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Q64409

- CP3AH_CAVPO

UniProt

Q64409 - CP3AH_CAVPO

Protein

Cytochrome P450 3A17

Gene

CYP3A17

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi442 – 4421Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 3A17 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIIA17
    Gene namesi
    Name:CYP3A17
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Cytochrome P450 3A17PRO_0000051800Add
    BLAST

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Interactioni

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000011684.

    Structurei

    3D structure databases

    ProteinModelPortaliQ64409.
    SMRiQ64409. Positions 30-496.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000039127.
    HOVERGENiHBG108567.
    InParanoidiQ64409.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q64409-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIPSFSLE TWVLLALSLV LLYQYATYSH GFFKKLGIPG PKPLPLFGNV    50
    LSYRKGIWNF DIECHKKYGN MWGLYDGPRP VLSITEPDMI KAVLVKECYS 100
    VFTNRRSIFP AGFMKKALSI SKDEEWKRIR TQLSQNFTSG KLKEMFPIIK 150
    QYGDVLVKNL RQEAEKGKPV QLKEIFGAYS MDIIIATAFG VNVDSLNNPH 200
    DPFVSKASKL FRFDFLSPFL LSVVIFPFLT QLYEMLNISI FPRDSLNFFT 250
    KFVKRTKENH LESNEKQRVN FLQMMLKSQN FKDTESHKAL SDVEILAQSI 300
    FFIVAGYETT SSTLCFIMYS LATHPDVQKK LQQEIDKTLP NKAFPTYDVM 350
    MEMEYLDMVV NETLRLYPVT NRIERMSKKD FEINGMSFPK GTGVMIPSFA 400
    LHRDSKYWPE PDEFRPERFS KKNKENIDPY IYMPFGNGPR NCIGMRMALM 450
    NLKLALIRLL QNFSFYTCKE TQIPLRLGSQ VILQPAKPII LKVVSRDETI 500
    RGA 503
    Length:503
    Mass (Da):58,203
    Last modified:November 1, 1996 - v1
    Checksum:i48A676A491F89047
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28515 mRNA. Translation: BAA05873.1.
    RefSeqiNP_001166540.1. NM_001173069.1.

    Genome annotation databases

    GeneIDi100301487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28515 mRNA. Translation: BAA05873.1 .
    RefSeqi NP_001166540.1. NM_001173069.1.

    3D structure databases

    ProteinModelPortali Q64409.
    SMRi Q64409. Positions 30-496.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000011684.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100301487.

    Organism-specific databases

    CTDi 100301487.

    Phylogenomic databases

    HOGENOMi HOG000039127.
    HOVERGENi HBG108567.
    InParanoidi Q64409.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR008072. Cyt_P450_E_CYP3A.
    IPR002402. Cyt_P450_E_grp-II.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00464. EP450II.
    PR01689. EP450IICYP3A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs."
      Mori T., Itoh S., Ohgiya S., Ishizaki K., Kamataki T.
      Arch. Biochem. Biophys. 348:268-277(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hartley.
      Tissue: Liver.

    Entry informationi

    Entry nameiCP3AH_CAVPO
    AccessioniPrimary (citable) accession number: Q64409
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3