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Protein

Angiogenin-2

Gene

Ang2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has ribonuclease activity (in vitro). Seems to lack angiogenic activity.1 Publication

Enzyme regulationi

Divalent metal ions, such as Cu2+ and Zn2+, may inhibit the ribonucleolytic activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32SubstrateBy similarity1
Active sitei37Proton acceptor1 Publication1
Active sitei641 Publication1
Metal bindingi65Zinc1
Metal bindingi106Zinc1
Active sitei137Proton donor1 Publication1
Metal bindingi137Zinc1

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • endonuclease activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • ribonuclease activity Source: MGI

GO - Biological processi

  • cellular response to glucose stimulus Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Angiogenin-2
Alternative name(s):
Angiogenin-related protein
Gene namesi
Name:Ang2
Synonyms:Angrp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:104984. Ang2.

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesicle lumen By similarity
  • Secreted By similarity
  • Nucleusnucleolus By similarity

  • Note: Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003085825 – 145Angiogenin-2Add BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 1041 Publication
Disulfide bondi63 ↔ 1151 Publication
Disulfide bondi81 ↔ 1301 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ64438.
PRIDEiQ64438.

Expressioni

Tissue specificityi

Expressed (at protein level) in macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000047894.
CleanExiMM_ANG2.
ExpressionAtlasiQ64438. baseline and differential.
GenevisibleiQ64438. MM.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062902.

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 37Combined sources10
Helixi47 – 56Combined sources10
Turni60 – 63Combined sources4
Beta strandi65 – 70Combined sources6
Helixi74 – 78Combined sources5
Helixi79 – 81Combined sources3
Turni82 – 84Combined sources3
Beta strandi85 – 87Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi99 – 106Combined sources8
Beta strandi111 – 114Combined sources4
Beta strandi117 – 124Combined sources8
Beta strandi127 – 131Combined sources5
Beta strandi134 – 138Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZBVX-ray1.64A25-145[»]
ProteinModelPortaliQ64438.
SMRiQ64438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 68Substrate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 59Nucleolar localization signalBy similarity5

Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZBW. Eukaryota.
ENOG410Y4FD. LUCA.
GeneTreeiENSGT00840000129759.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiQ64438.
KOiK16631.
OMAiINNECKE.
OrthoDBiEOG091G0YDD.
TreeFamiTF333393.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMSPGPLFL VFLLGLVVIP PTLSQDDSRY TKFLTQHYDA KPKGRDDRYC
60 70 80 90 100
ESMMVKRKLT SFCKDVNTFI HDTKNNIKAI CGKKGSPYGR NLRISKSHFQ
110 120 130 140
VTTCTHKGRS PRPPCRYRAS KGFRYIIIGC ENGWPVHFDE SFISP
Length:145
Mass (Da):16,593
Last modified:October 3, 2012 - v2
Checksum:i0F7D97E14429C4B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98H → R in AAA91367 (PubMed:8530072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22519 Genomic DNA. Translation: AAA91367.1.
AC163664 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20851.1.
CCDSiCCDS27040.1.
RefSeqiNP_031475.2. NM_007449.2.
UniGeneiMm.377077.

Genome annotation databases

EnsembliENSMUST00000051274; ENSMUSP00000062902; ENSMUSG00000047894.
GeneIDi11731.
KEGGimmu:11731.
UCSCiuc007tmu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22519 Genomic DNA. Translation: AAA91367.1.
AC163664 Genomic DNA. No translation available.
CH466605 Genomic DNA. Translation: EDL20851.1.
CCDSiCCDS27040.1.
RefSeqiNP_031475.2. NM_007449.2.
UniGeneiMm.377077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZBVX-ray1.64A25-145[»]
ProteinModelPortaliQ64438.
SMRiQ64438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062902.

Proteomic databases

PaxDbiQ64438.
PRIDEiQ64438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051274; ENSMUSP00000062902; ENSMUSG00000047894.
GeneIDi11731.
KEGGimmu:11731.
UCSCiuc007tmu.1. mouse.

Organism-specific databases

CTDi11731.
MGIiMGI:104984. Ang2.

Phylogenomic databases

eggNOGiENOG410IZBW. Eukaryota.
ENOG410Y4FD. LUCA.
GeneTreeiENSGT00840000129759.
HOGENOMiHOG000276883.
HOVERGENiHBG008396.
InParanoidiQ64438.
KOiK16631.
OMAiINNECKE.
OrthoDBiEOG091G0YDD.
TreeFamiTF333393.

Miscellaneous databases

PROiQ64438.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047894.
CleanExiMM_ANG2.
ExpressionAtlasiQ64438. baseline and differential.
GenevisibleiQ64438. MM.

Family and domain databases

Gene3Di3.10.130.10. 1 hit.
InterProiIPR001427. RNaseA.
IPR023411. RNaseA_AS.
IPR023412. RNaseA_domain.
[Graphical view]
PANTHERiPTHR11437. PTHR11437. 1 hit.
PfamiPF00074. RnaseA. 1 hit.
[Graphical view]
PRINTSiPR00794. RIBONUCLEASE.
ProDomiPD000535. RNaseA. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00092. RNAse_Pc. 1 hit.
[Graphical view]
SUPFAMiSSF54076. SSF54076. 1 hit.
PROSITEiPS00127. RNASE_PANCREATIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANG2_MOUSE
AccessioniPrimary (citable) accession number: Q64438
Secondary accession number(s): G5E8D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.