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Protein

UDP-glucuronosyltransferase 1-6

Gene

Ugt1a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
Short name:
UDPGT 1-6
Short name:
UGT1*6
Short name:
UGT1-06
Short name:
UGT1.6
Alternative name(s):
Phenol UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A6
Short name:
UGT1A6
UGP1A1
UGT1A7
Gene namesi
Name:Ugt1a6
Synonyms:Ugt1, Ugt1a6a, Ugt1a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2137698. Ugt1a6a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei489 – 505HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003601727 – 531UDP-glucuronosyltransferase 1-6Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ64435.
PaxDbiQ64435.
PeptideAtlasiQ64435.
PRIDEiQ64435.

PTM databases

iPTMnetiQ64435.
PhosphoSitePlusiQ64435.
SwissPalmiQ64435.

Expressioni

Tissue specificityi

Expressed in liver, kidney and at very low levels in colon.1 Publication

Inductioni

By dioxin.

Gene expression databases

BgeeiENSMUSG00000054545.
ExpressionAtlasiQ64435. baseline and differential.
GenevisibleiQ64435. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ64435. 1 interactor.
MINTiMINT-1853977.
STRINGi10090.ENSMUSP00000014263.

Structurei

3D structure databases

ProteinModelPortaliQ64435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ64435.
KOiK00699.
OrthoDBiEOG091G06JC.
PhylomeDBiQ64435.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q64435-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS
60 70 80 90 100
ERGHDIMVLV PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL
110 120 130 140 150
PGASLMGPLR EYRNNMIVVD MFFSNCQSLL KDSATLSFLR ENKFDALFTD
160 170 180 190 200
PAMPCGVILA EYLNLPSVYL FRGFPCSLEH MLGQSPSPVS YVPRFYTKFS
210 220 230 240 250
DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD VSLPSLHQNS
260 270 280 290 300
LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):60,439
Last modified:November 1, 1997 - v1
Checksum:iAE7CA5FC5818DC12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43K → G in BAA13483 (PubMed:7677729).Curated1
Sequence conflicti69E → R in BAA13483 (PubMed:7677729).Curated1
Sequence conflicti89T → N in AAP48596 (PubMed:14672974).Curated1
Sequence conflicti101P → L in AAP48596 (PubMed:14672974).Curated1
Sequence conflicti104S → L in BAA13483 (PubMed:7677729).Curated1
Sequence conflicti201D → G in AAP48596 (PubMed:14672974).Curated1
Sequence conflicti225L → P in BAA13483 (PubMed:7677729).Curated1
Sequence conflicti231I → V in AAP48596 (PubMed:14672974).Curated1
Sequence conflicti466H → K in AAA51871 (Ref. 2) Curated1
Sequence conflicti518G → V in AAP48596 (PubMed:14672974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09930 mRNA. Translation: AAA51871.1.
U16818 mRNA. Translation: AAA65979.1.
D87867 mRNA. Translation: BAA13483.1.
AY227197 mRNA. Translation: AAP48596.1.
CCDSiCCDS48314.1. [Q64435-1]
PIRiA55788.
RefSeqiNP_659545.2. NM_145079.3. [Q64435-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000014263; ENSMUSP00000014263; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113134; ENSMUSP00000108759; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113135; ENSMUSP00000108760; ENSMUSG00000090124. [Q64435-1]
GeneIDi94284.
KEGGimmu:94284.
UCSCiuc007bye.1. mouse. [Q64435-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09930 mRNA. Translation: AAA51871.1.
U16818 mRNA. Translation: AAA65979.1.
D87867 mRNA. Translation: BAA13483.1.
AY227197 mRNA. Translation: AAP48596.1.
CCDSiCCDS48314.1. [Q64435-1]
PIRiA55788.
RefSeqiNP_659545.2. NM_145079.3. [Q64435-1]
UniGeneiMm.300095.

3D structure databases

ProteinModelPortaliQ64435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ64435. 1 interactor.
MINTiMINT-1853977.
STRINGi10090.ENSMUSP00000014263.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ64435.
PhosphoSitePlusiQ64435.
SwissPalmiQ64435.

Proteomic databases

MaxQBiQ64435.
PaxDbiQ64435.
PeptideAtlasiQ64435.
PRIDEiQ64435.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014263; ENSMUSP00000014263; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113134; ENSMUSP00000108759; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113135; ENSMUSP00000108760; ENSMUSG00000090124. [Q64435-1]
GeneIDi94284.
KEGGimmu:94284.
UCSCiuc007bye.1. mouse. [Q64435-1]

Organism-specific databases

CTDi94284.
MGIiMGI:2137698. Ugt1a6a.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ64435.
KOiK00699.
OrthoDBiEOG091G06JC.
PhylomeDBiQ64435.
TreeFamiTF315472.

Miscellaneous databases

PROiQ64435.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054545.
ExpressionAtlasiQ64435. baseline and differential.
GenevisibleiQ64435. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD16_MOUSE
AccessioniPrimary (citable) accession number: Q64435
Secondary accession number(s): P70692, Q62580, Q6XL47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.