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Q64417

- CP3AE_CAVPO

UniProt

Q64417 - CP3AE_CAVPO

Protein

Cytochrome P450 3A14

Gene

CYP3A14

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (15 Jul 1999)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A14 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA14
    Gene namesi
    Name:CYP3A14
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A14PRO_0000051797Add
    BLAST

    Proteomic databases

    PRIDEiQ64417.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64417.
    SMRiQ64417. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiQ64417.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64417-1 [UniParc]FASTAAdd to Basket

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    MDLVPSFSLE TWVLLALSLV LLYRYATYSH GFFKKLGIPG PKPLPLFGNV    50
    LSYRKGMWSF DIECRKKYGN MWGLYDGPQP VLAITEPDMI KAVLVKECYS 100
    VFTNRRSLVP VGFMKKAVSL SEDEEWKRIR TQLSPNFTSG KLKEMFPIIK 150
    QYGDVLVKNL RQEAEKGKPV QLKEIFGAYS MDIIVATAFG VNVDSLNNPH 200
    DPFVSKARKL FRFDFLSPFL LSIVMFPFLT QLYEMLSISI FPRDSLKFFT 250
    KFVKKTKENH LESNKKQRVD FLQMMLNSQN FKDTESHKAL SDVEILAQSI 300
    IFIFAGYETT SSTLSFIMYS LATHPDVQKK LQQEIDKTLP NKAFPTYDVM 350
    MEMEYLDMVV NETLRLYPVT NRIERMSKKD FEINGMSFPK GTGVMIPSFA 400
    LHRDSKYWPE PDEFRPERFS KKNKENIDPY IYMPFGNGPR NCIGMRMALM 450
    NLKLALIRLL QNFSFYPCKE TQIPLRLGSE ALLQPAKPII LKVVSRDETI 500
    RGA 503
    Length:503
    Mass (Da):58,118
    Last modified:July 15, 1999 - v2
    Checksum:i2348B0B3013FD2DD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211S → P in BAA03865. 1 PublicationCurated
    Sequence conflicti452 – 4521L → I in BAA03865. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16363 mRNA. Translation: BAA03865.1.
    D49731 mRNA. Translation: BAA08568.1.
    RefSeqiNP_001166587.1. NM_001173116.1.

    Genome annotation databases

    GeneIDi100379244.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16363 mRNA. Translation: BAA03865.1 .
    D49731 mRNA. Translation: BAA08568.1 .
    RefSeqi NP_001166587.1. NM_001173116.1.

    3D structure databases

    ProteinModelPortali Q64417.
    SMRi Q64417. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q64417.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100379244.

    Organism-specific databases

    CTDi 100379244.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi Q64417.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequence of a novel cytochrome P450 from male guinea pig liver mRNA with high homology to CYP3A family."
      Mori T., Itoh S., Kamataki T.
      Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.
    2. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
      Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
      Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AE_CAVPO
    AccessioniPrimary (citable) accession number: Q64417
    Secondary accession number(s): Q64407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 15, 1999
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3