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Q64441

- CP24A_MOUSE

UniProt

Q64441 - CP24A_MOUSE

Protein

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

Gene

Cyp24a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.

    Catalytic activityi

    Calcitriol + NADPH + O2 = calcitetrol + NADP+ + H2O.
    Calcidiol + NADPH + O2 = secalciferol + NADP+ + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi462 – 4621Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Source: Ensembl
    2. 25-hydroxycholecalciferol-24-hydroxylase activity Source: MGI
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. osteoblast differentiation Source: Ensembl
    2. response to vitamin D Source: Ensembl
    3. vitamin D metabolic process Source: MGI

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    ReactomeiREACT_213027. Vitamins.
    REACT_218811. Vitamin D (calciferol) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (EC:1.14.13.126)
    Short name:
    24-OHase
    Short name:
    Vitamin D(3) 24-hydroxylase
    Alternative name(s):
    Cytochrome P450 24A1
    Cytochrome P450-CC24
    Gene namesi
    Name:Cyp24a1
    Synonyms:Cyp-24, Cyp24
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:88593. Cyp24a1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionBy similarityAdd
    BLAST
    Chaini36 – 5144791,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialPRO_0000003616Add
    BLAST

    Proteomic databases

    PaxDbiQ64441.
    PRIDEiQ64441.

    PTM databases

    PhosphoSiteiQ64441.

    Expressioni

    Inductioni

    By 1,25-dihydroxyvitamin D3 in kidney.1 Publication

    Gene expression databases

    BgeeiQ64441.
    GenevestigatoriQ64441.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000047954.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64441.
    SMRiQ64441. Positions 51-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117435.
    HOGENOMiHOG000276540.
    HOVERGENiHBG099053.
    InParanoidiQ64441.
    KOiK07436.
    OMAiQHDTLAE.
    OrthoDBiEOG7ZGX4B.
    PhylomeDBiQ64441.
    TreeFamiTF105094.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64441-1 [UniParc]FASTAAdd to Basket

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    MSCPIDKRRP LIAFLRRLRD LGQPPRSVTS KAHVKRAPKE VPLCPLMTDG    50
    ETRNVTSLPG PTNWPLLGSL LEIFWKGGLK KQHDTLAEYH KKYGQIFRMK 100
    LGSFDSVHLG SPSLLEALYR TESAHPQRLE IKPWKAYRDH RNEAYGLMIL 150
    EGQEWQRVRS AFQKKLMKPV EIMKLDKKIN EVLADFMGQI DELRDERGRI 200
    QDLYSELNKW SFESICLVLY EKRFGLLQKD TEEEALTFIA AIKTMMSTFG 250
    KMMVTPVELH KRLNTKVWQA HTLAWDTIFK SVKPCIDHRL ERYSQQPGAD 300
    FLCDIYQQDH LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ 350
    RLLREIQSVL PDNQTPRAED VRNMPYLKAC LKESMRLTPS VPFTTRTLDK 400
    PTVLGEYTLP KGTVLTLNTQ VLGSSEDNFE DADKFRPERW LEKEKKINPF 450
    AHLPFGVGKR MCIGRRLAEL QLHLALCWII QKYNIVATDS EPVEMLHLGI 500
    LVPSRELPIA FCPR 514
    Length:514
    Mass (Da):59,453
    Last modified:November 1, 1996 - v1
    Checksum:i3D38BA9235177A42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49438 mRNA. Translation: BAA08416.1.
    D89669 mRNA. Translation: BAA21843.1.
    CCDSiCCDS17122.1.
    PIRiS60033.
    RefSeqiNP_034126.1. NM_009996.3.
    UniGeneiMm.6575.

    Genome annotation databases

    EnsembliENSMUST00000038824; ENSMUSP00000047954; ENSMUSG00000038567.
    GeneIDi13081.
    KEGGimmu:13081.
    UCSCiuc008ocb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49438 mRNA. Translation: BAA08416.1 .
    D89669 mRNA. Translation: BAA21843.1 .
    CCDSi CCDS17122.1.
    PIRi S60033.
    RefSeqi NP_034126.1. NM_009996.3.
    UniGenei Mm.6575.

    3D structure databases

    ProteinModelPortali Q64441.
    SMRi Q64441. Positions 51-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000047954.

    PTM databases

    PhosphoSitei Q64441.

    Proteomic databases

    PaxDbi Q64441.
    PRIDEi Q64441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038824 ; ENSMUSP00000047954 ; ENSMUSG00000038567 .
    GeneIDi 13081.
    KEGGi mmu:13081.
    UCSCi uc008ocb.1. mouse.

    Organism-specific databases

    CTDi 1591.
    MGIi MGI:88593. Cyp24a1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117435.
    HOGENOMi HOG000276540.
    HOVERGENi HBG099053.
    InParanoidi Q64441.
    KOi K07436.
    OMAi QHDTLAE.
    OrthoDBi EOG7ZGX4B.
    PhylomeDBi Q64441.
    TreeFami TF105094.

    Enzyme and pathway databases

    Reactomei REACT_213027. Vitamins.
    REACT_218811. Vitamin D (calciferol) metabolism.

    Miscellaneous databases

    NextBioi 283038.
    PROi Q64441.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64441.
    Genevestigatori Q64441.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of 25-hydroxyvitamin D-3 24-hydroxylase (Cyp-24) from mouse kidney: its inducibility by vitamin D-3."
      Itoh S., Yoshimura T., Iemura O., Yamada E., Tsujikawa K., Kohama Y., Mimura T.
      Biochim. Biophys. Acta 1264:26-28(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Kidney.
    2. "Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3."
      Akeno N., Saikatsu S., Kawane T., Horiuchi N.
      Endocrinology 138:2233-2240(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Kidney.
    3. "Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system."
      Tsujikawa H., Kurotaki Y., Fujimori T., Fukuda K., Nabeshima Y.
      Mol. Endocrinol. 17:2393-2403(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiCP24A_MOUSE
    AccessioniPrimary (citable) accession number: Q64441
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3