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Q64408

- C11B1_CAVPO

UniProt

Q64408 - C11B1_CAVPO

Protein

Cytochrome P450 11B1, mitochondrial

Gene

CYP11B1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

    Catalytic activityi

    A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi447 – 4471Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. steroid 11-beta-monooxygenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. steroid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Lipid metabolism, Steroid metabolism, Steroidogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 11B1, mitochondrial
    Alternative name(s):
    Aldosterone synthase
    CYPXIB1
    Cytochrome P450C11
    Steroid 11-beta-hydroxylase (EC:1.14.15.4)
    Gene namesi
    Name:CYP11B1
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424MitochondrionAdd
    BLAST
    Chaini25 – 500476Cytochrome P450 11B1, mitochondrialPRO_0000003595Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ64408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000013161.
    HOVERGENiHBG051098.
    InParanoidiQ64408.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q64408-1 [UniParc]FASTAAdd to Basket

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    MAFRLKSDVR LAGSWLCLRG ARALGTRAVT ASKASVLPFE VIPQHQGNKR    50
    QRVLQFWKEQ NHDDLHLEMH QTFQELGPIF RCDVGSTRIV AVMLPEDCAR 100
    LHQAESPYPH RMHLEPWMAY REHRRQNLGV FLLNGPEWLS NRRWLNPNVL 150
    SPKAVQNLLP MVDTVARDFS EALKQKVLQS AQGSLTMDMQ PDIHKYTVEV 200
    SNFALFGERL GLFGCNPSSQ SLKFIHALEA VFKTTTQLMF LPRSLSRWMR 250
    SQAWKEHFEA WDYISEYAEN RIQKKYEELA RGCSQYNSIV ANLMLQGNLP 300
    LRAMKANIMD LVAGSVDTTA LPLMMTLFEL ARNPTVQQAL RQESMATEPN 350
    IYENPQRLRM ELPLLWAAIK ETLRMYPVGL FLERFLTSPL VLQNYHIPAG 400
    TLVHLNLYSM GRNPEVFLSP EHYNPQRWLE NKETYKHLAF GFGVRQCIGR 450
    RLAEVEMLLF LHHVLKSFCV ETAFQEDVKF AYRFVMMPTS APLLTFRPVS 500
    Length:500
    Mass (Da):57,820
    Last modified:November 1, 1996 - v1
    Checksum:iC4B5AB6041CD4AF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69785 mRNA. Translation: CAA93633.1.
    PIRiJC4709.
    RefSeqiNP_001166410.1. NM_001172939.1.

    Genome annotation databases

    GeneIDi100135511.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69785 mRNA. Translation: CAA93633.1 .
    PIRi JC4709.
    RefSeqi NP_001166410.1. NM_001172939.1.

    3D structure databases

    ProteinModelPortali Q64408.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100135511.

    Organism-specific databases

    CTDi 1584.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000013161.
    HOVERGENi HBG051098.
    InParanoidi Q64408.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and functional expression of the cytochrome P450 11B-hydroxylase of the guinea pig."
      Buelow H.E., Mobius K., Bahr V., Bernhardt R.
      Biochem. Biophys. Res. Commun. 221:304-312(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Dunkin-Hartley.
      Tissue: Adrenal gland.

    Entry informationi

    Entry nameiC11B1_CAVPO
    AccessioniPrimary (citable) accession number: Q64408
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3