Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q64437

- ADH7_MOUSE

UniProt

Q64437 - ADH7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alcohol dehydrogenase class 4 mu/sigma chain

Gene

Adh7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalyticBy similarity
Metal bindingi68 – 681Zinc 1; catalyticBy similarity
Metal bindingi98 – 981Zinc 2By similarity
Metal bindingi101 – 1011Zinc 2By similarity
Metal bindingi104 – 1041Zinc 2By similarity
Metal bindingi112 – 1121Zinc 2By similarity
Metal bindingi174 – 1741Zinc 1; catalyticBy similarity
Binding sitei223 – 2231NADBy similarity
Binding sitei228 – 2281NADBy similarity
Binding sitei369 – 3691NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2046NADBy similarity
Nucleotide bindingi292 – 2943NADBy similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: MGI
  2. alcohol dehydrogenase activity, zinc-dependent Source: InterPro
  3. aldehyde oxidase activity Source: Ensembl
  4. ethanol binding Source: InterPro
  5. oxidoreductase activity Source: MGI
  6. retinol binding Source: InterPro
  7. retinol dehydrogenase activity Source: MGI
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. ethanol catabolic process Source: MGI
  2. ethanol oxidation Source: InterPro
  3. extracellular negative regulation of signal transduction Source: Ensembl
  4. fatty acid omega-oxidation Source: Ensembl
  5. response to bacterium Source: Ensembl
  6. response to ethanol Source: Ensembl
  7. retinoic acid metabolic process Source: MGI
  8. retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiREACT_260489. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
Alternative name(s):
ADH-C2
Alcohol dehydrogenase 7
Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase
Gene namesi
Name:Adh7
Synonyms:Adh-3, Adh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:87926. Adh7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular region Source: Ensembl
  3. intracellular Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Alcohol dehydrogenase class 4 mu/sigma chainPRO_0000160692Add
BLAST

Proteomic databases

MaxQBiQ64437.
PaxDbiQ64437.
PRIDEiQ64437.

PTM databases

PhosphoSiteiQ64437.

Expressioni

Tissue specificityi

High expression in the stomach mucosa. Lower expression in eye, thymus, skin and ovary. Very low expression in small intestine, liver and uterus.

Gene expression databases

BgeeiQ64437.
ExpressionAtlasiQ64437. baseline and differential.
GenevestigatoriQ64437.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ64437.
SMRiQ64437. Positions 2-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ64437.
KOiK13951.
OMAiPFKQINE.
OrthoDBiEOG72NRQ6.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR028635. Zinc_ADH_IV.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PTHR11695:SF406. PTHR11695:SF406. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64437-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTAGKVIKC KAAVLWGVNQ PFSIEEIEVA PPKAKEVRVK ILATGICRTD
60 70 80 90 100
DHIIKGSMVS KFPVIVGHEA VGVVESVGEG VTTVRPGDKV IPLFLPQCRE
110 120 130 140 150
CNACLNPEGN LCIRSDLTGR GVLADGTTRF TCKGKPVQHF MNTSTFTEYT
160 170 180 190 200
VLDESSVAKV DGAAPPEKAC LIGCGFSTGY GAAVKTAKVT PGSTCVVFGL
210 220 230 240 250
GGVGLSVIMG CKAAGASRII GIDINKDKFQ KALAVGATEC ISPKDSTKPI
260 270 280 290 300
SEVLSDMTGN TIQYTFEVIG RLETMVDALS SCHMNYGTSV VVGAPPSAKM
310 320 330 340 350
LTYDPMLLFT GRTWKGCVFG GWKSRDDVPK LVTEFLEKKF DLDQLITHTL
360 370
PFNNINEGFE LLYSGKSIRT VLTF
Length:374
Mass (Da):39,904
Last modified:July 27, 2011 - v2
Checksum:iD615119A23B41843
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201R → C in AAA76735. (PubMed:7738026)Curated
Sequence conflicti120 – 1201R → C in AAC53124. (PubMed:9126489)Curated
Sequence conflicti262 – 2621I → V in AAA76735. (PubMed:7738026)Curated
Sequence conflicti262 – 2621I → V in AAC53124. (PubMed:9126489)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20257 mRNA. Translation: AAA76735.1.
U76734
, U76728, U76729, U76730, U76727, U76731, U76733, U76732 Genomic DNA. Translation: AAC53124.1.
AC079682 Genomic DNA. No translation available.
CCDSiCCDS38651.1.
PIRiA56436.
RefSeqiNP_033756.2. NM_009626.4.
XP_006500982.1. XM_006500919.1.
UniGeneiMm.8473.

Genome annotation databases

EnsembliENSMUST00000090171; ENSMUSP00000087633; ENSMUSG00000055301.
GeneIDi11529.
KEGGimmu:11529.
UCSCiuc008rnd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20257 mRNA. Translation: AAA76735.1 .
U76734
, U76728 , U76729 , U76730 , U76727 , U76731 , U76733 , U76732 Genomic DNA. Translation: AAC53124.1 .
AC079682 Genomic DNA. No translation available.
CCDSi CCDS38651.1.
PIRi A56436.
RefSeqi NP_033756.2. NM_009626.4.
XP_006500982.1. XM_006500919.1.
UniGenei Mm.8473.

3D structure databases

ProteinModelPortali Q64437.
SMRi Q64437. Positions 2-374.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q64437.

Proteomic databases

MaxQBi Q64437.
PaxDbi Q64437.
PRIDEi Q64437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090171 ; ENSMUSP00000087633 ; ENSMUSG00000055301 .
GeneIDi 11529.
KEGGi mmu:11529.
UCSCi uc008rnd.2. mouse.

Organism-specific databases

CTDi 131.
MGIi MGI:87926. Adh7.

Phylogenomic databases

eggNOGi COG1062.
HOGENOMi HOG000294674.
HOVERGENi HBG000195.
InParanoidi Q64437.
KOi K13951.
OMAi PFKQINE.
OrthoDBi EOG72NRQ6.
TreeFami TF300429.

Enzyme and pathway databases

Reactomei REACT_260489. Ethanol oxidation.

Miscellaneous databases

NextBioi 278964.
PROi Q64437.
SOURCEi Search...

Gene expression databases

Bgeei Q64437.
ExpressionAtlasi Q64437. baseline and differential.
Genevestigatori Q64437.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR028635. Zinc_ADH_IV.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
PTHR11695:SF406. PTHR11695:SF406. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 2 hits.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family."
    Zgombic-Knight M., Ang H.L., Foglio M.H., Duester G.
    J. Biol. Chem. 270:10868-10877(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Gastric mucosa.
  2. "Gene structure and promoter for Adh-3 encoding mouse class IV alcohol dehydrogenase (retinol dehydrogenase)."
    Zgombic-Knight M., Deltour L., Haselbeck R.J., Foglio M.H., Duester G.
    Genomics 41:105-109(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiADH7_MOUSE
AccessioniPrimary (citable) accession number: Q64437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3