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Q64409

- CP3AH_CAVPO

UniProt

Q64409 - CP3AH_CAVPO

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Protein
Cytochrome P450 3A17
Gene
CYP3A17
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A17 (EC:1.14.14.1)
Alternative name(s):
CYPIIIA17
Gene namesi
Name:CYP3A17
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Cytochrome P450 3A17
PRO_0000051800Add
BLAST

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000011684.

Structurei

3D structure databases

ProteinModelPortaliQ64409.
SMRiQ64409. Positions 30-496.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiQ64409.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q64409-1 [UniParc]FASTAAdd to Basket

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MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV    50
LSYRKGIWNF DIECHKKYGN MWGLYDGPRP VLSITEPDMI KAVLVKECYS 100
VFTNRRSIFP AGFMKKALSI SKDEEWKRIR TQLSQNFTSG KLKEMFPIIK 150
QYGDVLVKNL RQEAEKGKPV QLKEIFGAYS MDIIIATAFG VNVDSLNNPH 200
DPFVSKASKL FRFDFLSPFL LSVVIFPFLT QLYEMLNISI FPRDSLNFFT 250
KFVKRTKENH LESNEKQRVN FLQMMLKSQN FKDTESHKAL SDVEILAQSI 300
FFIVAGYETT SSTLCFIMYS LATHPDVQKK LQQEIDKTLP NKAFPTYDVM 350
MEMEYLDMVV NETLRLYPVT NRIERMSKKD FEINGMSFPK GTGVMIPSFA 400
LHRDSKYWPE PDEFRPERFS KKNKENIDPY IYMPFGNGPR NCIGMRMALM 450
NLKLALIRLL QNFSFYTCKE TQIPLRLGSQ VILQPAKPII LKVVSRDETI 500
RGA 503
Length:503
Mass (Da):58,203
Last modified:November 1, 1996 - v1
Checksum:i48A676A491F89047
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28515 mRNA. Translation: BAA05873.1.
RefSeqiNP_001166540.1. NM_001173069.1.

Genome annotation databases

GeneIDi100301487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D28515 mRNA. Translation: BAA05873.1 .
RefSeqi NP_001166540.1. NM_001173069.1.

3D structure databases

ProteinModelPortali Q64409.
SMRi Q64409. Positions 30-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000011684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100301487.

Organism-specific databases

CTDi 100301487.

Phylogenomic databases

HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi Q64409.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
    Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
    Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hartley.
    Tissue: Liver.

Entry informationi

Entry nameiCP3AH_CAVPO
AccessioniPrimary (citable) accession number: Q64409
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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