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Q64435 (UD16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-6

Short name=UDPGT 1-6
Short name=UGT1*6
Short name=UGT1-06
Short name=UGT1.6
EC=2.4.1.17
Alternative name(s):
Phenol UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A6
Short name=UGT1A6
UGP1A1
UGT1A7
Gene names
Name:Ugt1a6
Synonyms:Ugt1, Ugt1a6a, Ugt1a7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in liver, kidney and at very low levels in colon. Ref.4

Induction

By dioxin.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q64435-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 531505UDP-glucuronosyltransferase 1-6
PRO_0000036017

Regions

Transmembrane489 – 50517Helical; Potential

Amino acid modifications

Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict431K → G in BAA13483. Ref.3
Sequence conflict691E → R in BAA13483. Ref.3
Sequence conflict891T → N in AAP48596. Ref.4
Sequence conflict1011P → L in AAP48596. Ref.4
Sequence conflict1041S → L in BAA13483. Ref.3
Sequence conflict2011D → G in AAP48596. Ref.4
Sequence conflict2251L → P in BAA13483. Ref.3
Sequence conflict2311I → V in AAP48596. Ref.4
Sequence conflict4661H → K in AAA51871. Ref.2
Sequence conflict5181G → V in AAP48596. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: AE7CA5FC5818DC12

FASTA53160,439
        10         20         30         40         50         60 
MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS ERGHDIMVLV 

        70         80         90        100        110        120 
PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL PGASLMGPLR EYRNNMIVVD 

       130        140        150        160        170        180 
MFFSNCQSLL KDSATLSFLR ENKFDALFTD PAMPCGVILA EYLNLPSVYL FRGFPCSLEH 

       190        200        210        220        230        240 
MLGQSPSPVS YVPRFYTKFS DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD 

       250        260        270        280        290        300 
VSLPSLHQNS LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI 

       310        320        330        340        350        360 
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV KWLPQNDLLG 

       370        380        390        400        410        420 
HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK RMETRGAGVT LNVLEMTADD 

       430        440        450        460        470        480 
LENALKTVIN NKSYKENIMR LSSLHKDRPI EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT 

       490        500        510        520        530 
WYQYHSLDVI GFLLAIVLTV VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H 

« Hide

References

[1]"Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
Lamb J.G., Straub P., Tukey R.H.
Biochemistry 33:10513-10520(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: C57BL/6.
Tissue: Liver.
[2]"Characterization of the murine dioxin-inducible UDP glucuronosyltransferase (Ugt1-06) gene."
Reuter S.F., Vasiliou V., Puga A., Nebert D.W.
Toxicologist 14:410-410(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
Tissue: Liver.
[3]"Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations."
Koiwai O., Hasada K., Yasui Y., Sakai Y., Sato H., Watanabe T.
Biochem. Genet. 33:111-122(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
[4]"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
Zhang T., Haws P., Wu Q.
Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09930 mRNA. Translation: AAA51871.1.
U16818 mRNA. Translation: AAA65979.1.
D87867 mRNA. Translation: BAA13483.1.
AY227197 mRNA. Translation: AAP48596.1.
PIRA55788.
RefSeqNP_659545.2. NM_145079.3.
UniGeneMm.300095.

3D structure databases

ProteinModelPortalQ64435.
SMRQ64435. Positions 230-442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ64435. 1 interaction.
MINTMINT-1853977.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteQ64435.

Proteomic databases

PRIDEQ64435.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000014263; ENSMUSP00000014263; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113134; ENSMUSP00000108759; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113135; ENSMUSP00000108760; ENSMUSG00000054545. [Q64435-1]
GeneID94284.
KEGGmmu:94284.
UCSCuc007bye.1. mouse. [Q64435-1]

Organism-specific databases

CTD94284.
MGIMGI:2137698. Ugt1a6a.

Phylogenomic databases

GeneTreeENSGT00640000091365.
HOGENOMHOG000220832.
HOVERGENHBG004033.
KOK00699.
OMALKESKHY.
OrthoDBEOG7GBFWS.
PhylomeDBQ64435.
TreeFamTF315472.

Gene expression databases

BgeeQ64435.
GenevestigatorQ64435.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio352301.
PROQ64435.
SOURCESearch...

Entry information

Entry nameUD16_MOUSE
AccessionPrimary (citable) accession number: Q64435
Secondary accession number(s): P70692, Q62580, Q6XL47
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot