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Q64435

- UD16_MOUSE

UniProt

Q64435 - UD16_MOUSE

Protein

UDP-glucuronosyltransferase 1-6

Gene

Ugt1a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: MGI

    GO - Biological processi

    1. glucuronate metabolic process Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
    Short name:
    UDPGT 1-6
    Short name:
    UGT1*6
    Short name:
    UGT1-06
    Short name:
    UGT1.6
    Alternative name(s):
    Phenol UDP-glucuronosyltransferase
    UDP-glucuronosyltransferase 1A6
    Short name:
    UGT1A6
    UGP1A1
    UGT1A7
    Gene namesi
    Name:Ugt1a6
    Synonyms:Ugt1, Ugt1a6a, Ugt1a7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:2137698. Ugt1a6a.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 531505UDP-glucuronosyltransferase 1-6PRO_0000036017Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ64435.
    PRIDEiQ64435.

    PTM databases

    PhosphoSiteiQ64435.

    Expressioni

    Tissue specificityi

    Expressed in liver, kidney and at very low levels in colon.1 Publication

    Inductioni

    By dioxin.

    Gene expression databases

    BgeeiQ64435.
    GenevestigatoriQ64435.

    Interactioni

    Protein-protein interaction databases

    IntActiQ64435. 1 interaction.
    MINTiMINT-1853977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64435.
    SMRiQ64435. Positions 230-442.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei489 – 50517HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00640000091365.
    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.
    KOiK00699.
    OMAiLKESKHY.
    OrthoDBiEOG7GBFWS.
    PhylomeDBiQ64435.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q64435-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS    50
    ERGHDIMVLV PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL 100
    PGASLMGPLR EYRNNMIVVD MFFSNCQSLL KDSATLSFLR ENKFDALFTD 150
    PAMPCGVILA EYLNLPSVYL FRGFPCSLEH MLGQSPSPVS YVPRFYTKFS 200
    DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD VSLPSLHQNS 250
    LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI 300
    VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV 350
    KWLPQNDLLG HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK 400
    RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI 450
    EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV 500
    VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H 531
    Length:531
    Mass (Da):60,439
    Last modified:November 1, 1997 - v1
    Checksum:iAE7CA5FC5818DC12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431K → G in BAA13483. (PubMed:7677729)Curated
    Sequence conflicti69 – 691E → R in BAA13483. (PubMed:7677729)Curated
    Sequence conflicti89 – 891T → N in AAP48596. (PubMed:14672974)Curated
    Sequence conflicti101 – 1011P → L in AAP48596. (PubMed:14672974)Curated
    Sequence conflicti104 – 1041S → L in BAA13483. (PubMed:7677729)Curated
    Sequence conflicti201 – 2011D → G in AAP48596. (PubMed:14672974)Curated
    Sequence conflicti225 – 2251L → P in BAA13483. (PubMed:7677729)Curated
    Sequence conflicti231 – 2311I → V in AAP48596. (PubMed:14672974)Curated
    Sequence conflicti466 – 4661H → K in AAA51871. 1 PublicationCurated
    Sequence conflicti518 – 5181G → V in AAP48596. (PubMed:14672974)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09930 mRNA. Translation: AAA51871.1.
    U16818 mRNA. Translation: AAA65979.1.
    D87867 mRNA. Translation: BAA13483.1.
    AY227197 mRNA. Translation: AAP48596.1.
    CCDSiCCDS48314.1. [Q64435-1]
    PIRiA55788.
    RefSeqiNP_659545.2. NM_145079.3. [Q64435-1]
    UniGeneiMm.300095.

    Genome annotation databases

    EnsembliENSMUST00000014263; ENSMUSP00000014263; ENSMUSG00000054545. [Q64435-1]
    ENSMUST00000113134; ENSMUSP00000108759; ENSMUSG00000054545. [Q64435-1]
    ENSMUST00000113135; ENSMUSP00000108760; ENSMUSG00000054545. [Q64435-1]
    GeneIDi94284.
    KEGGimmu:94284.
    UCSCiuc007bye.1. mouse. [Q64435-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09930 mRNA. Translation: AAA51871.1 .
    U16818 mRNA. Translation: AAA65979.1 .
    D87867 mRNA. Translation: BAA13483.1 .
    AY227197 mRNA. Translation: AAP48596.1 .
    CCDSi CCDS48314.1. [Q64435-1 ]
    PIRi A55788.
    RefSeqi NP_659545.2. NM_145079.3. [Q64435-1 ]
    UniGenei Mm.300095.

    3D structure databases

    ProteinModelPortali Q64435.
    SMRi Q64435. Positions 230-442.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q64435. 1 interaction.
    MINTi MINT-1853977.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q64435.

    Proteomic databases

    MaxQBi Q64435.
    PRIDEi Q64435.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014263 ; ENSMUSP00000014263 ; ENSMUSG00000054545 . [Q64435-1 ]
    ENSMUST00000113134 ; ENSMUSP00000108759 ; ENSMUSG00000054545 . [Q64435-1 ]
    ENSMUST00000113135 ; ENSMUSP00000108760 ; ENSMUSG00000054545 . [Q64435-1 ]
    GeneIDi 94284.
    KEGGi mmu:94284.
    UCSCi uc007bye.1. mouse. [Q64435-1 ]

    Organism-specific databases

    CTDi 94284.
    MGIi MGI:2137698. Ugt1a6a.

    Phylogenomic databases

    GeneTreei ENSGT00640000091365.
    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.
    KOi K00699.
    OMAi LKESKHY.
    OrthoDBi EOG7GBFWS.
    PhylomeDBi Q64435.
    TreeFami TF315472.

    Miscellaneous databases

    NextBioi 352301.
    PROi Q64435.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q64435.
    Genevestigatori Q64435.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
      Lamb J.G., Straub P., Tukey R.H.
      Biochemistry 33:10513-10520(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: C57BL/6.
      Tissue: Liver.
    2. "Characterization of the murine dioxin-inducible UDP glucuronosyltransferase (Ugt1-06) gene."
      Reuter S.F., Vasiliou V., Puga A., Nebert D.W.
      Toxicologist 14:410-410(1994)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    3. "Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations."
      Koiwai O., Hasada K., Yasui Y., Sakai Y., Sato H., Watanabe T.
      Biochem. Genet. 33:111-122(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    4. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
      Zhang T., Haws P., Wu Q.
      Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Kidney.

    Entry informationi

    Entry nameiUD16_MOUSE
    AccessioniPrimary (citable) accession number: Q64435
    Secondary accession number(s): P70692, Q62580, Q6XL47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3