UDP-glucuronosyltransferase 1-6 precursor

Contribute

Send feedback

Read comments (?) or add your own

Q64435 (UD16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
UDP-glucuronosyltransferase 1-6
Short name=UDPGT 1-6
Short name=UGT1*6
Short name=UGT1-06
Short name=UGT1.6
EC=2.4.1.17

Alternative name(s):
Phenol UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A6
Short name=UGT1A6
UGP1A1
UGT1A7

Gene names

Name:	Ugt1a6
Synonyms:	Ugt1, Ugt1a6a, Ugt1a7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in liver, kidney and at very low levels in colon. Ref.4
Induction	By dioxin.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glucuronate metabolic process Inferred from direct assay Ref.1. Source: MGI
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from direct assay PubMed 12865426. Source: MGI
Molecular_function	glucuronosyltransferase activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64435-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Potential

Chain

27 – 531

505

UDP-glucuronosyltransferase 1-6

PRO_0000036017

Regions

Transmembrane

489 – 505

Helical; Potential

Amino acid modifications

Glycosylation

293

N-linked (GlcNAc...) Potential

Glycosylation

431

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

K → G in BAA13483. Ref.3

Sequence conflict

E → R in BAA13483. Ref.3

Sequence conflict

T → N in AAP48596. Ref.4

Sequence conflict

101

P → L in AAP48596. Ref.4

Sequence conflict

104

S → L in BAA13483. Ref.3

Sequence conflict

201

D → G in AAP48596. Ref.4

Sequence conflict

225

L → P in BAA13483. Ref.3

Sequence conflict

231

I → V in AAP48596. Ref.4

Sequence conflict

466

H → K in AAA51871. Ref.2

Sequence conflict

518

G → V in AAP48596. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Isoform 1 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: AE7CA5FC5818DC12
Show »

FASTA

531

60,439

        10         20         30         40         50         60 
MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS ERGHDIMVLV 

        70         80         90        100        110        120 
PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL PGASLMGPLR EYRNNMIVVD 

       130        140        150        160        170        180 
MFFSNCQSLL KDSATLSFLR ENKFDALFTD PAMPCGVILA EYLNLPSVYL FRGFPCSLEH 

       190        200        210        220        230        240 
MLGQSPSPVS YVPRFYTKFS DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD 

       250        260        270        280        290        300 
VSLPSLHQNS LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI 

       310        320        330        340        350        360 
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV KWLPQNDLLG 

       370        380        390        400        410        420 
HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK RMETRGAGVT LNVLEMTADD 

       430        440        450        460        470        480 
LENALKTVIN NKSYKENIMR LSSLHKDRPI EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT 

       490        500        510        520        530 
WYQYHSLDVI GFLLAIVLTV VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H

« Hide

References

[1]	"Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Lamb J.G., Straub P., Tukey R.H. Biochemistry 33:10513-10520(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: C57BL/6. Tissue: Liver.
[2]	"Characterization of the murine dioxin-inducible UDP glucuronosyltransferase (Ugt1-06) gene." Reuter S.F., Vasiliou V., Puga A., Nebert D.W. Toxicologist 14:410-410(1994) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
[3]	"Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations." Koiwai O., Hasada K., Yasui Y., Sakai Y., Sato H., Watanabe T. Biochem. Genet. 33:111-122(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver.
[4]	"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation." Zhang T., Haws P., Wu Q. Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09930 mRNA. Translation: AAA51871.1. U16818 mRNA. Translation: AAA65979.1. D87867 mRNA. Translation: BAA13483.1. AY227197 mRNA. Translation: AAP48596.1.
IPI	IPI00134432.
PIR	A55788.
RefSeq	NP_659545.2. NM_145079.3.
UniGene	Mm.300095.
3D structure databases
ProteinModelPortal	Q64435.
SMR	Q64435. Positions 230-442.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	Q64435.
Proteomic databases
PRIDE	Q64435.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000014263; ENSMUSP00000014263; ENSMUSG00000054545. ENSMUST00000113134; ENSMUSP00000108759; ENSMUSG00000054545. ENSMUST00000113135; ENSMUSP00000108760; ENSMUSG00000054545.
GeneID	94284.
KEGG	mmu:94284.
UCSC	uc007bye.1. mouse.
Organism-specific databases
CTD	94284.
MGI	MGI:2137698. Ugt1a6a.
Phylogenomic databases
GeneTree	ENSGT00640000091365.
HOGENOM	HOG000220832.
HOVERGEN	HBG004033.
KO	K00699.
OMA	LKESKHY.
Gene expression databases
ArrayExpress	Q64435.
Bgee	Q64435.
Genevestigator	Q64435.
GermOnline	ENSMUSG00000054545. Mus musculus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. PTHR11926. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	352301.
SOURCE	Search...

Entry information

Entry name

UD16_MOUSE

Accession

Primary (citable) accession number: Q64435
Secondary accession number(s): P70692, Q62580, Q6XL47

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents