Reviewed, UniProtKB/Swiss-Prot Q64435 (UD16_MOUSE)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-6
      Short name=UDPGT
      Short name=UGT1*6
    EC=2.4.1.17
Alternative name(s):
    UGT1-06
      Short name=UGT1.6
    UGT1A6
    UGP1A1
    Phenol UDP-glucuronosyltransferase

Gene names

Name:	Ugt1a6
Synonyms:	Ugt1, Ugt1a6a

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Induction	By dioxin.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	glucuronate metabolic process Ref.2 Inferred from direct assay. Source: MGI
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from direct assay. Source: MGI
Molecular function	glucuronosyltransferase activity Ref.2 Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q64435-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 531	505	UDP-glucuronosyltransferase 1-6		PRO_0000036017
Regions
	Transmembrane	489 – 505	17	Potential
Amino acid modifications
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	43	1	K → G in BAA13483. Ref.3
	Sequence conflict	69	1	E → R in BAA13483. Ref.3
	Sequence conflict	104	1	S → L in BAA13483. Ref.3
	Sequence conflict	225	1	L → P in BAA13483. Ref.3
	Sequence conflict	466	1	H → K in AAA51871. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: AE7CA5FC5818DC12	FASTA	531	60,439
	10 20 30 40 50 60 MACLLPAAQT LPAGFLFLVL WASVLGDKLL VVPQDGSHWL SMKEIVEHLS ERGHDIMVLV 70 80 90 100 110 120 PEVNLLLGES KYYRRKIFSV TYSLEELQTR FRTFGNNHFL PGASLMGPLR EYRNNMIVVD 130 140 150 160 170 180 MFFSNCQSLL KDSATLSFLR ENKFDALFTD PAMPCGVILA EYLNLPSVYL FRGFPCSLEH 190 200 210 220 230 240 MLGQSPSPVS YVPRFYTKFS DHMTFPQRLA NFIVNILENY LYYCLYSKYE IIASDLLKRD 250 260 270 280 290 300 VSLPSLHQNS LWLLRYDFVF EYPRPVMPNM IFLGGINCKK KGKLTQEFEA YVNASGEHGI 310 320 330 340 350 360 VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV KWLPQNDLLG 370 380 390 400 410 420 HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK RMETRGAGVT LNVLEMTADD 430 440 450 460 470 480 LENALKTVIN NKSYKENIMR LSSLHKDRPI EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT 490 500 510 520 530 WYQYHSLDVI GFLLAIVLTV VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H

References

[1]	Reuter S.F., Vasiliou V., Puga A., Nebert D.W. Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
[2]	"Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Lamb J.G., Straub P., Tukey R.H. Biochemistry 33:10513-10520(1994) [PubMed: 8068691] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Strain: C57BL/6. Tissue: Liver.
[3]	"Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations." Koiwai O., Hasada K., Yasui Y., Sakai Y., Sato H., Watanabe T. Biochem. Genet. 33:111-122(1995) [PubMed: 7677729] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U16818 mRNA. Translation: AAA65979.1. U09930 mRNA. Translation: AAA51871.1. D87867 mRNA. Translation: BAA13483.1.
IPI	IPI00134432.
PIR	A55788.
RefSeq	NP_659545.2.
UniGene	Mm.300095 Mm.466859
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	Q64435.
Genome annotation databases
Ensembl	ENSMUSG00000054545. Mus musculus. [Contig view]
GeneID	94284.
KEGG	mmu:94284.
Organism-specific databases
MGI	MGI:2137698. Ugt1a6a.
Phylogenomic databases
HOVERGEN	Q64435.
OMA	Q64435. CGNIVAR.
Enzyme and pathway databases
BRENDA	2.4.1.17. 244.
Gene expression databases
ArrayExpress	Q64435.
Bgee	Q64435.
GermOnline	ENSMUSG00000054545. Mus musculus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	352301.
SOURCE	Search...

Entry information

Entry name

UD16_MOUSE

Accession

Primary (citable) accession number: Q64435
Secondary accession number(s): P70692, Q62580

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	June 16, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)