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Q64430

- ATP7A_MOUSE

UniProt

Q64430 - ATP7A_MOUSE

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Protein

Copper-transporting ATPase 1

Gene

Atp7a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity).By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1035 – 103514-aspartylphosphate intermediateCurated
Metal bindingi1292 – 12921MagnesiumPROSITE-ProRule annotation
Metal bindingi1296 – 12961MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. copper-exporting ATPase activity Source: MGI
  3. copper ion binding Source: UniProtKB
  4. copper ion transmembrane transporter activity Source: MGI
  5. superoxide dismutase copper chaperone activity Source: MGI

GO - Biological processi

  1. ATP metabolic process Source: MGI
  2. blood vessel development Source: MGI
  3. blood vessel remodeling Source: MGI
  4. cartilage development Source: MGI
  5. catecholamine metabolic process Source: MGI
  6. cellular copper ion homeostasis Source: MGI
  7. central nervous system neuron development Source: MGI
  8. cerebellar Purkinje cell differentiation Source: MGI
  9. collagen fibril organization Source: MGI
  10. copper ion export Source: MGI
  11. copper ion import Source: MGI
  12. copper ion transport Source: UniProtKB
  13. dendrite morphogenesis Source: MGI
  14. detoxification of copper ion Source: MGI
  15. dopamine metabolic process Source: MGI
  16. elastic fiber assembly Source: MGI
  17. elastin biosynthetic process Source: MGI
  18. epinephrine metabolic process Source: MGI
  19. extracellular matrix organization Source: MGI
  20. hair follicle morphogenesis Source: MGI
  21. locomotory behavior Source: MGI
  22. lung alveolus development Source: MGI
  23. mitochondrion organization Source: MGI
  24. negative regulation of metalloenzyme activity Source: MGI
  25. negative regulation of neuron apoptotic process Source: MGI
  26. neuron projection morphogenesis Source: MGI
  27. norepinephrine biosynthetic process Source: MGI
  28. norepinephrine metabolic process Source: MGI
  29. peptidyl-lysine modification Source: MGI
  30. pigmentation Source: MGI
  31. positive regulation of catalytic activity Source: MGI
  32. positive regulation of metalloenzyme activity Source: MGI
  33. pyramidal neuron development Source: MGI
  34. regulation of gene expression Source: MGI
  35. regulation of oxidative phosphorylation Source: MGI
  36. release of cytochrome c from mitochondria Source: MGI
  37. removal of superoxide radicals Source: MGI
  38. serotonin metabolic process Source: MGI
  39. skin development Source: MGI
  40. T-helper cell differentiation Source: MGI
  41. tryptophan metabolic process Source: MGI
  42. tyrosine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.4. 3474.
ReactomeiREACT_250224. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-transporting ATPase 1 (EC:3.6.3.54)
Alternative name(s):
Copper pump 1
Menkes disease-associated protein homolog
Gene namesi
Name:Atp7a
Synonyms:Mnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:99400. Atp7a.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Constitutively cycles between the trans-Golgi network (TGN) and the plasma membrane. Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 644644CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei645 – 66622HelicalSequence AnalysisAdd
BLAST
Topological domaini667 – 70539ExtracellularSequence AnalysisAdd
BLAST
Transmembranei706 – 72520HelicalSequence AnalysisAdd
BLAST
Topological domaini726 – 7327CytoplasmicSequence Analysis
Transmembranei733 – 75321HelicalSequence AnalysisAdd
BLAST
Topological domaini754 – 77219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei773 – 79321HelicalSequence AnalysisAdd
BLAST
Topological domaini794 – 926133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei927 – 95024HelicalSequence AnalysisAdd
BLAST
Topological domaini951 – 98030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei981 – 100222HelicalSequence AnalysisAdd
BLAST
Topological domaini1003 – 1347345CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1348 – 136518HelicalSequence AnalysisAdd
BLAST
Topological domaini1366 – 137611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1377 – 139620HelicalSequence AnalysisAdd
BLAST
Topological domaini1397 – 149195CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: MGI
  2. Golgi apparatus Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. neuronal cell body Source: MGI
  6. neuron projection Source: MGI
  7. plasma membrane Source: MGI
  8. trans-Golgi network Source: MGI
  9. trans-Golgi network transport vesicle Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Atp7a are associated with mottled, an X-linked recessive condition characterized by mottled pigmentation of the coat, defects in connective tissue and neonatal or fetal death. It is due to a defect in absorption and transport of copper. The mottled mutants exhibit a diversity of phenotypes. Two of these mutants are called brindled and blotchy and their phenotypes resemble classical Menkes disease (MD) and occipital horn syndrome (OHS) in humans, respectively. Other mutants are called dappled, mosaic, tortoiseshell, pewter, etc.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14911491Copper-transporting ATPase 1PRO_0000046312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei339 – 3391PhosphoserineBy similarity
Modified residuei357 – 3571Phosphoserine1 Publication
Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence Analysis
Modified residuei1203 – 12031PhosphothreonineBy similarity
Modified residuei1457 – 14571Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ64430.
PaxDbiQ64430.
PRIDEiQ64430.

PTM databases

PhosphoSiteiQ64430.

Expressioni

Tissue specificityi

Found in most tissues except liver. In the kidney, it is detected in the proximal and distal tubules.

Developmental stagei

Widespread expressed throughout development.

Gene expression databases

BgeeiQ64430.
CleanExiMM_ATP7A.
ExpressionAtlasiQ64430. baseline and differential.
GenevestigatoriQ64430.

Interactioni

Subunit structurei

Monomer. Interacts with PDZD11 (By similarity).By similarity

Protein-protein interaction databases

BioGridi198268. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ64430.
SMRiQ64430. Positions 8-624, 704-1404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7567HMA 1PROSITE-ProRule annotationAdd
BLAST
Domaini172 – 23867HMA 2PROSITE-ProRule annotationAdd
BLAST
Domaini278 – 34467HMA 3PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 44467HMA 4PROSITE-ProRule annotationAdd
BLAST
Domaini480 – 54667HMA 5PROSITE-ProRule annotationAdd
BLAST
Domaini556 – 62267HMA 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1477 – 149115PDZD11-bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1478 – 14792Endocytosis signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi356 – 3627Poly-Ser

Domaini

The C-terminal di-leucine, 1478-Leu-Leu-1479, is an endocytic targeting signal which functions in retrieving recycling from the plasma membrane to the TGN. Mutation of the di-leucine signal results in the accumulation of the protein in the plasma membrane (By similarity).By similarity

Sequence similaritiesi

Contains 6 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2217.
GeneTreeiENSGT00530000063773.
HOGENOMiHOG000250397.
HOVERGENiHBG050616.
InParanoidiQ64430.
KOiK17686.
OrthoDBiEOG7C2R0G.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SUPFAMiSSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64430-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPSVDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATI
60 70 80 90 100
IYDPKLQTPK TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLTLPW
110 120 130 140 150
DHIQSTLLKT KGVTGVKISP QQRSAVVTII PSVVSASQIV ELVPDLSLDM
160 170 180 190 200
GTQEKKSGAC EEHSTPQAGE VMLKMKVEGM TCHSCTSTIE GKVGKLQGVQ
210 220 230 240 250
RIKVSLDNQE ATIVFQPHLI TAEEIKKQIE AVGFPAFIKK QPKYLKLGAI
260 270 280 290 300
DVERLKNTPV KSSEGSQQKS PSYPSDSTTM FTIEGMHCKS CVSNIESALS
310 320 330 340 350
TLQYVSSIVV SLENRSAIVK YNASLVTPEM LRKAIEAISP GQYRVSIASE
360 370 380 390 400
VESTASSPSS SSLQKMPLNI VSQPLTQEAV ININGMTCNS CVQSIEGVIS
410 420 430 440 450
KKPGVKSIHV SLANSTGTIE FDPLLTSPET LREAIEDMGF DAALPDMKEP
460 470 480 490 500
LVVIAQPSLE TPLLPSSNEL ENVMTSVQNK CYIQVSGMTC ASCVANIERN
510 520 530 540 550
LRREEGIYSV LVALMAGKAE VRYNPAVIQP RVIAEFIREL GFGAMVMENA
560 570 580 590 600
GEGNGILELV VRGMTCASCV HKIESTLTKH KGIFYCSVAL ATNKAHIKYD
610 620 630 640 650
PEIIGPRDII HTIGSLGFEA SLVKKDRSAN HLDHKREIKQ WRGSFLVSLF
660 670 680 690 700
FCIPVMGLMV YMMVMDHHLA TLHHNQNMSN EEMINMHSAM FLERQILPGL
710 720 730 740 750
SIMNLLSLLL CLPVQFCGGW YFYIQAYKAL KHKTANMDVL IVLATTIAFA
760 770 780 790 800
YSLVILLVAM FERAKVNPIT FFDTPPMLFV FIALGRWLEH IAKGKTSEAL
810 820 830 840 850
AKLISLQATE ATIVTLNSEN LLLSEEQVDV ELVQRGDIIK VVPGGKFPVD
860 870 880 890 900
GRVIEGHSMV DESLITGEAM PVAKKPGSTV IAGSINQNGS LLIRATHVGA
910 920 930 940 950
DTTLSQIVKL VEEAQTSKAP IQQFADKLSG YFVPFIVLVS IVTLLVWIII
960 970 980 990 1000
GFQNFEIVET YFPGYNRSIS RTETIIRFAF QASITVLCIA CPCSLGLATP
1010 1020 1030 1040 1050
TAVMVGTGVG AQNGILIKGG EPLEMAHKVK VVVFDKTGTI THGTPVVNQV
1060 1070 1080 1090 1100
KVLVESNKIS RNKILAIVGT AESNSEHPLG AAVTKYCKKE LDTETLGTCT
1110 1120 1130 1140 1150
DFQVVPGCGI SCKVTNIEGL LHKSNLKIEE NNIKNASLVQ IDAINEQSST
1160 1170 1180 1190 1200
SSSMIIDAHL SNAVNTQQYK VLIGNREWMI RNGLVISNDV DESMIEHERR
1210 1220 1230 1240 1250
GRTAVLVTID DELCGLIAIA DTVKPEAELA VHILKSMGLE VVLMTGDNSK
1260 1270 1280 1290 1300
TARSIASQVG ITKVFAEVLP SHKVAKVKQL QEEGKRVAMV GDGINDSPAL
1310 1320 1330 1340 1350
AMANVGIAIG TGTDVAIEAA DVVLIRNDLL DVVASIDLSR KTVKRIRINF
1360 1370 1380 1390 1400
VFALIYNLVG IPIAAGVFLP IGLVLQPWMG SAAMAASSVS VVLSSLFLKL
1410 1420 1430 1440 1450
YRKPTYDNYE LHPRSHTGQR SPSEISVHVG IDDTSRNSPR LGLLDRIVNY
1460 1470 1480 1490
SRASINSLLS DKRSLNSVVT SEPDKHSLLV GDFREDDDTT L
Length:1,491
Mass (Da):161,959
Last modified:July 27, 2011 - v3
Checksum:i2FADCC6806994CA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441E → D in AAA57445. (PubMed:8054976)Curated
Sequence conflicti44 – 441E → D in AAB37301. (PubMed:9215672)Curated
Sequence conflicti103 – 1031I → V in AAA57445. (PubMed:8054976)Curated
Sequence conflicti103 – 1031I → V in AAB37301. (PubMed:9215672)Curated
Sequence conflicti172 – 1721M → R in AAA57445. (PubMed:8054976)Curated
Sequence conflicti172 – 1721M → R in AAB37301. (PubMed:9215672)Curated
Sequence conflicti245 – 2462LK → PI in AAB08487. (PubMed:8054977)Curated
Sequence conflicti445 – 4451P → PA in AAB08487. (PubMed:8054977)Curated
Sequence conflicti445 – 4451P → PA in AAB37301. (PubMed:9215672)Curated
Sequence conflicti470 – 4701L → P in AAB08487. (PubMed:8054977)Curated
Sequence conflicti470 – 4701L → P in BAA22369. (PubMed:9385451)Curated
Sequence conflicti470 – 4701L → P in AAB37301. (PubMed:9215672)Curated
Sequence conflicti515 – 5151M → T in AAA57445. (PubMed:8054976)Curated
Sequence conflicti515 – 5151M → T in AAB37301. (PubMed:9215672)Curated
Sequence conflicti717 – 7171C → F in AAB08487. (PubMed:8054977)Curated
Sequence conflicti770 – 7701T → A in AAB08487. (PubMed:8054977)Curated
Sequence conflicti775 – 7751P → S in AAB08487. (PubMed:8054977)Curated
Sequence conflicti885 – 8851I → T in AAB08487. (PubMed:8054977)Curated
Sequence conflicti1169 – 11691Y → H in AAB08487. (PubMed:8054977)Curated
Sequence conflicti1204 – 12041A → P in AAB08487. (PubMed:8054977)Curated
Sequence conflicti1204 – 12041A → P in AAB37301. (PubMed:9215672)Curated
Sequence conflicti1217 – 12171I → M in AAA57445. (PubMed:8054976)Curated
Sequence conflicti1253 – 12531R → Q in AAA57445. (PubMed:8054976)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti674 – 6741H → R in MD. 1 Publication
Natural varianti1381 – 13811S → P in MD. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03434 mRNA. Translation: AAA57445.1.
U03736 mRNA. Translation: AAB08487.1.
AB007134 mRNA. Translation: BAA22369.1.
U71091 mRNA. Translation: AAB37301.1.
AL672288 Genomic DNA. Translation: CAM16891.1.
CCDSiCCDS41097.1.
PIRiS43793.
RefSeqiNP_033856.3. NM_009726.5.
UniGeneiMm.254297.

Genome annotation databases

EnsembliENSMUST00000113557; ENSMUSP00000109186; ENSMUSG00000033792.
GeneIDi11977.
KEGGimmu:11977.
UCSCiuc012hnn.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

Heavy metal - Issue 79 of February 2007

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03434 mRNA. Translation: AAA57445.1 .
U03736 mRNA. Translation: AAB08487.1 .
AB007134 mRNA. Translation: BAA22369.1 .
U71091 mRNA. Translation: AAB37301.1 .
AL672288 Genomic DNA. Translation: CAM16891.1 .
CCDSi CCDS41097.1.
PIRi S43793.
RefSeqi NP_033856.3. NM_009726.5.
UniGenei Mm.254297.

3D structure databases

ProteinModelPortali Q64430.
SMRi Q64430. Positions 8-624, 704-1404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198268. 1 interaction.

PTM databases

PhosphoSitei Q64430.

Proteomic databases

MaxQBi Q64430.
PaxDbi Q64430.
PRIDEi Q64430.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113557 ; ENSMUSP00000109186 ; ENSMUSG00000033792 .
GeneIDi 11977.
KEGGi mmu:11977.
UCSCi uc012hnn.1. mouse.

Organism-specific databases

CTDi 538.
MGIi MGI:99400. Atp7a.

Phylogenomic databases

eggNOGi COG2217.
GeneTreei ENSGT00530000063773.
HOGENOMi HOG000250397.
HOVERGENi HBG050616.
InParanoidi Q64430.
KOi K17686.
OrthoDBi EOG7C2R0G.

Enzyme and pathway databases

BRENDAi 3.6.3.4. 3474.
Reactomei REACT_250224. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSi Atp7a. mouse.
NextBioi 280111.
PROi Q64430.
SOURCEi Search...

Gene expression databases

Bgeei Q64430.
CleanExi MM_ATP7A.
ExpressionAtlasi Q64430. baseline and differential.
Genevestigatori Q64430.

Family and domain databases

Gene3Di 2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProi IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view ]
Pfami PF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SUPFAMi SSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsi TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mottled gene is the mouse homologue of the Menkes disease gene."
    Levinson B., Vulpe C., Elder B., Martin C., Verley F., Packman S., Gitschier J.
    Nat. Genet. 6:369-373(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice."
    Mercer J.F.B., Grimes A., Ambrosini L., Lockhart P., Paynter J.A., Dierick H., Glover T.W.
    Nat. Genet. 6:374-378(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c, DL and ICR X Swiss Webster.
    Tissue: Embryo and Kidney.
  3. "Occurrence of two missense mutations in Cu-ATPase of the macular mouse, a Menkes disease model."
    Ohta Y., Shiraishi N., Nishikimi M.
    Biochem. Mol. Biol. Int. 43:913-918(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ARG-674 AND PRO-1381.
    Strain: C3H.
    Tissue: Placenta.
  4. "Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease."
    Grimes A., Hearn C.J., Lockhart P., Newgreen D.F., Mercer J.F.B.
    Hum. Mol. Genet. 6:1037-1042(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA X C3H.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-357 AND SER-1457, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATP7A_MOUSE
AccessioniPrimary (citable) accession number: Q64430
Secondary accession number(s): A2AG69
, O35101, P97422, Q64431
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3