Reviewed, UniProtKB/Swiss-Prot Q64413 (ADH1_GEOBU)

Names and origin

Protein names

Recommended name:
    Alcohol dehydrogenase 1
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase A subunit

Gene names

Name:

ADH1

Organism

Geomys bursarius (Plains pocket gopher)

Taxonomic identifier

27682 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Geomyidae › Geomys

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 375	374	Alcohol dehydrogenase 1		PRO_0000160654
Sites
	Metal binding	47	1	Zinc 1; catalytic By similarity
	Metal binding	68	1	Zinc 1; catalytic By similarity
	Metal binding	98	1	Zinc 2 By similarity
	Metal binding	101	1	Zinc 2 By similarity
	Metal binding	104	1	Zinc 2 By similarity
	Metal binding	112	1	Zinc 2 By similarity
	Metal binding	175	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q64413-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: AB06F3F93C8A445B	FASTA	375	39,972
	10 20 30 40 50 60 MSTAGKVIKC RAAVLWEKNK PFSIEEVEVA PPKAYEVRIK IVATGICRSD DHVVNGSIIT 70 80 90 100 110 120 PLPAILGHEA GGIVESIGEG VTTVKPGDKV IPLFVPQCGK CRACKHPESN LCKHGDLGRA 130 140 150 160 170 180 QGTLMDGTSR FTCKGKPIHH FLGVTTFSEY TVVSEISVTK IDATSPLEKV CLIGCGFSTG 190 200 210 220 230 240 YGSAVKVGKV ARGSICSCVW SGRVGLSAII GCKAAGAARI IAVDINKDKF AKAKELGATE 250 260 270 280 290 300 CVNPQDYDKP IYQVLQEMTD GGVDFSFEVI GRLDTMVSAL MCCQESHGVS VIVGVPPNAQ 310 320 330 340 350 360 SLTMDPMVLL SGRSWKGAVF GGYKGKDDVP KLVADFMAKK FPLEPLITNV FPFAKINEGF 370 DLLRAGKSIR TVLTF

References

[1]	"Origin of a novel allele in a mammalian hybrid zone." Bradley R.D., Bull J.J., Johnson A.D., Hillis D.M. Proc. Natl. Acad. Sci. U.S.A. 90:8939-8941(1993) [PubMed: 8415634] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Isolate TK 30723. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L15466 mRNA. Translation: AAA03598.1.
3D structure databases
HSSP	HSSP built from PDB template 1HEU based on UniProtKB P00327.
SMR	Q64413. Positions 2-375.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q64413.
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_GEOBU

Accession

Primary (citable) accession number: Q64413

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 51 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)