Reviewed, UniProtKB/Swiss-Prot Q64420 (ACOD_MESAU)

Names and origin

Protein names

Recommended name:
    Acyl-CoA desaturase
    EC=1.14.19.1
Alternative name(s):
    Stearoyl-CoA desaturase
    Fatty acid desaturase
    Delta(9)-desaturase

Gene names

Name:	SCD
Synonyms:	FAR-17c

Organism

Mesocricetus auratus (Golden hamster)

Taxonomic identifier

10036 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA By similarity.
Catalytic activity	Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.
Cofactor	Iron.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.
Domain	The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence similarities	Belongs to the fatty acid desaturase family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	Iron
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW stearoyl-CoA 9-desaturase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Acyl-CoA desaturase		PRO_0000185396
Regions
	Transmembrane	71 – 91	21	Potential
	Transmembrane	93 – 113	21	Potential
	Transmembrane	218 – 238	21	Potential
	Transmembrane	310 – 330	21	Potential
	Motif	115 – 120	6	Histidine box-1
	Motif	152 – 156	5	Histidine box-2
	Motif	293 – 297	5	Histidine box-3
Amino acid modifications
	Modified residue	198	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64420-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B41A0831845EB874	FASTA	354	40,968
	10 20 30 40 50 60 MPGHLLQEEM TSSYTTTTTT ITEPPSESLQ KTVPLYLEED IRPEMKEDIY DPSYQDEEGP 70 80 90 100 110 120 PPKLEYVWRN IILMALLHLG ALYGLVLVPS SKVYTLLWAF VYYVISIEGI GAGVHRLWSH 130 140 150 160 170 180 RTYKARLPLR IFLIIANTMA FQNDVYEWAR DHRAHHKFSE TYADPHDSRR GFFFSHVGWL 190 200 210 220 230 240 LVRKHPAVKE KGGKLDMSDL KAEKLVMFQR RYYKPAILLM CFILPTFVPW YFWGEAFVNS 250 260 270 280 290 300 LCVSTFLRYT LVLNATWLVN SAAHLYGYRP YDKNIDPREN ALVSLGCLGE GFHNYHHAFP 310 320 330 340 350 YDYSASEYRW HINFTTFFID CMAALGLAYD RKKVSKAAVL ARIKRTGDGS CKSG

References

[1]	"Sequence analysis and characterization of FAR-17c, an androgen-dependent gene in the flank organs of hamsters." Ideta R., Seki T., Adachi K. J. Dermatol. Sci. 9:94-102(1995) [PubMed: 7772580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	L26956 mRNA. Translation: AAC42058.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q64420.
Enzyme and pathway databases
BRENDA	1.14.19.1. 824.
Family and domain databases
InterPro	IPR005804. Fatty_acid_desaturase-1. IPR001522. Fatty_acid_desaturase-1_C. IPR015876. Fatty_acid_desaturase-1_core. [Graphical view]
Pfam	PF00487. FA_desaturase. 1 hit. [Graphical view]
PRINTS	PR00075. FACDDSATRASE.
ProDom	PD002221. Desaturase. 1 hit. PD001081. FA_desat_sub. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00476. FATTY_ACID_DESATUR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACOD_MESAU

Accession

Primary (citable) accession number: Q64420

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)