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Q64409 (CP3AH_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 3A17

EC=1.14.14.1
Alternative name(s):
CYPIIIA17
Gene names
Name:CYP3A17
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length503 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 503503Cytochrome P450 3A17
PRO_0000051800

Sites

Metal binding4421Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64409 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 48A676A491F89047

FASTA50358,203
        10         20         30         40         50         60 
MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV LSYRKGIWNF 

        70         80         90        100        110        120 
DIECHKKYGN MWGLYDGPRP VLSITEPDMI KAVLVKECYS VFTNRRSIFP AGFMKKALSI 

       130        140        150        160        170        180 
SKDEEWKRIR TQLSQNFTSG KLKEMFPIIK QYGDVLVKNL RQEAEKGKPV QLKEIFGAYS 

       190        200        210        220        230        240 
MDIIIATAFG VNVDSLNNPH DPFVSKASKL FRFDFLSPFL LSVVIFPFLT QLYEMLNISI 

       250        260        270        280        290        300 
FPRDSLNFFT KFVKRTKENH LESNEKQRVN FLQMMLKSQN FKDTESHKAL SDVEILAQSI 

       310        320        330        340        350        360 
FFIVAGYETT SSTLCFIMYS LATHPDVQKK LQQEIDKTLP NKAFPTYDVM MEMEYLDMVV 

       370        380        390        400        410        420 
NETLRLYPVT NRIERMSKKD FEINGMSFPK GTGVMIPSFA LHRDSKYWPE PDEFRPERFS 

       430        440        450        460        470        480 
KKNKENIDPY IYMPFGNGPR NCIGMRMALM NLKLALIRLL QNFSFYTCKE TQIPLRLGSQ 

       490        500 
VILQPAKPII LKVVSRDETI RGA 

« Hide

References

[1]"Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hartley.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D28515 mRNA. Translation: BAA05873.1.
RefSeqNP_001166540.1. NM_001173069.1.

3D structure databases

ProteinModelPortalQ64409.
SMRQ64409. Positions 30-496.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000011684.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100301487.

Organism-specific databases

CTD100301487.

Phylogenomic databases

HOGENOMHOG000039127.
HOVERGENHBG108567.
InParanoidQ64409.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP3AH_CAVPO
AccessionPrimary (citable) accession number: Q64409
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families