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Q64435

- UD16_MOUSE

UniProt

Q64435 - UD16_MOUSE

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Protein

UDP-glucuronosyltransferase 1-6

Gene

Ugt1a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: MGI

GO - Biological processi

  1. glucuronate metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_257519. Glucuronidation.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-6 (EC:2.4.1.17)
Short name:
UDPGT 1-6
Short name:
UGT1*6
Short name:
UGT1-06
Short name:
UGT1.6
Alternative name(s):
Phenol UDP-glucuronosyltransferase
UDP-glucuronosyltransferase 1A6
Short name:
UGT1A6
UGP1A1
UGT1A7
Gene namesi
Name:Ugt1a6
Synonyms:Ugt1, Ugt1a6a, Ugt1a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2137698. Ugt1a6a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50517HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 531505UDP-glucuronosyltransferase 1-6PRO_0000036017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ64435.
PRIDEiQ64435.

PTM databases

PhosphoSiteiQ64435.

Expressioni

Tissue specificityi

Expressed in liver, kidney and at very low levels in colon.1 Publication

Inductioni

By dioxin.

Gene expression databases

BgeeiQ64435.
ExpressionAtlasiQ64435. baseline.
GenevestigatoriQ64435.

Interactioni

Protein-protein interaction databases

IntActiQ64435. 1 interaction.
MINTiMINT-1853977.

Structurei

3D structure databases

ProteinModelPortaliQ64435.
SMRiQ64435. Positions 230-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ64435.
KOiK00699.
OMAiLKESKHY.
OrthoDBiEOG7GBFWS.
PhylomeDBiQ64435.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64435-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS
60 70 80 90 100
ERGHDIMVLV PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL
110 120 130 140 150
PGASLMGPLR EYRNNMIVVD MFFSNCQSLL KDSATLSFLR ENKFDALFTD
160 170 180 190 200
PAMPCGVILA EYLNLPSVYL FRGFPCSLEH MLGQSPSPVS YVPRFYTKFS
210 220 230 240 250
DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD VSLPSLHQNS
260 270 280 290 300
LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):60,439
Last modified:November 1, 1997 - v1
Checksum:iAE7CA5FC5818DC12
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431K → G in BAA13483. (PubMed:7677729)Curated
Sequence conflicti69 – 691E → R in BAA13483. (PubMed:7677729)Curated
Sequence conflicti89 – 891T → N in AAP48596. (PubMed:14672974)Curated
Sequence conflicti101 – 1011P → L in AAP48596. (PubMed:14672974)Curated
Sequence conflicti104 – 1041S → L in BAA13483. (PubMed:7677729)Curated
Sequence conflicti201 – 2011D → G in AAP48596. (PubMed:14672974)Curated
Sequence conflicti225 – 2251L → P in BAA13483. (PubMed:7677729)Curated
Sequence conflicti231 – 2311I → V in AAP48596. (PubMed:14672974)Curated
Sequence conflicti466 – 4661H → K in AAA51871. 1 PublicationCurated
Sequence conflicti518 – 5181G → V in AAP48596. (PubMed:14672974)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09930 mRNA. Translation: AAA51871.1.
U16818 mRNA. Translation: AAA65979.1.
D87867 mRNA. Translation: BAA13483.1.
AY227197 mRNA. Translation: AAP48596.1.
CCDSiCCDS48314.1. [Q64435-1]
PIRiA55788.
RefSeqiNP_659545.2. NM_145079.3. [Q64435-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000014263; ENSMUSP00000014263; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113134; ENSMUSP00000108759; ENSMUSG00000054545. [Q64435-1]
ENSMUST00000113135; ENSMUSP00000108760; ENSMUSG00000090124. [Q64435-1]
GeneIDi94284.
KEGGimmu:94284.
UCSCiuc007bye.1. mouse. [Q64435-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09930 mRNA. Translation: AAA51871.1 .
U16818 mRNA. Translation: AAA65979.1 .
D87867 mRNA. Translation: BAA13483.1 .
AY227197 mRNA. Translation: AAP48596.1 .
CCDSi CCDS48314.1. [Q64435-1 ]
PIRi A55788.
RefSeqi NP_659545.2. NM_145079.3. [Q64435-1 ]
UniGenei Mm.300095.

3D structure databases

ProteinModelPortali Q64435.
SMRi Q64435. Positions 230-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64435. 1 interaction.
MINTi MINT-1853977.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q64435.

Proteomic databases

MaxQBi Q64435.
PRIDEi Q64435.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014263 ; ENSMUSP00000014263 ; ENSMUSG00000054545 . [Q64435-1 ]
ENSMUST00000113134 ; ENSMUSP00000108759 ; ENSMUSG00000054545 . [Q64435-1 ]
ENSMUST00000113135 ; ENSMUSP00000108760 ; ENSMUSG00000090124 . [Q64435-1 ]
GeneIDi 94284.
KEGGi mmu:94284.
UCSCi uc007bye.1. mouse. [Q64435-1 ]

Organism-specific databases

CTDi 94284.
MGIi MGI:2137698. Ugt1a6a.

Phylogenomic databases

GeneTreei ENSGT00760000118949.
HOGENOMi HOG000220832.
HOVERGENi HBG004033.
InParanoidi Q64435.
KOi K00699.
OMAi LKESKHY.
OrthoDBi EOG7GBFWS.
PhylomeDBi Q64435.
TreeFami TF315472.

Enzyme and pathway databases

Reactomei REACT_257519. Glucuronidation.

Miscellaneous databases

NextBioi 352301.
PROi Q64435.
SOURCEi Search...

Gene expression databases

Bgeei Q64435.
ExpressionAtlasi Q64435. baseline.
Genevestigatori Q64435.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin."
    Lamb J.G., Straub P., Tukey R.H.
    Biochemistry 33:10513-10520(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: C57BL/6.
    Tissue: Liver.
  2. "Characterization of the murine dioxin-inducible UDP glucuronosyltransferase (Ugt1-06) gene."
    Reuter S.F., Vasiliou V., Puga A., Nebert D.W.
    Toxicologist 14:410-410(1994)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Liver.
  3. "Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations."
    Koiwai O., Hasada K., Yasui Y., Sakai Y., Sato H., Watanabe T.
    Biochem. Genet. 33:111-122(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  4. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
    Zhang T., Haws P., Wu Q.
    Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.

Entry informationi

Entry nameiUD16_MOUSE
AccessioniPrimary (citable) accession number: Q64435
Secondary accession number(s): P70692, Q62580, Q6XL47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3