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Protein

10 kDa heat shock protein, mitochondrial

Gene

Hspe1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
10 kDa heat shock protein, mitochondrial
Short name:
Hsp10
Alternative name(s):
10 kDa chaperonin
Chaperonin 10
Short name:
CPN10
Gene namesi
Name:Hspe1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104680. Hspe1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10210110 kDa heat shock protein, mitochondrialPRO_0000174918Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei8 – 81N6-acetyllysineCombined sources
Modified residuei28 – 281N6-succinyllysineCombined sources
Modified residuei40 – 401N6-acetyllysine; alternateCombined sources
Modified residuei40 – 401N6-malonyllysine; alternateBy similarity
Modified residuei40 – 401N6-succinyllysine; alternateCombined sources
Modified residuei54 – 541N6-malonyllysine; alternateBy similarity
Modified residuei54 – 541N6-succinyllysine; alternateCombined sources
Modified residuei56 – 561N6-acetyllysine; alternateCombined sources
Modified residuei56 – 561N6-malonyllysine; alternateBy similarity
Modified residuei56 – 561N6-succinyllysine; alternateCombined sources
Modified residuei57 – 571PhosphoserineCombined sources
Modified residuei66 – 661N6-acetyllysine; alternateCombined sources
Modified residuei66 – 661N6-succinyllysine; alternateCombined sources
Modified residuei70 – 701N6-acetyllysine; alternateCombined sources
Modified residuei70 – 701N6-succinyllysine; alternateCombined sources
Modified residuei79 – 791PhosphothreonineBy similarity
Modified residuei80 – 801N6-acetyllysine; alternateCombined sources
Modified residuei80 – 801N6-succinyllysine; alternateCombined sources
Modified residuei86 – 861N6-acetyllysine; alternateCombined sources
Modified residuei86 – 861N6-succinyllysine; alternateCombined sources
Modified residuei99 – 991N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ64433.
MaxQBiQ64433.
PaxDbiQ64433.
PRIDEiQ64433.
TopDownProteomicsiQ64433.

2D gel databases

REPRODUCTION-2DPAGEQ64433.

PTM databases

iPTMnetiQ64433.
PhosphoSiteiQ64433.

Expressioni

Inductioni

By stress.

Gene expression databases

BgeeiENSMUSG00000073676.
CleanExiMM_HSPE1.
ExpressionAtlasiQ64433. baseline and differential.
GenevisibleiQ64433. MM.

Interactioni

Subunit structurei

Homohexamer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200459. 1 interaction.
IntActiQ64433. 2 interactions.
MINTiMINT-1839191.
STRINGi10090.ENSMUSP00000074724.

Structurei

3D structure databases

ProteinModelPortaliQ64433.
SMRiQ64433. Positions 3-102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GroES chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG1641. Eukaryota.
COG0234. LUCA.
GeneTreeiENSGT00390000006350.
HOGENOMiHOG000133897.
HOVERGENiHBG000385.
InParanoidiQ64433.
KOiK04078.
OMAiDTGKEKP.
OrthoDBiEOG091G0ZIY.
PhylomeDBiQ64433.
TreeFamiTF313814.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQAFRKFL PLFDRVLVER SAAETVTKGG IMLPEKSQGK VLQATVVAVG
60 70 80 90 100
SGGKGKSGEI EPVSVKVGDK VLLPEYGGTK VVLDDKDYFL FRDSDILGKY

VD
Length:102
Mass (Da):10,963
Last modified:January 23, 2007 - v2
Checksum:i08BEB5566DBE8A3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09659 mRNA. Translation: AAA62229.1.
AF251024 Genomic DNA. Translation: AAF67345.1.
AK088121 mRNA. Translation: BAC40159.1.
BC024385 mRNA. Translation: AAH24385.1.
CCDSiCCDS35570.1.
PIRiA55075.
RefSeqiNP_032329.1. NM_008303.4.
UniGeneiMm.215667.

Genome annotation databases

EnsembliENSMUST00000075242; ENSMUSP00000074724; ENSMUSG00000073676.
GeneIDi15528.
KEGGimmu:15528.
UCSCiuc007bac.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09659 mRNA. Translation: AAA62229.1.
AF251024 Genomic DNA. Translation: AAF67345.1.
AK088121 mRNA. Translation: BAC40159.1.
BC024385 mRNA. Translation: AAH24385.1.
CCDSiCCDS35570.1.
PIRiA55075.
RefSeqiNP_032329.1. NM_008303.4.
UniGeneiMm.215667.

3D structure databases

ProteinModelPortaliQ64433.
SMRiQ64433. Positions 3-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200459. 1 interaction.
IntActiQ64433. 2 interactions.
MINTiMINT-1839191.
STRINGi10090.ENSMUSP00000074724.

PTM databases

iPTMnetiQ64433.
PhosphoSiteiQ64433.

2D gel databases

REPRODUCTION-2DPAGEQ64433.

Proteomic databases

EPDiQ64433.
MaxQBiQ64433.
PaxDbiQ64433.
PRIDEiQ64433.
TopDownProteomicsiQ64433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075242; ENSMUSP00000074724; ENSMUSG00000073676.
GeneIDi15528.
KEGGimmu:15528.
UCSCiuc007bac.2. mouse.

Organism-specific databases

CTDi3336.
MGIiMGI:104680. Hspe1.

Phylogenomic databases

eggNOGiKOG1641. Eukaryota.
COG0234. LUCA.
GeneTreeiENSGT00390000006350.
HOGENOMiHOG000133897.
HOVERGENiHBG000385.
InParanoidiQ64433.
KOiK04078.
OMAiDTGKEKP.
OrthoDBiEOG091G0ZIY.
PhylomeDBiQ64433.
TreeFamiTF313814.

Miscellaneous databases

PROiQ64433.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073676.
CleanExiMM_HSPE1.
ExpressionAtlasiQ64433. baseline and differential.
GenevisibleiQ64433. MM.

Family and domain databases

CDDicd00320. cpn10. 1 hit.
Gene3Di2.30.33.40. 1 hit.
HAMAPiMF_00580. CH10. 1 hit.
InterProiIPR020818. Chaperonin_GroES.
IPR018369. Chaprnonin_Cpn10_CS.
IPR011032. GroES-like.
[Graphical view]
PfamiPF00166. Cpn10. 1 hit.
[Graphical view]
PRINTSiPR00297. CHAPERONIN10.
SMARTiSM00883. Cpn10. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00681. CHAPERONINS_CPN10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH10_MOUSE
AccessioniPrimary (citable) accession number: Q64433
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.