##gff-version 3 Q64430 UniProtKB Chain 1 1491 . . . ID=PRO_0000046312;Note=Copper-transporting ATPase 1 Q64430 UniProtKB Topological domain 1 644 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 645 666 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 667 705 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 706 725 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 726 732 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 733 753 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 754 772 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 773 793 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 794 926 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 927 950 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 951 980 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 981 1002 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 1003 1347 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 1348 1365 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 1366 1376 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Transmembrane 1377 1396 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Topological domain 1397 1491 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Domain 8 74 . . . Note=HMA 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Domain 85 151 . . . Note=HMA 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Domain 171 237 . . . Note=HMA 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Domain 277 343 . . . Note=HMA 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Domain 377 443 . . . Note=HMA 5;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Domain 479 545 . . . Note=HMA 6;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Domain 555 621 . . . Note=HMA 7;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Region 1477 1491 . . . Note=PDZD11-binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q64430 UniProtKB Motif 1458 1459 . . . Note=Endocytosis signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27337370;Dbxref=PMID:27337370 Q64430 UniProtKB Motif 1478 1479 . . . Note=Endocytosis signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27337370;Dbxref=PMID:27337370 Q64430 UniProtKB Active site 1035 1035 . . . Note=4-aspartylphosphate intermediate;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Binding site 18 18 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Binding site 19 19 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 22 22 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 182 182 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 185 185 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 288 288 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 291 291 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 388 388 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 391 391 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 490 490 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 493 493 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 566 566 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 569 569 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00280 Q64430 UniProtKB Binding site 1072 1072 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Binding site 1292 1292 . . . . Q64430 UniProtKB Binding site 1296 1296 . . . . Q64430 UniProtKB Modified residue 152 152 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 270 270 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 327 327 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 339 339 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 353 353 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70705 Q64430 UniProtKB Modified residue 357 357 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19144319,ECO:0007744|PubMed:21183079;Dbxref=PMID:19144319,PMID:21183079 Q64430 UniProtKB Modified residue 362 362 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q64430 UniProtKB Modified residue 1203 1203 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P70705 Q64430 UniProtKB Modified residue 1421 1421 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 1423 1423 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 1451 1451 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 1454 1454 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 1457 1457 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19144319;Dbxref=PMID:19144319 Q64430 UniProtKB Modified residue 1460 1460 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q04656 Q64430 UniProtKB Modified residue 1464 1464 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q64430 UniProtKB Modified residue 1467 1467 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q64430 UniProtKB Modified residue 1477 1477 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 Q64430 UniProtKB Glycosylation 677 677 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Glycosylation 966 966 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q64430 UniProtKB Natural variant 674 674 . . . Note=In MD. H->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9385451;Dbxref=PMID:9385451 Q64430 UniProtKB Natural variant 1381 1381 . . . Note=In MD. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9385451;Dbxref=PMID:9385451 Q64430 UniProtKB Mutagenesis 1443 1444 . . . Note=Impaired trafficking from endosome to TGN. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27337370;Dbxref=PMID:27337370 Q64430 UniProtKB Mutagenesis 1443 1444 . . . Note=Has no effect on trafficking from endosome to TGN. LL->VV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27337370;Dbxref=PMID:27337370 Q64430 UniProtKB Mutagenesis 1458 1459 . . . Note=Impaired trafficking from endosome to TGN. LL->AA%2CVV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27337370;Dbxref=PMID:27337370 Q64430 UniProtKB Mutagenesis 1478 1479 . . . Note=Impaired endocytosis associated with retention at the plasma membrane. LL->AA%2CVV;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:27337370;Dbxref=PMID:27337370 Q64430 UniProtKB Sequence conflict 44 44 . . . Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 103 103 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 172 172 . . . Note=M->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 245 246 . . . Note=LK->PI;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 445 445 . . . Note=P->PA;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 470 470 . . . Note=L->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 515 515 . . . Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 717 717 . . . Note=C->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 770 770 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 775 775 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 885 885 . . . Note=I->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 1169 1169 . . . Note=Y->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 1204 1204 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 1217 1217 . . . Note=I->M;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q64430 UniProtKB Sequence conflict 1253 1253 . . . Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305