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Reviewed, UniProtKB/Swiss-Prot Q64415 (ADH1_GEOKN)

Last modified November 25, 2008. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase A subunit
Gene names
Name: ADH1
OrganismGeomys knoxjonesi (Knox Jones's pocket gopher)
Taxonomic identifier27683 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Geomyidae › Geomys

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Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

An alcohol + NAD(+) = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

CytoplasmBy similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

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Ontologies

Keywords

   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 375374Alcohol dehydrogenase 1
PRO_0000160655

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding681Zinc 1; catalytic By similarity
Metal binding981Zinc 2 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1041Zinc 2 By similarity
Metal binding1121Zinc 2 By similarity
Metal binding1751Zinc 1; catalytic By similarity

Natural variations

Natural variant301V → A

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Sequences

Sequence LengthMass (Da)Tools
Q64415-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: EC882C191A9413C2

FASTA37539,943
        10         20         30         40         50         60 
MSTAGKVIKC RAAVLWEKNK PFSIEEVEVV PPKAYEVRIK IVATGICRSD DHVVNGSIIT 

        70         80         90        100        110        120 
PLPAILGHEA GGIVESIGEG VTTVKPGDKV IPLFVPQCGK CRACKHPESN LCTHGDLGRA 

       130        140        150        160        170        180 
QGTLMDGTSR FTCKGKPIHH FLGVTTFSEY TVVSEISVTK IDAASPLEKV CLIGCGFSTG 

       190        200        210        220        230        240 
YGSAVKVGKV ARGSICSCVW SGRVGLSAII GCKAAGAARI IAVDINKDKF AKAKELGATE 

       250        260        270        280        290        300 
CVNPQDYDKP IYQVLQEMTD GGVDFSFEVI GRLDTMVSAL MCCQESHGVS VIVGVPPNAQ 

       310        320        330        340        350        360 
SLTMDPMVLL SGRSWKGAVF GGYKGKDDVP KLVADFMAKK FPLEPLITNV FPFAKINEGF 

       370 
DLLRAGKSIR TVLTF

« Hide

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References

[1]"Origin of a novel allele in a mammalian hybrid zone."
Bradley R.D., Bull J.J., Johnson A.D., Hillis D.M.
Proc. Natl. Acad. Sci. U.S.A. 90:8939-8941(1993) [PubMed: 8415634] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-30.
Strain: Isolate TK 30715.
Tissue: Liver.

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Cross-references

Sequence databases

L15461 mRNA. Translation: AAA03600.1.
L15462 mRNA. Translation: AAA03599.1.
PIRI60973.

3D structure databases

HSSPHSSP built from PDB template 1HEU based on UniProtKB P00327.
SMRQ64415. Positions 2-375.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ64415.

Family and domain databases

InterProIPR013154. AlcDHase_GroES-like.
IPR002085. AlcDHase_SF_Zn.
IPR013149. AlcDHase_Zn-bd.
IPR002328. AlcDHase_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADH1_GEOKN
AccessionPrimary (citable) accession number: Q64415
Secondary accession number(s): Q64416
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents