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Q64433

- CH10_MOUSE

UniProt

Q64433 - CH10_MOUSE

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Protein

10 kDa heat shock protein, mitochondrial

Gene

Hspe1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. chaperone binding Source: UniProtKB
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. osteoblast differentiation Source: Ensembl
  2. protein folding Source: InterPro
  3. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa heat shock protein, mitochondrial
Short name:
Hsp10
Alternative name(s):
10 kDa chaperonin
Chaperonin 10
Short name:
CPN10
Gene namesi
Name:Hspe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:104680. Hspe1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. membrane Source: Ensembl
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 10210110 kDa heat shock protein, mitochondrialPRO_0000174918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei8 – 81N6-acetyllysine1 Publication
Modified residuei28 – 281N6-succinyllysine1 Publication
Modified residuei40 – 401N6-acetyllysine; alternate1 Publication
Modified residuei40 – 401N6-malonyllysine; alternateBy similarity
Modified residuei40 – 401N6-succinyllysine; alternate1 Publication
Modified residuei54 – 541N6-malonyllysine; alternateBy similarity
Modified residuei54 – 541N6-succinyllysine; alternate1 Publication
Modified residuei56 – 561N6-acetyllysine; alternate2 Publications
Modified residuei56 – 561N6-malonyllysine; alternateBy similarity
Modified residuei56 – 561N6-succinyllysine; alternate1 Publication
Modified residuei66 – 661N6-acetyllysine; alternate1 Publication
Modified residuei66 – 661N6-succinyllysine; alternate1 Publication
Modified residuei70 – 701N6-acetyllysine; alternate1 Publication
Modified residuei70 – 701N6-succinyllysine; alternate1 Publication
Modified residuei79 – 791PhosphothreonineBy similarity
Modified residuei80 – 801N6-acetyllysine; alternate1 Publication
Modified residuei80 – 801N6-succinyllysine; alternate1 Publication
Modified residuei86 – 861N6-acetyllysine; alternate1 Publication
Modified residuei86 – 861N6-succinyllysine; alternate1 Publication
Modified residuei99 – 991N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ64433.
PaxDbiQ64433.
PRIDEiQ64433.

2D gel databases

REPRODUCTION-2DPAGEQ64433.

PTM databases

PhosphoSiteiQ64433.

Expressioni

Inductioni

By stress.

Gene expression databases

BgeeiQ64433.
CleanExiMM_HSPE1.
ExpressionAtlasiQ64433. baseline and differential.
GenevestigatoriQ64433.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

IntActiQ64433. 1 interaction.
MINTiMINT-1839191.

Structurei

3D structure databases

ProteinModelPortaliQ64433.
SMRiQ64433. Positions 11-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiCOG0234.
GeneTreeiENSGT00390000006350.
HOGENOMiHOG000133897.
HOVERGENiHBG000385.
InParanoidiQ64433.
KOiK04078.
OMAiQDRIIVK.
OrthoDBiEOG71CFPD.
PhylomeDBiQ64433.
TreeFamiTF313814.

Family and domain databases

Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10.
InterProiIPR020818. Chaperonin_Cpn10.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PANTHERiPTHR10772. PTHR10772. 1 hit.
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64433-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG
60 70 80 90 100
SGGKGKSGEI EPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDSDILGKY

VD
Length:102
Mass (Da):10,963
Last modified:January 23, 2007 - v2
Checksum:i08BEB5566DBE8A3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09659 mRNA. Translation: AAA62229.1.
AF251024 Genomic DNA. Translation: AAF67345.1.
AK088121 mRNA. Translation: BAC40159.1.
BC024385 mRNA. Translation: AAH24385.1.
CCDSiCCDS35570.1.
PIRiA55075.
RefSeqiNP_032329.1. NM_008303.4.
UniGeneiMm.215667.

Genome annotation databases

EnsembliENSMUST00000075242; ENSMUSP00000074724; ENSMUSG00000073676.
GeneIDi15528.
KEGGimmu:15528.
UCSCiuc007bac.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09659 mRNA. Translation: AAA62229.1 .
AF251024 Genomic DNA. Translation: AAF67345.1 .
AK088121 mRNA. Translation: BAC40159.1 .
BC024385 mRNA. Translation: AAH24385.1 .
CCDSi CCDS35570.1.
PIRi A55075.
RefSeqi NP_032329.1. NM_008303.4.
UniGenei Mm.215667.

3D structure databases

ProteinModelPortali Q64433.
SMRi Q64433. Positions 11-98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q64433. 1 interaction.
MINTi MINT-1839191.

PTM databases

PhosphoSitei Q64433.

2D gel databases

REPRODUCTION-2DPAGE Q64433.

Proteomic databases

MaxQBi Q64433.
PaxDbi Q64433.
PRIDEi Q64433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075242 ; ENSMUSP00000074724 ; ENSMUSG00000073676 .
GeneIDi 15528.
KEGGi mmu:15528.
UCSCi uc007bac.2. mouse.

Organism-specific databases

CTDi 3336.
MGIi MGI:104680. Hspe1.

Phylogenomic databases

eggNOGi COG0234.
GeneTreei ENSGT00390000006350.
HOGENOMi HOG000133897.
HOVERGENi HBG000385.
InParanoidi Q64433.
KOi K04078.
OMAi QDRIIVK.
OrthoDBi EOG71CFPD.
PhylomeDBi Q64433.
TreeFami TF313814.

Miscellaneous databases

NextBioi 288450.
PROi Q64433.
SOURCEi Search...

Gene expression databases

Bgeei Q64433.
CleanExi MM_HSPE1.
ExpressionAtlasi Q64433. baseline and differential.
Genevestigatori Q64433.

Family and domain databases

Gene3Di 2.30.33.40. 1 hit.
HAMAPi MF_00580. CH10.
InterProi IPR020818. Chaperonin_Cpn10.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view ]
PANTHERi PTHR10772. PTHR10772. 1 hit.
Pfami PF00166. Cpn10. 1 hit.
[Graphical view ]
PRINTSi PR00297. CHAPERONIN10.
SMARTi SM00883. Cpn10. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression, and purification of a functional nonacetylated mammalian mitochondrial chaperonin 10."
    Dickson R., Larsen B., Viitanen P.V., Tormey M.B., Geske J., Strange R., Bemis L.T.
    J. Biol. Chem. 269:26858-26864(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The murine chaperonin 10 gene family contains an intronless, putative gene for early pregnancy factor, Cpn10-rs1."
    Fletcher B.H., Cassady A.I., Summers K.M., Cavanagh A.C.
    Mamm. Genome 12:133-140(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Thymus.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 8-15; 29-36; 41-54 AND 71-92, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-56, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-28; LYS-40; LYS-54; LYS-56; LYS-66; LYS-70; LYS-80 AND LYS-86, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast and Liver.
  7. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-40; LYS-56; LYS-66; LYS-70; LYS-80; LYS-86 AND LYS-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCH10_MOUSE
AccessioniPrimary (citable) accession number: Q64433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3