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Q64408 (C11B1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 11B1, mitochondrial
Alternative name(s):
Aldosterone synthase
CYPXIB1
Cytochrome P450C11
Steroid 11-beta-hydroxylase
EC=1.14.15.4
Gene names
Name:CYP11B1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

Catalytic activity

A steroid + reduced adrenodoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenodoxin + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Mitochondrion membrane.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion
Chain25 – 500476Cytochrome P450 11B1, mitochondrial
PRO_0000003595

Sites

Metal binding4471Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q64408 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C4B5AB6041CD4AF2

FASTA50057,820
        10         20         30         40         50         60 
MAFRLKSDVR LAGSWLCLRG ARALGTRAVT ASKASVLPFE VIPQHQGNKR QRVLQFWKEQ 

        70         80         90        100        110        120 
NHDDLHLEMH QTFQELGPIF RCDVGSTRIV AVMLPEDCAR LHQAESPYPH RMHLEPWMAY 

       130        140        150        160        170        180 
REHRRQNLGV FLLNGPEWLS NRRWLNPNVL SPKAVQNLLP MVDTVARDFS EALKQKVLQS 

       190        200        210        220        230        240 
AQGSLTMDMQ PDIHKYTVEV SNFALFGERL GLFGCNPSSQ SLKFIHALEA VFKTTTQLMF 

       250        260        270        280        290        300 
LPRSLSRWMR SQAWKEHFEA WDYISEYAEN RIQKKYEELA RGCSQYNSIV ANLMLQGNLP 

       310        320        330        340        350        360 
LRAMKANIMD LVAGSVDTTA LPLMMTLFEL ARNPTVQQAL RQESMATEPN IYENPQRLRM 

       370        380        390        400        410        420 
ELPLLWAAIK ETLRMYPVGL FLERFLTSPL VLQNYHIPAG TLVHLNLYSM GRNPEVFLSP 

       430        440        450        460        470        480 
EHYNPQRWLE NKETYKHLAF GFGVRQCIGR RLAEVEMLLF LHHVLKSFCV ETAFQEDVKF 

       490        500 
AYRFVMMPTS APLLTFRPVS 

« Hide

References

[1]"Molecular cloning and functional expression of the cytochrome P450 11B-hydroxylase of the guinea pig."
Buelow H.E., Mobius K., Bahr V., Bernhardt R.
Biochem. Biophys. Res. Commun. 221:304-312(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Dunkin-Hartley.
Tissue: Adrenal gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z69785 mRNA. Translation: CAA93633.1.
PIRJC4709.
RefSeqNP_001166410.1. NM_001172939.1.

3D structure databases

ProteinModelPortalQ64408.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100135511.

Organism-specific databases

CTD1584.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000013161.
HOVERGENHBG051098.
InParanoidQ64408.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC11B1_CAVPO
AccessionPrimary (citable) accession number: Q64408
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families