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Protein

Liver carboxylesterase

Gene
N/A
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei227Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei345Charge relay systemBy similarity1
Active sitei459Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Protein family/group databases

ESTHERimesau-cxest. Carb_B_Chordata.
MEROPSiS09.956.

Names & Taxonomyi

Protein namesi
Recommended name:
Liver carboxylesterase (EC:3.1.1.1)
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000000857328 – 561Liver carboxylesteraseAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi95 ↔ 122By similarity
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi280 ↔ 291By similarity
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ64419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi558 – 561Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLNRFPCWR YAVACGLLLL LVHVHGQDSV SPIRNTHTGQ VRGKLVYVKE
60 70 80 90 100
GVTGVYAFLG IPFAKPPVGP LRFAPPEPPE PWSGVRDGTS EPAMCLQTDF
110 120 130 140 150
MRPQISKERK IILPTISMSE DCLYLNIYTP AHAHEGSNLP VMVWIHGGAL
160 170 180 190 200
VMGMASMNDG SLLAATEDIV IVSIQYRLGI LGFFSTGDEH ARGNWGYLDQ
210 220 230 240 250
VAALHWVQQN IASFGGNPGQ VTIFGVSAGG TSVSSLVVSP MSKGLFHGAI
260 270 280 290 300
MQSGVALLPD LISDTPEAVY TPVVANQSGC EAKDSEALVH CLREKTEAEI
310 320 330 340 350
LAINQVFIMT PGVVDGIFLP RHPQELLASV DFHPVPSIIG VDSDECGWGV
360 370 380 390 400
PLFMGLDHVI KNITRETLPA FLKSRAEHMM LPPECSDLLM QEYMGDVEDP
410 420 430 440 450
QTLQAQFREL MKDFMFVIPA LKVAYFQRSH APVYFYEFQH QSSFIKNKDA
460 470 480 490 500
RPSHVRADHG DHVAFVFGSD FWGLKIDLTE EEKLLNKRMM KYWANFARHG
510 520 530 540 550
NPNSEGLPYW PELVHDDQYL KLDIQPAVGR ALKSRKLHFW TKILPQKIQE
560
LKGAQGKHSE L
Length:561
Mass (Da):62,331
Last modified:November 1, 1996 - v1
Checksum:i48EA11E422475321
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28566 mRNA. Translation: BAA05913.1.
PIRiS47655.
RefSeqiNP_001297488.1. NM_001310559.1.

Genome annotation databases

GeneIDi106022736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28566 mRNA. Translation: BAA05913.1.
PIRiS47655.
RefSeqiNP_001297488.1. NM_001310559.1.

3D structure databases

ProteinModelPortaliQ64419.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimesau-cxest. Carb_B_Chordata.
MEROPSiS09.956.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106022736.

Phylogenomic databases

HOVERGENiHBG008839.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEST1_MESAU
AccessioniPrimary (citable) accession number: Q64419
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.