Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q64417 (CP3AE_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A14

EC=1.14.14.1
Alternative name(s):
CYPIIIA14
Gene names
Name:CYP3A14
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A14
PRO_0000051797

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Experimental info

Sequence conflict1211S → P in BAA03865. Ref.1
Sequence conflict4521L → I in BAA03865. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q64417 [UniParc].

Last modified July 15, 1999. Version 2.
Checksum: 2348B0B3013FD2DD

FASTA50358,118
        10         20         30         40         50         60 
MDLVPSFSLE TWVLLALSLV LLYRYATYSH GFFKKLGIPG PKPLPLFGNV LSYRKGMWSF 

        70         80         90        100        110        120 
DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS VFTNRRSLVP VGFMKKAVSL 

       130        140        150        160        170        180 
SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK QYGDVLVKNL RQEAEKGKPV QLKEIFGAYS 

       190        200        210        220        230        240 
MDIIVATAFG VNVDSLNNPH DPFVSKARKL FRFDFLSPFL LSIVMFPFLT QLYEMLSISI 

       250        260        270        280        290        300 
FPRDSLKFFT KFVKKTKENH LESNKKQRVD FLQMMLNSQN FKDTESHKAL SDVEILAQSI 

       310        320        330        340        350        360 
IFIFAGYETT SSTLSFIMYS LATHPDVQKK LQQEIDKTLP NKAFPTYDVM MEMEYLDMVV 

       370        380        390        400        410        420 
NETLRLYPVT NRIERMSKKD FEINGMSFPK GTGVMIPSFA LHRDSKYWPE PDEFRPERFS 

       430        440        450        460        470        480 
KKNKENIDPY IYMPFGNGPR NCIGMRMALM NLKLALIRLL QNFSFYPCKE TQIPLRLGSE 

       490        500 
ALLQPAKPII LKVVSRDETI RGA 

« Hide

References

[1]"cDNA and deduced amino acid sequence of a novel cytochrome P450 from male guinea pig liver mRNA with high homology to CYP3A family."
Mori T., Itoh S., Kamataki T.
Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Liver.
[2]"Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16363 mRNA. Translation: BAA03865.1.
D49731 mRNA. Translation: BAA08568.1.
RefSeqNP_001166587.1. NM_001173116.1.

3D structure databases

ProteinModelPortalQ64417.
SMRQ64417. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ64417.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100379244.

Organism-specific databases

CTD100379244.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidQ64417.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AE_CAVPO
AccessionPrimary (citable) accession number: Q64417
Secondary accession number(s): Q64407
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: December 11, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families