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Q64410

- CP17A_CAVPO

UniProt

Q64410 - CP17A_CAVPO

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene
CYP17A1, CYP17
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

Heme group By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB

GO - Biological processi

  1. glucocorticoid biosynthetic process Source: Ensembl
  2. hormone biosynthetic process Source: UniProtKB
  3. progesterone metabolic process Source: UniProtKB
  4. steroid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.9. 1225.
UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Membrane Reviewed prediction

GO - Cellular componenti

  1. axon Source: Ensembl
  2. membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: Ensembl
  4. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051928Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000013107.

Structurei

3D structure databases

ProteinModelPortaliQ64410.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00750000117317.
HOGENOMiHOG000036991.
HOVERGENiHBG106944.
InParanoidiQ64410.
OrthoDBiEOG7RBZ85.
TreeFamiTF105095.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64410-1 [UniParc]FASTAAdd to Basket

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MWELVTLLGL ILAYLFWPRQ GSSGTKYPKS LPSLPVVGSL PFLPKSGHMH    50
VNFFKLQKKY GPIYSFRLGS TTTVVIGHHQ LARELLIKKG KEFSGRPLTT 100
TVALLSDNGK GIAFADSSAT WQLHRRLVLS SFSLFRDGEQ KLENIICQEL 150
SALCDFLATC DGQVKDLSSS IFMTVVNIIC MICFSVSYKE GDMELVTIRR 200
FTTGFVNSLS DDNLVDIFPW LKIFPNKTLE MIRKYTEIRG AMLSKILKEC 250
KEKFRSDSVS NLIDLLIQAK VNENNNNSSL DQDSNLFSDK HILTTLGDIF 300
GAGVETSSSV VLWVIAFLLH NPQVKKKIQE EIDHNVGFSR TPTFSDRNHL 350
LMLEATIREV LRIRPVAPIL IPHKANTDSS IGEFAIDKDT NVLVNLWALH 400
HNEQEWDRPD QFMPERFLDP TGSQIIVPSS SYLPFGAGPR SCVGEALARQ 450
EIFLITAWLL QKFDLEVPEG GQLPSLEGIP KIVFLIDPFK VKITVRPAWK 500
EAQAEGSA 508
Length:508
Mass (Da):57,026
Last modified:November 1, 1996 - v1
Checksum:i5F7D6EBFB5B5CC8E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621P → S in AAB33048. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82878 Genomic DNA. Translation: CAA58059.1.
S75277 mRNA. Translation: AAB33048.1.
PIRiI53018.
S52756.
RefSeqiXP_003475015.1. XM_003474967.1.

Genome annotation databases

EnsembliENSCPOT00000014691; ENSCPOP00000013107; ENSCPOG00000014546.
GeneIDi100729670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X82878 Genomic DNA. Translation: CAA58059.1 .
S75277 mRNA. Translation: AAB33048.1 .
PIRi I53018.
S52756.
RefSeqi XP_003475015.1. XM_003474967.1.

3D structure databases

ProteinModelPortali Q64410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000013107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000014691 ; ENSCPOP00000013107 ; ENSCPOG00000014546 .
GeneIDi 100729670.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00750000117317.
HOGENOMi HOG000036991.
HOVERGENi HBG106944.
InParanoidi Q64410.
OrthoDBi EOG7RBZ85.
TreeFami TF105095.

Enzyme and pathway databases

UniPathwayi UPA00062 .
BRENDAi 1.14.99.9. 1225.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of guinea pig adrenal CYP17."
    Huang Y., Voigt J.M., Colby H.D.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: English short hair.
    Tissue: Adrenal cortex.
  2. "Molecular cloning and expression of guinea pig cytochrome P450c17 cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue distribution, regulation, and substrate specificity of the expressed enzyme."
    Tremblay Y., Fleury A., Beaudoin C., Vallee M., Belanger A.
    DNA Cell Biol. 13:1199-1212(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adrenal gland.
  3. "Partial amino acid sequences of two mitochondrial and two microsomal cytochrome P-450's from adrenal cortex."
    Ogishima T., Okada Y., Kominami S., Takemori S., Omura T.
    J. Biochem. 94:1711-1714(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-15.

Entry informationi

Entry nameiCP17A_CAVPO
AccessioniPrimary (citable) accession number: Q64410
Secondary accession number(s): Q64659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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