Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q64420 (ACOD_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-CoA desaturase

EC=1.14.19.1
Alternative name(s):
Delta(9)-desaturase
Short name=Delta-9 desaturase
Fatty acid desaturase
Stearoyl-CoA desaturase
Gene names
Name:SCD
Synonyms:FAR-17c
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA By similarity.

Catalytic activity

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

Cofactor

Iron.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.

Domain

The histidine box domains may contain the active site and/or be involved in metal ion binding.

Sequence similarities

Belongs to the fatty acid desaturase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Acyl-CoA desaturase
PRO_0000185396

Regions

Topological domain1 – 6666Cytoplasmic Potential
Transmembrane67 – 8822Helical; Potential
Topological domain89 – 979Lumenal Potential
Transmembrane98 – 11417Helical; Potential
Topological domain115 – 21197Cytoplasmic Potential
Transmembrane212 – 23019Helical; Potential
Topological domain231 – 24515Lumenal Potential
Transmembrane246 – 26823Helical; Potential
Topological domain269 – 35486Cytoplasmic Potential
Motif115 – 1206Histidine box-1
Motif152 – 1565Histidine box-2
Motif293 – 2975Histidine box-3

Amino acid modifications

Modified residue1981Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64420 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B41A0831845EB874

FASTA35440,968
        10         20         30         40         50         60 
MPGHLLQEEM TSSYTTTTTT ITEPPSESLQ KTVPLYLEED IRPEMKEDIY DPSYQDEEGP 

        70         80         90        100        110        120 
PPKLEYVWRN IILMALLHLG ALYGLVLVPS SKVYTLLWAF VYYVISIEGI GAGVHRLWSH 

       130        140        150        160        170        180 
RTYKARLPLR IFLIIANTMA FQNDVYEWAR DHRAHHKFSE TYADPHDSRR GFFFSHVGWL 

       190        200        210        220        230        240 
LVRKHPAVKE KGGKLDMSDL KAEKLVMFQR RYYKPAILLM CFILPTFVPW YFWGEAFVNS 

       250        260        270        280        290        300 
LCVSTFLRYT LVLNATWLVN SAAHLYGYRP YDKNIDPREN ALVSLGCLGE GFHNYHHAFP 

       310        320        330        340        350 
YDYSASEYRW HINFTTFFID CMAALGLAYD RKKVSKAAVL ARIKRTGDGS CKSG 

« Hide

References

[1]"Sequence analysis and characterization of FAR-17c, an androgen-dependent gene in the flank organs of hamsters."
Ideta R., Seki T., Adachi K.
J. Dermatol. Sci. 9:94-102(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L26956 mRNA. Translation: AAC42058.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG003367.

Family and domain databases

InterProIPR005804. Fatty_acid_desaturase-1.
IPR001522. Fatty_acid_desaturase-1_C.
IPR015876. Fatty_acid_desaturase-1_core.
[Graphical view]
PfamPF00487. FA_desaturase. 1 hit.
[Graphical view]
PRINTSPR00075. FACDDSATRASE.
PROSITEPS00476. FATTY_ACID_DESATUR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACOD_MESAU
AccessionPrimary (citable) accession number: Q64420
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families