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Protein

Alcohol dehydrogenase class 4 mu/sigma chain

Gene

Adh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi47 – 471Zinc 1; catalyticBy similarity
Metal bindingi68 – 681Zinc 1; catalyticBy similarity
Metal bindingi98 – 981Zinc 2By similarity
Metal bindingi101 – 1011Zinc 2By similarity
Metal bindingi104 – 1041Zinc 2By similarity
Metal bindingi112 – 1121Zinc 2By similarity
Metal bindingi174 – 1741Zinc 1; catalyticBy similarity
Binding sitei223 – 2231NADBy similarity
Binding sitei228 – 2281NADBy similarity
Binding sitei369 – 3691NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi199 – 2046NADBy similarity
Nucleotide bindingi292 – 2943NADBy similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: MGI
  2. alcohol dehydrogenase activity, zinc-dependent Source: MGI
  3. aldehyde oxidase activity Source: MGI
  4. ethanol binding Source: MGI
  5. oxidoreductase activity Source: MGI
  6. receptor antagonist activity Source: MGI
  7. retinol binding Source: MGI
  8. retinol dehydrogenase activity Source: MGI
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. ethanol catabolic process Source: MGI
  2. ethanol oxidation Source: MGI
  3. extracellular negative regulation of signal transduction Source: MGI
  4. fatty acid omega-oxidation Source: MGI
  5. oxidation-reduction process Source: MGI
  6. response to bacterium Source: MGI
  7. response to ethanol Source: MGI
  8. retinoic acid metabolic process Source: MGI
  9. retinoid metabolic process Source: MGI
  10. retinol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiREACT_309926. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
Alternative name(s):
ADH-C2
Alcohol dehydrogenase 7
Alcohol dehydrogenase class IV mu/sigma chain
Gastric alcohol dehydrogenase
Retinol dehydrogenase
Gene namesi
Name:Adh7
Synonyms:Adh-3, Adh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:87926. Adh7.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: MGI
  3. intracellular Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Alcohol dehydrogenase class 4 mu/sigma chainPRO_0000160692Add
BLAST

Proteomic databases

MaxQBiQ64437.
PaxDbiQ64437.
PRIDEiQ64437.

PTM databases

PhosphoSiteiQ64437.

Expressioni

Tissue specificityi

High expression in the stomach mucosa. Lower expression in eye, thymus, skin and ovary. Very low expression in small intestine, liver and uterus.

Gene expression databases

BgeeiQ64437.
ExpressionAtlasiQ64437. baseline and differential.
GenevestigatoriQ64437.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliQ64437.
SMRiQ64437. Positions 2-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1062.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ64437.
KOiK13951.
OMAiFMAKKFD.
OrthoDBiEOG72NRQ6.
TreeFamiTF300429.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR028635. Zinc_ADH_IV.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PTHR11695:SF406. PTHR11695:SF406. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTAGKVIKC KAAVLWGVNQ PFSIEEIEVA PPKAKEVRVK ILATGICRTD
60 70 80 90 100
DHIIKGSMVS KFPVIVGHEA VGVVESVGEG VTTVRPGDKV IPLFLPQCRE
110 120 130 140 150
CNACLNPEGN LCIRSDLTGR GVLADGTTRF TCKGKPVQHF MNTSTFTEYT
160 170 180 190 200
VLDESSVAKV DGAAPPEKAC LIGCGFSTGY GAAVKTAKVT PGSTCVVFGL
210 220 230 240 250
GGVGLSVIMG CKAAGASRII GIDINKDKFQ KALAVGATEC ISPKDSTKPI
260 270 280 290 300
SEVLSDMTGN TIQYTFEVIG RLETMVDALS SCHMNYGTSV VVGAPPSAKM
310 320 330 340 350
LTYDPMLLFT GRTWKGCVFG GWKSRDDVPK LVTEFLEKKF DLDQLITHTL
360 370
PFNNINEGFE LLYSGKSIRT VLTF
Length:374
Mass (Da):39,904
Last modified:July 27, 2011 - v2
Checksum:iD615119A23B41843
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201R → C in AAA76735 (PubMed:7738026).Curated
Sequence conflicti120 – 1201R → C in AAC53124 (PubMed:9126489).Curated
Sequence conflicti262 – 2621I → V in AAA76735 (PubMed:7738026).Curated
Sequence conflicti262 – 2621I → V in AAC53124 (PubMed:9126489).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20257 mRNA. Translation: AAA76735.1.
U76734
, U76728, U76729, U76730, U76727, U76731, U76733, U76732 Genomic DNA. Translation: AAC53124.1.
AC079682 Genomic DNA. No translation available.
CCDSiCCDS38651.1.
PIRiA56436.
RefSeqiNP_033756.2. NM_009626.4.
XP_006500982.1. XM_006500919.2.
UniGeneiMm.8473.

Genome annotation databases

EnsembliENSMUST00000090171; ENSMUSP00000087633; ENSMUSG00000055301.
GeneIDi11529.
KEGGimmu:11529.
UCSCiuc008rnd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20257 mRNA. Translation: AAA76735.1.
U76734
, U76728, U76729, U76730, U76727, U76731, U76733, U76732 Genomic DNA. Translation: AAC53124.1.
AC079682 Genomic DNA. No translation available.
CCDSiCCDS38651.1.
PIRiA56436.
RefSeqiNP_033756.2. NM_009626.4.
XP_006500982.1. XM_006500919.2.
UniGeneiMm.8473.

3D structure databases

ProteinModelPortaliQ64437.
SMRiQ64437. Positions 2-374.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ64437.

Proteomic databases

MaxQBiQ64437.
PaxDbiQ64437.
PRIDEiQ64437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090171; ENSMUSP00000087633; ENSMUSG00000055301.
GeneIDi11529.
KEGGimmu:11529.
UCSCiuc008rnd.2. mouse.

Organism-specific databases

CTDi131.
MGIiMGI:87926. Adh7.

Phylogenomic databases

eggNOGiCOG1062.
HOGENOMiHOG000294674.
HOVERGENiHBG000195.
InParanoidiQ64437.
KOiK13951.
OMAiFMAKKFD.
OrthoDBiEOG72NRQ6.
TreeFamiTF300429.

Enzyme and pathway databases

ReactomeiREACT_309926. Ethanol oxidation.

Miscellaneous databases

NextBioi278964.
PROiQ64437.
SOURCEiSearch...

Gene expression databases

BgeeiQ64437.
ExpressionAtlasiQ64437. baseline and differential.
GenevestigatoriQ64437.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR028635. Zinc_ADH_IV.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PTHR11695:SF406. PTHR11695:SF406. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family."
    Zgombic-Knight M., Ang H.L., Foglio M.H., Duester G.
    J. Biol. Chem. 270:10868-10877(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
    Tissue: Gastric mucosa.
  2. "Gene structure and promoter for Adh-3 encoding mouse class IV alcohol dehydrogenase (retinol dehydrogenase)."
    Zgombic-Knight M., Deltour L., Haselbeck R.J., Foglio M.H., Duester G.
    Genomics 41:105-109(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiADH7_MOUSE
AccessioniPrimary (citable) accession number: Q64437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.