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Q64437

- ADH7_MOUSE

UniProt

Q64437 - ADH7_MOUSE

Protein

Alcohol dehydrogenase class 4 mu/sigma chain

Gene

Adh7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation.

    Catalytic activityi

    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471Zinc 1; catalyticBy similarity
    Metal bindingi68 – 681Zinc 1; catalyticBy similarity
    Metal bindingi98 – 981Zinc 2By similarity
    Metal bindingi101 – 1011Zinc 2By similarity
    Metal bindingi104 – 1041Zinc 2By similarity
    Metal bindingi112 – 1121Zinc 2By similarity
    Metal bindingi174 – 1741Zinc 1; catalyticBy similarity
    Binding sitei223 – 2231NADBy similarity
    Binding sitei228 – 2281NADBy similarity
    Binding sitei369 – 3691NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi199 – 2046NADBy similarity
    Nucleotide bindingi292 – 2943NADBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: MGI
    2. alcohol dehydrogenase activity, zinc-dependent Source: Ensembl
    3. aldehyde oxidase activity Source: Ensembl
    4. ethanol binding Source: Ensembl
    5. oxidoreductase activity Source: MGI
    6. retinol binding Source: Ensembl
    7. retinol dehydrogenase activity Source: MGI
    8. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ethanol catabolic process Source: MGI
    2. ethanol oxidation Source: Ensembl
    3. extracellular negative regulation of signal transduction Source: Ensembl
    4. fatty acid omega-oxidation Source: Ensembl
    5. response to bacterium Source: Ensembl
    6. response to ethanol Source: Ensembl
    7. retinoic acid metabolic process Source: MGI
    8. retinol metabolic process Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase class 4 mu/sigma chain (EC:1.1.1.1)
    Alternative name(s):
    ADH-C2
    Alcohol dehydrogenase 7
    Alcohol dehydrogenase class IV mu/sigma chain
    Gastric alcohol dehydrogenase
    Retinol dehydrogenase
    Gene namesi
    Name:Adh7
    Synonyms:Adh-3, Adh3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:87926. Adh7.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: Ensembl
    3. intracellular Source: MGI
    4. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Alcohol dehydrogenase class 4 mu/sigma chainPRO_0000160692Add
    BLAST

    Proteomic databases

    MaxQBiQ64437.
    PaxDbiQ64437.
    PRIDEiQ64437.

    PTM databases

    PhosphoSiteiQ64437.

    Expressioni

    Tissue specificityi

    High expression in the stomach mucosa. Lower expression in eye, thymus, skin and ovary. Very low expression in small intestine, liver and uterus.

    Gene expression databases

    ArrayExpressiQ64437.
    BgeeiQ64437.
    GenevestigatoriQ64437.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64437.
    SMRiQ64437. Positions 2-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1062.
    HOGENOMiHOG000294674.
    HOVERGENiHBG000195.
    InParanoidiQ64437.
    KOiK13951.
    OMAiPFKQINE.
    OrthoDBiEOG72NRQ6.
    TreeFamiTF300429.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    IPR028635. Zinc_ADH_IV.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PTHR11695:SF406. PTHR11695:SF406. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 2 hits.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTAGKVIKC KAAVLWGVNQ PFSIEEIEVA PPKAKEVRVK ILATGICRTD    50
    DHIIKGSMVS KFPVIVGHEA VGVVESVGEG VTTVRPGDKV IPLFLPQCRE 100
    CNACLNPEGN LCIRSDLTGR GVLADGTTRF TCKGKPVQHF MNTSTFTEYT 150
    VLDESSVAKV DGAAPPEKAC LIGCGFSTGY GAAVKTAKVT PGSTCVVFGL 200
    GGVGLSVIMG CKAAGASRII GIDINKDKFQ KALAVGATEC ISPKDSTKPI 250
    SEVLSDMTGN TIQYTFEVIG RLETMVDALS SCHMNYGTSV VVGAPPSAKM 300
    LTYDPMLLFT GRTWKGCVFG GWKSRDDVPK LVTEFLEKKF DLDQLITHTL 350
    PFNNINEGFE LLYSGKSIRT VLTF 374
    Length:374
    Mass (Da):39,904
    Last modified:July 27, 2011 - v2
    Checksum:iD615119A23B41843
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti120 – 1201R → C in AAA76735. (PubMed:7738026)Curated
    Sequence conflicti120 – 1201R → C in AAC53124. (PubMed:9126489)Curated
    Sequence conflicti262 – 2621I → V in AAA76735. (PubMed:7738026)Curated
    Sequence conflicti262 – 2621I → V in AAC53124. (PubMed:9126489)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20257 mRNA. Translation: AAA76735.1.
    U76734
    , U76728, U76729, U76730, U76727, U76731, U76733, U76732 Genomic DNA. Translation: AAC53124.1.
    AC079682 Genomic DNA. No translation available.
    CCDSiCCDS38651.1.
    PIRiA56436.
    RefSeqiNP_033756.2. NM_009626.4.
    XP_006500982.1. XM_006500919.1.
    UniGeneiMm.8473.

    Genome annotation databases

    EnsembliENSMUST00000090171; ENSMUSP00000087633; ENSMUSG00000055301.
    GeneIDi11529.
    KEGGimmu:11529.
    UCSCiuc008rnd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20257 mRNA. Translation: AAA76735.1 .
    U76734
    , U76728 , U76729 , U76730 , U76727 , U76731 , U76733 , U76732 Genomic DNA. Translation: AAC53124.1 .
    AC079682 Genomic DNA. No translation available.
    CCDSi CCDS38651.1.
    PIRi A56436.
    RefSeqi NP_033756.2. NM_009626.4.
    XP_006500982.1. XM_006500919.1.
    UniGenei Mm.8473.

    3D structure databases

    ProteinModelPortali Q64437.
    SMRi Q64437. Positions 2-374.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q64437.

    Proteomic databases

    MaxQBi Q64437.
    PaxDbi Q64437.
    PRIDEi Q64437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090171 ; ENSMUSP00000087633 ; ENSMUSG00000055301 .
    GeneIDi 11529.
    KEGGi mmu:11529.
    UCSCi uc008rnd.2. mouse.

    Organism-specific databases

    CTDi 131.
    MGIi MGI:87926. Adh7.

    Phylogenomic databases

    eggNOGi COG1062.
    HOGENOMi HOG000294674.
    HOVERGENi HBG000195.
    InParanoidi Q64437.
    KOi K13951.
    OMAi PFKQINE.
    OrthoDBi EOG72NRQ6.
    TreeFami TF300429.

    Miscellaneous databases

    NextBioi 278964.
    PROi Q64437.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q64437.
    Bgeei Q64437.
    Genevestigatori Q64437.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    IPR028635. Zinc_ADH_IV.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    PTHR11695:SF406. PTHR11695:SF406. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 2 hits.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family."
      Zgombic-Knight M., Ang H.L., Foglio M.H., Duester G.
      J. Biol. Chem. 270:10868-10877(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
      Tissue: Gastric mucosa.
    2. "Gene structure and promoter for Adh-3 encoding mouse class IV alcohol dehydrogenase (retinol dehydrogenase)."
      Zgombic-Knight M., Deltour L., Haselbeck R.J., Foglio M.H., Duester G.
      Genomics 41:105-109(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiADH7_MOUSE
    AccessioniPrimary (citable) accession number: Q64437
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3