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Q64437

- ADH7_MOUSE

UniProt

Q64437 - ADH7_MOUSE

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Protein
Alcohol dehydrogenase class 4 mu/sigma chain
Gene
Adh7, Adh-3, Adh3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalytic By similarity
Metal bindingi68 – 681Zinc 1; catalytic By similarity
Metal bindingi98 – 981Zinc 2 By similarity
Metal bindingi101 – 1011Zinc 2 By similarity
Metal bindingi104 – 1041Zinc 2 By similarity
Metal bindingi112 – 1121Zinc 2 By similarity
Metal bindingi174 – 1741Zinc 1; catalytic By similarity
Binding sitei223 – 2231NAD By similarity
Binding sitei228 – 2281NAD By similarity
Binding sitei369 – 3691NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2046NAD By similarity
Nucleotide bindingi292 – 2943NAD By similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: MGI
  2. alcohol dehydrogenase activity, zinc-dependent Source: Ensembl
  3. aldehyde oxidase activity Source: Ensembl
  4. ethanol binding Source: Ensembl
  5. oxidoreductase activity Source: MGI
  6. retinol binding Source: Ensembl
  7. retinol dehydrogenase activity Source: MGI
  8. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ethanol catabolic process Source: MGI
  2. ethanol oxidation Source: Ensembl
  3. extracellular negative regulation of signal transduction Source: Ensembl
  4. fatty acid omega-oxidation Source: Ensembl
  5. response to bacterium Source: Ensembl
  6. response to ethanol Source: Ensembl
  7. retinoic acid metabolic process Source: MGI
  8. retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
Alternative name(s):
ADH-C2
Alcohol dehydrogenase 7
Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase
Gene namesi
Name:Adh7
Synonyms:Adh-3, Adh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:87926. Adh7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: Ensembl
  3. intracellular Source: MGI
  4. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Alcohol dehydrogenase class 4 mu/sigma chain
PRO_0000160692Add
BLAST

Proteomic databases

MaxQBiQ64437.
PaxDbiQ64437.
PRIDEiQ64437.

PTM databases

PhosphoSiteiQ64437.

Expressioni

Tissue specificityi

High expression in the stomach mucosa. Lower expression in eye, thymus, skin and ovary. Very low expression in small intestine, liver and uterus.

Gene expression databases

ArrayExpressiQ64437.
BgeeiQ64437.
GenevestigatoriQ64437.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ64437.
SMRiQ64437. Positions 2-374.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ64437.
KOiK13951.
OMAiPFKQINE.
OrthoDBiEOG72NRQ6.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR028635. Zinc_ADH_IV.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PTHR11695:SF406. PTHR11695:SF406. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64437-1 [UniParc]FASTAAdd to Basket

« Hide

MGTAGKVIKC KAAVLWGVNQ PFSIEEIEVA PPKAKEVRVK ILATGICRTD    50
DHIIKGSMVS KFPVIVGHEA VGVVESVGEG VTTVRPGDKV IPLFLPQCRE 100
CNACLNPEGN LCIRSDLTGR GVLADGTTRF TCKGKPVQHF MNTSTFTEYT 150
VLDESSVAKV DGAAPPEKAC LIGCGFSTGY GAAVKTAKVT PGSTCVVFGL 200
GGVGLSVIMG CKAAGASRII GIDINKDKFQ KALAVGATEC ISPKDSTKPI 250
SEVLSDMTGN TIQYTFEVIG RLETMVDALS SCHMNYGTSV VVGAPPSAKM 300
LTYDPMLLFT GRTWKGCVFG GWKSRDDVPK LVTEFLEKKF DLDQLITHTL 350
PFNNINEGFE LLYSGKSIRT VLTF 374
Length:374
Mass (Da):39,904
Last modified:July 27, 2011 - v2
Checksum:iD615119A23B41843
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201R → C in AAA76735. 1 Publication
Sequence conflicti120 – 1201R → C in AAC53124. 1 Publication
Sequence conflicti262 – 2621I → V in AAA76735. 1 Publication
Sequence conflicti262 – 2621I → V in AAC53124. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20257 mRNA. Translation: AAA76735.1.
U76734
, U76728, U76729, U76730, U76727, U76731, U76733, U76732 Genomic DNA. Translation: AAC53124.1.
AC079682 Genomic DNA. No translation available.
CCDSiCCDS38651.1.
PIRiA56436.
RefSeqiNP_033756.2. NM_009626.4.
XP_006500982.1. XM_006500919.1.
UniGeneiMm.8473.

Genome annotation databases

EnsembliENSMUST00000090171; ENSMUSP00000087633; ENSMUSG00000055301.
GeneIDi11529.
KEGGimmu:11529.
UCSCiuc008rnd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20257 mRNA. Translation: AAA76735.1 .
U76734
, U76728 , U76729 , U76730 , U76727 , U76731 , U76733 , U76732 Genomic DNA. Translation: AAC53124.1 .
AC079682 Genomic DNA. No translation available.
CCDSi CCDS38651.1.
PIRi A56436.
RefSeqi NP_033756.2. NM_009626.4.
XP_006500982.1. XM_006500919.1.
UniGenei Mm.8473.

3D structure databases

ProteinModelPortali Q64437.
SMRi Q64437. Positions 2-374.
ModBasei Search...

PTM databases

PhosphoSitei Q64437.

Proteomic databases

MaxQBi Q64437.
PaxDbi Q64437.
PRIDEi Q64437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090171 ; ENSMUSP00000087633 ; ENSMUSG00000055301 .
GeneIDi 11529.
KEGGi mmu:11529.
UCSCi uc008rnd.2. mouse.

Organism-specific databases

CTDi 131.
MGIi MGI:87926. Adh7.

Phylogenomic databases

eggNOGi COG1062.
HOGENOMi HOG000294674.
HOVERGENi HBG000195.
InParanoidi Q64437.
KOi K13951.
OMAi PFKQINE.
OrthoDBi EOG72NRQ6.
TreeFami TF300429.

Miscellaneous databases

NextBioi 278964.
PROi Q64437.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q64437.
Bgeei Q64437.
Genevestigatori Q64437.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR028635. Zinc_ADH_IV.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
PTHR11695:SF406. PTHR11695:SF406. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 2 hits.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family."
    Zgombic-Knight M., Ang H.L., Foglio M.H., Duester G.
    J. Biol. Chem. 270:10868-10877(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Gastric mucosa.
  2. "Gene structure and promoter for Adh-3 encoding mouse class IV alcohol dehydrogenase (retinol dehydrogenase)."
    Zgombic-Knight M., Deltour L., Haselbeck R.J., Foglio M.H., Duester G.
    Genomics 41:105-109(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiADH7_MOUSE
AccessioniPrimary (citable) accession number: Q64437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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