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Q64417

- CP3AE_CAVPO

UniProt

Q64417 - CP3AE_CAVPO

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Protein

Cytochrome P450 3A14

Gene

CYP3A14

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A14 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA14
Gene namesi
Name:CYP3A14
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A14PRO_0000051797Add
BLAST

Proteomic databases

PRIDEiQ64417.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Structurei

3D structure databases

ProteinModelPortaliQ64417.
SMRiQ64417. Positions 30-496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64417.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64417-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLVPSFSLE TWVLLALSLV LLYRYATYSH GFFKKLGIPG PKPLPLFGNV
60 70 80 90 100
LSYRKGMWSF DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS
110 120 130 140 150
VFTNRRSLVP VGFMKKAVSL SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK
160 170 180 190 200
QYGDVLVKNL RQEAEKGKPV QLKEIFGAYS MDIIVATAFG VNVDSLNNPH
210 220 230 240 250
DPFVSKARKL FRFDFLSPFL LSIVMFPFLT QLYEMLSISI FPRDSLKFFT
260 270 280 290 300
KFVKKTKENH LESNKKQRVD FLQMMLNSQN FKDTESHKAL SDVEILAQSI
310 320 330 340 350
IFIFAGYETT SSTLSFIMYS LATHPDVQKK LQQEIDKTLP NKAFPTYDVM
360 370 380 390 400
MEMEYLDMVV NETLRLYPVT NRIERMSKKD FEINGMSFPK GTGVMIPSFA
410 420 430 440 450
LHRDSKYWPE PDEFRPERFS KKNKENIDPY IYMPFGNGPR NCIGMRMALM
460 470 480 490 500
NLKLALIRLL QNFSFYPCKE TQIPLRLGSE ALLQPAKPII LKVVSRDETI

RGA
Length:503
Mass (Da):58,118
Last modified:July 15, 1999 - v2
Checksum:i2348B0B3013FD2DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211S → P in BAA03865. 1 PublicationCurated
Sequence conflicti452 – 4521L → I in BAA03865. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16363 mRNA. Translation: BAA03865.1.
D49731 mRNA. Translation: BAA08568.1.
RefSeqiNP_001166587.1. NM_001173116.1.

Genome annotation databases

GeneIDi100379244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16363 mRNA. Translation: BAA03865.1 .
D49731 mRNA. Translation: BAA08568.1 .
RefSeqi NP_001166587.1. NM_001173116.1.

3D structure databases

ProteinModelPortali Q64417.
SMRi Q64417. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q64417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100379244.

Organism-specific databases

CTDi 100379244.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi Q64417.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and deduced amino acid sequence of a novel cytochrome P450 from male guinea pig liver mRNA with high homology to CYP3A family."
    Mori T., Itoh S., Kamataki T.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Liver.
  2. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
    Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
    Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AE_CAVPO
AccessioniPrimary (citable) accession number: Q64417
Secondary accession number(s): Q64407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 15, 1999
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3