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Protein

Gastricsin

Gene

PGC

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes a variety of proteins.

Catalytic activityi

More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97PROSITE-ProRule annotation1
Active sitei283PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
Biological processDigestion

Protein family/group databases

MEROPSiA01.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastricsin (EC:3.4.23.3)
Alternative name(s):
Pepsinogen C
Gene namesi
Name:PGC
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000002605417 – 65Activation peptideAdd BLAST49
ChainiPRO_000002605566 – 394GastricsinAdd BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 115By similarity
Disulfide bondi273 ↔ 277By similarity
Disulfide bondi316 ↔ 349By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Expressioni

Gene expression databases

BgeeiENSCPOG00000007183.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000006477.

Structurei

3D structure databases

ProteinModelPortaliQ64411.
SMRiQ64411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 391Peptidase A1PROSITE-ProRule annotationAdd BLAST313

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ64411.
OMAiHARFNPS.
OrthoDBiEOG091G0JP7.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033735. Gastricsin.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF471. PTHR13683:SF471. 1 hit.
PfamiView protein in Pfam
PF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q64411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWMVVVLLC LPLLEATQIK VPLKKIKSIR EVLREKGLLG DFLKNHKPQH
60 70 80 90 100
ARKFFRNRLA KTGDFSVLYE PMSYMDAAYF GQISLGTPPQ SFQVLFDTGS
110 120 130 140 150
SNLWVPSVYC SSLACTTHTR FNPRDSSTYV ATDQSFSLEY GTGSLTGVFG
160 170 180 190 200
YDTMTIQDIQ VPKQEFGLSE TEPGSDFVYA EFDGILGLGY PGLSEGGATT
210 220 230 240 250
AMQGLLREGA LSQSLFSVYL GSQQGSDEGQ LILGGVDESL YTGDIYWTPV
260 270 280 290 300
TQELYWQIGI EGFLIDGSAS GWCSRGCQGI VDTGTSLLTV PSDYLSTLVQ
310 320 330 340 350
AIGAEENEYG EYFVSCSSIQ DLPTLTFVIS GVEFPLSPSA YILSGENYCM
360 370 380 390
VGLESTYVSP GGGEPVWILG DVFLRSYYSV YDLANNRVGF ATAA
Length:394
Mass (Da):42,996
Last modified:November 1, 1996 - v1
Checksum:i114F08E105D49865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88652 mRNA. Translation: AAA37053.1.
PIRiB43356.
RefSeqiNP_001166470.1. NM_001172999.1.

Genome annotation databases

EnsembliENSCPOT00000007255; ENSCPOP00000006477; ENSCPOG00000007183.
GeneIDi100135598.

Similar proteinsi

Entry informationi

Entry nameiPEPC_CAVPO
AccessioniPrimary (citable) accession number: Q64411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families