) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (EC:1.14.13.126)
Short name:
24-OHase
Short name:
Vitamin D(3) 24-hydroxylase
Alternative name(s):
Cytochrome P450 24A1
Cytochrome P450-CC24
Gene namesi
Name:Cyp24a1
Synonyms:Cyp-24, Cyp24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:88593. Cyp24a1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535Mitochondrion By similarityAdd
BLAST
Chaini36 – 5144791,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialPRO_0000003616Add
BLAST

Proteomic databases

PaxDbiQ64441.
PRIDEiQ64441.

PTM databases

PhosphoSiteiQ64441.

Expressioni

Inductioni

By 1,25-dihydroxyvitamin D3 in kidney.1 Publication

Gene expression databases

BgeeiQ64441.
GenevestigatoriQ64441.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047954.

Structurei

3D structure databases

ProteinModelPortaliQ64441.
SMRiQ64441. Positions 51-514.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117435.
HOGENOMiHOG000276540.
HOVERGENiHBG099053.
InParanoidiQ64441.
KOiK07436.
OMAiQHDTLAE.
OrthoDBiEOG7ZGX4B.
PhylomeDBiQ64441.
TreeFamiTF105094.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64441-1 [UniParc]FASTAAdd to Basket

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MSCPIDKRRP LIAFLRRLRD LGQPPRSVTS KAHVKRAPKE VPLCPLMTDG    50
ETRNVTSLPG PTNWPLLGSL LEIFWKGGLK KQHDTLAEYH KKYGQIFRMK 100
LGSFDSVHLG SPSLLEALYR TESAHPQRLE IKPWKAYRDH RNEAYGLMIL 150
EGQEWQRVRS AFQKKLMKPV EIMKLDKKIN EVLADFMGQI DELRDERGRI 200
QDLYSELNKW SFESICLVLY EKRFGLLQKD TEEEALTFIA AIKTMMSTFG 250
KMMVTPVELH KRLNTKVWQA HTLAWDTIFK SVKPCIDHRL ERYSQQPGAD 300
FLCDIYQQDH LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ 350
RLLREIQSVL PDNQTPRAED VRNMPYLKAC LKESMRLTPS VPFTTRTLDK 400
PTVLGEYTLP KGTVLTLNTQ VLGSSEDNFE DADKFRPERW LEKEKKINPF 450
AHLPFGVGKR MCIGRRLAEL QLHLALCWII QKYNIVATDS EPVEMLHLGI 500
LVPSRELPIA FCPR 514
Length:514
Mass (Da):59,453
Last modified:November 1, 1996 - v1
Checksum:i3D38BA9235177A42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49438 mRNA. Translation: BAA08416.1.
D89669 mRNA. Translation: BAA21843.1.
CCDSiCCDS17122.1.
PIRiS60033.
RefSeqiNP_034126.1. NM_009996.3.
UniGeneiMm.6575.

Genome annotation databases

EnsembliENSMUST00000038824; ENSMUSP00000047954; ENSMUSG00000038567.
GeneIDi13081.
KEGGimmu:13081.
UCSCiuc008ocb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49438 mRNA. Translation: BAA08416.1 .
D89669 mRNA. Translation: BAA21843.1 .
CCDSi CCDS17122.1.
PIRi S60033.
RefSeqi NP_034126.1. NM_009996.3.
UniGenei Mm.6575.

3D structure databases

ProteinModelPortali Q64441.
SMRi Q64441. Positions 51-514.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000047954.

PTM databases

PhosphoSitei Q64441.

Proteomic databases

PaxDbi Q64441.
PRIDEi Q64441.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038824 ; ENSMUSP00000047954 ; ENSMUSG00000038567 .
GeneIDi 13081.
KEGGi mmu:13081.
UCSCi uc008ocb.1. mouse.

Organism-specific databases

CTDi 1591.
MGIi MGI:88593. Cyp24a1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117435.
HOGENOMi HOG000276540.
HOVERGENi HBG099053.
InParanoidi Q64441.
KOi K07436.
OMAi QHDTLAE.
OrthoDBi EOG7ZGX4B.
PhylomeDBi Q64441.
TreeFami TF105094.

Enzyme and pathway databases

Reactomei REACT_213027. Vitamins.
REACT_218811. Vitamin D (calciferol) metabolism.

Miscellaneous databases

NextBioi 283038.
PROi Q64441.
SOURCEi Search...

Gene expression databases

Bgeei Q64441.
Genevestigatori Q64441.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3."
    Itoh S., Yoshimura T., Iemura O., Yamada E., Tsujikawa K., Kohama Y., Mimura T.
    Biochim. Biophys. Acta 1264:26-28(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3."
    Akeno N., Saikatsu S., Kawane T., Horiuchi N.
    Endocrinology 138:2233-2240(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Kidney.
  3. "Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system."
    Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y.
    Mol. Endocrinol. 17:2393-2403(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCP24A_MOUSE
AccessioniPrimary (citable) accession number: Q64441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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